The 41 references with contexts in paper M. Pokrovsky V., V. Gureev V., E. Stupakova G., O. Antsiferova E., T. Lokteva I., L. Zhilinkova A., М. Покровский В., В. Гуреев В., Е. Ступакова Г., О. Анциферова Е., Т. Локтева И., Л. Жилинкова А. (2018) “Биологические механизмы естественной цитопротекции - перспективное направление создания новых лекарственных препаратов для профилактики и лечения преэклампсии // Biological mechanisms of natural cytoprotection - a promising trend in the development of new medicines aimed at prevention and treatment of preeclampsia” / spz:neicon:vedomostincesmp:y:2016:i:4:p:20-27

1
WHO.Maternalmortality.Newsletter¹ 348.May2012 http://www.who.int/mediacentre/factsheets/fs348/ru/index.html (in Russian).
Total in-text references: 1
  1. In-text reference with the coordinate start=2047
    Prefix
    Âåäîìîñòè Íàó÷íîãî öåíòðà ýêñïåðòèçû ñðåäñòâ ìåäèöèíñêîãî ïðèìåíåíèÿ 2016; (4): 20–27. Ïðåýêëàìïñèÿ ÿâëÿåòñÿ îäíèì èç ñàìûõ ÷àñòûõ è îïàñíûõ çàáîëåâàíèé, âñòðå÷àþùèõñÿ â àêóøåðñêîé ïðàêòèêå. Ïî äàííûì ðàçíûõ àâòîðîâ ÷àñòîòà äàííîé ïàòîëîãèè êîëåáëåòñÿ îò 6 äî 20 %
    Exact
    [1–5]
    Suffix
    . Ëåòàëüíîñòü ïðè ïðåýêëàìïñèè äîñòèãàåò 25 % ñðåäè âñåõ ñëó÷àåâ ìàòåðèíñêîé ñìåðòíîñòè [3], ïðåæäåâðåìåííûå ðîäû íàáëþäàþòñÿ â 20–30 % ñëó÷àåâ. Ïåðèíàòàëüíàÿ çàáîëåâàåìîñòü ñîñòàâëÿåò 56 %, à ïåðèíàòàëüíàÿ ñìåðòíîñòü â 3–4 ðàçà ïðåâûøàåò ïîïóëÿöèîííóþ, äîñòèãàÿ 12 % [6].

3
Shuvalova MP, Frolova OG, Ratushnyak SS, Grebennik TK, Guseva EV. Pre-eclampsia and eclampsia as a cause of maternal mortality. Akusherstvo i ginekologiya 2014; (1): 81–7 (in Russian).
Total in-text references: 1
  1. In-text reference with the coordinate start=2138
    Prefix
    Ïðåýêëàìïñèÿ ÿâëÿåòñÿ îäíèì èç ñàìûõ ÷àñòûõ è îïàñíûõ çàáîëåâàíèé, âñòðå÷àþùèõñÿ â àêóøåðñêîé ïðàêòèêå. Ïî äàííûì ðàçíûõ àâòîðîâ ÷àñòîòà äàííîé ïàòîëîãèè êîëåáëåòñÿ îò 6 äî 20 % [1–5]. Ëåòàëüíîñòü ïðè ïðåýêëàìïñèè äîñòèãàåò 25 % ñðåäè âñåõ ñëó÷àåâ ìàòåðèíñêîé ñìåðòíîñòè
    Exact
    [3]
    Suffix
    , ïðåæäåâðåìåííûå ðîäû íàáëþäàþòñÿ â 20–30 % ñëó÷àåâ. Ïåðèíàòàëüíàÿ çàáîëåâàåìîñòü ñîñòàâëÿåò 56 %, à ïåðèíàòàëüíàÿ ñìåðòíîñòü â 3–4 ðàçà ïðåâûøàåò ïîïóëÿöèîííóþ, äîñòèãàÿ 12 % [6]. Ýòèîëîãè÷åñêèå àñïåêòû ðàçâèòèÿ ïðåýêëàìïñèè â íàó÷íûõ êðóãàõ ïî-ïðåæíåìó âûçûâàþò æàðêèå äèñêóññèè.

6
Savelieva GM, Shalina RI, Panina OB, Kurtser MA. Obstetrics: a textbook. Moscow: GEOTAR Media; 2011 (in Russian).
Total in-text references: 2
  1. In-text reference with the coordinate start=2320
    Prefix
    Ëåòàëüíîñòü ïðè ïðåýêëàìïñèè äîñòèãàåò 25 % ñðåäè âñåõ ñëó÷àåâ ìàòåðèíñêîé ñìåðòíîñòè [3], ïðåæäåâðåìåííûå ðîäû íàáëþäàþòñÿ â 20–30 % ñëó÷àåâ. Ïåðèíàòàëüíàÿ çàáîëåâàåìîñòü ñîñòàâëÿåò 56 %, à ïåðèíàòàëüíàÿ ñìåðòíîñòü â 3–4 ðàçà ïðåâûøàåò ïîïóëÿöèîííóþ, äîñòèãàÿ 12 %
    Exact
    [6]
    Suffix
    . Ýòèîëîãè÷åñêèå àñïåêòû ðàçâèòèÿ ïðåýêëàìïñèè â íàó÷íûõ êðóãàõ ïî-ïðåæíåìó âûçûâàþò æàðêèå äèñêóññèè. Ñóùåñòâóåò íåñêîëüêî òåîðèé ðàçâèòèÿ ãåñòîçà: èììóííàÿ, òåîðèÿ äåçàäàïòàöèè, èøåìèè ïëàöåíòû, ãîðìîíàëüíàÿ, òîêñè÷åñêîãî âîçäåéñòâèÿ, íàñëåäñòâåííàÿ è ò.ä. [6–8].

  2. In-text reference with the coordinate start=2576
    Prefix
    Ýòèîëîãè÷åñêèå àñïåêòû ðàçâèòèÿ ïðåýêëàìïñèè â íàó÷íûõ êðóãàõ ïî-ïðåæíåìó âûçûâàþò æàðêèå äèñêóññèè. Ñóùåñòâóåò íåñêîëüêî òåîðèé ðàçâèòèÿ ãåñòîçà: èììóííàÿ, òåîðèÿ äåçàäàïòàöèè, èøåìèè ïëàöåíòû, ãîðìîíàëüíàÿ, òîêñè÷åñêîãî âîçäåéñòâèÿ, íàñëåäñòâåííàÿ è ò.ä.
    Exact
    [6–8]
    Suffix
    .  îòíîøåíèè ïàòîãåíåçà ïðåýêëàìïñèè õîòü è îñòàåòñÿ áîëüøîå êîëè÷åñòâî áåëûõ ïÿòåí, íî îïðåäåëåíû îñíîâíûå åãî ïîëîæåíèÿ, à âñå âíîâü îòêðûâàåìûå ñâåäåíèÿ ñêîðåå äîïîëíÿþò ïîëíîòó ïàòîëîãè÷åñêèõ ñîáûòèé.

7
Sánchez-Aranguren LC, Prada CE, Riaño-Medina CE, Lopez M. Endothelial dysfunction and preeclampsia: role of oxidative stress. Front Physiol. 2014; (5): 372.
Total in-text references: 3
  1. In-text reference with the coordinate start=4135
    Prefix
    Ãóìîðàëüíûå ôàêòîðû, îáðàçîâàâøèåñÿ â îòâåò íà èøåìèþ, à òàêæå, âîçìîæíî, àíòèãåíû ïëîäà, ïðîøåäøèå ÷åðåç ôåòîïëàöåíòàðíûé áàðüåð ñ ïîâûøåííîé ïðîíèöàåìîñòüþ, ïðè ïîïàäàíèè â îðãàíèçì ìàòåðè ïðîâîöèðóþò íàêîïëåíèå â ïëàçìå àñèììåòðè÷íîãî äèìåòèëàðãèíèíà (ADMA), ðàçâèòèå ãåíåðàëèçîâàííîé ýíäîòåëèàëüíîé äèñôóíêöèè, âòîðè÷íûõ èøåìè÷åñêèõ ÿâëåíèé è îêñèäàòèâíîãî ñòðåññà
    Exact
    [7, 11, 17, 18]
    Suffix
    . Ïåðå÷èñëåííûå ïàòîëîãè÷åñêèå ÿâëåíèÿ âåäóò ê ñíèæåíèþ âûðàáîòêè NO, êîòîðûé ÿâëÿåòñÿ íå òîëüêî âàçîäèëàòàòîðîì, íî è îïîñðåäóåò äåéñòâèå è îáðàçîâàíèå ôàêòîðîâ ðîñòà ýíäîòåëèÿ è ïîäàâëÿåò àïîïòîç â ïëàöåíòå.

  2. In-text reference with the coordinate start=5151
    Prefix
    Ñîâðåìåííûå äàííûå ñâèäåòåëüñòâóþò î ïîâûøåíèè â ìàòåðèíñêîé ïëàçìå êîíöåíòðàöèè ADMA ó æåíùèí ñ ïðåýêëàìïñèåé. Ìíîãèå àâòîðû äàííîå ÿâëåíèå ñ÷èòàþò ïðåäøåñòâåííèêîì ïðåýêëàìïñèè [21–23]. 3.  ïàòîãåíåçå ãåñòîçà íàøåë ñâîå ìåñòî è îêñèäàòèâíûé ñòðåññ
    Exact
    [7, 24–26]
    Suffix
    . Óâåëè÷åíèå ñâîáîäíûõ ðàäèêàëîâ è ñíèæåíèå àêòèâíîñòè àíòèîêñèäàíòíûõ ñèñòåì ìîæåò âîçíèêàòü íå òîëüêî êàê ñëåäñòâèå âûøåîïèñàííûõ ïðîöåññîâ, íî è ñàìîñòîÿòåëüíî íà ôîíå âîçäåéñòâèÿ âíåøíèõ ôàêòîðîâ.

  3. In-text reference with the coordinate start=6485
    Prefix
    Ñóùåñòâóåò öåëûé ðÿä ôàêòîðîâ, êîòîðûå ìîãóò ñëóæèòü ïàðàëëåëüíûìè ïóòÿìè ðåàëèçàöèè ïàòîëîãè÷åñêèõ ïðîöåññîâ èëè çàìûêàíèÿ ïîðî÷íûõ êðóãîâ. Ïðè èøåìèè ïëàöåíòû îïðåäåëÿåòñÿ ïîâûøåííîå ñîäåðæàíèå ýíäîòåëèíà-1 (ET-1), ôàêòîðà íåêðîçà îïóõîëè(TNF-á)è äðóãèõ ïðîâîñïàëèòåëüíûõ èíòåðëåéêèíîâ, êîòîðûå ñíèæàþò âûðàáîòêó NO
    Exact
    [7, 28–30]
    Suffix
    .  òå÷åíèå âñåé íîðìàëüíî ïðîòåêàþùåé áåðåìåííîñòè â êðîâè îïðåäåëÿåòñÿ ïîâûøåííîå ñîäåðæàíèå ðåíèíà, íî ÷óâñòâèòåëüíîñòü ê íåìó ñíèæåíà. Ïðè ïðåýêëàìïñèè íàáëþäàåòñÿ ïîâûøåíèå ÷óâñòâèòåëüíîñòè.

9
Zainulina MS. Endothelial dysfunction and its markers in preeclampsia. Zhurnal akusherstva i zhenskih bolezney 1997; (3): 18–22 (in Russian).
Total in-text references: 1
  1. In-text reference with the coordinate start=2891
    Prefix
     îòíîøåíèè ïàòîãåíåçà ïðåýêëàìïñèè õîòü è îñòàåòñÿ áîëüøîå êîëè÷åñòâî áåëûõ ïÿòåí, íî îïðåäåëåíû îñíîâíûå åãî ïîëîæåíèÿ, à âñå âíîâü îòêðûâàåìûå ñâåäåíèÿ ñêîðåå äîïîëíÿþò ïîëíîòó ïàòîëîãè÷åñêèõ ñîáûòèé. Ïðèçíàíî, ÷òî åãî êëþ÷åâûì ïàòîãåíåòè÷åñêèì çâåíîì ÿâëÿåòñÿ ãåíåðàëèçîâàííàÿ äèñôóíêöèÿ ýíäîòåëèÿ
    Exact
    [9–11]
    Suffix
    . Âûäåëÿþò íåñêîëüêî âîçìîæíûõ ïðè÷èí, ïðèâîäÿùèõ ê íàðóøåíèþ ôóíêöèè ýíäîòåëèÿ. 1. Íàðóøåíèå àíãèîãåíåçà è àïîïòîçà â ïëàöåíòå. Ìíîãèå àâòîðû ïðè ìîðôîëîãè÷åñêîì èññëåäîâàíèè ïëàöåíòû îïèñûâàþò ñïåöèôè÷åñêóþ ãèñòîëîãè÷åñêóþ êàðòèíó, çàêëþ÷àþùóþñÿ â äèñïðîïîðöèÿõ ðàçâèòèÿ åå ïîãðàíè÷íîãî ó÷àñòêà ìåæäó ìàòåðèíñêîé è ïëîäíûìè ÷àñòÿìè [12–14].

11
Bloschinskaya IA. The functional state of the vascular endothelium and microcirculation disorders in pregnancy complicated by preeclampsia and the effects of normobaric hypoxic therapy. Dr. Med. Sci [dissertation]. Khabarovsk: 2003 (in Russian).
Total in-text references: 2
  1. In-text reference with the coordinate start=4135
    Prefix
    Ãóìîðàëüíûå ôàêòîðû, îáðàçîâàâøèåñÿ â îòâåò íà èøåìèþ, à òàêæå, âîçìîæíî, àíòèãåíû ïëîäà, ïðîøåäøèå ÷åðåç ôåòîïëàöåíòàðíûé áàðüåð ñ ïîâûøåííîé ïðîíèöàåìîñòüþ, ïðè ïîïàäàíèè â îðãàíèçì ìàòåðè ïðîâîöèðóþò íàêîïëåíèå â ïëàçìå àñèììåòðè÷íîãî äèìåòèëàðãèíèíà (ADMA), ðàçâèòèå ãåíåðàëèçîâàííîé ýíäîòåëèàëüíîé äèñôóíêöèè, âòîðè÷íûõ èøåìè÷åñêèõ ÿâëåíèé è îêñèäàòèâíîãî ñòðåññà
    Exact
    [7, 11, 17, 18]
    Suffix
    . Ïåðå÷èñëåííûå ïàòîëîãè÷åñêèå ÿâëåíèÿ âåäóò ê ñíèæåíèþ âûðàáîòêè NO, êîòîðûé ÿâëÿåòñÿ íå òîëüêî âàçîäèëàòàòîðîì, íî è îïîñðåäóåò äåéñòâèå è îáðàçîâàíèå ôàêòîðîâ ðîñòà ýíäîòåëèÿ è ïîäàâëÿåò àïîïòîç â ïëàöåíòå.

  2. In-text reference with the coordinate start=15431
    Prefix
     êëèíè÷åñêîé ïðàêòèêå îïèñàíû äàííûå î ïîëîæèòåëüíûõ ýôôåêòàõ íîðìîáàðè÷åñêîé ãèïîêñèòåðàïèè, êîòîðóþ ìîæíî ðàññìàòðèâàòü êàê ãèïîêñè÷åñêîå ïðåêîíäèöèîíèðîâàíèå, ïðè ïðîôèëàêòèêå è ëå÷åíèè ïðåýêëàìñèè, ÷òî òàêæå ñâèäåòåëüñòâóåò î ïåðñïåêòèâíîñòè âûáðàííîãî íàïðàâëåíèÿ
    Exact
    [11]
    Suffix
    . Ïðèâåäåííûå âûøå ðåçóëüòàòû ýêñïåðèìåíòîâ è êëèíè÷åñêèå äàííûå ñâèäåòåëüñòâóþò î ïåðñïåêòèâíîñòè íàïðàâëåíèÿ ñîçäàíèÿ ëåêàðñòâåííûõ ïðåïàðàòîâ äëÿ ïðîôèëàêòèêè è ëå÷åíèÿ ïðåýêëàìïñèè, ìåõàíèçì äåéñòâèÿ êîòîðûõ áóäåò ðåàëèçîâûâàòüñÿ ÷åðåç àêòèâàöèþ çàùèòíûõ áèîëîãè÷åñêèõ ïðîöåññîâ, ïðîòåêàþùèõ ïðè èøåìè÷åñêîì ïðåêîíäèöèîíèðîâàíèè.

12
Pereira RD, De Long NE, Wang RC, Yazdi FT, Holloway AC, Raha S. Angiogenesis in the Placenta: The Role of Reactive Oxygen SpeciesSignaling.BiomedResInt.2015;2015:814543.doi: 10.1155/2015/814543.
Total in-text references: 1
  1. In-text reference with the coordinate start=3229
    Prefix
    Ìíîãèå àâòîðû ïðè ìîðôîëîãè÷åñêîì èññëåäîâàíèè ïëàöåíòû îïèñûâàþò ñïåöèôè÷åñêóþ ãèñòîëîãè÷åñêóþ êàðòèíó, çàêëþ÷àþùóþñÿ â äèñïðîïîðöèÿõ ðàçâèòèÿ åå ïîãðàíè÷íîãî ó÷àñòêà ìåæäó ìàòåðèíñêîé è ïëîäíûìè ÷àñòÿìè
    Exact
    [12–14]
    Suffix
    . Ïðîèñõîäèò íåïîëíàÿ èíâàçèÿ öèòîòðîôîáëàñòà â ñïèðàëüíûå àðòåðèè ìàòåðè. Óðîâåíü çðåëîñòè ñàìèõ ñïèðàëüíûõ àðòåðèé ïðè ïðåýêëàìïñèè íå äîñòèãàåò óðîâíÿ íîðìàëüíîé áåðåìåííîñòè.  ðåçóëüòàòå ñïèðàëüíûå àðòåðèè ñîõðàíÿþò ýíäîòåëèé, ýëàñòè÷åñêèé ñëîé è ñðåäíèé ìûøå÷íûé ñëîé.

14
Ducray JF, Naicker T, Moodley J. Pilot study of comparative placental morphometry in pre-eclamptic and normotensive pregnancies suggests possible maladaptations of the fetal component of the placenta. Eur J Obstet Gynecol Reprod Biol. 2011; 156(1): 29–34.
Total in-text references: 1
  1. In-text reference with the coordinate start=3751
    Prefix
    Óâåëè÷åííîå ïðîñòðàíñòâî ìåæäó êðîâîòîêàìè â ñïèðàëüíûõ àðòåðèÿõ è âîðñèíàìè õîðèîíà, à òàêæå ñîõðàíèâøàÿñÿ ñïîñîáíîñòü ñàìèõ ñïèðàëüíûõ àðòåðèé ê âàçîêîíñòðèêöèè ïðèâîäÿò ê èøåìèè òðîôîáëàñòà è ïîâûøåíèþ ïðîíèöàåìîñòè ôåòîïëàöåíòàðíîãî áàðüåðà
    Exact
    [14–16]
    Suffix
    . Ãóìîðàëüíûå ôàêòîðû, îáðàçîâàâøèåñÿ â îòâåò íà èøåìèþ, à òàêæå, âîçìîæíî, àíòèãåíû ïëîäà, ïðîøåäøèå ÷åðåç ôåòîïëàöåíòàðíûé áàðüåð ñ ïîâûøåííîé ïðîíèöàåìîñòüþ, ïðè ïîïàäàíèè â îðãàíèçì ìàòåðè ïðîâîöèðóþò íàêîïëåíèå â ïëàçìå àñèììåòðè÷íîãî äèìåòèëàðãèíèíà (ADMA), ðàçâèòèå ãåíåðàëèçîâàííîé ýíäîòåëèàëüíîé äèñôóíêöèè, âòîðè÷íûõ èøåìè÷åñêèõ ÿâëåíèé è îêñèäàòèâíîãî ñòðåññà [7, 11, 17, 18].

17
Bloschinskaya IA. The role of the main vasoactive factors of the vascular endothelium in the development of preeclampsia. Rossiyskiy vestnik akushera-ginekologa 2003; (4): 7–10 (in Russian).
Total in-text references: 1
  1. In-text reference with the coordinate start=4135
    Prefix
    Ãóìîðàëüíûå ôàêòîðû, îáðàçîâàâøèåñÿ â îòâåò íà èøåìèþ, à òàêæå, âîçìîæíî, àíòèãåíû ïëîäà, ïðîøåäøèå ÷åðåç ôåòîïëàöåíòàðíûé áàðüåð ñ ïîâûøåííîé ïðîíèöàåìîñòüþ, ïðè ïîïàäàíèè â îðãàíèçì ìàòåðè ïðîâîöèðóþò íàêîïëåíèå â ïëàçìå àñèììåòðè÷íîãî äèìåòèëàðãèíèíà (ADMA), ðàçâèòèå ãåíåðàëèçîâàííîé ýíäîòåëèàëüíîé äèñôóíêöèè, âòîðè÷íûõ èøåìè÷åñêèõ ÿâëåíèé è îêñèäàòèâíîãî ñòðåññà
    Exact
    [7, 11, 17, 18]
    Suffix
    . Ïåðå÷èñëåííûå ïàòîëîãè÷åñêèå ÿâëåíèÿ âåäóò ê ñíèæåíèþ âûðàáîòêè NO, êîòîðûé ÿâëÿåòñÿ íå òîëüêî âàçîäèëàòàòîðîì, íî è îïîñðåäóåò äåéñòâèå è îáðàçîâàíèå ôàêòîðîâ ðîñòà ýíäîòåëèÿ è ïîäàâëÿåò àïîïòîç â ïëàöåíòå.

18
Sidorova IS. Preeclampsia. Moscow: Meditsina; 2003 (in Russian).
Total in-text references: 1
  1. In-text reference with the coordinate start=4135
    Prefix
    Ãóìîðàëüíûå ôàêòîðû, îáðàçîâàâøèåñÿ â îòâåò íà èøåìèþ, à òàêæå, âîçìîæíî, àíòèãåíû ïëîäà, ïðîøåäøèå ÷åðåç ôåòîïëàöåíòàðíûé áàðüåð ñ ïîâûøåííîé ïðîíèöàåìîñòüþ, ïðè ïîïàäàíèè â îðãàíèçì ìàòåðè ïðîâîöèðóþò íàêîïëåíèå â ïëàçìå àñèììåòðè÷íîãî äèìåòèëàðãèíèíà (ADMA), ðàçâèòèå ãåíåðàëèçîâàííîé ýíäîòåëèàëüíîé äèñôóíêöèè, âòîðè÷íûõ èøåìè÷åñêèõ ÿâëåíèé è îêñèäàòèâíîãî ñòðåññà
    Exact
    [7, 11, 17, 18]
    Suffix
    . Ïåðå÷èñëåííûå ïàòîëîãè÷åñêèå ÿâëåíèÿ âåäóò ê ñíèæåíèþ âûðàáîòêè NO, êîòîðûé ÿâëÿåòñÿ íå òîëüêî âàçîäèëàòàòîðîì, íî è îïîñðåäóåò äåéñòâèå è îáðàçîâàíèå ôàêòîðîâ ðîñòà ýíäîòåëèÿ è ïîäàâëÿåò àïîïòîç â ïëàöåíòå.

19
Böger RH, Diemert A, Schwedhelm E, Lüneburg N, Maas R, Hecher K. The role of nitric oxide synthase inhibition by asymmetric dimethylarginine in the pathophysiology of preeclampsia. Gynecol Obstet Invest. 2010; 69(1): 1–13.
Total in-text references: 1
  1. In-text reference with the coordinate start=4796
    Prefix
    Íàêîïëåíèå â êðîâè áåðåìåííûõ æåíùèí ìåòèëèðîâàííûõ àíàëîãîâ L-àðãèíèíà — àñèììåòðè÷íîãî äèìåòèëàðãèíèíà (ADMA) è ìîíîìåòèëàðãèíèíà (MMA), ÿâëÿþùèõñÿ ýíäîãåííûìè èíãèáèòîðàìè ýíäîòåëèàëüíîé NO-ñèíòàçû (åNOS)
    Exact
    [19]
    Suffix
    . NO ÿâëÿåòñÿ ìîùíûì ñîñóäîðàñøèðÿþùèì ôàêòîðîì, è åãî íåäîñòàòîê ïðèâîäèò ê íàðóøåíèþ âàçîäèëàòàöèè. Ñîâðåìåííûå äàííûå ñâèäåòåëüñòâóþò î ïîâûøåíèè â ìàòåðèíñêîé ïëàçìå êîíöåíòðàöèè ADMA ó æåíùèí ñ ïðåýêëàìïñèåé.

21
Augustine MS, Rogers LK. Measurement of arginine metabolites: regulators of nitric oxide metabolism. Curr Protoc Toxicol. 2013. doi: 10.1002/0471140856.tx1716s58.
Total in-text references: 1
  1. In-text reference with the coordinate start=5079
    Prefix
    NO ÿâëÿåòñÿ ìîùíûì ñîñóäîðàñøèðÿþùèì ôàêòîðîì, è åãî íåäîñòàòîê ïðèâîäèò ê íàðóøåíèþ âàçîäèëàòàöèè. Ñîâðåìåííûå äàííûå ñâèäåòåëüñòâóþò î ïîâûøåíèè â ìàòåðèíñêîé ïëàçìå êîíöåíòðàöèè ADMA ó æåíùèí ñ ïðåýêëàìïñèåé. Ìíîãèå àâòîðû äàííîå ÿâëåíèå ñ÷èòàþò ïðåäøåñòâåííèêîì ïðåýêëàìïñèè
    Exact
    [21–23]
    Suffix
    . 3.  ïàòîãåíåçå ãåñòîçà íàøåë ñâîå ìåñòî è îêñèäàòèâíûé ñòðåññ [7, 24–26]. Óâåëè÷åíèå ñâîáîäíûõ ðàäèêàëîâ è ñíèæåíèå àêòèâíîñòè àíòèîêñèäàíòíûõ ñèñòåì ìîæåò âîçíèêàòü íå òîëüêî êàê ñëåäñòâèå âûøåîïèñàííûõ ïðîöåññîâ, íî è ñàìîñòîÿòåëüíî íà ôîíå âîçäåéñòâèÿ âíåøíèõ ôàêòîðîâ.

24
Micle O, Muresan M, Antal L. The influence of homocysteine and oxidative stress on pregnancy outcome. J Med Life 2012; 5(1): 68–73.
Total in-text references: 1
  1. In-text reference with the coordinate start=5151
    Prefix
    Ñîâðåìåííûå äàííûå ñâèäåòåëüñòâóþò î ïîâûøåíèè â ìàòåðèíñêîé ïëàçìå êîíöåíòðàöèè ADMA ó æåíùèí ñ ïðåýêëàìïñèåé. Ìíîãèå àâòîðû äàííîå ÿâëåíèå ñ÷èòàþò ïðåäøåñòâåííèêîì ïðåýêëàìïñèè [21–23]. 3.  ïàòîãåíåçå ãåñòîçà íàøåë ñâîå ìåñòî è îêñèäàòèâíûé ñòðåññ
    Exact
    [7, 24–26]
    Suffix
    . Óâåëè÷åíèå ñâîáîäíûõ ðàäèêàëîâ è ñíèæåíèå àêòèâíîñòè àíòèîêñèäàíòíûõ ñèñòåì ìîæåò âîçíèêàòü íå òîëüêî êàê ñëåäñòâèå âûøåîïèñàííûõ ïðîöåññîâ, íî è ñàìîñòîÿòåëüíî íà ôîíå âîçäåéñòâèÿ âíåøíèõ ôàêòîðîâ.

27
Bouras G, Deftereos S, Tousoulis D, Giannopoulos G, Chatzis G, Tsounis D, et al. Asymmetric Dimethylarginine (ADMA): a promising biomarker for cardiovascular disease? Curr Top Med Chem. 2013; 13(2): 180–200.
Total in-text references: 1
  1. In-text reference with the coordinate start=5862
    Prefix
    Ñâîáîäíîðàäèêàëüíîå ïîâðåæäåíèå êëåòî÷íûõ ñòðóêòóð è íåäîñòàòîê NO ïðèâîäÿò òàêæå ê óñèëåíèþ àïîïòîçà â ïëàöåíòå, ÷òî, íåñîìíåííî, óñèëèâàåò äèñàíãèîãåíåç. Íåìàëîâàæíûì ôàêòîðîì ÿâëÿåòñÿ òî, ÷òî îêèñëèòåëüíûé ñòðåññ ñíèæàåò àêòèâíîñòü DDAh
    Exact
    [27, 28]
    Suffix
    . Ýòî ïðèâîäèò, êàê îòìå÷àëîñü âûøå, ê íàêîïëåíèþ â êðîâè ADMA è MMA. Òàêèì îáðàçîì, ìû íàáëþäàåì çàìûêàíèå ñëåäóþùåãî ïîðî÷íîãî êðóãà: îêèñëèòåëüíûé ñòðåññ óñóãóáëÿåò ýíäîòåëèàëüíóþ äèñôóíêöèþ, ýíäîòåëèàëüíàÿ äèñôóíêöèÿ óñèëèâàåò èøåìèþ è ïðèâîäèò ê áîëüøåìó îáðàçîâàíèþ ïåðåêèñíûõ ðàäèêàëîâ.

28
Yi-Ping Leng, Ni Qiu, Wei-jin Fang, Mei Zhang, Zhi-Min He. Involvement of increased endogenous asymmetric dimethylarginine in the hepatic endoplasmic reticulum stress of type 2 diabetic rats. doi: 10.1371/journal.pone.0097125.
Total in-text references: 2
  1. In-text reference with the coordinate start=5862
    Prefix
    Ñâîáîäíîðàäèêàëüíîå ïîâðåæäåíèå êëåòî÷íûõ ñòðóêòóð è íåäîñòàòîê NO ïðèâîäÿò òàêæå ê óñèëåíèþ àïîïòîçà â ïëàöåíòå, ÷òî, íåñîìíåííî, óñèëèâàåò äèñàíãèîãåíåç. Íåìàëîâàæíûì ôàêòîðîì ÿâëÿåòñÿ òî, ÷òî îêèñëèòåëüíûé ñòðåññ ñíèæàåò àêòèâíîñòü DDAh
    Exact
    [27, 28]
    Suffix
    . Ýòî ïðèâîäèò, êàê îòìå÷àëîñü âûøå, ê íàêîïëåíèþ â êðîâè ADMA è MMA. Òàêèì îáðàçîì, ìû íàáëþäàåì çàìûêàíèå ñëåäóþùåãî ïîðî÷íîãî êðóãà: îêèñëèòåëüíûé ñòðåññ óñóãóáëÿåò ýíäîòåëèàëüíóþ äèñôóíêöèþ, ýíäîòåëèàëüíàÿ äèñôóíêöèÿ óñèëèâàåò èøåìèþ è ïðèâîäèò ê áîëüøåìó îáðàçîâàíèþ ïåðåêèñíûõ ðàäèêàëîâ.

  2. In-text reference with the coordinate start=6485
    Prefix
    Ñóùåñòâóåò öåëûé ðÿä ôàêòîðîâ, êîòîðûå ìîãóò ñëóæèòü ïàðàëëåëüíûìè ïóòÿìè ðåàëèçàöèè ïàòîëîãè÷åñêèõ ïðîöåññîâ èëè çàìûêàíèÿ ïîðî÷íûõ êðóãîâ. Ïðè èøåìèè ïëàöåíòû îïðåäåëÿåòñÿ ïîâûøåííîå ñîäåðæàíèå ýíäîòåëèíà-1 (ET-1), ôàêòîðà íåêðîçà îïóõîëè(TNF-á)è äðóãèõ ïðîâîñïàëèòåëüíûõ èíòåðëåéêèíîâ, êîòîðûå ñíèæàþò âûðàáîòêó NO
    Exact
    [7, 28–30]
    Suffix
    .  òå÷åíèå âñåé íîðìàëüíî ïðîòåêàþùåé áåðåìåííîñòè â êðîâè îïðåäåëÿåòñÿ ïîâûøåííîå ñîäåðæàíèå ðåíèíà, íî ÷óâñòâèòåëüíîñòü ê íåìó ñíèæåíà. Ïðè ïðåýêëàìïñèè íàáëþäàåòñÿ ïîâûøåíèå ÷óâñòâèòåëüíîñòè.

31
Blois SM, Dechend R, Barrientos G, Staff AC. A potential pathophysiological role for galectins and the renin-angiotensin system in preeclampsia. Cell Mol Life Sci. 2015; 72(1): 39–50.
Total in-text references: 1
  1. In-text reference with the coordinate start=6839
    Prefix
    Ïðè ïðåýêëàìïñèè íàáëþäàåòñÿ ïîâûøåíèå ÷óâñòâèòåëüíîñòè. Õîòÿ ìåõàíèçìû ýòîãî ÿâëåíèÿ äî êîíöà íå ÿñíû, âîâëå÷åíèå â ïàòîëîãè÷åñêèé ïðîöåññ ðåíèí-àíãèîòåíçèíîâîé ñèñòåìû ïðèâëåêàåò âíèìàíèå ðÿäà àâòîðîâ
    Exact
    [31, 32]
    Suffix
    . Ïîâûøåííàÿ êîíöåíòðàöèÿ ãîìîöèñòåèíà â ïëàçìå íà ðàííèõ ñðîêàõ áåðåìåííîñòè êîððåëèðóåò ñ áîëåå âûñîêîé ñòåïåíüþ âåðîÿòíîñòè ïðåýêëàìïñèè è çàäåðæêîé âíóòðèóòðîáíîãî ðàçâèòèÿ [33, 34]. Â ýêñïåðèìåíòå áûëî ïîêàçàíî, ÷òî âî âðåìÿ áåðåìåííîñòè ïðîèñõîäèò ïîâûøåíèå ÷óâñòâèòåëüíîñòè ñîñóäèñòîé ñòåíêè ê ãîìîöèñòåèíó [35].

32
Thomason J, Reyes M, Allen SR, Jones RO, Beeram MR, Kuehl TJ, et al. Elevation of (Pro)Renin and (Pro)Renin Receptor in Preeclampsia. Am J Hypertens. 2015; 28(10): 1277–84.
Total in-text references: 1
  1. In-text reference with the coordinate start=6839
    Prefix
    Ïðè ïðåýêëàìïñèè íàáëþäàåòñÿ ïîâûøåíèå ÷óâñòâèòåëüíîñòè. Õîòÿ ìåõàíèçìû ýòîãî ÿâëåíèÿ äî êîíöà íå ÿñíû, âîâëå÷åíèå â ïàòîëîãè÷åñêèé ïðîöåññ ðåíèí-àíãèîòåíçèíîâîé ñèñòåìû ïðèâëåêàåò âíèìàíèå ðÿäà àâòîðîâ
    Exact
    [31, 32]
    Suffix
    . Ïîâûøåííàÿ êîíöåíòðàöèÿ ãîìîöèñòåèíà â ïëàçìå íà ðàííèõ ñðîêàõ áåðåìåííîñòè êîððåëèðóåò ñ áîëåå âûñîêîé ñòåïåíüþ âåðîÿòíîñòè ïðåýêëàìïñèè è çàäåðæêîé âíóòðèóòðîáíîãî ðàçâèòèÿ [33, 34]. Â ýêñïåðèìåíòå áûëî ïîêàçàíî, ÷òî âî âðåìÿ áåðåìåííîñòè ïðîèñõîäèò ïîâûøåíèå ÷óâñòâèòåëüíîñòè ñîñóäèñòîé ñòåíêè ê ãîìîöèñòåèíó [35].

33
Wang J, Cui Y, Ge J, Ma M. Folic acid supplementation attenuates hyperhomocysteinemia-induced preeclampsia-like symptoms in rats. Neural Regen Res. 2012; 7(25): 1954–9.
Total in-text references: 1
  1. In-text reference with the coordinate start=7027
    Prefix
    Õîòÿ ìåõàíèçìû ýòîãî ÿâëåíèÿ äî êîíöà íå ÿñíû, âîâëå÷åíèå â ïàòîëîãè÷åñêèé ïðîöåññ ðåíèí-àíãèîòåíçèíîâîé ñèñòåìû ïðèâëåêàåò âíèìàíèå ðÿäà àâòîðîâ [31, 32]. Ïîâûøåííàÿ êîíöåíòðàöèÿ ãîìîöèñòåèíà â ïëàçìå íà ðàííèõ ñðîêàõ áåðåìåííîñòè êîððåëèðóåò ñ áîëåå âûñîêîé ñòåïåíüþ âåðîÿòíîñòè ïðåýêëàìïñèè è çàäåðæêîé âíóòðèóòðîáíîãî ðàçâèòèÿ
    Exact
    [33, 34]
    Suffix
    .  ýêñïåðèìåíòå áûëî ïîêàçàíî, ÷òî âî âðåìÿ áåðåìåííîñòè ïðîèñõîäèò ïîâûøåíèå ÷óâñòâèòåëüíîñòè ñîñóäèñòîé ñòåíêè ê ãîìîöèñòåèíó [35]. Ïðåäïîëîæèòåëüíî, ýòî ìîæåò áûòü ñëåäñòâèåì íàðóøåíèÿ ôóíêöèè àêòèâíîãî öåíòðà NO-ñèíòàçû — òåòðàãèäðîáèîïòåðèíà âñëåäñòâèå îêèñëèòåëüíîãî ñòðåññà, ÷òî ïðèâîäèò ê óãíåòåíèþ âàçîäèëàòàöèè, âûçûâàåìîé îêñèäîì àçîòà [35].

34
Pérez-Sepúlveda A, España-Perrot PP, Fernández XB, Ahumada V, Bustos V, Arraztoa JA, et al. Levels of key enzymes of methionine-homocysteine metabolism in preeclampsia. Biomed Res Int. 2013. 2013:731962. doi: 10.1155/2013/731962.
Total in-text references: 1
  1. In-text reference with the coordinate start=7027
    Prefix
    Õîòÿ ìåõàíèçìû ýòîãî ÿâëåíèÿ äî êîíöà íå ÿñíû, âîâëå÷åíèå â ïàòîëîãè÷åñêèé ïðîöåññ ðåíèí-àíãèîòåíçèíîâîé ñèñòåìû ïðèâëåêàåò âíèìàíèå ðÿäà àâòîðîâ [31, 32]. Ïîâûøåííàÿ êîíöåíòðàöèÿ ãîìîöèñòåèíà â ïëàçìå íà ðàííèõ ñðîêàõ áåðåìåííîñòè êîððåëèðóåò ñ áîëåå âûñîêîé ñòåïåíüþ âåðîÿòíîñòè ïðåýêëàìïñèè è çàäåðæêîé âíóòðèóòðîáíîãî ðàçâèòèÿ
    Exact
    [33, 34]
    Suffix
    .  ýêñïåðèìåíòå áûëî ïîêàçàíî, ÷òî âî âðåìÿ áåðåìåííîñòè ïðîèñõîäèò ïîâûøåíèå ÷óâñòâèòåëüíîñòè ñîñóäèñòîé ñòåíêè ê ãîìîöèñòåèíó [35]. Ïðåäïîëîæèòåëüíî, ýòî ìîæåò áûòü ñëåäñòâèåì íàðóøåíèÿ ôóíêöèè àêòèâíîãî öåíòðà NO-ñèíòàçû — òåòðàãèäðîáèîïòåðèíà âñëåäñòâèå îêèñëèòåëüíîãî ñòðåññà, ÷òî ïðèâîäèò ê óãíåòåíèþ âàçîäèëàòàöèè, âûçûâàåìîé îêñèäîì àçîòà [35].

35
Powers RW, Gandley RE, Lykins DL, Roberts JM. Moderate hyperhomocysteinemia decreases endothelial-dependent vasorelaxation in pregnant but not nonpregnant mice. Hypertension 2004; 44: 327–33.
Total in-text references: 2
  1. In-text reference with the coordinate start=7163
    Prefix
    Ïîâûøåííàÿ êîíöåíòðàöèÿ ãîìîöèñòåèíà â ïëàçìå íà ðàííèõ ñðîêàõ áåðåìåííîñòè êîððåëèðóåò ñ áîëåå âûñîêîé ñòåïåíüþ âåðîÿòíîñòè ïðåýêëàìïñèè è çàäåðæêîé âíóòðèóòðîáíîãî ðàçâèòèÿ [33, 34]. Â ýêñïåðèìåíòå áûëî ïîêàçàíî, ÷òî âî âðåìÿ áåðåìåííîñòè ïðîèñõîäèò ïîâûøåíèå ÷óâñòâèòåëüíîñòè ñîñóäèñòîé ñòåíêè ê ãîìîöèñòåèíó
    Exact
    [35]
    Suffix
    . Ïðåäïîëîæèòåëüíî, ýòî ìîæåò áûòü ñëåäñòâèåì íàðóøåíèÿ ôóíêöèè àêòèâíîãî öåíòðà NO-ñèíòàçû — òåòðàãèäðîáèîïòåðèíà âñëåäñòâèå îêèñëèòåëüíîãî ñòðåññà, ÷òî ïðèâîäèò ê óãíåòåíèþ âàçîäèëàòàöèè, âûçûâàåìîé îêñèäîì àçîòà [35].

  2. In-text reference with the coordinate start=7383
    Prefix
    Ïðåäïîëîæèòåëüíî, ýòî ìîæåò áûòü ñëåäñòâèåì íàðóøåíèÿ ôóíêöèè àêòèâíîãî öåíòðà NO-ñèíòàçû — òåòðàãèäðîáèîïòåðèíà âñëåäñòâèå îêèñëèòåëüíîãî ñòðåññà, ÷òî ïðèâîäèò ê óãíåòåíèþ âàçîäèëàòàöèè, âûçûâàåìîé îêñèäîì àçîòà
    Exact
    [35]
    Suffix
    . Îïèñàííàÿ äàëåêî íå ïîëíàÿ ñõåìà ïàòîãåíåçà ïîêàçûâàåò, ÷òî äàííîå çàáîëåâàíèå ñâÿçàíî ñ âîçíèêíîâåíèåì íåñêîëüêèõ ïîðî÷íûõ êðóãîâ, îáÿçàòåëüíûìè çâåíüÿìè êîòîðûõ ÿâëÿþòñÿ íàðóøåíèå ôóíêöèè ýíäîòåëèÿ èëè èøåìè÷åñêèå ïîâðåæäåíèÿ.

36
Shcherbakova ES, Dunaeva AR, Zagidullin NSh. Ischemic preconditioning in internal medicine and vascular surgery. Meditsinskiy vestnik Bashkortostana 2014; 9(1): 118–23 (in Russian).
Total in-text references: 1
  1. In-text reference with the coordinate start=8791
    Prefix
    Ïîä ìåõàíèçìàìè åñòåñòâåííîé öèòîïðîòåêöèè ïîäðàçóìåâàåòñÿ êîìïëåêñ çàùèòíûõ áèîëîãè÷åñêèõ ïðîöåññîâ, ïðîòåêàþùèõ ïðè èøåìè÷åñêîì ïðåêîíäèöèîíèðîâàíèè. Èñòîðèÿîòêðûòèÿ èèçó÷åíèÿèøåìè÷åñêîãî ïðåêîíäèöèîíèðîâàíèÿ íàñ÷èòûâàåò áîëåå 20 ëåò
    Exact
    [36, 37]
    Suffix
    .  îáùåïðèíÿòîì ïîíèìàíèè ýòî äâóõôàçíîå ÿâëåíèå çàêëþ÷àåòñÿ â óâåëè÷åíèè óñòîé÷èâîñòè ê èøåìèè òêàíè èëè îðãàíà ïîñëå êðàòêîâðåìåííîãî ýïèçîäà èøåìèè-ðåïåðôóçèè. Âî âðåìÿ ðàííåé ôàçû («êëàññè÷åñêîå »èëè «ðàííåå ïðåêîíäèöèîíèðîâàíèå ») ïðîèñõîäèò âûäåëåíèå öåëîãî ðÿäà ãóìîðàëüíûõ ôàêòîðîâ (òðèããåðîâ): àäåíîçèí, áðàäèêèíèí, îïèîèäû, ñâîáîäíûå ðàäèêàëû è äð. [38–40].

37
Karpov ES, Kotelnikova EV, Lyamina NP. Ischemic preconditioning and its cardioprotective effect in patients with cardio-rehabilitation programs with coronary heart disease after percutaneous coronary intervention. Rossiyskiy kardiologicheskiy zhurnal 2012; 4(96): 104–8 (in Russian).
Total in-text references: 1
  1. In-text reference with the coordinate start=8791
    Prefix
    Ïîä ìåõàíèçìàìè åñòåñòâåííîé öèòîïðîòåêöèè ïîäðàçóìåâàåòñÿ êîìïëåêñ çàùèòíûõ áèîëîãè÷åñêèõ ïðîöåññîâ, ïðîòåêàþùèõ ïðè èøåìè÷åñêîì ïðåêîíäèöèîíèðîâàíèè. Èñòîðèÿîòêðûòèÿ èèçó÷åíèÿèøåìè÷åñêîãî ïðåêîíäèöèîíèðîâàíèÿ íàñ÷èòûâàåò áîëåå 20 ëåò
    Exact
    [36, 37]
    Suffix
    .  îáùåïðèíÿòîì ïîíèìàíèè ýòî äâóõôàçíîå ÿâëåíèå çàêëþ÷àåòñÿ â óâåëè÷åíèè óñòîé÷èâîñòè ê èøåìèè òêàíè èëè îðãàíà ïîñëå êðàòêîâðåìåííîãî ýïèçîäà èøåìèè-ðåïåðôóçèè. Âî âðåìÿ ðàííåé ôàçû («êëàññè÷åñêîå »èëè «ðàííåå ïðåêîíäèöèîíèðîâàíèå ») ïðîèñõîäèò âûäåëåíèå öåëîãî ðÿäà ãóìîðàëüíûõ ôàêòîðîâ (òðèããåðîâ): àäåíîçèí, áðàäèêèíèí, îïèîèäû, ñâîáîäíûå ðàäèêàëû è äð. [38–40].

38
Griecsová L, Farkašová V, Gáblovský I, Khandelwal VK, Bernátová I, TatarkováZ, et al. Effect of maturation on the resistance of rat hearts against ischemia. Study of potential molecular mechanisms. Physiol Res 2015 Dec 15. [Epub ahead of print].
Total in-text references: 1
  1. In-text reference with the coordinate start=9163
    Prefix
    Âî âðåìÿ ðàííåé ôàçû («êëàññè÷åñêîå »èëè «ðàííåå ïðåêîíäèöèîíèðîâàíèå ») ïðîèñõîäèò âûäåëåíèå öåëîãî ðÿäà ãóìîðàëüíûõ ôàêòîðîâ (òðèããåðîâ): àäåíîçèí, áðàäèêèíèí, îïèîèäû, ñâîáîäíûå ðàäèêàëû è äð.
    Exact
    [38–40]
    Suffix
    . Âî âðåìÿ îòñðî÷åííîé ôàçû èøåìè÷åñêîãî ïðåêîíäèöèîíèðîâàíèÿ ïðîèñõîäèò àêòèâàöèÿ ãåíîìà. Âêëþ÷àåòñÿ èíäóêöèÿ ñèíòåçà îêñèäà àçîòà, ñóïåðîêñèääèñìóòàçû è äðóãèõ àíòèîêñèäàíòíûõ ôåðìåíòîâ, à òàêæå áåëêîâ òåïëîâîãî øîêà, êîòîðûå âîâëå÷åíû â ñòàáèëèçàöèþ öèòîñêåëåòà [40, 41].

40
Alleman RJ, Stewart LM, Tsang AM, Brown DA. Why Does Exercise «Trigger» Adaptive Protective Responses in the Heart? Dose Response. 2015 Jan-Mar; 13(1). doi: 10.2203/dose-response.14–023.Alleman
Total in-text references: 4
  1. In-text reference with the coordinate start=9436
    Prefix
    Âî âðåìÿ îòñðî÷åííîé ôàçû èøåìè÷åñêîãî ïðåêîíäèöèîíèðîâàíèÿ ïðîèñõîäèò àêòèâàöèÿ ãåíîìà. Âêëþ÷àåòñÿ èíäóêöèÿ ñèíòåçà îêñèäà àçîòà, ñóïåðîêñèääèñìóòàçû è äðóãèõ àíòèîêñèäàíòíûõ ôåðìåíòîâ, à òàêæå áåëêîâ òåïëîâîãî øîêà, êîòîðûå âîâëå÷åíû â ñòàáèëèçàöèþ öèòîñêåëåòà
    Exact
    [40, 41]
    Suffix
    . Êîíå÷íûì èòîãîì ñëîæíûõ âíóòðèêëåòî÷íûõ ïðîöåññîâ ÿâëÿåòñÿ îòêðûòèå Ê+ÀÒÔêàíàëîâ, ÷òî ïðèâîäèò ê óìåíüøåíèþ ïðîíèöàåìîñòè ìåìáðàí äëÿ Ñà2+[40].  ïåðâûå ãîäû îñíîâíûå èññëåäîâàíèÿ ïðîâîäèëèñü â íàïðàâëåíèè èçó÷åíèÿ èçìåíåíèé â îðãàíå, íåïîñðåäñòâåííî ïîäâåðãøåìñÿ èøåìè÷åñêîìó ïðåêîíäèöèîíèðîâàíèþ (ïðÿìîå èëè êëàññè÷åñêîå ïðåêîíäèöèîíèðîâàíèå).

  2. In-text reference with the coordinate start=9589
    Prefix
    Âêëþ÷àåòñÿ èíäóêöèÿ ñèíòåçà îêñèäà àçîòà, ñóïåðîêñèääèñìóòàçû è äðóãèõ àíòèîêñèäàíòíûõ ôåðìåíòîâ, à òàêæå áåëêîâ òåïëîâîãî øîêà, êîòîðûå âîâëå÷åíû â ñòàáèëèçàöèþ öèòîñêåëåòà [40, 41]. Êîíå÷íûì èòîãîì ñëîæíûõ âíóòðèêëåòî÷íûõ ïðîöåññîâ ÿâëÿåòñÿ îòêðûòèå Ê+ÀÒÔêàíàëîâ, ÷òî ïðèâîäèò ê óìåíüøåíèþ ïðîíèöàåìîñòè ìåìáðàí äëÿ Ñà2+
    Exact
    [40]
    Suffix
    .  ïåðâûå ãîäû îñíîâíûå èññëåäîâàíèÿ ïðîâîäèëèñü â íàïðàâëåíèè èçó÷åíèÿ èçìåíåíèé â îðãàíå, íåïîñðåäñòâåííî ïîäâåðãøåìñÿ èøåìè÷åñêîìó ïðåêîíäèöèîíèðîâàíèþ (ïðÿìîå èëè êëàññè÷åñêîå ïðåêîíäèöèîíèðîâàíèå).

  3. In-text reference with the coordinate start=11980
    Prefix
    Èìåííî ïîýòîìó â ïîñëåäíåå âðåìÿ âñå áîëüøèé èíòåðåñ âûçûâàþò èññëåäîâàíèÿ íå òîëüêî ëîêàëüíûõ ÿâëåíèé ïîñëå ýïèçîäà èøåìèè-ðåïåðôóçèè èëè åãî âëèÿíèÿ íà ðåîëîãèþ è òðîìáîîáðàçóþùèå ñâîéñòâà êðîâè [43, 48], íî è ÿâëåíèé â ñîñåäíèõ îðãàíàõ [43, 47, 49–52]. Ðåàëèçàöèÿ äàííîãî ÿâëåíèÿ îñóùåñòâëÿåòñÿ çà ñ÷åò ãóìîðàëüíûõ ôàêòîðîâ è èçìåíåíèÿ àêòèâíîñòè ðàçëè÷íûõ îòäåëîâ íåðâíîé ñèñòåìû
    Exact
    [40]
    Suffix
    .  ïîñëåäíåå âðåìÿ â èñòî÷íèêàõ ëèòåðàòóðû ïîÿâèëèñü äàííûå î ñðàâíèòåëüíîì èññëåäîâàíèè ýôôåêòèâíîñòè ïðÿìîãî è äèñòàíòíîãî ïðåêîíäèöèîíèðîâàíèÿ. È õîòÿ ðåçóëüòàòû ïðîâåäåííûõ èññëåäîâàíèé ïðîòèâîðå÷èâû, î÷åâèäíî, ÷òî äèñòàíòíîå èøåìè÷åñêîå ïðåêîíäèöèîíèðîâàíèå èìååò ðÿä ïðåèìóùåñòâ ïåðåä ïðÿìûì èøåìè÷åñêèì ïðåêîíäèöèîíèðîâàíèåì, çàêëþ÷àþùèõñÿ íå òîëüêî â óäîáñòâå è ïðîñòîòå èñïîëíåíèÿ, íî â

  4. In-text reference with the coordinate start=13908
    Prefix
    Äëÿ çàïóñêà áèîëîãè÷åñêèõ ïðîöåññîâ åñòåñòâåííîé öèòîïðîòåêöèè ïðè ôèçè÷åñêèõ óïðàæíåíèÿõ áîëüøóþ ðîëü èãðàåò äëèòåëüíîñòü è èíòåíñèâíîñòü íàãðóçêè, êàê ïðè èøåìè÷åñêîì ïðåêîíäèöèîíèðîâàíèè — äëèòåëüíîñòü èøåìè÷åñêîãî ñòèìóëà
    Exact
    [40, 53]
    Suffix
    , ò.å. ñòèìóë äîëæåí áûòü äîñòàòî÷íûì äëÿ èõ àêòèâàöèè. Ïðè ðåàëèçàöèè çàùèòíûõ ìåõàíèçìîâ áèîëîãè÷åñêèõ ïðîöåññîâ, àêòèâèðóåìûõ êîðîòêèìè ýïèçîäàìè èøåìèè-ðåïåðôóçèè, ïðîèñõîäèò âîâëå÷åíèå áîëüøîãî êîëè÷åñòâà âíóòðè- è âíåêëåòî÷íûõ ñòðóêòóð: èîííûõ êàíàëîâ, âíóòðèêëåòî÷íûõ ìåññåíäæåðîâ, ãóìîðàëüíûõ ôàêòîðîâ, ðåöåïòîðíûõ êîìïëåêñîâ, ôåðìåíòîâ è äð. [47, 56–63].

41
Veighey K, Macallister RJ. Clinical applications of remote ischemic preconditioning. Cardiol Res Pract. 2012. 2012:620681. doi: 10.1155/2012/620681.
Total in-text references: 1
  1. In-text reference with the coordinate start=9436
    Prefix
    Âî âðåìÿ îòñðî÷åííîé ôàçû èøåìè÷åñêîãî ïðåêîíäèöèîíèðîâàíèÿ ïðîèñõîäèò àêòèâàöèÿ ãåíîìà. Âêëþ÷àåòñÿ èíäóêöèÿ ñèíòåçà îêñèäà àçîòà, ñóïåðîêñèääèñìóòàçû è äðóãèõ àíòèîêñèäàíòíûõ ôåðìåíòîâ, à òàêæå áåëêîâ òåïëîâîãî øîêà, êîòîðûå âîâëå÷åíû â ñòàáèëèçàöèþ öèòîñêåëåòà
    Exact
    [40, 41]
    Suffix
    . Êîíå÷íûì èòîãîì ñëîæíûõ âíóòðèêëåòî÷íûõ ïðîöåññîâ ÿâëÿåòñÿ îòêðûòèå Ê+ÀÒÔêàíàëîâ, ÷òî ïðèâîäèò ê óìåíüøåíèþ ïðîíèöàåìîñòè ìåìáðàí äëÿ Ñà2+[40].  ïåðâûå ãîäû îñíîâíûå èññëåäîâàíèÿ ïðîâîäèëèñü â íàïðàâëåíèè èçó÷åíèÿ èçìåíåíèé â îðãàíå, íåïîñðåäñòâåííî ïîäâåðãøåìñÿ èøåìè÷åñêîìó ïðåêîíäèöèîíèðîâàíèþ (ïðÿìîå èëè êëàññè÷åñêîå ïðåêîíäèöèîíèðîâàíèå).

42
Kocman EA, Ozatik O, Sahin A, Guney T, Kose AA, Dag I, et al. Effects of ischemic preconditioning protocols on skeletal muscle ischemia-reperfusion injury. J Surg Res. 2015; 193(2): 942–52.
Total in-text references: 2
  1. In-text reference with the coordinate start=10512
    Prefix
    Âîñïðîèçâåäåíèå êîðîòêèõ ýïèçîäîâ èøåìèèðåïåðôóçèè ïîñëå âîçíèêíîâåíèÿ ïàòîëîãè÷åñêîãî ÿâëåíèÿ ïîëó÷èëî íàçâàíèå «èøåìè÷åñêîå ïîñòêîíäèöèîíèðîâàíèå». Ïðèìåíåíèå åãî â êëèíè÷åñêîé ïðàêòèêå ïðåäñòàâëÿåòñÿ íàèáîëåå âåðîÿòíûì, íî ïî ñèëå âûðàæåííîñòè çàùèòíîãî ýôôåêòà èøåìè÷åñêîå ïîñòêîíäèöèîíèðîâàíèå óñòóïàåò èøåìè÷åñêîìó ïðåêîíäèöèîíèðîâàíèþ
    Exact
    [42]
    Suffix
    . Èøåìèÿ ÿâëÿåòñÿ îäíèì èç íàèáîëåå ñèëüíûõ è óíèâåðñàëüíûõ ñòèìóëîâ â îðãàíèçìå. Èøåìè÷åñêîå ïîâðåæäåíèå îäíîãî îðãàíà íå ìîæåò íå îòðàæàòüñÿ íà ñîñòîÿíèè ñîñåäíèõ îðãàíîâ è âûçûâàåò ïåðåñòðîéêó â ôóíêöèîíèðîâàíèè ðàçëè÷íûõ ñèñòåì öåëîãî îðãàíèçìà.

  2. In-text reference with the coordinate start=11374
    Prefix
    Ýòè îáñòîÿòåëüñòâà è äàííûå î ìåõàíèçìàõ ðåàëèçàöèè çàùèòíûõ ïðîöåññîâ èøåìè÷åñêîãî ïðåêîíäèöèîíèðîâàíèè, ïîëó÷åííûå ïðè ïðîâåäåíèè èññëåäîâàíèé, äàëè ïðåäïîñûëêó äëÿ èñïîëüçîâàíèÿ íàðÿäó ñ ïðÿìûì èøåìè÷åñêèì ïðåêîíäèöèîíèðîâàíèåì — äèñòàíòíîãî èøåìè÷åñêîãî ïðåêîíäèöèîíèðîâàíèÿ
    Exact
    [42–45]
    Suffix
    . Îíî çàêëþ÷àåòñÿ â òîì, ÷òî ïîñëå âîñïðîèçâåäåíèÿ êîðîòêèõ ýïèçîäîâ èøåìèè-ðåïåðôóçèè â îäíîì îðãàíå (êîíå÷íîñòü) ïðîèñõîäèò àêòèâàöèÿ çàùèòíûõ ìåõàíèçìîâ öèòîïðîòåêöèè â äðóãèõ îðãàíàõ (ñåðäöå) [44–47].

43
Lanza GA, Stazi A, Villano A, Torrini F, Milo M, Laurito M. Effect of Remote Ischemic Preconditioning on Platelet Activation Induced by Coronary Procedures. Am J Cardiol. 2016; 117(3): 359–65.
Total in-text references: 2
  1. In-text reference with the coordinate start=11786
    Prefix
    Èìåííî ïîýòîìó â ïîñëåäíåå âðåìÿ âñå áîëüøèé èíòåðåñ âûçûâàþò èññëåäîâàíèÿ íå òîëüêî ëîêàëüíûõ ÿâëåíèé ïîñëå ýïèçîäà èøåìèè-ðåïåðôóçèè èëè åãî âëèÿíèÿ íà ðåîëîãèþ è òðîìáîîáðàçóþùèå ñâîéñòâà êðîâè
    Exact
    [43, 48]
    Suffix
    , íî è ÿâëåíèé â ñîñåäíèõ îðãàíàõ [43, 47, 49–52]. Ðåàëèçàöèÿ äàííîãî ÿâëåíèÿ îñóùåñòâëÿåòñÿ çà ñ÷åò ãóìîðàëüíûõ ôàêòîðîâ è èçìåíåíèÿ àêòèâíîñòè ðàçëè÷íûõ îòäåëîâ íåðâíîé ñèñòåìû [40].  ïîñëåäíåå âðåìÿ â èñòî÷íèêàõ ëèòåðàòóðû ïîÿâèëèñü äàííûå î ñðàâíèòåëüíîì èññëåäîâàíèè ýôôåêòèâíîñòè ïðÿìîãî è äèñòàíòíîãî ïðåêîíäèöèîíèðîâàíèÿ.

  2. In-text reference with the coordinate start=11835
    Prefix
    Èìåííî ïîýòîìó â ïîñëåäíåå âðåìÿ âñå áîëüøèé èíòåðåñ âûçûâàþò èññëåäîâàíèÿ íå òîëüêî ëîêàëüíûõ ÿâëåíèé ïîñëå ýïèçîäà èøåìèè-ðåïåðôóçèè èëè åãî âëèÿíèÿ íà ðåîëîãèþ è òðîìáîîáðàçóþùèå ñâîéñòâà êðîâè [43, 48], íî è ÿâëåíèé â ñîñåäíèõ îðãàíàõ
    Exact
    [43, 47, 49–52]
    Suffix
    . Ðåàëèçàöèÿ äàííîãî ÿâëåíèÿ îñóùåñòâëÿåòñÿ çà ñ÷åò ãóìîðàëüíûõ ôàêòîðîâ è èçìåíåíèÿ àêòèâíîñòè ðàçëè÷íûõ îòäåëîâ íåðâíîé ñèñòåìû [40].  ïîñëåäíåå âðåìÿ â èñòî÷íèêàõ ëèòåðàòóðû ïîÿâèëèñü äàííûå î ñðàâíèòåëüíîì èññëåäîâàíèè ýôôåêòèâíîñòè ïðÿìîãî è äèñòàíòíîãî ïðåêîíäèöèîíèðîâàíèÿ.

44
Kierulf-Lassen Ñ, Kristensen ML, Birn H, Jespersen B, Nørregaard R. No Effect of Remote Ischemic Conditioning Strategies on Recovery from Renal Ischemia-Reperfusion Injury and Protective Molecular Mediators. PLoS One. 2015 Dec 31; 10(12): e0146109. doi: 10.1371/journal.pone.0146109. eCollection 2015.
Total in-text references: 1
  1. In-text reference with the coordinate start=11575
    Prefix
    , ïîëó÷åííûå ïðè ïðîâåäåíèè èññëåäîâàíèé, äàëè ïðåäïîñûëêó äëÿ èñïîëüçîâàíèÿ íàðÿäó ñ ïðÿìûì èøåìè÷åñêèì ïðåêîíäèöèîíèðîâàíèåì — äèñòàíòíîãî èøåìè÷åñêîãî ïðåêîíäèöèîíèðîâàíèÿ [42–45]. Îíî çàêëþ÷àåòñÿ â òîì, ÷òî ïîñëå âîñïðîèçâåäåíèÿ êîðîòêèõ ýïèçîäîâ èøåìèè-ðåïåðôóçèè â îäíîì îðãàíå (êîíå÷íîñòü) ïðîèñõîäèò àêòèâàöèÿ çàùèòíûõ ìåõàíèçìîâ öèòîïðîòåêöèè â äðóãèõ îðãàíàõ (ñåðäöå)
    Exact
    [44–47]
    Suffix
    . Èìåííî ïîýòîìó â ïîñëåäíåå âðåìÿ âñå áîëüøèé èíòåðåñ âûçûâàþò èññëåäîâàíèÿ íå òîëüêî ëîêàëüíûõ ÿâëåíèé ïîñëå ýïèçîäà èøåìèè-ðåïåðôóçèè èëè åãî âëèÿíèÿ íà ðåîëîãèþ è òðîìáîîáðàçóþùèå ñâîéñòâà êðîâè [43, 48], íî è ÿâëåíèé â ñîñåäíèõ îðãàíàõ [43, 47, 49–52].

45
Damous LL, da Silva SM, Carbonel AA, Simões MJ, Baracat EC, Montero EF. Progressive Evaluation of Apoptosis, Proliferation, and Angiogenesis in Fresh Rat Ovarian Autografts Under Remote Ischemic Preconditioning. Reprod Sci. 2015 Dec 16. pii: 1933719115620493. [Epub ahead of print].
Total in-text references: 1
  1. In-text reference with the coordinate start=12464
    Prefix
    È õîòÿ ðåçóëüòàòû ïðîâåäåííûõ èññëåäîâàíèé ïðîòèâîðå÷èâû, î÷åâèäíî, ÷òî äèñòàíòíîå èøåìè÷åñêîå ïðåêîíäèöèîíèðîâàíèå èìååò ðÿä ïðåèìóùåñòâ ïåðåä ïðÿìûì èøåìè÷åñêèì ïðåêîíäèöèîíèðîâàíèåì, çàêëþ÷àþùèõñÿ íå òîëüêî â óäîáñòâå è ïðîñòîòå èñïîëíåíèÿ, íî â íàëè÷èè ñèñòåìíîãî ïîëîæèòåëüíîãî îòâåòà ñî ñòîðîíû äðóãèõ îðãàíîâ è ñèñòåì
    Exact
    [45, 53]
    Suffix
    . Îðèãèíàëüíûì âàðèàíòîì äèñòàíòíîãî èøåìè÷åñêîãî ïðåêîíäèöèîíèðîâàíèÿ ÿâëÿåòñÿ ãèïîêñè÷åñêîå ïðåêîíäèöèîíèðîâàíèå [54, 55].  äàííîì ñëó÷àå âîñïðîèçâîäèòñÿ òîòàëüíàÿ ãèïîêñèÿ âñåãî îðãàíèçìà. Ñîîòâåòñòâåííî, ãèïîêñèè ïîäâåðãàþòñÿ è îðãàí ìèøåíü, è îòäàëåííûå òêàíè.

47
Bautin AE, Galagudza MM, Datsenko SV, Tashkhanov DM, Marichev AO, Bakanov AU, et al. Effect of ischemic preconditioning on the distant during the perioperative period in isolated aortic valve replacement. Anestesiologiya i reanimatologiya 2014; (3): 11–7 (in Russian).
Total in-text references: 2
  1. In-text reference with the coordinate start=11835
    Prefix
    Èìåííî ïîýòîìó â ïîñëåäíåå âðåìÿ âñå áîëüøèé èíòåðåñ âûçûâàþò èññëåäîâàíèÿ íå òîëüêî ëîêàëüíûõ ÿâëåíèé ïîñëå ýïèçîäà èøåìèè-ðåïåðôóçèè èëè åãî âëèÿíèÿ íà ðåîëîãèþ è òðîìáîîáðàçóþùèå ñâîéñòâà êðîâè [43, 48], íî è ÿâëåíèé â ñîñåäíèõ îðãàíàõ
    Exact
    [43, 47, 49–52]
    Suffix
    . Ðåàëèçàöèÿ äàííîãî ÿâëåíèÿ îñóùåñòâëÿåòñÿ çà ñ÷åò ãóìîðàëüíûõ ôàêòîðîâ è èçìåíåíèÿ àêòèâíîñòè ðàçëè÷íûõ îòäåëîâ íåðâíîé ñèñòåìû [40].  ïîñëåäíåå âðåìÿ â èñòî÷íèêàõ ëèòåðàòóðû ïîÿâèëèñü äàííûå î ñðàâíèòåëüíîì èññëåäîâàíèè ýôôåêòèâíîñòè ïðÿìîãî è äèñòàíòíîãî ïðåêîíäèöèîíèðîâàíèÿ.

  2. In-text reference with the coordinate start=14271
    Prefix
    Ïðè ðåàëèçàöèè çàùèòíûõ ìåõàíèçìîâ áèîëîãè÷åñêèõ ïðîöåññîâ, àêòèâèðóåìûõ êîðîòêèìè ýïèçîäàìè èøåìèè-ðåïåðôóçèè, ïðîèñõîäèò âîâëå÷åíèå áîëüøîãî êîëè÷åñòâà âíóòðè- è âíåêëåòî÷íûõ ñòðóêòóð: èîííûõ êàíàëîâ, âíóòðèêëåòî÷íûõ ìåññåíäæåðîâ, ãóìîðàëüíûõ ôàêòîðîâ, ðåöåïòîðíûõ êîìïëåêñîâ, ôåðìåíòîâ è äð.
    Exact
    [47, 56–63]
    Suffix
    . Òåîðåòè÷åñêè, ëþáîé èç íèõ ìîæåò áûòü âîñïðîèçâåäåíin vitroèëè ÿâëÿòüñÿ òî÷êîé ïðèëîæåíèÿ äåéñòâèÿ ôàðìàêîëîãè÷åñêîãî àãåíòà. Ïîýòîìó, ñ íàêîïëåíèåì ýêñïåðèìåíòàëüíûõ äàííûõ è êëèíè÷åñêèõ íàáëþäåíèé, ýâîëþöèîííî-ïðåäîïðåäåëåííûì ñòàëî ïîÿâëåíèå ôàðìàêîëîãè÷åñêîãî ïðåêîíäèöèîíèðîâàíèÿ [64–67].

48
Gallyamov NV. Ischemic preconditioning and remote ischemic preconditioning in healthy subjects and patients with stable angina, and their effect on platelet aggregation. Dr. Med. Sci [dissertation]. Kazan; 2009 (in Russian).
Total in-text references: 1
  1. In-text reference with the coordinate start=11786
    Prefix
    Èìåííî ïîýòîìó â ïîñëåäíåå âðåìÿ âñå áîëüøèé èíòåðåñ âûçûâàþò èññëåäîâàíèÿ íå òîëüêî ëîêàëüíûõ ÿâëåíèé ïîñëå ýïèçîäà èøåìèè-ðåïåðôóçèè èëè åãî âëèÿíèÿ íà ðåîëîãèþ è òðîìáîîáðàçóþùèå ñâîéñòâà êðîâè
    Exact
    [43, 48]
    Suffix
    , íî è ÿâëåíèé â ñîñåäíèõ îðãàíàõ [43, 47, 49–52]. Ðåàëèçàöèÿ äàííîãî ÿâëåíèÿ îñóùåñòâëÿåòñÿ çà ñ÷åò ãóìîðàëüíûõ ôàêòîðîâ è èçìåíåíèÿ àêòèâíîñòè ðàçëè÷íûõ îòäåëîâ íåðâíîé ñèñòåìû [40].  ïîñëåäíåå âðåìÿ â èñòî÷íèêàõ ëèòåðàòóðû ïîÿâèëèñü äàííûå î ñðàâíèòåëüíîì èññëåäîâàíèè ýôôåêòèâíîñòè ïðÿìîãî è äèñòàíòíîãî ïðåêîíäèöèîíèðîâàíèÿ.

49
Maslov LN, Kolar F, Krig T. Distant ischemic preconditioning. Uspehi fiziologicheskih nauk 2009; (4): 64–78 (in Russian).
Total in-text references: 1
  1. In-text reference with the coordinate start=11835
    Prefix
    Èìåííî ïîýòîìó â ïîñëåäíåå âðåìÿ âñå áîëüøèé èíòåðåñ âûçûâàþò èññëåäîâàíèÿ íå òîëüêî ëîêàëüíûõ ÿâëåíèé ïîñëå ýïèçîäà èøåìèè-ðåïåðôóçèè èëè åãî âëèÿíèÿ íà ðåîëîãèþ è òðîìáîîáðàçóþùèå ñâîéñòâà êðîâè [43, 48], íî è ÿâëåíèé â ñîñåäíèõ îðãàíàõ
    Exact
    [43, 47, 49–52]
    Suffix
    . Ðåàëèçàöèÿ äàííîãî ÿâëåíèÿ îñóùåñòâëÿåòñÿ çà ñ÷åò ãóìîðàëüíûõ ôàêòîðîâ è èçìåíåíèÿ àêòèâíîñòè ðàçëè÷íûõ îòäåëîâ íåðâíîé ñèñòåìû [40].  ïîñëåäíåå âðåìÿ â èñòî÷íèêàõ ëèòåðàòóðû ïîÿâèëèñü äàííûå î ñðàâíèòåëüíîì èññëåäîâàíèè ýôôåêòèâíîñòè ïðÿìîãî è äèñòàíòíîãî ïðåêîíäèöèîíèðîâàíèÿ.

53
Johnsen J, Pryds K, Salman R, Lofgren B, Kristiansen SB, Botker HE. The remote ischemic preconditioning algorithm: effect of number of cycles, cycle duration and effector organ mass on efficacy of protection. Basic Res Cardiol 2016; 111(2): 10.
Total in-text references: 3
  1. In-text reference with the coordinate start=12464
    Prefix
    È õîòÿ ðåçóëüòàòû ïðîâåäåííûõ èññëåäîâàíèé ïðîòèâîðå÷èâû, î÷åâèäíî, ÷òî äèñòàíòíîå èøåìè÷åñêîå ïðåêîíäèöèîíèðîâàíèå èìååò ðÿä ïðåèìóùåñòâ ïåðåä ïðÿìûì èøåìè÷åñêèì ïðåêîíäèöèîíèðîâàíèåì, çàêëþ÷àþùèõñÿ íå òîëüêî â óäîáñòâå è ïðîñòîòå èñïîëíåíèÿ, íî â íàëè÷èè ñèñòåìíîãî ïîëîæèòåëüíîãî îòâåòà ñî ñòîðîíû äðóãèõ îðãàíîâ è ñèñòåì
    Exact
    [45, 53]
    Suffix
    . Îðèãèíàëüíûì âàðèàíòîì äèñòàíòíîãî èøåìè÷åñêîãî ïðåêîíäèöèîíèðîâàíèÿ ÿâëÿåòñÿ ãèïîêñè÷åñêîå ïðåêîíäèöèîíèðîâàíèå [54, 55].  äàííîì ñëó÷àå âîñïðîèçâîäèòñÿ òîòàëüíàÿ ãèïîêñèÿ âñåãî îðãàíèçìà. Ñîîòâåòñòâåííî, ãèïîêñèè ïîäâåðãàþòñÿ è îðãàí ìèøåíü, è îòäàëåííûå òêàíè.

  2. In-text reference with the coordinate start=13423
    Prefix
     ïîñëåäíèõ èññëåäîâàíèÿõ áûëî ïîêàçàíî, ÷òî ïðè âûïîëíåíèè ôèçè÷åñêèõ óïðàæíåíèé ïðîèñõîäèò àêòèâàöèÿ âíóòðèêëåòî÷íûõ è ñèñòåìíûõ çàùèòíûõ ìåõàíèçìîâ, êàê è ïðè êîðîòêèõ ýïèçîäàõ èøåìèè-ðåïåðôóçèè
    Exact
    [53]
    Suffix
    . Ñ îäíîé ñòîðîíû, îïóáëèêîâàííûå ðåçóëüòàòû ýòèõ èññëåäîâàíèé ÷àñòè÷íî îáúÿñíÿþò ìåõàíèçìû ïîëîæèòåëüíûõ ýôôåêòîâ ôèçè÷åñêèõ óïðàæíåíèé, ñ äðóãîé — åùå áîëüøå àêòóàëèçèðóþò íåîáõîäèìîñòü ñèñòåìàòè÷åñêèõ çàíÿòèé ôèçè÷åñêîé êóëüòóðîé.

  3. In-text reference with the coordinate start=13908
    Prefix
    Äëÿ çàïóñêà áèîëîãè÷åñêèõ ïðîöåññîâ åñòåñòâåííîé öèòîïðîòåêöèè ïðè ôèçè÷åñêèõ óïðàæíåíèÿõ áîëüøóþ ðîëü èãðàåò äëèòåëüíîñòü è èíòåíñèâíîñòü íàãðóçêè, êàê ïðè èøåìè÷åñêîì ïðåêîíäèöèîíèðîâàíèè — äëèòåëüíîñòü èøåìè÷åñêîãî ñòèìóëà
    Exact
    [40, 53]
    Suffix
    , ò.å. ñòèìóë äîëæåí áûòü äîñòàòî÷íûì äëÿ èõ àêòèâàöèè. Ïðè ðåàëèçàöèè çàùèòíûõ ìåõàíèçìîâ áèîëîãè÷åñêèõ ïðîöåññîâ, àêòèâèðóåìûõ êîðîòêèìè ýïèçîäàìè èøåìèè-ðåïåðôóçèè, ïðîèñõîäèò âîâëå÷åíèå áîëüøîãî êîëè÷åñòâà âíóòðè- è âíåêëåòî÷íûõ ñòðóêòóð: èîííûõ êàíàëîâ, âíóòðèêëåòî÷íûõ ìåññåíäæåðîâ, ãóìîðàëüíûõ ôàêòîðîâ, ðåöåïòîðíûõ êîìïëåêñîâ, ôåðìåíòîâ è äð. [47, 56–63].

54
Naryzhnaya NV, Maslov LN, Vychuzhanova EA, Sementsov AS, Podoksenov YuK, Portnichenko AG, et al. Effect of hypoxic preconditioningon theindicatorsof stress reaction in rats. Bulleten eksperimentalnoy biologii i meditsiny 2015; 159(4): 439 (in Russian).
Total in-text references: 2
  1. In-text reference with the coordinate start=12588
    Prefix
    ÷èâû, î÷åâèäíî, ÷òî äèñòàíòíîå èøåìè÷åñêîå ïðåêîíäèöèîíèðîâàíèå èìååò ðÿä ïðåèìóùåñòâ ïåðåä ïðÿìûì èøåìè÷åñêèì ïðåêîíäèöèîíèðîâàíèåì, çàêëþ÷àþùèõñÿ íå òîëüêî â óäîáñòâå è ïðîñòîòå èñïîëíåíèÿ, íî â íàëè÷èè ñèñòåìíîãî ïîëîæèòåëüíîãî îòâåòà ñî ñòîðîíû äðóãèõ îðãàíîâ è ñèñòåì [45, 53]. Îðèãèíàëüíûì âàðèàíòîì äèñòàíòíîãî èøåìè÷åñêîãî ïðåêîíäèöèîíèðîâàíèÿ ÿâëÿåòñÿ ãèïîêñè÷åñêîå ïðåêîíäèöèîíèðîâàíèå
    Exact
    [54, 55]
    Suffix
    .  äàííîì ñëó÷àå âîñïðîèçâîäèòñÿ òîòàëüíàÿ ãèïîêñèÿ âñåãî îðãàíèçìà. Ñîîòâåòñòâåííî, ãèïîêñèè ïîäâåðãàþòñÿ è îðãàí ìèøåíü, è îòäàëåííûå òêàíè. Íåñìîòðÿ íà òî, ÷òî ïîäàâëÿþùåå áîëüøèíñòâî ýêñïåðèìåíòàëüíûõ èññëåäîâàíèé ñ èñïîëüçîâàíèåì ãèïîêñè÷åñêîãî ïðåêîíäèöèîíèðîâàíèÿ ïîÿâèëîñü òîëüêî â ïîñëåäíèå ãîäû, èìåþòñÿ èññëåäîâàíèÿ ïî åãî èñïîëüçîâàíèþ â ïðîôèëàêòèêå è ëå÷åíèè çàáîëåâàíèé ó ëþäåé, ïð

  2. In-text reference with the coordinate start=13022
    Prefix
    Íåñìîòðÿ íà òî, ÷òî ïîäàâëÿþùåå áîëüøèíñòâî ýêñïåðèìåíòàëüíûõ èññëåäîâàíèé ñ èñïîëüçîâàíèåì ãèïîêñè÷åñêîãî ïðåêîíäèöèîíèðîâàíèÿ ïîÿâèëîñü òîëüêî â ïîñëåäíèå ãîäû, èìåþòñÿ èññëåäîâàíèÿ ïî åãî èñïîëüçîâàíèþ â ïðîôèëàêòèêå è ëå÷åíèè çàáîëåâàíèé ó ëþäåé, ïðîâîäèâøèåñÿ íàìíîãî ðàíüøå
    Exact
    [54]
    Suffix
    . Îäíàêî, ïî âñåé âèäèìîñòè, äàííàÿ ôîðìà ëå÷åáíûõ ìåðîïðèÿòèé áóäåò èìåòü áîëüøå îãðàíè÷åíèé ïî ñðàâíåíèþ ñ äðóãèìè. Âñåì èçâåñòíî ïîëîæèòåëüíîå âëèÿíèå ôèçè÷åñêèõ óïðàæíåíèé íà çäîðîâüå ÷åëîâåêà.

55
Zarbock A, Schmidt C, Van Aken H, Wempe C, Martens S, Zahn PK, et al. Effects of remote ischemic preconditioning in high-risk patients undergoing cardiac surgery (Remote Impact): a randomized controlled trial. CMAJ 2015; 313(21): 2133–41.
Total in-text references: 1
  1. In-text reference with the coordinate start=12588
    Prefix
    ÷èâû, î÷åâèäíî, ÷òî äèñòàíòíîå èøåìè÷åñêîå ïðåêîíäèöèîíèðîâàíèå èìååò ðÿä ïðåèìóùåñòâ ïåðåä ïðÿìûì èøåìè÷åñêèì ïðåêîíäèöèîíèðîâàíèåì, çàêëþ÷àþùèõñÿ íå òîëüêî â óäîáñòâå è ïðîñòîòå èñïîëíåíèÿ, íî â íàëè÷èè ñèñòåìíîãî ïîëîæèòåëüíîãî îòâåòà ñî ñòîðîíû äðóãèõ îðãàíîâ è ñèñòåì [45, 53]. Îðèãèíàëüíûì âàðèàíòîì äèñòàíòíîãî èøåìè÷åñêîãî ïðåêîíäèöèîíèðîâàíèÿ ÿâëÿåòñÿ ãèïîêñè÷åñêîå ïðåêîíäèöèîíèðîâàíèå
    Exact
    [54, 55]
    Suffix
    .  äàííîì ñëó÷àå âîñïðîèçâîäèòñÿ òîòàëüíàÿ ãèïîêñèÿ âñåãî îðãàíèçìà. Ñîîòâåòñòâåííî, ãèïîêñèè ïîäâåðãàþòñÿ è îðãàí ìèøåíü, è îòäàëåííûå òêàíè. Íåñìîòðÿ íà òî, ÷òî ïîäàâëÿþùåå áîëüøèíñòâî ýêñïåðèìåíòàëüíûõ èññëåäîâàíèé ñ èñïîëüçîâàíèåì ãèïîêñè÷åñêîãî ïðåêîíäèöèîíèðîâàíèÿ ïîÿâèëîñü òîëüêî â ïîñëåäíèå ãîäû, èìåþòñÿ èññëåäîâàíèÿ ïî åãî èñïîëüçîâàíèþ â ïðîôèëàêòèêå è ëå÷åíèè çàáîëåâàíèé ó ëþäåé, ïð

56
Saxena S, Shukla D, Bansal A. Expression of Monocarboxylate Transporter Isoforms in Rat Skeletal Muscle Under Hypoxic Preconditioning and Endurance Training. High Alt Med Biol. 2015 Dec 30. [Epub ahead of print].
Total in-text references: 1
  1. In-text reference with the coordinate start=14271
    Prefix
    Ïðè ðåàëèçàöèè çàùèòíûõ ìåõàíèçìîâ áèîëîãè÷åñêèõ ïðîöåññîâ, àêòèâèðóåìûõ êîðîòêèìè ýïèçîäàìè èøåìèè-ðåïåðôóçèè, ïðîèñõîäèò âîâëå÷åíèå áîëüøîãî êîëè÷åñòâà âíóòðè- è âíåêëåòî÷íûõ ñòðóêòóð: èîííûõ êàíàëîâ, âíóòðèêëåòî÷íûõ ìåññåíäæåðîâ, ãóìîðàëüíûõ ôàêòîðîâ, ðåöåïòîðíûõ êîìïëåêñîâ, ôåðìåíòîâ è äð.
    Exact
    [47, 56–63]
    Suffix
    . Òåîðåòè÷åñêè, ëþáîé èç íèõ ìîæåò áûòü âîñïðîèçâåäåíin vitroèëè ÿâëÿòüñÿ òî÷êîé ïðèëîæåíèÿ äåéñòâèÿ ôàðìàêîëîãè÷åñêîãî àãåíòà. Ïîýòîìó, ñ íàêîïëåíèåì ýêñïåðèìåíòàëüíûõ äàííûõ è êëèíè÷åñêèõ íàáëþäåíèé, ýâîëþöèîííî-ïðåäîïðåäåëåííûì ñòàëî ïîÿâëåíèå ôàðìàêîëîãè÷åñêîãî ïðåêîíäèöèîíèðîâàíèÿ [64–67].

64
Ávalos R, Martinez-Sanz R, JiménezJJ, Iribarren JL, Montoto J, Lacruz A, et al. Levosimendan preconditioning in patients undergoing elective cardiac surgery with poor ejection fraction. preliminary results. J Cardiothorac Surg. 2015; 10(Suppl 1): A310. doi: 10.1186/1749–8090–10-S1-A310.
Total in-text references: 1
  1. In-text reference with the coordinate start=14575
    Prefix
    Òåîðåòè÷åñêè, ëþáîé èç íèõ ìîæåò áûòü âîñïðîèçâåäåíin vitroèëè ÿâëÿòüñÿ òî÷êîé ïðèëîæåíèÿ äåéñòâèÿ ôàðìàêîëîãè÷åñêîãî àãåíòà. Ïîýòîìó, ñ íàêîïëåíèåì ýêñïåðèìåíòàëüíûõ äàííûõ è êëèíè÷åñêèõ íàáëþäåíèé, ýâîëþöèîííî-ïðåäîïðåäåëåííûì ñòàëî ïîÿâëåíèå ôàðìàêîëîãè÷åñêîãî ïðåêîíäèöèîíèðîâàíèÿ
    Exact
    [64–67]
    Suffix
    . Èñïîëüçîâàíèå ôàðìàêîëîãè÷åñêèõ àãåíòîâ ìîæåò áûòüêàê âðåæèìåïðåêîíäèöèîíèðîâàíèÿ, òàê è ïîñòêîíäèöèîíèðîâàíèÿ [67].  ýêñïåðèìåíòàëüíûõ èññëåäîâàíèÿõ ïðè ìîäåëèðîâàíèè ADMA-ïîäîáíîé ïðåýêëàìïñèè áûëè ïîêàçàíû ïîëîæèòåëüíûå ýôôåêòû êîðîòêèõ ýïèçîäîâ èøåìèè-ðåïåðôóçèè, âàæíûì ìîìåíòîì êîòîðûõ ÿâëÿåòñÿ àêòèâàöèÿ Ê+ÀÒÔêàíàëîâ [68–73].

67
Li W, Jia D. Pharmacological preconditioning and postconditioning with nicorandil attenuates ischemia/reperfusion-induced myocardial necrosis and apoptosis in hypercholesterolemic rats. Exp Ther Med. 2015; 10(6): 2197–205.
Total in-text references: 1
  1. In-text reference with the coordinate start=14692
    Prefix
    Ïîýòîìó, ñ íàêîïëåíèåì ýêñïåðèìåíòàëüíûõ äàííûõ è êëèíè÷åñêèõ íàáëþäåíèé, ýâîëþöèîííî-ïðåäîïðåäåëåííûì ñòàëî ïîÿâëåíèå ôàðìàêîëîãè÷åñêîãî ïðåêîíäèöèîíèðîâàíèÿ [64–67]. Èñïîëüçîâàíèå ôàðìàêîëîãè÷åñêèõ àãåíòîâ ìîæåò áûòüêàê âðåæèìåïðåêîíäèöèîíèðîâàíèÿ, òàê è ïîñòêîíäèöèîíèðîâàíèÿ
    Exact
    [67]
    Suffix
    .  ýêñïåðèìåíòàëüíûõ èññëåäîâàíèÿõ ïðè ìîäåëèðîâàíèè ADMA-ïîäîáíîé ïðåýêëàìïñèè áûëè ïîêàçàíû ïîëîæèòåëüíûå ýôôåêòû êîðîòêèõ ýïèçîäîâ èøåìèè-ðåïåðôóçèè, âàæíûì ìîìåíòîì êîòîðûõ ÿâëÿåòñÿ àêòèâàöèÿ Ê+ÀÒÔêàíàëîâ [68–73].

68
Gureev VV, Pokrovsky MV, Korokin MV, Pokrovskaya TG, Gudyrev OS, Kochkarev VI, et al. ADMA-eNOS-deterministic ways of pharmacological correction of preeclampsia. Belgorod: Izdatelstvo BelGU; 2014 (in Russian).
Total in-text references: 1
  1. In-text reference with the coordinate start=14907
    Prefix
    Â ýêñïåðèìåíòàëüíûõ èññëåäîâàíèÿõ ïðè ìîäåëèðîâàíèè ADMA-ïîäîáíîé ïðåýêëàìïñèè áûëè ïîêàçàíû ïîëîæèòåëüíûå ýôôåêòû êîðîòêèõ ýïèçîäîâ èøåìèè-ðåïåðôóçèè, âàæíûì ìîìåíòîì êîòîðûõ ÿâëÿåòñÿ àêòèâàöèÿ Ê+ÀÒÔêàíàëîâ
    Exact
    [68–73]
    Suffix
    . Èñïîëüçîâàíèå ôàðìàêîëîãè÷åñêèõ ïðåïàðàòîâ ñ ïðåêîíäèöèîíèðóþùèìè ýôôåêòàìè òàêæå ïðèâîäèëî ê êîððåêöèè ìîðôîôóíêöèîíàëüíûõ íàðóøåíèé ïðè ADMA-ïîäîáíîé ïðåýêëàìïñèè, à àêòèâàöèÿ Ê+ÀÒÔ êàíàëîâ ÿâëÿåòñÿ îäíèì èç êëþ÷åâûõ ìîìåíòîâ [74, 75].

74
Gureev VV, Zhilinkova LA, Stupakova EG. Nikorandil tetrahydrobiopterin and resveratrol correction of endothelial dysfunction in modeling experimental preeclampsia. Fundamentalnye issledovaniya 2015; (1): 58–62 (in Russian).
Total in-text references: 1
  1. In-text reference with the coordinate start=15152
    Prefix
    Èñïîëüçîâàíèå ôàðìàêîëîãè÷åñêèõ ïðåïàðàòîâ ñ ïðåêîíäèöèîíèðóþùèìè ýôôåêòàìè òàêæå ïðèâîäèëî ê êîððåêöèè ìîðôîôóíêöèîíàëüíûõ íàðóøåíèé ïðè ADMA-ïîäîáíîé ïðåýêëàìïñèè, à àêòèâàöèÿ Ê+ÀÒÔ êàíàëîâ ÿâëÿåòñÿ îäíèì èç êëþ÷åâûõ ìîìåíòîâ
    Exact
    [74, 75]
    Suffix
    .  êëèíè÷åñêîé ïðàêòèêå îïèñàíû äàííûå î ïîëîæèòåëüíûõ ýôôåêòàõ íîðìîáàðè÷åñêîé ãèïîêñèòåðàïèè, êîòîðóþ ìîæíî ðàññìàòðèâàòü êàê ãèïîêñè÷åñêîå ïðåêîíäèöèîíèðîâàíèå, ïðè ïðîôèëàêòèêå è ëå÷åíèè ïðåýêëàìñèè, ÷òî òàêæå ñâèäåòåëüñòâóåò î ïåðñïåêòèâíîñòè âûáðàííîãî íàïðàâëåíèÿ [11].

75
Gureev VV, Alekhin SA, Dolzhikov AA, Mostovoy AS. Correction of ADMA-like preeclampsia in the experiment. Kursk scientific-practical bulletin «Chelovek i ego zdorovie» 2012; (1): 14–9 (in Russian). AUTHORS Federal State Autonomous Educational Institution of Higher Professional Education «Belgorod State National Research University»,
Total in-text references: 1
  1. In-text reference with the coordinate start=15152
    Prefix
    Èñïîëüçîâàíèå ôàðìàêîëîãè÷åñêèõ ïðåïàðàòîâ ñ ïðåêîíäèöèîíèðóþùèìè ýôôåêòàìè òàêæå ïðèâîäèëî ê êîððåêöèè ìîðôîôóíêöèîíàëüíûõ íàðóøåíèé ïðè ADMA-ïîäîáíîé ïðåýêëàìïñèè, à àêòèâàöèÿ Ê+ÀÒÔ êàíàëîâ ÿâëÿåòñÿ îäíèì èç êëþ÷åâûõ ìîìåíòîâ
    Exact
    [74, 75]
    Suffix
    .  êëèíè÷åñêîé ïðàêòèêå îïèñàíû äàííûå î ïîëîæèòåëüíûõ ýôôåêòàõ íîðìîáàðè÷åñêîé ãèïîêñèòåðàïèè, êîòîðóþ ìîæíî ðàññìàòðèâàòü êàê ãèïîêñè÷åñêîå ïðåêîíäèöèîíèðîâàíèå, ïðè ïðîôèëàêòèêå è ëå÷åíèè ïðåýêëàìñèè, ÷òî òàêæå ñâèäåòåëüñòâóåò î ïåðñïåêòèâíîñòè âûáðàííîãî íàïðàâëåíèÿ [11].