The 6 references with contexts in paper E. Beskhmelnitsyna A., D. Kravchenko V., M. Pokrovsky V., M. Korokin V., A. Peresypkina A., E. Varavin I., D. Kostina A., Е. Бесхмельницына А., Д. Кравченко В., М. Покровский В., М. Корокин В., А. Пересыпкина А., Е. Варавин И., Д. Костина А. (2018) “Молекулярный поиск перспективных молекул-кандидатов в селективные антагонисты ионного канала TRPA1 // Molecular screening for potential selective antagonists of TRPA1 ion channel” / spz:neicon:vedomostincesmp:y:2017:i:3:p:186-189

1
Tactics and emergency treatment of pain. Research and information material. Moscow: Association of Moscow universities; 2010 (in Russian).
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    ñîâðåìåííîì ýòàïå èññëåäîâàíèÿ ôèçèîëîãèè è ïàòîôèçèîëîãèè áîëè ñ ïðèìåíåíèåì íîâåéøèõ äîñòèæåíèé â îáëàñòè íàóêè è òåõíèêè ïðèâåëè ê îòêðûòèþ íîâûõ ðåöåïòîðîâ, ó÷àñòâóþùèõ â ïåðåäà÷å áîëåâûõ ðàçäðàæåíèé, ÷òî îòêðûëî ïåðñïåêòèâó íà ñîçäàíèå êà÷åñòâåííî íîâîé ãðóïïû àíàëüãåòè÷åñêèõ ëåêàðñòâåííûõ ïðåïàðàòîâ, ñïîñîáíûõ îáåñïå÷èòü äîñòàòî÷íî ýôôåêòèâíóþ è áåçîïàñíóþ ôàðìàêîòåðàïèþ áîëåâîãî ñèíäðîìà
    Exact
    [1]
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    . Îäíèì èç òàêèõ ðåöåïòîðîâ ÿâëÿåòñÿ àíêèðèíîâûé ðåöåïòîð TRPA1, ýêñïðåññèÿ êîòîðîãî íàèáîëåå âûðàæåíà â íîöèöåïòîðàõ ìàëîãî äèàìåòðà [2–5]. Ïðîâîäèìîå íà ñåãîäíÿøíèé äåíü îãðîìíîå êîëè÷åñòâî èññëåäîâàíèé ïîäòâåðäèëî åãî ðîëü â âîñïðèÿòèè áîëè, ÷òî ïîâûñèëî ê íåìó èíòåðåñ èññëåäîâàòåëåé êàê ê ïîòåíöèàëüíîé áèîëîãè÷åñêîé ìèøåíè [6–8].

2
Jordt SE, Bautista DM, Chuang HH, McKemy DD, Zygmunt PM, Hogestatt ED, et al. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 2004; 427(6971): 260–5.
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    íîâûõ ðåöåïòîðîâ, ó÷àñòâóþùèõ â ïåðåäà÷å áîëåâûõ ðàçäðàæåíèé, ÷òî îòêðûëî ïåðñïåêòèâó íà ñîçäàíèå êà÷åñòâåííî íîâîé ãðóïïû àíàëüãåòè÷åñêèõ ëåêàðñòâåííûõ ïðåïàðàòîâ, ñïîñîáíûõ îáåñïå÷èòü äîñòàòî÷íî ýôôåêòèâíóþ è áåçîïàñíóþ ôàðìàêîòåðàïèþ áîëåâîãî ñèíäðîìà [1]. Îäíèì èç òàêèõ ðåöåïòîðîâ ÿâëÿåòñÿ àíêèðèíîâûé ðåöåïòîð TRPA1, ýêñïðåññèÿ êîòîðîãî íàèáîëåå âûðàæåíà â íîöèöåïòîðàõ ìàëîãî äèàìåòðà
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    . Ïðîâîäèìîå íà ñåãîäíÿøíèé äåíü îãðîìíîå êîëè÷åñòâî èññëåäîâàíèé ïîäòâåðäèëî åãî ðîëü â âîñïðèÿòèè áîëè, ÷òî ïîâûñèëî ê íåìó èíòåðåñ èññëåäîâàòåëåé êàê ê ïîòåíöèàëüíîé áèîëîãè÷åñêîé ìèøåíè [6–8]. Íåêîòîðûå àâòîðû îòìå÷àëè äàæå óâåëè÷åíèå ýêñïðåññèè TRPA1â óñëîâèÿõ õðîíè÷åñêîé áîëè è âîñïàëåíèÿ [9–12].

6
Asai Y, Holt JR, Geleoc GS. A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea. J Assoc Res Otolaryngol. 2010; 11(1): 27–37.
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    Îäíèì èç òàêèõ ðåöåïòîðîâ ÿâëÿåòñÿ àíêèðèíîâûé ðåöåïòîð TRPA1, ýêñïðåññèÿ êîòîðîãî íàèáîëåå âûðàæåíà â íîöèöåïòîðàõ ìàëîãî äèàìåòðà [2–5]. Ïðîâîäèìîå íà ñåãîäíÿøíèé äåíü îãðîìíîå êîëè÷åñòâî èññëåäîâàíèé ïîäòâåðäèëî åãî ðîëü â âîñïðèÿòèè áîëè, ÷òî ïîâûñèëî ê íåìó èíòåðåñ èññëåäîâàòåëåé êàê ê ïîòåíöèàëüíîé áèîëîãè÷åñêîé ìèøåíè
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    . Íåêîòîðûå àâòîðû îòìå÷àëè äàæå óâåëè÷åíèå ýêñïðåññèè TRPA1â óñëîâèÿõ õðîíè÷åñêîé áîëè è âîñïàëåíèÿ [9–12]. Ñåãîäíÿ ðÿä çàïàäíûõ ôàðìàöåâòè÷åñêèõ êîìïàíèé ðàáîòàåò íàä âûâîäîì íà ðûíîê íîâûõ ëåêàðñòâåííûõ ïðåïàðàòîâ íà îñíîâå ñåëåêòèâíûõ àíòàãîíèñòîâ èîííîãî êàíàëà TRPA1, êîòîðûå íàõîäÿòñÿ íà ðàçíûõ ôàçàõ êëèíè÷åñêèõ èñïûòàíèé [13, 14].

9
Nie Y, Huang C, Zhong C, Wortley MA, Luo Y, Luo W, et al. Cigarette smoke extract (CSE) induces transient receptor potential ankyrin 1 (TRPA1) expression via activation of HIF1áin A549 cells. Free Radic Biol Med. 2016; (99): 498–507.
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    Ïðîâîäèìîå íà ñåãîäíÿøíèé äåíü îãðîìíîå êîëè÷åñòâî èññëåäîâàíèé ïîäòâåðäèëî åãî ðîëü â âîñïðèÿòèè áîëè, ÷òî ïîâûñèëî ê íåìó èíòåðåñ èññëåäîâàòåëåé êàê ê ïîòåíöèàëüíîé áèîëîãè÷åñêîé ìèøåíè [6–8]. Íåêîòîðûå àâòîðû îòìå÷àëè äàæå óâåëè÷åíèå ýêñïðåññèè TRPA1â óñëîâèÿõ õðîíè÷åñêîé áîëè è âîñïàëåíèÿ
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    . Ñåãîäíÿ ðÿä çàïàäíûõ ôàðìàöåâòè÷åñêèõ êîìïàíèé ðàáîòàåò íàä âûâîäîì íà ðûíîê íîâûõ ëåêàðñòâåííûõ ïðåïàðàòîâ íà îñíîâå ñåëåêòèâíûõ àíòàãîíèñòîâ èîííîãî êàíàëà TRPA1, êîòîðûå íàõîäÿòñÿ íà ðàçíûõ ôàçàõ êëèíè÷åñêèõ èñïûòàíèé [13, 14].

13
Skerratt S. Recent Progress in the Discovery and Development of TRPA1 Modulators. Prog Med Chem. 2017; (56): 81–115.
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    Ñåãîäíÿ ðÿä çàïàäíûõ ôàðìàöåâòè÷åñêèõ êîìïàíèé ðàáîòàåò íàä âûâîäîì íà ðûíîê íîâûõ ëåêàðñòâåííûõ ïðåïàðàòîâ íà îñíîâå ñåëåêòèâíûõ àíòàãîíèñòîâ èîííîãî êàíàëà TRPA1, êîòîðûå íàõîäÿòñÿ íà ðàçíûõ ôàçàõ êëèíè÷åñêèõ èñïûòàíèé
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    . Öåëü ðàáîòû– ïîäòâåðæäåíèå àêòèâíîñòè ïåðñïåêòèâíûõ ìîëåêóë-êàíäèäàòîâ â ñåëåêòèâíûå àíòàãîíèñòû èîííîãî êàíàëà TRPA1, ïîëó÷åííûõ â ðåçóëüòàòå âûñîêîïðîèçâîäèòåëüíîãî ñêðèíèíãà ñôîêóñèðîâàííîé áèáëèîòåêè.

14
Mukhopadhyay I, Kulkarni A, Aranake S, Karnik P, Shetty M, Thorat S, et al. Transient receptor potential ankyrin 1 receptor activation in vitro and in vivo by pro-tussive agents: GRC 17536 as a promising anti-tussive therapeutic. PLoS One 2014; 9(5): e97005. AUTHORS
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    Ñåãîäíÿ ðÿä çàïàäíûõ ôàðìàöåâòè÷åñêèõ êîìïàíèé ðàáîòàåò íàä âûâîäîì íà ðûíîê íîâûõ ëåêàðñòâåííûõ ïðåïàðàòîâ íà îñíîâå ñåëåêòèâíûõ àíòàãîíèñòîâ èîííîãî êàíàëà TRPA1, êîòîðûå íàõîäÿòñÿ íà ðàçíûõ ôàçàõ êëèíè÷åñêèõ èñïûòàíèé
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    . Öåëü ðàáîòû– ïîäòâåðæäåíèå àêòèâíîñòè ïåðñïåêòèâíûõ ìîëåêóë-êàíäèäàòîâ â ñåëåêòèâíûå àíòàãîíèñòû èîííîãî êàíàëà TRPA1, ïîëó÷åííûõ â ðåçóëüòàòå âûñîêîïðîèçâîäèòåëüíîãî ñêðèíèíãà ñôîêóñèðîâàííîé áèáëèîòåêè.