The 25 references with contexts in paper A. Osipov S., O. Popova A., T. Gretskaya N., A. Sulimenkova I., M. Nezdolieva V., А. Осипов С., О. Попова А., Т. Грецкая Н., А. Сулименкова И., М. Нездольева В. (2018) “Применение колонок с амино- и нитрильными сорбентами в жидкостной хроматографии гидрофильных взаимодействий // Use of columns with amine and nitrile sorbents for hydrophylic interaction liquid chromatography” / spz:neicon:vedomostincesmp:y:2017:i:1:p:9-14

1
British Pharmacopoeia 2016. Monograph: Hydroxycarbamide Capsules.
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    Prefix
    Äëÿ ýòèõ öåëåé èñïîëüçóþò ëèáî ìåòîäèêó Åâðîïåéñêîé ôàðìàêîïåè (ÒÑÕ íà ïëàñòèíêàõ ñ ñèëèêàãåëåì; ïîäâèæíàÿ ôàçà — ñìåñü ïèðèäèíà, âîäû è ýòèëàöåòàòà (2:2:10), ëèáî ìåòîäèêó Áðèòàíñêîé ôàðìàêîïåè (ÒÑÕ íà ïëàñòèíêàõ ñ öåëëþëîçîé F; ïîäâèæíàÿ ôàçà — ñìåñü óêñóñíîé êèñëîòû, âîäû è áóòàíîëà-1 (1:1:4).  îáåèõ ìåòîäèêàõ ïðîÿâëÿþò ïëàñòèíêè ñîëÿíîêèñëûìè ðàñòâîðàìè äèìåòèëàìèíîáåíçàëüäåãèäà
    Exact
    [1, 2]
    Suffix
    . Ïðèìåíåíèå ìåòîäà ÂÝÆÕ äëÿ ðàçäåëåíèÿ ãèäðîêñèêàðáàìèäà è ìî÷åâèíû â çàðóáåæíûõ ôàðìàêîïåÿõ íå îïèñàíî. Íåîáõîäèìî îòìåòèòü, ÷òî â óñëîâèÿõ îáðàùåííî-ôàçîâîé õðîìàòîãðàôèè ãèäðîêñèêàðáàìèä è ìî÷åâèíà íå ðàçäåëÿþòñÿ.

2
European Pharmacopoeia. 8th ed. Monograph: Hydroxycarbamide.
Total in-text references: 1
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    Äëÿ ýòèõ öåëåé èñïîëüçóþò ëèáî ìåòîäèêó Åâðîïåéñêîé ôàðìàêîïåè (ÒÑÕ íà ïëàñòèíêàõ ñ ñèëèêàãåëåì; ïîäâèæíàÿ ôàçà — ñìåñü ïèðèäèíà, âîäû è ýòèëàöåòàòà (2:2:10), ëèáî ìåòîäèêó Áðèòàíñêîé ôàðìàêîïåè (ÒÑÕ íà ïëàñòèíêàõ ñ öåëëþëîçîé F; ïîäâèæíàÿ ôàçà — ñìåñü óêñóñíîé êèñëîòû, âîäû è áóòàíîëà-1 (1:1:4).  îáåèõ ìåòîäèêàõ ïðîÿâëÿþò ïëàñòèíêè ñîëÿíîêèñëûìè ðàñòâîðàìè äèìåòèëàìèíîáåíçàëüäåãèäà
    Exact
    [1, 2]
    Suffix
    . Ïðèìåíåíèå ìåòîäà ÂÝÆÕ äëÿ ðàçäåëåíèÿ ãèäðîêñèêàðáàìèäà è ìî÷åâèíû â çàðóáåæíûõ ôàðìàêîïåÿõ íå îïèñàíî. Íåîáõîäèìî îòìåòèòü, ÷òî â óñëîâèÿõ îáðàùåííî-ôàçîâîé õðîìàòîãðàôèè ãèäðîêñèêàðáàìèä è ìî÷åâèíà íå ðàçäåëÿþòñÿ.

3
Bobylev PV, Osipov AS, Nechaeva EB, Nozdrin ÊV. Application of high performance liquid chromatography method for the analysis of urea. Development, research and marketing of new pharmaceutical products. Collection of scientific papers. Issue 67. Pyatigorsk; 2012. P. 215–6 (in Russian).
Total in-text references: 1
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    Íåîáõîäèìî îòìåòèòü, ÷òî â óñëîâèÿõ îáðàùåííî-ôàçîâîé õðîìàòîãðàôèè ãèäðîêñèêàðáàìèä è ìî÷åâèíà íå ðàçäåëÿþòñÿ. Ðàíåå áûëà ïîêàçàíà âîçìîæíîñòü ïðèìåíåíèÿ õðîìàòîãðàôè÷åñêèõ êîëîíîê ñ àìèíî- è äèîëüíûìè ñîðáåíòàìè äëÿ àíàëèçà ìî÷åâèíû
    Exact
    [3]
    Suffix
    . Íà õðîìàòîãðàôè÷åñêèõ êîëîíêàõ ñ àìèíî- è äèîëüíûìè ñîðáåíòàìè ãèäðîêñèêàðáàìèä è ìî÷åâèíà òàêæå óâåðåííî ðàçäåëÿþòñÿ â óñëîâèÿõ æèäêîñòíîé õðîìàòîãðàôèè ãèäðîôèëüíûõ âçàèìîäåéñòâèé [4]. Ñëåäóåò îòìåòèòü, ÷òî ñ óâåëè÷åíèåì ñîäåðæàíèÿ àöåòîíèòðèëà â ïîäâèæíîé ôàçå óâåëè÷èâàþòñÿ âðåìåíà óäåðæèâàíèÿ ìî÷åâèíû è ãèäðîêñèêàðáàìèäà, à òàêæå óëó÷øàåòñÿ èõ ðàçäåëåíèå, ÷òî äåìîíñòðèðóåò — íà äàííûõ êîëîíê

4
Osipov AS, Nechaeva EB, Pobedin OA. Application of hydrophilic interaction liquid chromatography for the analysis hydroxycarbamide. Razrabotka i registratsiya lekarstvennyh sredstv 2015; (2): 140–4 (in Russian).
Total in-text references: 2
  1. In-text reference with the coordinate start=4033
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    Ðàíåå áûëà ïîêàçàíà âîçìîæíîñòü ïðèìåíåíèÿ õðîìàòîãðàôè÷åñêèõ êîëîíîê ñ àìèíî- è äèîëüíûìè ñîðáåíòàìè äëÿ àíàëèçà ìî÷åâèíû [3]. Íà õðîìàòîãðàôè÷åñêèõ êîëîíêàõ ñ àìèíî- è äèîëüíûìè ñîðáåíòàìè ãèäðîêñèêàðáàìèä è ìî÷åâèíà òàêæå óâåðåííî ðàçäåëÿþòñÿ â óñëîâèÿõ æèäêîñòíîé õðîìàòîãðàôèè ãèäðîôèëüíûõ âçàèìîäåéñòâèé
    Exact
    [4]
    Suffix
    . Ñëåäóåò îòìåòèòü, ÷òî ñ óâåëè÷åíèåì ñîäåðæàíèÿ àöåòîíèòðèëà â ïîäâèæíîé ôàçå óâåëè÷èâàþòñÿ âðåìåíà óäåðæèâàíèÿ ìî÷åâèíû è ãèäðîêñèêàðáàìèäà, à òàêæå óëó÷øàåòñÿ èõ ðàçäåëåíèå, ÷òî äåìîíñòðèðóåò — íà äàííûõ êîëîíêàõ èìååò ìåñòî íîðìàëüíî-ôàçîâûé ìåõàíèçì ðàçäåëåíèÿ â æèäêîñòíîé õðîìàòîãðàôèè ãèäðîôèëüíûõ âçàèìîäåéñòâèé.

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    Ðèñ. 1.Õðîìàòîãðàììà ïðåïàðàòà «Ãèäðîêñèêàðáàìèä-ËÝÍÑ», êàïñóëû 500 ìã ñ äîáàâêîé ìî÷åâèíû. Óñëîâèÿ àíàëèçà: êîëîíêà Zorbax NH2150 ́4,6 ìì (5 ìêì); ïîäâèæíàÿ ôàçà — àöåòîíèòðèë–âîäà (90:10); ñêîðîñò üïîòîêà — 1 ìë/ìèí; äåòåêòèðîâàíèå 200 íì
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    [4]
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    Ðèñ. 2.Õðîìàòîãðàììà ïðåïàðàòà «Ãèäðîêñèêàðáàìèä-ËÝÍÑ», êàïñóëû 500 ìã ñ äîáàâêîé ìî÷åâèíû. Óñëîâèÿ àíàëèçà: êîëîíêà Zorbax SB CN 150 ́4,6 ìì (5 ìêì); ïîäâèæíàÿ ôàçà — àöåòîíèòðèë–âîäà (93:7); ñêîðîñò üïîòîêà — 1 ìë/ìèí; äåòåêòèðîâàíèå 200 íì [5] Ðèñ. 3.

5
Osipov AS, Nechaeva EB, Truhacheva LA. Application of a chromatographic column with a nitrile sorbent for HPLC analysis hydroxycarbamide. Vedomosti Nauchnogo tsentra ekspertizy sredstv meditsinskogo primeneniya 2016; (3): 58–61 (in Russian).
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    ÷åíèåì ñîäåðæàíèÿ àöåòîíèòðèëà â ïîäâèæíîé ôàçå óâåëè÷èâàþòñÿ âðåìåíà óäåðæèâàíèÿ ìî÷åâèíû è ãèäðîêñèêàðáàìèäà, à òàêæå óëó÷øàåòñÿ èõ ðàçäåëåíèå, ÷òî äåìîíñòðèðóåò — íà äàííûõ êîëîíêàõ èìååò ìåñòî íîðìàëüíî-ôàçîâûé ìåõàíèçì ðàçäåëåíèÿ â æèäêîñòíîé õðîìàòîãðàôèè ãèäðîôèëüíûõ âçàèìîäåéñòâèé. Àíàëîãè÷íàÿ êàðòèíà ðàçäåëåíèÿ àíàëèçèðóåìûõ ñîåäèíåíèé íàáëþäàåòñÿ íà íèòðèëüíîé êîëîíêå Zorbax SB CN
    Exact
    [5]
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    . Íåîáõîäèìî îòìåòèòü, ÷òî íà êîëîíêå Zorbax SB CN ìåíÿåòñÿ î÷åðåäíîñòü ýëþèðîâàíèÿ ãèäðîêñèêàðáàìèäà è ìî÷åâèíû (ðèñ. 1, 2) ïî ñðàâíåíèþ ñ êîëîíêîé Zorbax NH2. ÏÐÈÌÅÍÅÍÈÅ ÆÈÄÊÎÑÒÍÎÉ ÕÐÎÌÀÒÎÃÐÀÔÈÈ ÃÈÄÐÎÔÈËÜÍÛÕ ÂÇÀÈÌÎÄÅÉÑÒÂÈÉ ÄËß ÀÍÀËÈÇÀ ÊÎÎÐÄÈÍÀÖÈÎÍÍÛÕ ÑÎÅÄÈÍÅÍÈÉ ÏËÀÒÈÍÛ Êîîðäèíàöèîííûå ñîåäèíåíèÿ ïëàòèíû (II) ïðèìåíÿþò â ìåäèöèíñêîé ïðàêòèêå äëÿ ëå÷åíèÿ îíêîëîãè÷åñêèõ çàáîëåâàíèé.

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    Óñëîâèÿ àíàëèçà: êîëîíêà Zorbax NH2150 ́4,6 ìì (5 ìêì); ïîäâèæíàÿ ôàçà — àöåòîíèòðèë–âîäà (90:10); ñêîðîñò üïîòîêà — 1 ìë/ìèí; äåòåêòèðîâàíèå 200 íì [4] Ðèñ. 2.Õðîìàòîãðàììà ïðåïàðàòà «Ãèäðîêñèêàðáàìèä-ËÝÍÑ», êàïñóëû 500 ìã ñ äîáàâêîé ìî÷åâèíû. Óñëîâèÿ àíàëèçà: êîëîíêà Zorbax SB CN 150 ́4,6 ìì (5 ìêì); ïîäâèæíàÿ ôàçà — àöåòîíèòðèë–âîäà (93:7); ñêîðîñò üïîòîêà — 1 ìë/ìèí; äåòåêòèðîâàíèå 200 íì
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    [5]
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    Ðèñ. 3.Õðîìàòîãðàììà ðàçäåëåíèÿ ñìåñè ñòàíäàðòíûõ îáðàçöîâ êîîðäèíàöèîííûõ ñîåäèíåíèé ïëàòèíû íà êîëîíêå Equisil APS-2 150 ́4,6 ìì (3 ìêì) (êîëîíêà ñ àìèíîñîðáåíòîì). Óñëîâèÿ àíàëèçà: ïîäâèæíàÿ ôàçà — àöåòîíèòðèë–âîäà (90:10); ñêîðîñòü ïîòîêà — 1,5 ìë/ìèí; äåòåêòèðîâàíèå ïðè 220 íì [17] Ðèñ. 4.

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United State Pharmacopoeia. 39th ed. Monograph: Cisplatin for Injection.
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     íàñòîÿùåå âðåìÿ èç ëåêàðñòâåííûõ ñðåäñòâ äàííîé ôàðìàêîëîãè÷åñêîé ãðóïïû ïðèìåíÿþò â îñíîâíîì öèñïëàòèí, êàðáîïëàòèí è îêñàëèïëàòèí. Ñëåäóåò áîëåå äåòàëüíî îñòàíîâèòüñÿ íà ïðèìåíåíèè õðîìàòîãðàôè÷åñêèõ êîëîíîê ñ ïðèâèòûìè àìèíîïðîïèëñèëèëüíûìè (àìèíî) ôàçàìè.  ôàðìàêîïåÿõ ÑØÀ è ßïîíèè
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    äëÿ êîëè÷åñòâåííîãî îïðåäåëåíèÿ öèñïëàòèíà ðåêîìåíäîâàíî õðîìàòîãðàôèðîâàíèå íà êîëîíêàõ ñ àìèíîôàçîé (L8 ïî êëàññèôèêàöèè Ôàðìàêîïåè ÑØÀ) ñ èñïîëüçîâàíèåì ïîäâèæíîé ôàçû: ýòèëàöåòàò–ìåòàíîë–äèìåòèëôîðìàìèä–âîäà (25:16:5:5).

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Japanese Pharmacopoeia 2016. Monograph: Cisplatin.
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     íàñòîÿùåå âðåìÿ èç ëåêàðñòâåííûõ ñðåäñòâ äàííîé ôàðìàêîëîãè÷åñêîé ãðóïïû ïðèìåíÿþò â îñíîâíîì öèñïëàòèí, êàðáîïëàòèí è îêñàëèïëàòèí. Ñëåäóåò áîëåå äåòàëüíî îñòàíîâèòüñÿ íà ïðèìåíåíèè õðîìàòîãðàôè÷åñêèõ êîëîíîê ñ ïðèâèòûìè àìèíîïðîïèëñèëèëüíûìè (àìèíî) ôàçàìè.  ôàðìàêîïåÿõ ÑØÀ è ßïîíèè
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    äëÿ êîëè÷åñòâåííîãî îïðåäåëåíèÿ öèñïëàòèíà ðåêîìåíäîâàíî õðîìàòîãðàôèðîâàíèå íà êîëîíêàõ ñ àìèíîôàçîé (L8 ïî êëàññèôèêàöèè Ôàðìàêîïåè ÑØÀ) ñ èñïîëüçîâàíèåì ïîäâèæíîé ôàçû: ýòèëàöåòàò–ìåòàíîë–äèìåòèëôîðìàìèä–âîäà (25:16:5:5).

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British Pharmacopoeia 2016. Monograph: Cisplatin Injection.
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     ôàðìàêîïåÿõ ÑØÀ è ßïîíèè [6, 7] äëÿ êîëè÷åñòâåííîãî îïðåäåëåíèÿ öèñïëàòèíà ðåêîìåíäîâàíî õðîìàòîãðàôèðîâàíèå íà êîëîíêàõ ñ àìèíîôàçîé (L8 ïî êëàññèôèêàöèè Ôàðìàêîïåè ÑØÀ) ñ èñïîëüçîâàíèåì ïîäâèæíîé ôàçû: ýòèëàöåòàò–ìåòàíîë–äèìåòèëôîðìàìèä–âîäà (25:16:5:5).  ñîîòâåòñòâóþùåé ìîíîãðàôèè Áðèòàíñêîé ôàðìàêîïåè (ÂÐ)
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    äëÿ êîëè÷åñòâåííîãî îïðåäåëåíèè öèñïëàòèíà íà êîëîíêå Lichrosorb NH2èñïîëüçóåòñÿ ïîäâèæíàÿ ôàçà èíîãî ñîñòàâà: àöåòîíèòðèë–âîäà (90:10). Ïðè êîëè÷åñòâåííîì îïðåäåëåíèè è îöåíêå õðîìàòîãðàôè÷åñêîé ÷èñòîòû êàðáîïëàòèíà (â ñóáñòàíöèè è ëåêàðñòâåííîé ôîðìå [9, 10]) ðåêîìåíäîâàíî èñïîëüçîâàòü êîëîíêè àíàëîãè÷íîãî òèïà è ïîäâèæíóþ ôàçó àöåòîíèòðèë–âîäà (87:13).

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European Pharmacopoeia. 8th ed. Monograph: Carboplatin.
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     ñîîòâåòñòâóþùåé ìîíîãðàôèè Áðèòàíñêîé ôàðìàêîïåè (ÂÐ) [8] äëÿ êîëè÷åñòâåííîãî îïðåäåëåíèè öèñïëàòèíà íà êîëîíêå Lichrosorb NH2èñïîëüçóåòñÿ ïîäâèæíàÿ ôàçà èíîãî ñîñòàâà: àöåòîíèòðèë–âîäà (90:10). Ïðè êîëè÷åñòâåííîì îïðåäåëåíèè è îöåíêå õðîìàòîãðàôè÷åñêîé ÷èñòîòû êàðáîïëàòèíà (â ñóáñòàíöèè è ëåêàðñòâåííîé ôîðìå
    Exact
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    ) ðåêîìåíäîâàíî èñïîëüçîâàòü êîëîíêè àíàëîãè÷íîãî òèïà è ïîäâèæíóþ ôàçó àöåòîíèòðèë–âîäà (87:13). Íà îñíîâàíèè ñðàâíåíèÿ ýëåêòðîííûõ êîíôèãóðàöèé àìèíî- è ãèäðîêñèãðóïï, ìîæíî ðåêîìåíäîâàòü äëÿ èñïîëüçîâàíèÿ ïðè õðîìàòîãðàôèðîâàíèè êîîðäèíàöèîííûõ ñîåäèíåíèé ïëàòèíû äèãèäðîêñèïðîïèëñèëèëüíûå (äèîëüíûå) ñîðáåíòû íàðàâíå ñ àìèíîñîðáåíòàìè.

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United State Pharmacopoeia. 39th ed. Monograph: Carboplatin for Injection.
Total in-text references: 1
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     ñîîòâåòñòâóþùåé ìîíîãðàôèè Áðèòàíñêîé ôàðìàêîïåè (ÂÐ) [8] äëÿ êîëè÷åñòâåííîãî îïðåäåëåíèè öèñïëàòèíà íà êîëîíêå Lichrosorb NH2èñïîëüçóåòñÿ ïîäâèæíàÿ ôàçà èíîãî ñîñòàâà: àöåòîíèòðèë–âîäà (90:10). Ïðè êîëè÷åñòâåííîì îïðåäåëåíèè è îöåíêå õðîìàòîãðàôè÷åñêîé ÷èñòîòû êàðáîïëàòèíà (â ñóáñòàíöèè è ëåêàðñòâåííîé ôîðìå
    Exact
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    ) ðåêîìåíäîâàíî èñïîëüçîâàòü êîëîíêè àíàëîãè÷íîãî òèïà è ïîäâèæíóþ ôàçó àöåòîíèòðèë–âîäà (87:13). Íà îñíîâàíèè ñðàâíåíèÿ ýëåêòðîííûõ êîíôèãóðàöèé àìèíî- è ãèäðîêñèãðóïï, ìîæíî ðåêîìåíäîâàòü äëÿ èñïîëüçîâàíèÿ ïðè õðîìàòîãðàôèðîâàíèè êîîðäèíàöèîííûõ ñîåäèíåíèé ïëàòèíû äèãèäðîêñèïðîïèëñèëèëüíûå (äèîëüíûå) ñîðáåíòû íàðàâíå ñ àìèíîñîðáåíòàìè.

11
Osipov AS, Bobylev PV, Novak ÀÀ, Nechaeva EB. Application of HPLC for analysis platinum compounds in medicaments. Biomeditsina 2010; (5): 107–9 (in Russian).
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    ñðàâíåíèÿ ýëåêòðîííûõ êîíôèãóðàöèé àìèíî- è ãèäðîêñèãðóïï, ìîæíî ðåêîìåíäîâàòü äëÿ èñïîëüçîâàíèÿ ïðè õðîìàòîãðàôèðîâàíèè êîîðäèíàöèîííûõ ñîåäèíåíèé ïëàòèíû äèãèäðîêñèïðîïèëñèëèëüíûå (äèîëüíûå) ñîðáåíòû íàðàâíå ñ àìèíîñîðáåíòàìè. Î÷åðåäíîñòü ýëþèðîâàíèÿ êîìïîíåíòîâ àíàëèçèðóåìîé ñìåñè íà äèîëüíîé êîëîíêå Nucleosil 100-5 OH èìåëà òîò æå õàðàêòåð, ÷òî è íà êîëîíêàõ ñ àìèíîñîðáåíòàìè
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    [11, 12]
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    , ïåðâûì ýëþèðóåòñÿ öèñïëàòèí, çàòåì îêñàëèïëàòèí è êàðáîïëàòèí (ðèñ. 3). Íà êîëîíêå ñ íèòðèëüíûì ñîðáåíòîì Nova-Pak CN HP [13] áûëî äîñòèãíóòî ëó÷øåå ðàçðåøåíèå àíàëèçèðóåìûõ ñîåäèíåíèé (ðèñ. 4). Íà ýòîé æå êîëîíêå âîçìîæíî ðàçäåëåíèå àíàëèçèðóåìûõ ñîåäèíåíèé è â óñëîâèÿõ îáðàùåííî-ôàçîâîé õðîìàòîãðàôèè ïðè èñïîëüçîâàíèè ïîäâèæíîé ôàçû àöåòîíèòðèë–âîäà (3:97).

12
Osipov AS, Nechaeva EB, Pobedin OA. Application of a chromatographic column with a diol sorbent for the analysis of platinum coordination compounds. Himiko-farmatsevticheskiy zhurnal 2013; 47(6): 51–3 (in Russian).
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    ñðàâíåíèÿ ýëåêòðîííûõ êîíôèãóðàöèé àìèíî- è ãèäðîêñèãðóïï, ìîæíî ðåêîìåíäîâàòü äëÿ èñïîëüçîâàíèÿ ïðè õðîìàòîãðàôèðîâàíèè êîîðäèíàöèîííûõ ñîåäèíåíèé ïëàòèíû äèãèäðîêñèïðîïèëñèëèëüíûå (äèîëüíûå) ñîðáåíòû íàðàâíå ñ àìèíîñîðáåíòàìè. Î÷åðåäíîñòü ýëþèðîâàíèÿ êîìïîíåíòîâ àíàëèçèðóåìîé ñìåñè íà äèîëüíîé êîëîíêå Nucleosil 100-5 OH èìåëà òîò æå õàðàêòåð, ÷òî è íà êîëîíêàõ ñ àìèíîñîðáåíòàìè
    Exact
    [11, 12]
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    , ïåðâûì ýëþèðóåòñÿ öèñïëàòèí, çàòåì îêñàëèïëàòèí è êàðáîïëàòèí (ðèñ. 3). Íà êîëîíêå ñ íèòðèëüíûì ñîðáåíòîì Nova-Pak CN HP [13] áûëî äîñòèãíóòî ëó÷øåå ðàçðåøåíèå àíàëèçèðóåìûõ ñîåäèíåíèé (ðèñ. 4). Íà ýòîé æå êîëîíêå âîçìîæíî ðàçäåëåíèå àíàëèçèðóåìûõ ñîåäèíåíèé è â óñëîâèÿõ îáðàùåííî-ôàçîâîé õðîìàòîãðàôèè ïðè èñïîëüçîâàíèè ïîäâèæíîé ôàçû àöåòîíèòðèë–âîäà (3:97).

13
Osipov AS, Nechaeva EB. Application of Chromatographic Columns with Nitrile and Phenyl Sorbents to the Analysis of Platinum Coordination Compounds. Himiko-farmatsevticheskiy zhurnal 2014; 48(8): 45–8 (in Russian).
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    Î÷åðåäíîñòü ýëþèðîâàíèÿ êîìïîíåíòîâ àíàëèçèðóåìîé ñìåñè íà äèîëüíîé êîëîíêå Nucleosil 100-5 OH èìåëà òîò æå õàðàêòåð, ÷òî è íà êîëîíêàõ ñ àìèíîñîðáåíòàìè [11, 12], ïåðâûì ýëþèðóåòñÿ öèñïëàòèí, çàòåì îêñàëèïëàòèí è êàðáîïëàòèí (ðèñ. 3). Íà êîëîíêå ñ íèòðèëüíûì ñîðáåíòîì Nova-Pak CN HP
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    áûëî äîñòèãíóòî ëó÷øåå ðàçðåøåíèå àíàëèçèðóåìûõ ñîåäèíåíèé (ðèñ. 4). Íà ýòîé æå êîëîíêå âîçìîæíî ðàçäåëåíèå àíàëèçèðóåìûõ ñîåäèíåíèé è â óñëîâèÿõ îáðàùåííî-ôàçîâîé õðîìàòîãðàôèè ïðè èñïîëüçîâàíèè ïîäâèæíîé ôàçû àöåòîíèòðèë–âîäà (3:97).

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    Óñëîâèÿ àíàëèçà: ïîäâèæíàÿ ôàçà — àöåòîíèòðèë–âîäà (90:10); ñêîðîñòü ïîòîêà — 1,5 ìë/ìèí; äåòåêòèðîâàíèå ïðè 220 íì [17] Ðèñ. 4.Õðîìàòîãðàììà ðàçäåëåíèÿ ñìåñè ñòàíäàðòíûõ îáðàçöîâ êîîðäèíàöèîííûõ ñîåäèíåíèé ïëàòèíû íà êîëîíêå Nova-Pak CN HP 150 ́3,9 ìì (4 ìêì). Óñëîâèÿ àíàëèçà: ïîäâèæíàÿ ôàçà — àöåòîíèòðèë–âîäà (95:5); ñêîðîñò üïîòîêà — 0,72 ìë/ìèí; äåòåêòèðîâàíèå ïðè 220 íì
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    Ðèñ. 5.Õðîìàòîãðàììà ðàçäåëåíèÿ ñìåñè ñòàíäàðòíûõ îáðàçöîâ êîîðäèíàöèîííûõ ñîåäèíåíèé ïëàòèíû íà êîëîíêå Nova-Pak CN HP 150 ́3,9 ìì (4 ìêì). Óñëîâèÿ àíàëèçà: ïîäâèæíàÿ ôàçà — àöåòîíèòðèë–âîäà (3:97); ñêîðîñò üïîòîêà — 0,72 ìë/ìèí; äåòåêòèðîâàíèå ïðè 220 íì [13] Ïðè ýòîì ìåíÿåòñÿ î÷åðåäíîñòü ýëþèðîâàíèÿ êàðáîïëàòèíà è îêñàëèïëàòèíà (ðèñ. 5).

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    Óñëîâèÿ àíàëèçà: ïîäâèæíàÿ ôàçà — àöåòîíèòðèë–âîäà (95:5); ñêîðîñò üïîòîêà — 0,72 ìë/ìèí; äåòåêòèðîâàíèå ïðè 220 íì [13] Ðèñ. 5.Õðîìàòîãðàììà ðàçäåëåíèÿ ñìåñè ñòàíäàðòíûõ îáðàçöîâ êîîðäèíàöèîííûõ ñîåäèíåíèé ïëàòèíû íà êîëîíêå Nova-Pak CN HP 150 ́3,9 ìì (4 ìêì). Óñëîâèÿ àíàëèçà: ïîäâèæíàÿ ôàçà — àöåòîíèòðèë–âîäà (3:97); ñêîðîñò üïîòîêà — 0,72 ìë/ìèí; äåòåêòèðîâàíèå ïðè 220 íì
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    Ïðè ýòîì ìåíÿåòñÿ î÷åðåäíîñòü ýëþèðîâàíèÿ êàðáîïëàòèíà è îêñàëèïëàòèíà (ðèñ. 5). Ñëåäóåò îòìåòèòü, ÷òî ðàçäåëåíèå àíàëèçèðóåìûõ ñîåäèíåíèé â óñëîâèÿõ îáðàùåííî-ôàçîâîé õðîìàòîãðàôèè ñóùåñòâåííî õóæå, ÷åì ïðè õðîìàòîãðàôèè ãèäðîôèëüíûõ âçàèìîäåéñòâèé (ðèñ. 4, 5).

14
European Pharmacopoeia. 8th ed. Monograph: Butylated Hydroxyanisole.
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    ÏÐÈÌÅÍÅÍÈÅ ÆÈÄÊÎÑÒÍÎÉ ÕÐÎÌÀÒÎÃÐÀÔÈÈ ÃÈÄÐÎÔÈËÜÍÛÕ ÂÇÀÈÌÎÄÅÉÑÒÂÈÉ ÄËß ÐÀÇÄÅËÅÍÈß ÈÇÎÌÅÐΠÁÓÒÈËÃÈÄÐÎÊÑÈÀÍÈÇÎËÀ È ÀÍÀËÈÇÀ ÃÎÌÎËÎÃÈ×ÅÑÊÎÃÎ ÐßÄÀ ÏÀÐÀÁÅÍΠÁóòèëãèäðîêñèàíèçîë (ÁÎÀ) ïðèìåíÿþò â êà÷åñòâå àíòèîêñèäàíòà äëÿ ïðåäîòâðàùåíèÿ îêèñëåíèÿ ëàáèëüíûõ ëåêàðñòâåííûõ ïðåïàðàòîâ. ÁÎÀ îïèñàí â Åâðîïåéñêîé ôàðìàêîïåå è Ôàðìàêîïåå ÑØÀ
    Exact
    [14, 15]
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    .  Åâðîïåéñêîé ôàðìàêîïåå óêàçàíî, ÷òî îñíîâíûì àíòèîêñèäàíòîì ÿâëÿåòñÿ 2-ÁÎÀ èçîìåð (2-(1,1–äèìåòèëýòèë)-4-ìåòîêñèôåíîë), à â êà÷åñòâå ïðèìåñè íîðìèðóåòñÿ ñîäåðæàíèå 3-ÁÎÀ èçîìåðà (3-(1,1–äèìåòèëýòèë)-4-ìåòîêñèôåíîë), êîòîðîãî â ôàðìàêîïåéíîé ñóáñòàíöèè äîëæíî áûòü íå áîëåå 10 %.

15
United States Pharmacopoeia. 39th ed. Monograph: Butylated Hydroxyanisole.
Total in-text references: 1
  1. In-text reference with the coordinate start=9145
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    ÏÐÈÌÅÍÅÍÈÅ ÆÈÄÊÎÑÒÍÎÉ ÕÐÎÌÀÒÎÃÐÀÔÈÈ ÃÈÄÐÎÔÈËÜÍÛÕ ÂÇÀÈÌÎÄÅÉÑÒÂÈÉ ÄËß ÐÀÇÄÅËÅÍÈß ÈÇÎÌÅÐΠÁÓÒÈËÃÈÄÐÎÊÑÈÀÍÈÇÎËÀ È ÀÍÀËÈÇÀ ÃÎÌÎËÎÃÈ×ÅÑÊÎÃÎ ÐßÄÀ ÏÀÐÀÁÅÍΠÁóòèëãèäðîêñèàíèçîë (ÁÎÀ) ïðèìåíÿþò â êà÷åñòâå àíòèîêñèäàíòà äëÿ ïðåäîòâðàùåíèÿ îêèñëåíèÿ ëàáèëüíûõ ëåêàðñòâåííûõ ïðåïàðàòîâ. ÁÎÀ îïèñàí â Åâðîïåéñêîé ôàðìàêîïåå è Ôàðìàêîïåå ÑØÀ
    Exact
    [14, 15]
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    .  Åâðîïåéñêîé ôàðìàêîïåå óêàçàíî, ÷òî îñíîâíûì àíòèîêñèäàíòîì ÿâëÿåòñÿ 2-ÁÎÀ èçîìåð (2-(1,1–äèìåòèëýòèë)-4-ìåòîêñèôåíîë), à â êà÷åñòâå ïðèìåñè íîðìèðóåòñÿ ñîäåðæàíèå 3-ÁÎÀ èçîìåðà (3-(1,1–äèìåòèëýòèë)-4-ìåòîêñèôåíîë), êîòîðîãî â ôàðìàêîïåéíîé ñóáñòàíöèè äîëæíî áûòü íå áîëåå 10 %.

16
Osipov AS, Nechaeva EB, Mironova MM, Kovaleva EL. Use of hydrophilic interaction liquid chromatography to separate butylhydroxyanisole isomers. Himiko-farmatsevticheskiy zhurnal 2015; 49(3): 50–2 (in Russian).
Total in-text references: 3
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    Âðåìÿ óäåðæèâàíèÿ 3-èçîìåðà ÁÎÀ — îêîëî 4,2 ìèí, 2-èçîìåðà ÁÎÀ — 4,6 ìèí.  óñëîâèÿõ õðîìàòîãðàôèè ãèäðîôèëüíûõ âçàèìîäåéñòâèé ïðè ñîäåðæàíèè àöåòîíèòðèëà â ïîäâèæíîé ôàçå áîëåå 98 % èçîìåðû ÁÎÀ ðàçäåëÿþòñÿ íà êîëîíêå Zorbax NH2
    Exact
    [16]
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    . Ïðè ïðîâåäåíèè õðîìàòîãðàôèè ãèäðîôèëüíûõ âçàèìîäåéñòâèé ìåíÿåòñÿ î÷åðåäíîñòü ýëþèðîâàíèÿ èçîìåðîâ ÁÎÀ ïî ñðàâíåíèþ ñ îáðàùåííî-ôàçîâîé õðîìàòîãðàôèåé (ðèñ. 6, 7). Ñëåäóåò îòìåòèòü, ÷òî â îáðàùåííî-ôàçîâûõ óñëîâèÿõ íà ôåíèëüíûõ êîëîíêàõ èëè êîëîíêàõ Ñ18 ìîæíî äîñòè÷ü ñóùåñòâåííî ëó÷øåãî ðàçäåëåíèÿ èçîìåðîâ ÁÎÀ, ÷åì ïðè õðîìàòîãðàôèè â óñëîâèÿõ ãèäðîôèëüíûõ âçàèìîäåéñòâèé [17].

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    Íà êîëîíêàõ ñ íèòðèëüíûìè è äèîëüíûìè ñîðáåíòàìè íå ïðîèñõîäèò ðàçäåëåíèÿ èçîìåðîâ ÁÎÀ íè â óñëîâèÿõ îáðàùåííî-ôàçîâîé õðîìàòîãðàôèè (ïðè ñîäåðæàíèè àöåòîíèòðèëà èëè ìåòàíîëà â ïîäâèæíîé ôàçå 10–45 %), íè â óñëîâèÿõ æèäêîñòíîé õðîìàòîãðàôèè ãèäðîôèëüíûõ âçàèìîäåéñòâèé (ïðè ñîäåðæàíèè àöåòîíèòðèëà â ïîäâèæíîé ôàçå ñâûøå 95 %)
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    . Ýôèðû ïàðàãèäðîêñèáåíçîéíîé êèñëîòû (íàçâàíèå ñîåäèíåíèé ïî Åâðîïåéñêîé ôàðìàêîïåå), èëè ïàðàáåíû (íàçâàíèå ñîåäèíåíèé ïî Ôàðìàêîïåå ÑØÀ), ïðèìåíÿþò ïðè èçãîòîâëåíèè ñóñïåíçèé è ìèêñòóð, à òàêæå íåêîòîðûõ äðóãèõ ëåêàðñòâåííûõ ôîðì â êà÷åñòâå àíòèìèêðîáíûõ êîíñåðâàíòîâ.

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    Ñëåäóåò îòìåòèòü, ÷òî ðàçðåøåíèå ìåæäó ïèêàìè ïàðàáåíîâ â óñëîâèÿõ æèäêîñòíîé õðîìàòîãðàôèè ãèäðîôèëüíûõ âçàèìîäåéñòâèé ñóùåñòâåííî ìåíüøå, ÷åì â óñëîâèÿõ îáðàùåííî-ôàçîÐèñ. 6.Õðîìàòîãðàììà ñòàíäàðòíîãî îáðàçöà áóòèëãèäðîêñèàíèçîëà («Sigma»). Óñëîâèÿ àíàëèçà: êîëîíêà Zorbax NH2 150 ́4,6 ìì (5 ìêì); ïîäâèæíàÿ ôàçà — àöåòîíèòðèë–âîäà (99:1); ñêîðîñò üïîòîêà — 1,0 ìë/ìèí; äåòåêòèðîâàíèå ïðè 290 íì
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    Ðèñ. 7.Õðîìàòîãðàììà ñòàíäàðòíîãî îáðàçöà áóòèëãèäðîêñèàíèçîëà («Sigma»). Óñëîâèÿ àíàëèçà: êîëîíêà Zorbax SB Phenyl 150 ́4,6 ìì (3,5 ìêì); ïîäâèæíàÿ ôàçà — àöåòîíèòðèë–âîäà (45:55); ñêîðîñò üïîòîêà — 1,0 ìë/ìèí; äåòåêòèðîâàíèå ïðè 290 íì [17] âîé õðîìàòîãðàôèè (ðèñ. 9).

17
Osipov AS, Nechaeva EB, Pobedin OA. The use of chromatographic columns with phenyl sorbents for separation butylhydroxyanisole isomers. Razrabotka i registratsiya lekarstvennyh sredstv 2013; (4): 82–6 (in Russian).
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    ́4,6 ìì (5 ìêì); ïîäâèæíàÿ ôàçà — àöåòîíèòðèë–âîäà (93:7); ñêîðîñò üïîòîêà — 1 ìë/ìèí; äåòåêòèðîâàíèå 200 íì [5] Ðèñ. 3.Õðîìàòîãðàììà ðàçäåëåíèÿ ñìåñè ñòàíäàðòíûõ îáðàçöîâ êîîðäèíàöèîííûõ ñîåäèíåíèé ïëàòèíû íà êîëîíêå Equisil APS-2 150 ́4,6 ìì (3 ìêì) (êîëîíêà ñ àìèíîñîðáåíòîì). Óñëîâèÿ àíàëèçà: ïîäâèæíàÿ ôàçà — àöåòîíèòðèë–âîäà (90:10); ñêîðîñòü ïîòîêà — 1,5 ìë/ìèí; äåòåêòèðîâàíèå ïðè 220 íì
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    Ðèñ. 4.Õðîìàòîãðàììà ðàçäåëåíèÿ ñìåñè ñòàíäàðòíûõ îáðàçöîâ êîîðäèíàöèîííûõ ñîåäèíåíèé ïëàòèíû íà êîëîíêå Nova-Pak CN HP 150 ́3,9 ìì (4 ìêì). Óñëîâèÿ àíàëèçà: ïîäâèæíàÿ ôàçà — àöåòîíèòðèë–âîäà (95:5); ñêîðîñò üïîòîêà — 0,72 ìë/ìèí; äåòåêòèðîâàíèå ïðè 220 íì [13] Ðèñ. 5.

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    Ñëåäóåò îòìåòèòü, ÷òî â îáðàùåííî-ôàçîâûõ óñëîâèÿõ íà ôåíèëüíûõ êîëîíêàõ èëè êîëîíêàõ Ñ18 ìîæíî äîñòè÷ü ñóùåñòâåííî ëó÷øåãî ðàçäåëåíèÿ èçîìåðîâ ÁÎÀ, ÷åì ïðè õðîìàòîãðàôèè â óñëîâèÿõ ãèäðîôèëüíûõ âçàèìîäåéñòâèé
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    . Íà êîëîíêàõ ñ íèòðèëüíûìè è äèîëüíûìè ñîðáåíòàìè íå ïðîèñõîäèò ðàçäåëåíèÿ èçîìåðîâ ÁÎÀ íè â óñëîâèÿõ îáðàùåííî-ôàçîâîé õðîìàòîãðàôèè (ïðè ñîäåðæàíèè àöåòîíèòðèëà èëè ìåòàíîëà â ïîäâèæíîé ôàçå 10–45 %), íè â óñëîâèÿõ æèäêîñòíîé õðîìàòîãðàôèè ãèäðîôèëüíûõ âçàèìîäåéñòâèé (ïðè ñîäåðæàíèè àöåòîíèòðèëà â ïîäâèæíîé ôàçå ñâûøå 95 %) [16].

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    Óñëîâèÿ àíàëèçà: êîëîíêà Zorbax NH2 150 ́4,6 ìì (5 ìêì); ïîäâèæíàÿ ôàçà — àöåòîíèòðèë–âîäà (99:1); ñêîðîñò üïîòîêà — 1,0 ìë/ìèí; äåòåêòèðîâàíèå ïðè 290 íì [16] Ðèñ. 7.Õðîìàòîãðàììà ñòàíäàðòíîãî îáðàçöà áóòèëãèäðîêñèàíèçîëà («Sigma»). Óñëîâèÿ àíàëèçà: êîëîíêà Zorbax SB Phenyl 150 ́4,6 ìì (3,5 ìêì); ïîäâèæíàÿ ôàçà — àöåòîíèòðèë–âîäà (45:55); ñêîðîñò üïîòîêà — 1,0 ìë/ìèí; äåòåêòèðîâàíèå ïðè 290 íì
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    âîé õðîìàòîãðàôèè (ðèñ. 9).  îòëè÷èå îò àìèíîãðóïï, íèòðèëüíûå ãðóïïû ïðàêòè÷åñêè íå îáëàäàþò ñðîäñòâîì ê ôåíîëüíûì ãèäðîêñèëüíûì ãðóïïàì ïàðàáåíîâ. Òàê, ïðè èñïîëüçîâàíèè â êà÷åñòâå ïîäâèæíûõ ôàç ñìåñåé àöåòîíèòðèëà è âîäû, âðåìÿ óäåðæèâàíèÿ ìåòèëïàðàáåíà íà êîëîíêå Zorbax XDB CN 150 ́4,6 ìì (5 ìêì) âîçðàñòàëî òîëüêî ñ 1,64 ìèí äî 1,73 ìèí ïðè óâåëè÷åíèè ñîäåðæàíèÿ àöåòîíèòðèëà â ïîäâèæíîé ôàçå

18
European Pharmacopoeia. 8th ed. Monograph: Methyl parahydroxybenzoate.
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    êèñëîòû (íàçâàíèå ñîåäèíåíèé ïî Åâðîïåéñêîé ôàðìàêîïåå), èëè ïàðàáåíû (íàçâàíèå ñîåäèíåíèé ïî Ôàðìàêîïåå ÑØÀ), ïðèìåíÿþò ïðè èçãîòîâëåíèè ñóñïåíçèé è ìèêñòóð, à òàêæå íåêîòîðûõ äðóãèõ ëåêàðñòâåííûõ ôîðì â êà÷åñòâå àíòèìèêðîáíûõ êîíñåðâàíòîâ. Óñëîâèÿ õðîìàòîãðàôèðîâàíèÿ ïàðàáåíîâ ïîëíîñòüþ ãàðìîíèçèðîâàíû â ñîîòâåòñòâóþùèõ ôàðìàêîïåéíûõ ñòàòüÿõ Åâðîïåéñêîé ôàðìàêîïåè è Ôàðìàêîïåè ÑØÀ
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    .  ìîíîãðàôèÿõ çàðóáåæíûõ ôàðìàêîïåé ïðèâåäåíà ìåòîäèêà õðîìàòîãðàôèðîâàíèÿ ïàðàáåíîâ íà êîëîíêàõ Ñ18 150 ́4,6 ìì (5 ìêì).  êà÷åñòâå ïîäâèæíîé ôàçû ïðèìåíÿþò ñìåñü 6,8 ã/ë ÊÍ2ÐÎ4 â âîäå–ìåòàíîë (35:65).

19
United States Pharmacopoeia. 39th ed. Monograph: Methylparaben Sodium.
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    êèñëîòû (íàçâàíèå ñîåäèíåíèé ïî Åâðîïåéñêîé ôàðìàêîïåå), èëè ïàðàáåíû (íàçâàíèå ñîåäèíåíèé ïî Ôàðìàêîïåå ÑØÀ), ïðèìåíÿþò ïðè èçãîòîâëåíèè ñóñïåíçèé è ìèêñòóð, à òàêæå íåêîòîðûõ äðóãèõ ëåêàðñòâåííûõ ôîðì â êà÷åñòâå àíòèìèêðîáíûõ êîíñåðâàíòîâ. Óñëîâèÿ õðîìàòîãðàôèðîâàíèÿ ïàðàáåíîâ ïîëíîñòüþ ãàðìîíèçèðîâàíû â ñîîòâåòñòâóþùèõ ôàðìàêîïåéíûõ ñòàòüÿõ Åâðîïåéñêîé ôàðìàêîïåè è Ôàðìàêîïåè ÑØÀ
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    .  ìîíîãðàôèÿõ çàðóáåæíûõ ôàðìàêîïåé ïðèâåäåíà ìåòîäèêà õðîìàòîãðàôèðîâàíèÿ ïàðàáåíîâ íà êîëîíêàõ Ñ18 150 ́4,6 ìì (5 ìêì).  êà÷åñòâå ïîäâèæíîé ôàçû ïðèìåíÿþò ñìåñü 6,8 ã/ë ÊÍ2ÐÎ4 â âîäå–ìåòàíîë (35:65).

20
Osipov AS, Popova OA, Suleymanov RR, Nezdolieva MV. Application of HPLC analysis esters of 4-hydroxybenzoic acid. Uspekhi sovremennogo estestvoznaniya 2016; 11(2): 256–60.
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    Íà ðèñóíêå 8 ïðèâåäåíà õðîìàòîãðàììà ðàçäåëåíèÿ ìîäåëüíîé ñìåñè ïàðàáåíîâ â äàííûõ óñëîâèÿõ õðîìàòîãðàôèðîâàíèÿ, ïðè ýòîì ìåíÿåòñÿ î÷åðåäíîñòü ýëþèðîâàíèÿ àíàëèçèðóåìûõ ñîåäèíåíèé ïî ñðàâíåíèþ ñ îáðàùåííî-ôàçîâîé õðîìàòîãðàôèåé
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    . Ñëåäóåò îòìåòèòü, ÷òî ðàçðåøåíèå ìåæäó ïèêàìè ïàðàáåíîâ â óñëîâèÿõ æèäêîñòíîé õðîìàòîãðàôèè ãèäðîôèëüíûõ âçàèìîäåéñòâèé ñóùåñòâåííî ìåíüøå, ÷åì â óñëîâèÿõ îáðàùåííî-ôàçîÐèñ. 6.Õðîìàòîãðàììà ñòàíäàðòíîãî îáðàçöà áóòèëãèäðîêñèàíèçîëà («Sigma»).

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    Ðèñ. 8.Õðîìàòîãðàììà ìîäåëüíîé ñìåñè ñòàíäàðòíûõ îáðàçöîâ ïàðàáåíîâ. Óñëîâèÿ àíàëèçà: êîëîíêà Zorbax NH2150 ́4,6 ìì (5 ìêì); ïîäâèæíàÿ ôàçà — àöåòîíèòðèë–2 ìÌ ÊÍ2ÐÎ4(98:2); ñêîðîñòü ïîòîêà — 1,0 ìë/ìèí; äåòåêòèðîâàíèå 260 íì
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    Ðèñ. 9.Õðîìàòîãðàììà ìîäåëüíîé ñìåñè ñòàíäàðòíûõ îáðàçöîâ ïàðàáåíîâ. Óñëîâèÿ àíàëèçà: êîëîíêà Zorbax XDB CN 150 ́4,6 ìì (5 ìêì); ïîäâèæíàÿ ôàçà — àöåòîíèòðèë–âîäà (40:60); ñêîðîñò üïîòîêà — 1,0 ìë/ìèí; äåòåêòèðîâàíèå 260 íì [20] Ðèñ. 10.

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    Óñëîâèÿ àíàëèçà: êîëîíêà Zorbax NH2150 ́4,6 ìì (5 ìêì); ïîäâèæíàÿ ôàçà — àöåòîíèòðèë–2 ìÌ ÊÍ2ÐÎ4(98:2); ñêîðîñòü ïîòîêà — 1,0 ìë/ìèí; äåòåêòèðîâàíèå 260 íì [20] Ðèñ. 9.Õðîìàòîãðàììà ìîäåëüíîé ñìåñè ñòàíäàðòíûõ îáðàçöîâ ïàðàáåíîâ. Óñëîâèÿ àíàëèçà: êîëîíêà Zorbax XDB CN 150 ́4,6 ìì (5 ìêì); ïîäâèæíàÿ ôàçà — àöåòîíèòðèë–âîäà (40:60); ñêîðîñò üïîòîêà — 1,0 ìë/ìèí; äåòåêòèðîâàíèå 260 íì
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    Ðèñ. 10.Õðîìàòîãðàììà ìîäåëüíîé ñìåñè ñòàíäàðòíûõ îáðàçöîâ èçîñîðáèäà äèíèòðàòà è èçîìåðîâ èçîñîðáèäà ìîíîíèòðàòà. Óñëîâèÿ àíàëèçà: êîëîíêà Zorbax NH2150 ́4,6 ìì (5 ìêì); ïîäâèæíàÿ ôàçà — àöåòîíèòðèë–âîäà (99,5:0,5); ñêîðîñò üïîòîêà — 1,0 ìë/ìèí; äåòåêòèðîâàíèå 210 íì [24] Ðèñ. 11.

21
United States Pharmacopoeia. 39th ed. Monograph: Diluted Isosorbide Mononitrate.
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    Äåéñòâóþùèì âåùåñòâîì ÈÑÌÍ ÿâëÿåòñÿ 5-íèòðîèçîìåð ÈÑÌÍ (5-èçîìåð ÈÑÌÍ). Ñîäåðæàíèå ïðèìåñè 2-íèòðîèçîìåðà ÈÑÌÍ (2-èçîìåð ÈÑÌÍ), à òàêæå ÈÑÄÍ êîíòðîëèðóåòñÿ â ñóáñòàíöèè è ëåêàðñòâåííûõ ïðåïàðàòàõ ÈÑÌÍ
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    . Çàâèñèìîñòü âðåìåíè óäåðæèâàíèÿ íèòðîãëèöåðèíà îò ñîñòàâà ïîäâèæíîé ôàçû èçó÷àëè íà êîëîíêå Zorbax NH2150 ́4,6 ìì, 5 ìêì.  êà÷åñòâå ïîäâèæíûõ ôàç ïðèìåíÿëè ñìåñè àöåòîíèòðèëà è âîäû â ñîîòíîøåíèè îò 90:10 (ôàçà 1) äî 99,5:0,5 (ôàçà 5).

22
British Pharmacopoeia 2016. Monograph: Isosorbide Mononitrate Tablets.
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    Äåéñòâóþùèì âåùåñòâîì ÈÑÌÍ ÿâëÿåòñÿ 5-íèòðîèçîìåð ÈÑÌÍ (5-èçîìåð ÈÑÌÍ). Ñîäåðæàíèå ïðèìåñè 2-íèòðîèçîìåðà ÈÑÌÍ (2-èçîìåð ÈÑÌÍ), à òàêæå ÈÑÄÍ êîíòðîëèðóåòñÿ â ñóáñòàíöèè è ëåêàðñòâåííûõ ïðåïàðàòàõ ÈÑÌÍ
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    . Çàâèñèìîñòü âðåìåíè óäåðæèâàíèÿ íèòðîãëèöåðèíà îò ñîñòàâà ïîäâèæíîé ôàçû èçó÷àëè íà êîëîíêå Zorbax NH2150 ́4,6 ìì, 5 ìêì.  êà÷åñòâå ïîäâèæíûõ ôàç ïðèìåíÿëè ñìåñè àöåòîíèòðèëà è âîäû â ñîîòíîøåíèè îò 90:10 (ôàçà 1) äî 99,5:0,5 (ôàçà 5).

23
Osipov AS, Orlov EN. Application of hydrophilic interaction liquid chromatography for analysis of nitroglycerin. Development, research and marketing of new pharmaceutical products. Collection of scientific papers. Issue 71. Pyatigorsk; 2016. P. 177–80 (in Russian).
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     îòëè÷èå îò ýòîãî, ïðè õðîìàòîãðàôèðîâàíèè íà íèòðèëüíîé êîëîíêå Zorbax SB CN 150 ́4,6 ìì, 5 ìêì âðåìÿ óäåðæèâàíèÿ íèòðîãëèöåðèíà íå òîëüêî íå âîçðàñòàåò, íî äàæå íåñêîëüêî óìåíüøàåòñÿ ñ óâåëè÷åíèåì ñîäåðæàíèÿ àöåòîíèòðèëà â ïîäâèæíîé ôàçå — 1,84 ìèí (ôàçà 1) ïðîòèâ 1,81 ìèí (ôàçà 5)
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    . Äëÿ àíàëèçà ÈÑÌÍ è ÈÑÄÍ íàðÿäó ñ íîðìàëüíî-ôàçîâîé õðîìàòîãðàôèåé ïðèìåíÿþò îáðàùåííî-ôàçîâóþ õðîìàòîãðàôèþ. Êðîìå ýòîãî, íà êîëîíêàõ ñ àìèíîñîðáåíòàìè íèòðàòû èçîñîðáèäà óâåðåííî ðàçäåëÿþòñÿ â óñëîâèÿõ æèäêîñòíîé õðîìàòîãðàôèè ãèäðîôèëüíûõ âçàèìîäåéñòâèé [24].

24
Osipov AS, Nechaeva EB, Truhacheva LA. Application of hydrophilic interaction liquid chromatography for analysis of organic nitrates. Razrabotka i registratsiya lekarstvennyh sredstv 2016; (3): 108–11 (in Russian).
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    Äëÿ àíàëèçà ÈÑÌÍ è ÈÑÄÍ íàðÿäó ñ íîðìàëüíî-ôàçîâîé õðîìàòîãðàôèåé ïðèìåíÿþò îáðàùåííî-ôàçîâóþ õðîìàòîãðàôèþ. Êðîìå ýòîãî, íà êîëîíêàõ ñ àìèíîñîðáåíòàìè íèòðàòû èçîñîðáèäà óâåðåííî ðàçäåëÿþòñÿ â óñëîâèÿõ æèäêîñòíîé õðîìàòîãðàôèè ãèäðîôèëüíûõ âçàèìîäåéñòâèé
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    . Ñëåäóåò òàêæå îòìåòèòü, ÷òî ñ óâåëè÷åíèåì ñîäåðæàíèÿ àöåòîíèòðèëà â ïîäâèæíîé ôàçå óâåëè÷èâàåòñÿ ðàçðåøåíèå ìåæäó ïèêàìè ÈÑÄÍ è èçîìåðîâ ÈÑÌÍ. Ïî ñðàâíåíèþ ñ îáðàùåííî-ôàçîâîé õðîìàòîãðàôèåé íà êîëîíêàõ Ñ18 (ïîäâèæíûå ôàçû: ñìåñè ìåòàíîë–âîäà èëè àöåòîíèòðèë–âîäà) ìåíÿåòñÿ î÷åðåäíîñòü ýëþèðîâàíèÿ ÈÑÄÍ è 5-èçîìåðà ÈÑÌÍ.

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    XDB CN 150 ́4,6 ìì (5 ìêì); ïîäâèæíàÿ ôàçà — àöåòîíèòðèë–âîäà (40:60); ñêîðîñò üïîòîêà — 1,0 ìë/ìèí; äåòåêòèðîâàíèå 260 íì [20] Ðèñ. 10.Õðîìàòîãðàììà ìîäåëüíîé ñìåñè ñòàíäàðòíûõ îáðàçöîâ èçîñîðáèäà äèíèòðàòà è èçîìåðîâ èçîñîðáèäà ìîíîíèòðàòà. Óñëîâèÿ àíàëèçà: êîëîíêà Zorbax NH2150 ́4,6 ìì (5 ìêì); ïîäâèæíàÿ ôàçà — àöåòîíèòðèë–âîäà (99,5:0,5); ñêîðîñò üïîòîêà — 1,0 ìë/ìèí; äåòåêòèðîâàíèå 210 íì
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    Ðèñ. 11.Õðîìàòîãðàììà ìîäåëüíîé ñìåñè ñòàíäàðòíûõ îáðàçöîâ è èçîìåðîâ èçîñîðáèäà ìîíîíèòðàòà è èçîñîðáèäà äèíèòðàòà. Óñëîâèÿ àíàëèçà: êîëîíêà Chromolith Speed ROD RP-18e 50 ́4,6 ìì; ïîäâèæíàÿ ôàçà — ìåòàíîë–âîäà (10:90); ñêîðîñòü ïîòîêà — 1,0 ìë/ìèí; äåòåêòèðîâàíèå 210 íì [25] Îäíàêî ïîñëåäîâàòåëüíîñòü ýëþèðîâàíèÿ 2-èçîìåðà è 5-èçîìåðà ÈÑÌÍ îñòàåòñÿ òîé æå, ÷òî è äëÿ îáðàùåííî-ôàçîâîé õðîìàòîãðàô

25
Osipov AS, Nechaeva EB, Orlov EN. Application of monolithic column Chromolith Speed ROD RP-18e for separate isosorbide nitrates. Voprosy biologicheskoy, meditsinskoy i farmatsevticheskoy khimii 2012; (8): 20–3 (in Russian). AUTHORS
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    ́4,6 ìì (5 ìêì); ïîäâèæíàÿ ôàçà — àöåòîíèòðèë–âîäà (99,5:0,5); ñêîðîñò üïîòîêà — 1,0 ìë/ìèí; äåòåêòèðîâàíèå 210 íì [24] Ðèñ. 11.Õðîìàòîãðàììà ìîäåëüíîé ñìåñè ñòàíäàðòíûõ îáðàçöîâ è èçîìåðîâ èçîñîðáèäà ìîíîíèòðàòà è èçîñîðáèäà äèíèòðàòà. Óñëîâèÿ àíàëèçà: êîëîíêà Chromolith Speed ROD RP-18e 50 ́4,6 ìì; ïîäâèæíàÿ ôàçà — ìåòàíîë–âîäà (10:90); ñêîðîñòü ïîòîêà — 1,0 ìë/ìèí; äåòåêòèðîâàíèå 210 íì
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    Îäíàêî ïîñëåäîâàòåëüíîñòü ýëþèðîâàíèÿ 2-èçîìåðà è 5-èçîìåðà ÈÑÌÍ îñòàåòñÿ òîé æå, ÷òî è äëÿ îáðàùåííî-ôàçîâîé õðîìàòîãðàôèè (ðèñ. 10, 11). Íåîáõîäèìî òàêæå îòìåòèòü, ÷òî äàæå ïðè ïðèìåíåíèè ïîäâèæíîé ôàçû: àöåòîíèòðèë–âîäà (99:1) ÈÑÄÍ è èçîìåðû ÈÑÌÍ íå ðàçäåëÿþòñÿ è ýëþèðóþòñÿ ñ êîëîíêè Zorbax SB CN îäíèì ïèêîì (1,69 ìèí).