The 8 references with contexts in paper L. Krasnykh M., V. Smirnov V., G. Vasilenko F., O. Goroshko A., E. Egorenkov A., V. Zozina I., Л. Красных М., В. Смирнов В., Г. Василенко Ф., О. Горошко А., Е. Егоренков А., В. Зозина И. (2018) “Различия в фармакокинетике ибупрофена в моно- и многокомпонентных препаратах // Differences in the pharmacokinetics of ibuprofen in monoand multi-component drugs” / spz:neicon:vedomostincesmp:y:2017:i:2:p:117-121

1
Mazaleuskaya LL, Theken KN, Gong L, Thorn CF, FitzGerald GA, Altman RB, Klein TE. PharmGKB summary: ibuprofen pathways. Pharmacogenet Genomics. 2015; 25(2): 96–106.
Total in-text references: 2
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    Åãî îñíîâíûå ýôôåêòû — æàðîïîíèæàþùèé è ïðîòèâîâîñïàëèòåëüíûé — îïîñðåäîâàíû èíãèáèðîâàíèåì àêòèâíîñòè öèêëîîêñèãåíàçû è, ñîîòâåòñòâåííî, ñèíòåçà ïðîñòàãëàíäèíî⠗ ìåäèàòîðîâ áîëè, âîñïàëåíèÿ è òåìïåðàòóðíîé ðåàêöèè
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    . Èáóïðîôåí òàêæå îáëàäàåò àíàëüãåçèðóþùèì ýôôåêòîì, ÷òî øèðîêî èñïîëüçóåòñÿ äëÿ êóïèðîâàíèÿ ãîëîâíîé áîëè (ìèãðåíè) [2], çóáíîé áîëè [3], áîëè â ãîðëå [4] è ïð. Èáóïðîôåí, îáëàäàÿ âûñîêîé ýôôåêòèâíîñòüþ è íèçêîé òîêñè÷íîñòüþ, øèðîêî ïðèìåíÿåòñÿ ïðè äëèòåëüíîì ëå÷åíèè ðàçëè÷íûõ âîñïàëèòåëüíûõ è äåãåíåðàòèâíûõ çàáîëåâàíèé îïîðíî-äâèãàòåëüíîãî àïïàðàòà [5].

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    Èáóïðîôåí ìåòàáîëèçèðóåòñÿ â ïå÷åíè èçîôåðìåíòàìè öèòîõðîìà Ð450 (CYP) CYP2Ñ9 è CYP2Ñ8. Èìåííî áûñòðûì ìåòàáîëèçìîì è îòñóòñòâèåì îáðàçîâàíèÿ àêòèâíûõ ìåòàáîëèòîâ îáúÿñíÿåòñÿ íèçêàÿ òîêñè÷íîñòü èáóïðîôåíà
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    . Èáóïðîôåí âîçìîæíî èñïîëüçîâàòü êàê â ìîíîòåðàïèè, òàê è â ñîñòàâå êîìáèíèðîâàííîé òåðàïèè â ñî÷åòàíèè ñ äðóãèìè ëåêàðñòâåííûìè ñðåäñòâàìè. Òàê, äîáàâëåíèå ê èáóïðîôåíó òèçàíèäèíà íå òîëüêî ïîâûøàåò ýôôåêòèâíîñòü òåðàïèè, íî è ñíèæàåò ÷àñòîòó íåæåëàòåëüíûõ ÿâëåíèé îò ïðèìåíåíèÿ ÍÏÂÑ.

2
Holland S, Silberstein SD, Freitag F, Dodick DW, Argoff C, Ashman E. Evidence-based guideline update: NSAIDs and other complementary treatments for episodic migraine prevention in adults. Neurology 2012; 78(17): 1346–53.
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    Åãî îñíîâíûå ýôôåêòû — æàðîïîíèæàþùèé è ïðîòèâîâîñïàëèòåëüíûé — îïîñðåäîâàíû èíãèáèðîâàíèåì àêòèâíîñòè öèêëîîêñèãåíàçû è, ñîîòâåòñòâåííî, ñèíòåçà ïðîñòàãëàíäèíî⠗ ìåäèàòîðîâ áîëè, âîñïàëåíèÿ è òåìïåðàòóðíîé ðåàêöèè [1]. Èáóïðîôåí òàêæå îáëàäàåò àíàëüãåçèðóþùèì ýôôåêòîì, ÷òî øèðîêî èñïîëüçóåòñÿ äëÿ êóïèðîâàíèÿ ãîëîâíîé áîëè (ìèãðåíè)
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    [2]
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    , çóáíîé áîëè [3], áîëè â ãîðëå [4] è ïð. Èáóïðîôåí, îáëàäàÿ âûñîêîé ýôôåêòèâíîñòüþ è íèçêîé òîêñè÷íîñòüþ, øèðîêî ïðèìåíÿåòñÿ ïðè äëèòåëüíîì ëå÷åíèè ðàçëè÷íûõ âîñïàëèòåëüíûõ è äåãåíåðàòèâíûõ çàáîëåâàíèé îïîðíî-äâèãàòåëüíîãî àïïàðàòà [5].

3
Hersh EV, Kane WT, O’Neil MG, Kenna GA, Katz NP, Golubic S, et al. Prescribing recommendations for the treatment of acute pain in dentistry. Compend Contin Educ Dent. 2011; 32(3): 24–30.
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    Åãî îñíîâíûå ýôôåêòû — æàðîïîíèæàþùèé è ïðîòèâîâîñïàëèòåëüíûé — îïîñðåäîâàíû èíãèáèðîâàíèåì àêòèâíîñòè öèêëîîêñèãåíàçû è, ñîîòâåòñòâåííî, ñèíòåçà ïðîñòàãëàíäèíî⠗ ìåäèàòîðîâ áîëè, âîñïàëåíèÿ è òåìïåðàòóðíîé ðåàêöèè [1]. Èáóïðîôåí òàêæå îáëàäàåò àíàëüãåçèðóþùèì ýôôåêòîì, ÷òî øèðîêî èñïîëüçóåòñÿ äëÿ êóïèðîâàíèÿ ãîëîâíîé áîëè (ìèãðåíè) [2], çóáíîé áîëè
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    , áîëè â ãîðëå [4] è ïð. Èáóïðîôåí, îáëàäàÿ âûñîêîé ýôôåêòèâíîñòüþ è íèçêîé òîêñè÷íîñòüþ, øèðîêî ïðèìåíÿåòñÿ ïðè äëèòåëüíîì ëå÷åíèè ðàçëè÷íûõ âîñïàëèòåëüíûõ è äåãåíåðàòèâíûõ çàáîëåâàíèé îïîðíî-äâèãàòåëüíîãî àïïàðàòà [5].

4
Brain P, Leyva R, Doyle G, Kellstein D. Onset of analgesia and efficacy of ibuprofen sodium in postsurgical dental pain. Clin J Pain. 2015; 31(5): 444–50.
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    Åãî îñíîâíûå ýôôåêòû — æàðîïîíèæàþùèé è ïðîòèâîâîñïàëèòåëüíûé — îïîñðåäîâàíû èíãèáèðîâàíèåì àêòèâíîñòè öèêëîîêñèãåíàçû è, ñîîòâåòñòâåííî, ñèíòåçà ïðîñòàãëàíäèíî⠗ ìåäèàòîðîâ áîëè, âîñïàëåíèÿ è òåìïåðàòóðíîé ðåàêöèè [1]. Èáóïðîôåí òàêæå îáëàäàåò àíàëüãåçèðóþùèì ýôôåêòîì, ÷òî øèðîêî èñïîëüçóåòñÿ äëÿ êóïèðîâàíèÿ ãîëîâíîé áîëè (ìèãðåíè) [2], çóáíîé áîëè [3], áîëè â ãîðëå
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    è ïð. Èáóïðîôåí, îáëàäàÿ âûñîêîé ýôôåêòèâíîñòüþ è íèçêîé òîêñè÷íîñòüþ, øèðîêî ïðèìåíÿåòñÿ ïðè äëèòåëüíîì ëå÷åíèè ðàçëè÷íûõ âîñïàëèòåëüíûõ è äåãåíåðàòèâíûõ çàáîëåâàíèé îïîðíî-äâèãàòåëüíîãî àïïàðàòà [5].

5
Khalifa N, El-Husseini T, Morrah A, Mostafa E, Hamoud H. Use of ibuprofen sustained release for treating osteoarthritic pain: findings from 15 general medical practices in Egypt. Open Access Rheumatol. 2014; (6): 49–56.
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    Èáóïðîôåí òàêæå îáëàäàåò àíàëüãåçèðóþùèì ýôôåêòîì, ÷òî øèðîêî èñïîëüçóåòñÿ äëÿ êóïèðîâàíèÿ ãîëîâíîé áîëè (ìèãðåíè) [2], çóáíîé áîëè [3], áîëè â ãîðëå [4] è ïð. Èáóïðîôåí, îáëàäàÿ âûñîêîé ýôôåêòèâíîñòüþ è íèçêîé òîêñè÷íîñòüþ, øèðîêî ïðèìåíÿåòñÿ ïðè äëèòåëüíîì ëå÷åíèè ðàçëè÷íûõ âîñïàëèòåëüíûõ è äåãåíåðàòèâíûõ çàáîëåâàíèé îïîðíî-äâèãàòåëüíîãî àïïàðàòà
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    . Îáû÷íàÿ ïåðîðàëüíàÿ äîçà äëÿ âçðîñëûõ ñîñòàâëÿåò 400–800 ìã/ñóò äëÿ ëå÷åíèÿ áîëåâîãî ñèíäðîìà è 1600–2400 ìã/ñóò äëÿ ïðîòèâîâîñïàëèòåëüíîãî äåéñòâèÿ. Àíàëüãåçèðóþùèé ýôôåêò íà÷èíàåòñÿ ÷åðåç 30 ìèí è äëèòñÿ 4–6 ÷, æàðîïîíèæàþùåå äåéñòâèå ïðîÿâëÿåòñÿ ÷åðåç 2–4 ÷ è ïðîäîëæàåòñÿ 4–8 ÷ [6].

6
Beaver WT. Review of the analgesic efficacy of ibuprofen. Int J Clin Pract. 2003; (135): 13–7.
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    Îáû÷íàÿ ïåðîðàëüíàÿ äîçà äëÿ âçðîñëûõ ñîñòàâëÿåò 400–800 ìã/ñóò äëÿ ëå÷åíèÿ áîëåâîãî ñèíäðîìà è 1600–2400 ìã/ñóò äëÿ ïðîòèâîâîñïàëèòåëüíîãî äåéñòâèÿ. Àíàëüãåçèðóþùèé ýôôåêò íà÷èíàåòñÿ ÷åðåç 30 ìèí è äëèòñÿ 4–6 ÷, æàðîïîíèæàþùåå äåéñòâèå ïðîÿâëÿåòñÿ ÷åðåç 2–4 ÷ è ïðîäîëæàåòñÿ 4–8 ÷
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    . Ïîñëå ïðèåìà âíóòðü ïðåïàðàò õîðîøî âñàñûâàåòñÿ â æåëóäî÷íî-êèøå÷íîì òðàêòå. Ïèùà ìàëî âëèÿåò íà áèîäîñòóïíîñòü èáóïðîôåíà, êîòîðàÿ ñîñòàâëÿåò ìåíåå 80 %. Ïðåïàðàò ñâÿçûâàåòñÿ ñ áåëêàìè ïëàçìû íà 90 %, ìåòàáîëèçèðóåòñÿ â ïå÷åíè äî äâóõ íåàêòèâíûõ ìåòàáîëèòîâ, áûñòðî è ïðàêòè÷åñêè ïîëíîñòüþ âûäåëÿåòñÿ ïî÷êàìè.

7
Berry H, Hutchinson DR. Tizanidine and ibuprofen in acute low-back pain: results of a double-blind multicentre study in general practice. J Int Med Res. 1988; 16(2): 83–91.
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    Òàê, äîáàâëåíèå ê èáóïðîôåíó òèçàíèäèíà íå òîëüêî ïîâûøàåò ýôôåêòèâíîñòü òåðàïèè, íî è ñíèæàåò ÷àñòîòó íåæåëàòåëüíûõ ÿâëåíèé îò ïðèìåíåíèÿ ÍÏÂÑ. Ïàöèåíòû, ïîëó÷àâøèå êîìáèíèðîâàííóþ òåðàïèþ èáóïðîôåí/òèçàíèäèí, çíà÷èìî ðåæå îòìå÷àëè ïîáî÷íûå ýôôåêòû ñî ñòîðîíû æåëóäî÷íî-êèøå÷íîãî òðàêòà ïî ñðàâíåíèþ ñ ãðóïïîé ïëàöåáî/èáóïðîôåí (ð< 0,002)
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    . Êîìáèíàöèÿ èáóïðîôåí/ïàðàöåòàìîë ó ïàöèåíòîâ ñ áîëåâûì ñèíäðîìîì ïîñëå ïåðâîãî ïðèìåíåíèÿ äåìîíñòðèðóåò âûðàæåííûé àíàëüãåòè÷åñêèé ýôôåêò, êîòîðûé ñîõðàíÿåòñÿ íåñêîëüêî äîëüøå, ÷åì ïðè ïðèìåíåíèè ìîíîïðåïàðàòîâ è íàðàñòàåò ïîñëå âòîðîãî è òðåòüåãî ïðèåìîâ â òå÷åíèå ïåðâûõ ñóòîê, à ñ òðåòüåãî äíÿ ëå÷åíèÿ ñòàíîâèòñÿ óñòîé÷èâûì è äîñòîâåðíî ïðåâûøàåò àíàëîãè÷íûå ïîêàçàòåëè ìîíîïðåïàðàòîâ [8].

8
Baranova LN, Kupryashina NV, Lvova LV, Mazurenko DV, Morozenko OA, Muratkhuzina AR, et al. Efficacy and safety of fixed ibufprofen/paracetamol combination in fever and pain syndromes in ambulatory practice. Clinical Pharmacology and Therapy 2014; (4): 95–8 (in Russian).
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    Êîìáèíàöèÿ èáóïðîôåí/ïàðàöåòàìîë ó ïàöèåíòîâ ñ áîëåâûì ñèíäðîìîì ïîñëå ïåðâîãî ïðèìåíåíèÿ äåìîíñòðèðóåò âûðàæåííûé àíàëüãåòè÷åñêèé ýôôåêò, êîòîðûé ñîõðàíÿåòñÿ íåñêîëüêî äîëüøå, ÷åì ïðè ïðèìåíåíèè ìîíîïðåïàðàòîâ è íàðàñòàåò ïîñëå âòîðîãî è òðåòüåãî ïðèåìîâ â òå÷åíèå ïåðâûõ ñóòîê, à ñ òðåòüåãî äíÿ ëå÷åíèÿ ñòàíîâèòñÿ óñòîé÷èâûì è äîñòîâåðíî ïðåâûøàåò àíàëîãè÷íûå ïîêàçàòåëè ìîíîïðåïàðàòîâ
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    . Êëèíè÷åñêèé îïûò èñïîëüçîâàíèÿ èáóïðîôåíà ïðè ñàìûõ ÷àñòûõ ôîðìàõ áîëåâûõ ñèíäðîìîâ äåìîíñòðèðóåò åãî ýôôåêòèâíîñòü íå òîëüêî êàê ñðåäñòâà äëÿ êóïèðîâàíèÿ áîëåâûõ ýïèçîäîâ, íî è äëÿ êóðñîâîãî ëå÷åíèÿ õðîíè÷åñêîé áîëè.

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    0,165**0,2883,46**5,53* GMean46,21,12285,4291,20,1600,2933,295,45 SD7,40,5561,265,20,0200,0510,620,70 CV32,229,421,526,312,415,425,014,2 Median47,21,20274,1305,00,1620,2963,115,23 L–9043,41,12269,3286,30,1580,2683,245,35 U–9052,81,38302,2315,00,1720,3003,585,69 *ð< 0,05 **ð> 0,05 ïåâòè÷åñêèé ýôôåêò êîìáèíèðîâàííîé ôîðìû Èáóïðîôåíà (èáóïðîôåí+ïàðàöåòîìîë) ïî ñðàâíåíèþ ñ ìîíîïðåïàðàòîì Èáóïðîôåíà
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    . ËÈÒÅÐÀÒÓÐÀ 1. Mazaleuskaya LL, Theken KN, Gong L, Thorn CF, FitzGerald GA, Altman RB, Klein TE. PharmGKB summary: ibuprofen pathways. Pharmacogenet Genomics. 2015; 25(2): 96–106. 2. Holland S, Silberstein SD, Freitag F, Dodick DW, Argoff C, Ashman E.