The 8 references with contexts in paper O. Baturina A., E. Chaykovskaya V., E. Gernikova P., T. Bokovikova N., L. Stronova A., Yu. Biglova R., S. Manaeva A., E. Tolmacheva S., О. Батурина А., Е. Чайковская В., Е. Герникова П., Т. Боковикова Н., Л. Стронова А., Ю. Биглова Р., С. Манаева А., Е. Толмачева С. (2018) “Обоснование выбора условий определения родственных примесей методом ВЭЖХ в фармацевтической субстанции бисопролола фумарат // Substantiation of conditions for determination of related substances in bisoprolol fumarate by HPLC” / spz:neicon:vedomostincesmp:y:2017:i:3:p:164-169

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Bisoprolol. Patient information, use and formula. Register of medicines marketed in Russia [Internet]. 2017 [cited 2017 June 16]. Available from: https://goo.gl/PY254m (in Russian).
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    Áèñîïðîëîë — ëåêàðñòâåííûé ïðåïàðàò ãðóïïû áåòà-àäðåíîáëîêàòîðîâ, øèðîêî ïðèìåíÿåìûé äëÿ ëå÷åíèÿ ñåðäå÷íî-ñîñóäèñòûõ çàáîëåâàíèé è ãèïåðòîíèè, îáëàäàåò âûðàæåííûì ïðîòèâîèøåìè÷åñêèì äåéñòâèåì, ïîçâîëÿåò ñíèçèòü óðîâåíü àðòåðèàëüíîãî äàâëåíèÿ è íîðìàëèçîâàòü ÷àñòîòó ñåðäå÷íûõ ñîêðàùåíèé, áëîêèðóåò âûðàáîòêó àäðåíàëèíà, ïðîâîöèðóþùåãî ñòîéêîå ïîâûøåíèå àðòåðèàëüíîãî äàâëåíèÿ
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    . Áèñîïðîëîë âêëþ÷åí â «Ïåðå÷åíü æèçíåííî íåîáõîäèìûõ è âàæíåéøèõ ëåêàðñòâåííûõ ïðåïàðàòîâ äëÿ ìåäèöèíñêîãî ïðèìåíåíèÿ íà 2017 ãîä »[2, 3], à òàêæå â «Ïåðå÷åíü îñíîâíûõ ëåêàðñòâåííûõ ñðåäñòâ Âñåìèðíîé îðãàíèçàöèè çäðàâîîõðàíåíèÿ »[4].

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Order of the Government of the Russian Federation of 28.12.2016, No. 2885-r «On the approval of the list of vital and essential drugs for 2017». Available from: https://goo.gl/vgvPzL (in Russian).
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    çàáîëåâàíèé è ãèïåðòîíèè, îáëàäàåò âûðàæåííûì ïðîòèâîèøåìè÷åñêèì äåéñòâèåì, ïîçâîëÿåò ñíèçèòü óðîâåíü àðòåðèàëüíîãî äàâëåíèÿ è íîðìàëèçîâàòü ÷àñòîòó ñåðäå÷íûõ ñîêðàùåíèé, áëîêèðóåò âûðàáîòêó àäðåíàëèíà, ïðîâîöèðóþùåãî ñòîéêîå ïîâûøåíèå àðòåðèàëüíîãî äàâëåíèÿ [1]. Áèñîïðîëîë âêëþ÷åí â «Ïåðå÷åíü æèçíåííî íåîáõîäèìûõ è âàæíåéøèõ ëåêàðñòâåííûõ ïðåïàðàòîâ äëÿ ìåäèöèíñêîãî ïðèìåíåíèÿ íà 2017 ãîä »
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    , à òàêæå â «Ïåðå÷åíü îñíîâíûõ ëåêàðñòâåííûõ ñðåäñòâ Âñåìèðíîé îðãàíèçàöèè çäðàâîîõðàíåíèÿ »[4].  Ãîñóäàðñòâåííîé ôàðìàêîïåå Ðîññèéñêîé Ôåäåðàöèè (ÃÔ ÐÔ) XIII èçäàíèÿ ôàðìàêîïåéíàÿ ñòàòüÿ íà ôàðìàöåâòè÷åñêóþ ñóáñòàíöèþ (ÔÑ) áèñîïðîëîëà ôóìàðàò íå ïðåäñòàâëåíà, â ñâÿçè ñ ýòèì ÿâëÿåòñÿ àêòóàëüíûì ôîðìèðîâàíèå ôàðìàêîïåéíîãî ñòàíäàðòà, ðåãëàìåíòèðóþùåãî êà÷åñòâî äàííîé ÔÑ, âûáîð ïîêàçàòåëåé êà

3
Romanov BK, Olefir YuV, Merkulov VA, Pegova YuO. The revision of the restrictive lists of medicinal products. Safety and Risks of Pharmacotherapy 2016; (1): 5–9 (in Russian).
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    çàáîëåâàíèé è ãèïåðòîíèè, îáëàäàåò âûðàæåííûì ïðîòèâîèøåìè÷åñêèì äåéñòâèåì, ïîçâîëÿåò ñíèçèòü óðîâåíü àðòåðèàëüíîãî äàâëåíèÿ è íîðìàëèçîâàòü ÷àñòîòó ñåðäå÷íûõ ñîêðàùåíèé, áëîêèðóåò âûðàáîòêó àäðåíàëèíà, ïðîâîöèðóþùåãî ñòîéêîå ïîâûøåíèå àðòåðèàëüíîãî äàâëåíèÿ [1]. Áèñîïðîëîë âêëþ÷åí â «Ïåðå÷åíü æèçíåííî íåîáõîäèìûõ è âàæíåéøèõ ëåêàðñòâåííûõ ïðåïàðàòîâ äëÿ ìåäèöèíñêîãî ïðèìåíåíèÿ íà 2017 ãîä »
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    , à òàêæå â «Ïåðå÷åíü îñíîâíûõ ëåêàðñòâåííûõ ñðåäñòâ Âñåìèðíîé îðãàíèçàöèè çäðàâîîõðàíåíèÿ »[4].  Ãîñóäàðñòâåííîé ôàðìàêîïåå Ðîññèéñêîé Ôåäåðàöèè (ÃÔ ÐÔ) XIII èçäàíèÿ ôàðìàêîïåéíàÿ ñòàòüÿ íà ôàðìàöåâòè÷åñêóþ ñóáñòàíöèþ (ÔÑ) áèñîïðîëîëà ôóìàðàò íå ïðåäñòàâëåíà, â ñâÿçè ñ ýòèì ÿâëÿåòñÿ àêòóàëüíûì ôîðìèðîâàíèå ôàðìàêîïåéíîãî ñòàíäàðòà, ðåãëàìåíòèðóþùåãî êà÷åñòâî äàííîé ÔÑ, âûáîð ïîêàçàòåëåé êà

4
19th Model List of Essential Medicines of the World Health Organization (WHO) (April 2015) [Internet]. 2017 [cited 2017 June 16]. Available from: http://www.apteka.ua/article/333051 (in Russian).
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    Áèñîïðîëîë âêëþ÷åí â «Ïåðå÷åíü æèçíåííî íåîáõîäèìûõ è âàæíåéøèõ ëåêàðñòâåííûõ ïðåïàðàòîâ äëÿ ìåäèöèíñêîãî ïðèìåíåíèÿ íà 2017 ãîä »[2, 3], à òàêæå â «Ïåðå÷åíü îñíîâíûõ ëåêàðñòâåííûõ ñðåäñòâ Âñåìèðíîé îðãàíèçàöèè çäðàâîîõðàíåíèÿ »
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    .  Ãîñóäàðñòâåííîé ôàðìàêîïåå Ðîññèéñêîé Ôåäåðàöèè (ÃÔ ÐÔ) XIII èçäàíèÿ ôàðìàêîïåéíàÿ ñòàòüÿ íà ôàðìàöåâòè÷åñêóþ ñóáñòàíöèþ (ÔÑ) áèñîïðîëîëà ôóìàðàò íå ïðåäñòàâëåíà, â ñâÿçè ñ ýòèì ÿâëÿåòñÿ àêòóàëüíûì ôîðìèðîâàíèå ôàðìàêîïåéíîãî ñòàíäàðòà, ðåãëàìåíòèðóþùåãî êà÷åñòâî äàííîé ÔÑ, âûáîð ïîêàçàòåëåé êà÷åñòâà è ìåòîäîâ àíàëèçà, îáîñíîâàíèå ââîäèìûõ ïðåäåëîâ íîðìèðîâàíèÿ, âûáîð ñòàíäàðòíûõ îáðàçöî

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Mironov AN, Sakaeva IV, Sakanyan EI, Bunyatyan ND, Kovaleva EL, Mit’kina LI, Shemeryankina TB, Yashkir VA. Reference standards in international and domestic pharmaceutical analysis. The Bulletin of the Scientific Centre for Expert Evaluation of Medicinal Products 2012; (3): 56–60 (in Russian).
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    ÷åñêóþ ñóáñòàíöèþ (ÔÑ) áèñîïðîëîëà ôóìàðàò íå ïðåäñòàâëåíà, â ñâÿçè ñ ýòèì ÿâëÿåòñÿ àêòóàëüíûì ôîðìèðîâàíèå ôàðìàêîïåéíîãî ñòàíäàðòà, ðåãëàìåíòèðóþùåãî êà÷åñòâî äàííîé ÔÑ, âûáîð ïîêàçàòåëåé êà÷åñòâà è ìåòîäîâ àíàëèçà, îáîñíîâàíèå ââîäèìûõ ïðåäåëîâ íîðìèðîâàíèÿ, âûáîð ñòàíäàðòíûõ îáðàçöîâ è ãàðìîíèçàöèÿ òðåáîâàíèé ê êà÷åñòâó ÔÑ áèñîïðîëîëà ôóìàðàò ñ òðåáîâàíèÿìè âåäóùèõ ôàðìàêîïåé ìèðà
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    ; è, â ÷àñòíîñòè, ÿâëÿåòñÿ àêòóàëüíûì ðàçðàáîòêà ìåòîäèêè îïðåäåëåíèÿ ðîäñòâåííûõ ïðèìåñåé äëÿ ôàðìàêîïåéíîé ñòàòüè «Áèñîïðîëîëà ôóìàðàò »äëÿ ÃÔ ÐÔ XIV èçäàíèÿ. Ïðîâåäåíû èíôîðìàöèîííî-àíàëèòè÷åñêèå èññëåäîâàíèÿ âîçìîæíûõ ñõåì ñèíòåçà ÔÑ áèñîïðîëîëà ôóìàðàò, ïðåäñòàâëåííûõ ïðè ðåãèñòðàöèè ëåêàðñòâåííîãî ñðåäñòâà, è ìåòîäèê àíàëèçà ðîäñòâåííûõ ïðèìåñåé, âêëþ÷åííûõ êàê â íîðìàòèâíóþ äîêóìåíòàöèþ (ÍÄ

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Kovaleva EL, Bagirova VL, Shanazarov KS. Developing methodological approaches to standartization of pharmaceuticals. Pharmaceutical Chemistry Journal 2010; 44(1): 35–42 (in Russian).
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    ÷åñêóþ ñóáñòàíöèþ (ÔÑ) áèñîïðîëîëà ôóìàðàò íå ïðåäñòàâëåíà, â ñâÿçè ñ ýòèì ÿâëÿåòñÿ àêòóàëüíûì ôîðìèðîâàíèå ôàðìàêîïåéíîãî ñòàíäàðòà, ðåãëàìåíòèðóþùåãî êà÷åñòâî äàííîé ÔÑ, âûáîð ïîêàçàòåëåé êà÷åñòâà è ìåòîäîâ àíàëèçà, îáîñíîâàíèå ââîäèìûõ ïðåäåëîâ íîðìèðîâàíèÿ, âûáîð ñòàíäàðòíûõ îáðàçöîâ è ãàðìîíèçàöèÿ òðåáîâàíèé ê êà÷åñòâó ÔÑ áèñîïðîëîëà ôóìàðàò ñ òðåáîâàíèÿìè âåäóùèõ ôàðìàêîïåé ìèðà
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    ; è, â ÷àñòíîñòè, ÿâëÿåòñÿ àêòóàëüíûì ðàçðàáîòêà ìåòîäèêè îïðåäåëåíèÿ ðîäñòâåííûõ ïðèìåñåé äëÿ ôàðìàêîïåéíîé ñòàòüè «Áèñîïðîëîëà ôóìàðàò »äëÿ ÃÔ ÐÔ XIV èçäàíèÿ. Ïðîâåäåíû èíôîðìàöèîííî-àíàëèòè÷åñêèå èññëåäîâàíèÿ âîçìîæíûõ ñõåì ñèíòåçà ÔÑ áèñîïðîëîëà ôóìàðàò, ïðåäñòàâëåííûõ ïðè ðåãèñòðàöèè ëåêàðñòâåííîãî ñðåäñòâà, è ìåòîäèê àíàëèçà ðîäñòâåííûõ ïðèìåñåé, âêëþ÷åííûõ êàê â íîðìàòèâíóþ äîêóìåíòàöèþ (ÍÄ

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United States Pharmacopeia. 39th ed. [Internet]. 2017 [cited 2017 June 16]. Available from: http:// www.uspnf.com/uspnf.
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    ïðèìåñè ñ íîðìîé ñîäåðæàíèÿ: ïðèìåñèÀ—íåáîëåå 0,3 %, ïðèìåñèŗíåáîëåå0,2%,ïðèìåñèG—íåáîëåå 0,5 %, òàêæå íîðìèðóåòñÿ ñîäåðæàíèå ëþáîé äðóãîé èëè íåèäåíòèôèöèðîâàííîé ïðèìåñè — íå áîëåå 0,1 % è ñóììû ïðèìåñåé — íå áîëåå 0,5 %.  ìîíîãðàôèè «Áèñîïðîëîëà ôóìàðàò »USP íå ïðåäóñìîòðåíû èäåíòèôèêàöèÿ è íîðìèðîâàíèå ñîäåðæàíèÿ åäèíè÷íûõ ïðèìåñåé; íîðìèðóåòñÿ òîëüêî îáùåå èõ ñîäåðæàíèå — íå áîëåå 0,5 %
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    . Àíàëèç òåõíîëîãè÷åñêèõ ïðîöåññîâ ïîëó÷åíèÿ áèñîïðîëîëà ôóìàðàòà ïîêàçàë, ÷òî ñõåìû ñèíòåçà äàííîé ÔÑ ðàçëè÷àþòñÿ êîëè÷åñòâîì ñòàäèé ñèíòåçà è î÷èñòêè (îò ÷åòûðåõ äî ñåìè) è, ñîîòâåòñòâåííî, êîëè÷åñòâîì ïðîìåæóòî÷íûõ ïðîäóêòîâ ñèíòåçà, à òàêæå îñíîâíûìè èñõîäíûìè ïðîäóêòàìè: 4-ãèäðîêñèáåíçèëîâûé ñïèðò, 4-ãèäðîêñèáåíçàëüäåãèä, îêñàçîëèäèíîíà áåíçàëüäåãèä.

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Mit’kina LI, Kovaleva EL. Approaches to evaluation of analytical methods suitability when performing medicines quality evaluation. The Bulletin of the Scientific Centre for Expert Evaluation of Medicinal Products 2012; (2): 6–9 (in Russian). AUTHORS
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    Ïðè ýòîì ó÷èòûâàëè, ÷òî ìåòîäèêà îïðåäåëåíèÿ ðîäñòâåííûõ ïðèìåñåé äîëæíà áûòü ñïåöèôè÷íîé (ïîçâîëÿòü ðàçäåëÿòü ïîñòîðîííèå ïðèìåñè ìåæäó ñîáîé è îòäåëÿòü èõ îò äåéñòâóþùåãî âåùåñòâà), îáëàäàòü äîñòàòî÷íîé ÷óâñòâèòåëüíîñòüþ, áûòü ëèíåéíîé â àíàëèòè÷åñêîé îáëàñòè, èìåòü óäîâëåòâîðèòåëüíóþ ïðåöèçèîííîñòü è ïðàâèëüíîñòü
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    .  ìîíîãðàôèè «Áèñîïðîëîëà ôóìàðàò »USP ïðåäóñìîòðåíî õðîìàòîãðàôèðîâàíèå íà êîëîíêå (L7) 4,6 ìì ́12,5 ñì â èçîêðàòè÷åñêîì ðåæèìå (ïîäâèæíàÿ ôàçà (ÏÔ): âîäà–àöåòîíèòðèë (65:35) ñ äîáàâëåíèåì 5 ìë ãåïòàôòîðìàñëÿíîé êèñëîòû, 5 ìë äèýòèëàìèíà è 2,5 ìë ìóðàâüèíîé êèñëîòû) ñî ñïåêòðîôîòîìåòðè÷åñêèì (ÑÔ) äåòåêòèðîâàíèåì ïðè äëèíå âîëíû — 273 íì.