The 20 references with contexts in paper A. Syroeshkin V., T. Pleteneva V., M. Morozova A., E. Uspenskaya V., O. Titorovich V., E. Lesnikov V., V. Dobrovolsky I., А. Сыроешкин В., Т. Плетенева В., М. Морозова А., Е. Успенская В., О. Титорович В., Е. Лесников В., В. Добровольский И. (2018) “О возможности применения лазерного метода для контроля качества высоких разведений жидких лекарственных средств // The possibility of using laser methods for the quality control of highly diluted liquid pharmaceuticals” / spz:neicon:vedomostincesmp:y:2016:i:3:p:31-36

1
European Pharmacopoeia. 8th ed. EDQM; 2014 [cited 2015 January 14]. Available from: http:// online.edqm.eu/entry.htm.
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    æèâîòíîãî ïðîèñõîæäåíèÿ, èçãîòîâëåííûå ïî ñïåöèàëüíîé òåõíîëîãèè, ñîäåðæàíèå êîòîðûõ â ëåêàðñòâåííîìïðåïàðàòåáûëîñíèæåíîïóòåììíîãîêðàòíîãî ðàçâåäåíèÿ â âîäíîì èëè âîäíî-ñïèðòîâîì ðàñòâîðå èëè ïóòåì òðèòóðàöèé, âûäåëÿþòñÿ â Åâðîïåéñêîé ôàðìàêîïåå è â Ôåäåðàëüíîì çàêîíå ¹ 61-ÔÇ «Îá îáðàùåíèè ëåêàðñòâåííûõ ñðåäñòâ» â îòäåëüíóþ ãðóïïó ãîìåîïàòè÷åñêèõ ëåêàðñòâåííûõ ñðåäñòâ ïî ñïîñîáó ïðèãîòîâëåíèÿ
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    . Ðàíäîìèçèðîâàííûå êëèíè÷åñêèå èñïûòàíèÿ âûñîêèõ è ñâåðõâûñîêèõ ðàçâåäåíèé ëåêàðñòâåííûõ ñðåäñòâ äåìîíñòðèðóþò âûñîêèå ïîêàçàòåëè ïî òåðàïåâòè÷åñêîìó ýôôåêòó, íè÷åì íå óñòóïàþùèå àëëîïàòè÷åñêèì ñðåäñòâàì[2, 13].

2
Epshtein OI. Phenomenon of release activity and the hypothesis of «spatial» homeostasis. Uspehi fiziologicheskih nauk 2013; 44(3): 54–76 (in Russian).
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    Ðàíäîìèçèðîâàííûå êëèíè÷åñêèå èñïûòàíèÿ âûñîêèõ è ñâåðõâûñîêèõ ðàçâåäåíèé ëåêàðñòâåííûõ ñðåäñòâ äåìîíñòðèðóþò âûñîêèå ïîêàçàòåëè ïî òåðàïåâòè÷åñêîìó ýôôåêòó, íè÷åì íå óñòóïàþùèå àëëîïàòè÷åñêèì ñðåäñòâàì
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    .Âîòå÷åñòâåííîéïðàêòèêåòåõíîëîãèÿ ìíîãîêðàòíîãî ðàçâåäåíèÿ ðàñòâîðîâ, ñîäåðæàùèõ àôôèííî î÷èùåííûå àíòèòåëà ê ãàììà-èíòåðôåðîíó ÷åëîâåêà è ê ãèñòàìèíó, áûëà óñïåøíî ïðèìåíåíà äëÿ ðàçðàáîòêè îðèãèíàëüíûõ ëåêàðñòâåííûõ ñðåäñòâ [2].

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    âûñîêèõ è ñâåðõâûñîêèõ ðàçâåäåíèé ëåêàðñòâåííûõ ñðåäñòâ äåìîíñòðèðóþò âûñîêèå ïîêàçàòåëè ïî òåðàïåâòè÷åñêîìó ýôôåêòó, íè÷åì íå óñòóïàþùèå àëëîïàòè÷åñêèì ñðåäñòâàì[2, 13].Âîòå÷åñòâåííîéïðàêòèêåòåõíîëîãèÿ ìíîãîêðàòíîãî ðàçâåäåíèÿ ðàñòâîðîâ, ñîäåðæàùèõ àôôèííî î÷èùåííûå àíòèòåëà ê ãàììà-èíòåðôåðîíó ÷åëîâåêà è ê ãèñòàìèíó, áûëà óñïåøíî ïðèìåíåíà äëÿ ðàçðàáîòêè îðèãèíàëüíûõ ëåêàðñòâåííûõ ñðåäñòâ
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    . Îòëè÷èòåëüíîé îñîáåííîñòüþ äàííîé ãðóïïû ëåêàðñòâåííûõ ñðåäñòâ ÿâëÿåòñÿ ïðîÿâëåíèå èìèàêòèâíîñòè,àññîöèèðîâàííîéñðàñòâîðèòåëåìâ ïðîöåññå ìíîãîêðàòíîãî óìåíüøåíèÿ ñîäåðæàíèÿ äåéñòâóþùåãî âåùåñòâà. Ïðèìåíåíèå óêàçàííîé òåõíîëîãèè ñîïðîâîæäàåòñÿ ñòðóêòóðíûìè èçìåíåíèÿìè ðàñòâîðèòåëÿ è, êàê ñëåäñòâèå, ïðîÿâëåíèåì ìîäèôèöèðîâàííûõ ôèçèêî-õèìè÷åñêèõ è áèîëîãè÷åñêèõ ñâîéñòâ èñõîäíîãî âåùåñòâà.

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     îòëè÷èå îò ãîìåîïàòè÷åñêèõ ïðåïàðàòîâ, êëèíè÷åñêóþ ýôôåêòèâíîñòü êîòîðûõ äîêàçûâàþò íà çäîðîâûõ äîáðîâîëüöàõ, ýôôåêòèâíîñòü ñâåðõâûñîêèõ ðàçâåäåíèé ëåêàðñòâåííûõ ñðåäñòâ, îáëàäàþùèõ ìîäèôèöèðóþùåé àêòèâíîñòüþ, áûëà äîêàçàíà â ðåçóëüòàòå êëèíè÷åñêèõ èññëåäîâàíèé â ñîîòâåòñòâèè ñî âñåìè òðåáîâàíèÿìè ê èñïûòàíèÿì àëëîïàòè÷åñêèõ ïðåïàðàòîâ
    Exact
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    . Íåîáõîäèìûì óñëîâèåì äëÿ êîíòðîëÿ êà÷åñòâà ñâåðõâûñîêèõðàçâåäåíèéëåêàðñòâåííûõñðåäñòâ,îáëàäàþùèõ ìîäèôèöèðóþùåé àêòèâíîñòüþ, ÿâëÿëàñü ðàçðàáîòêà ìåòîäèêè ôèçèêî-õèìè÷åñêîãî àíàëèçà.  èññëåäîâàíèè èñïîëüçîâàí ðàçðàáîòàííûé íàìè ðàíåå ìåòîä êîíòðîëÿ êà÷åñòâà âîäíûõ ðàñòâîðîâ ëåêàðñòâåííûõ âåùåñòâ [4], îñíîâàííûé íà àíàëèçå äâóìåðíîãî (2D) ðàññåÿíèÿ ñâåòà è ïðåäñòàâëåíèÿõ î ñòðóêòóðå âîäíûõ ðàñòâî

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    È ÎÁÑÓÆÄÅÍÈÅ Îñîáåííîñòüþ ïîñòàâëåííîé çàäà÷è ÿâëÿåòñÿ òîò ôàêò, ÷òî ïðè êîíòðîëå ðàñòâîðîâ âûñîêèõ ðàçâåäåíèé îòñóòñòâóåò âîçìîæíîñòü èõ àíàëèçà ñ ïðèâëå÷åíèåì èçâåñòíûõ àíàëèòè÷åñêèõ ìåòîäîâ â ñâÿçè ñ íåäîñòàòî÷íûìè ïðåäåëàìè îáíàðóæåíèÿ è êîëè÷åñòâåííîãî îïðåäåëåíèÿ äåéñòâóþùåãî âåùåñòâà. Ôîðìóëèðóÿ ïîëîæåíèÿ îá ó÷àñòèè â ïåðåäà÷å áèîëîãè÷åñêè àêòèâíîãî «ñèãíàëà» ñóïðàìîëåêóëÿðíûõ ñòðóêòóð
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    ìûïðåäïîëîæèëè,÷òîàíòèòåëàêèíòåðôåðîíó-ãàììà èíäóöèðóþò äåéòåðèé-ñòàáèëèçèðîâàííûå Ãà Êâîäû [14] ñî ñïåöèôè÷åñêèì ðàçìåðíûì ñïåêòðîì. Äåéñòâèòåëüíî, ýòîò èíäóêöèîííûé ýôôåêò ïðîÿâèëè è áåëêîâûå íàíî÷àñòèöû, àíàëîãè÷íî ñòàíäàðòèçîâàííûì ëàòåêñíûì íàíî÷àñòèöàì [6].

3
Vasiliev AN, Sergeeva SA, Kachanova MV, et al. Application of ultrafine doses of antibodies to gamma-interferon in the treatment and prevention of viral infections. Antibiotiki i himioterapiya 2008; 53(3–4): 32–5 (in Russian).
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     îòëè÷èå îò ãîìåîïàòè÷åñêèõ ïðåïàðàòîâ, êëèíè÷åñêóþ ýôôåêòèâíîñòü êîòîðûõ äîêàçûâàþò íà çäîðîâûõ äîáðîâîëüöàõ, ýôôåêòèâíîñòü ñâåðõâûñîêèõ ðàçâåäåíèé ëåêàðñòâåííûõ ñðåäñòâ, îáëàäàþùèõ ìîäèôèöèðóþùåé àêòèâíîñòüþ, áûëà äîêàçàíà â ðåçóëüòàòå êëèíè÷åñêèõ èññëåäîâàíèé â ñîîòâåòñòâèè ñî âñåìè òðåáîâàíèÿìè ê èñïûòàíèÿì àëëîïàòè÷åñêèõ ïðåïàðàòîâ
    Exact
    [2, 3]
    Suffix
    . Íåîáõîäèìûì óñëîâèåì äëÿ êîíòðîëÿ êà÷åñòâà ñâåðõâûñîêèõðàçâåäåíèéëåêàðñòâåííûõñðåäñòâ,îáëàäàþùèõ ìîäèôèöèðóþùåé àêòèâíîñòüþ, ÿâëÿëàñü ðàçðàáîòêà ìåòîäèêè ôèçèêî-õèìè÷åñêîãî àíàëèçà.  èññëåäîâàíèè èñïîëüçîâàí ðàçðàáîòàííûé íàìè ðàíåå ìåòîä êîíòðîëÿ êà÷åñòâà âîäíûõ ðàñòâîðîâ ëåêàðñòâåííûõ âåùåñòâ [4], îñíîâàííûé íà àíàëèçå äâóìåðíîãî (2D) ðàññåÿíèÿ ñâåòà è ïðåäñòàâëåíèÿõ î ñòðóêòóðå âîäíûõ ðàñòâî

4
Ulyantsev AS, Uspenskaya EV, Pleteneva TV, et al. Rapid method of determining the authenticity of aqueous solutions of drugs. Himiko-farmatsevticheskiy zhurnal 2009;43(12): 47–51 (in Russian).
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    Íåîáõîäèìûì óñëîâèåì äëÿ êîíòðîëÿ êà÷åñòâà ñâåðõâûñîêèõðàçâåäåíèéëåêàðñòâåííûõñðåäñòâ,îáëàäàþùèõ ìîäèôèöèðóþùåé àêòèâíîñòüþ, ÿâëÿëàñü ðàçðàáîòêà ìåòîäèêè ôèçèêî-õèìè÷åñêîãî àíàëèçà.  èññëåäîâàíèè èñïîëüçîâàí ðàçðàáîòàííûé íàìè ðàíåå ìåòîä êîíòðîëÿ êà÷åñòâà âîäíûõ ðàñòâîðîâ ëåêàðñòâåííûõ âåùåñòâ
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    , îñíîâàííûé íà àíàëèçå äâóìåðíîãî (2D) ðàññåÿíèÿ ñâåòà è ïðåäñòàâëåíèÿõ î ñòðóêòóðå âîäíûõ ðàñòâîðîâ êàê ãåòåðîãåííûõ ñðåäàõ [5]. Çàäà÷à ðàáîòûñîñòîÿëà â ñðàâíåíèè ñîòåííûõ ðàçâåäåíèé ïðåïàðàòîâ àíòèòåë ñ êîíòðîëüíûìè îáðàçöàìè – àíàëîãè÷íî ïðèãîòîâëåííûìè ðàçâåäåíèÿìè áóôåðíîãî ðàñòâîðà â äèàïàçîíå îò Ñ10 äî Ñ50.

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    Äëÿ èçó÷åíèÿ êèíåòèêè ìåðöàíèÿ ãèãàíòñêèõ ãåòåðîôàçíûõ êëàñòåðîâ (ÃÃÊ) âîäû ïðèìåíÿëè ìåòîä ëàçåðíîãî 2D-ðàññåÿíèÿ ñâåòà, îñíîâàííûé íà ðàññåÿíèèìîíîõðîìàòè÷åñêîãîñâåòàèàíàëèçåäèíàìèêè ïîëó÷åííûõ èíòåðôåðåíöèîííûõ êàðòèí
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    . Ìàòåìàòè÷åñêóþ îáðàáîòêó ïðîâîäèëè ñ ïîìîùüþ òîïîëîãè÷åñêèõ äåñêðèïòîðîâd1,d2,d3(êðèòåðèåâ äèíàìèêè ðàçëè÷èÿ 2D-ðàñïðåäåëåíèÿ èíòåíñèâíîñòè ëàçåðíîãî ñâåòà, ïðîãðàììíîå îáåñïå÷åíèå «Vidan»), àíàëîãè÷íî QSAR ïîäõîäàì ê àíàëèçó îðãàíè÷åñêèõ ñîåäèíåíèé [11, 12].

5
Syroeshkin AV, Smirnov AN, Goncharuk VV, et al. Water as a heterogeneous structure. Electronic journal «Issledovano v Rossii» 2006; 88: 843–54. Available from: http://www.sci-journal.ru/articles/2006/088.pdf (in Russian).
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     èññëåäîâàíèè èñïîëüçîâàí ðàçðàáîòàííûé íàìè ðàíåå ìåòîä êîíòðîëÿ êà÷åñòâà âîäíûõ ðàñòâîðîâ ëåêàðñòâåííûõ âåùåñòâ [4], îñíîâàííûé íà àíàëèçå äâóìåðíîãî (2D) ðàññåÿíèÿ ñâåòà è ïðåäñòàâëåíèÿõ î ñòðóêòóðå âîäíûõ ðàñòâîðîâ êàê ãåòåðîãåííûõ ñðåäàõ
    Exact
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    . Çàäà÷à ðàáîòûñîñòîÿëà â ñðàâíåíèè ñîòåííûõ ðàçâåäåíèé ïðåïàðàòîâ àíòèòåë ñ êîíòðîëüíûìè îáðàçöàìè – àíàëîãè÷íî ïðèãîòîâëåííûìè ðàçâåäåíèÿìè áóôåðíîãî ðàñòâîðà â äèàïàçîíå îò Ñ10 äî Ñ50. ÌÀÒÅÐÈÀËÛ È ÌÅÒÎÄÛ Âûñîêîîìíóþ âîäó (18 ÌÎì·ñì ïðè 25 °Ñ) ãîòîâèëè ïóòåì î÷èñòêè äèñòèëëèðîâàííîé àïèðîãåííîé âîäû ñèñòåìû Milli-Q (ôèðìà «Millipore», Âåëèêîáðèòàíèÿ).

6
Goncharuk VV, Lapshin VB, Burdeinaya TN, et al. Physicochemical properties and biological activity of the water depleted of heavy isotopes. J Water Chem Technol. 2011;33(1): 8–13.
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    ÌÀÒÅÐÈÀËÛ È ÌÅÒÎÄÛ Âûñîêîîìíóþ âîäó (18 ÌÎì·ñì ïðè 25 °Ñ) ãîòîâèëè ïóòåì î÷èñòêè äèñòèëëèðîâàííîé àïèðîãåííîé âîäû ñèñòåìû Milli-Q (ôèðìà «Millipore», Âåëèêîáðèòàíèÿ). Äëÿ ñíèæåíèÿ «øóìà» ñîáñòâåííîãî ñâåòîðàññåÿíèÿ âîäû äëÿ ïðèãîòîâëåíèÿ ðàçâåäåíèé ïðèìåíÿëè âîäó, îáåäíåííóþ ïî ñîäåðæàíèþ äåéòåðèÿ (DDW – deuterium depleted water)
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    . DDW áûëà ïîëó÷åíà íà ïðåäïðèÿòèè ÎÀÎ «Àëìàç» ìåòîäîì âàêóóìíîé ðåêòèôèêàöèè. Ñîäåðæàíèå äåéòåðèÿ (D) âëåãêîéâîäåñîñòàâëÿëîD/H = 4 ppm,òÿæåëîãîèçîòîïà êèñëîðîäà (O18)O18/O16= 750 ppm â îòëè÷èå îò äåèîíèçîâàííîé âîäû, â êîòîðîé D/H = 140 ppm è O18/O16= 1966 ppm.

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    Ôîðìóëèðóÿ ïîëîæåíèÿ îá ó÷àñòèè â ïåðåäà÷å áèîëîãè÷åñêè àêòèâíîãî «ñèãíàëà» ñóïðàìîëåêóëÿðíûõ ñòðóêòóð[2]ìûïðåäïîëîæèëè,÷òîàíòèòåëàêèíòåðôåðîíó-ãàììà èíäóöèðóþò äåéòåðèé-ñòàáèëèçèðîâàííûå Ãà Êâîäû [14] ñî ñïåöèôè÷åñêèì ðàçìåðíûì ñïåêòðîì. Äåéñòâèòåëüíî, ýòîò èíäóêöèîííûé ýôôåêò ïðîÿâèëè è áåëêîâûå íàíî÷àñòèöû, àíàëîãè÷íî ñòàíäàðòèçîâàííûì ëàòåêñíûì íàíî÷àñòèöàì
    Exact
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    . Ìåòîäîì DLS (ïðåäåë îáíàðóæåíèÿ 2 ìêã/ìë) íàìè Ðèñ. 1.Äèàãðàììà çàâèñèìîñòè âàðèàáåëüíîñòè sd3 îò çíà÷åíèÿ äåñêðèïòîðà d3 (ñðåäíèå äàííûå èç 361 ïîâòîðà). ×åðíûå êðóæêè — ðàçâåäåíèÿ àíòèòåë ê èíòåðôåðîíó-ãàììà; ïîëûå êðóæêè — êîíòðîëüíûå ðàçâåäåíèÿ ãëèöèíîâîãî áóôåðà (100 ìÌ, pH = 7,2).

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    Äðóãàÿ âîçìîæíîñòü — çà ñ÷åò ñëîæíîé êèíåòèêè êîìáèíàöèè îáðàòèìûõ ïðîöåññîâ ñáîðêè ñóáìèëëèìåòðîâûõ ïëîòíîñòíûõ íåîäíîðîäíîñòåéèçáîëååìåëêèõ«âèõðåé»è/èëèäðîáëåíèå óæå ñôîðìèðîâàííûõ ãèãàíòñêèõ êëàñòåðîâ, êàê ðàíåå îòìå÷àëîñü íàìè
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    [6, 18]
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    . Ïîðÿäîê ðàçìåðîâ ñóáìèëëèìåòðîâûõ ïëîòíîñòíûõ íåîäíîðîäíîñòåé âîäû íå ñëó÷àéíî ñîâïàäàåò ñ êîëìîãîðîâñêèì ìàñøòàáîì ïåðåõîäà êèíåòè÷åñêîé ýíåðãèè â òåïëîâóþ (äëÿ âîäû — 0,1 ìì): â âîäå óæå ñóùåñòâóåò ñòðóêòóðà, îáåñïå÷èâàþùàÿ ñîïðÿæåíèå ýòèõ ïðîöåññîâ.

7
Epshtein OI, Shtark MB, Kolyadko TM. Method of treating a pathological syndrome and a pharmaceutical agent. US Patent, ¹ 8535664 B2; 2013.
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    Prefix
    Ïðè ïðîáîïîäãîòîâêå âñåõ îáðàçöîâ (ðàçâåäåíèé àíòèòåë è ãëèöèíîâîãî áóôåðà) èç ñîîòâåòñòâóþùåãî èñõîäíîãî ðàñòâîðà ïîñëåäîâàòåëüíî ãîòîâèëè ëèíåéêó ñîòåííûõ ðàçâåäåíèé â ëåãêîé âîäå Ñ1–Ñ50. Èñõîäíûé è êàæäûé ñòîêîâûé ðàñòâîð ïîñëåäîâàòåëüíî ïîäâåðãàëè ñîòåííîìó ðàçâåäåíèþ ñ ïîñëåäóþùèì àíàëèçîì
    Exact
    [7, 8]
    Suffix
    . Ðàçâåäåíèÿ Ñ1–Ñ50 ñîîòâåòñòâîâàëè èíòåðâàëó ðàñ÷åòíûõ êîíöåíòðàöèé àíòèòåë ê èíòåðôåðîíó-ãàììà (2,36·10–2– 2,36·10–100) ìã/ìë. Äèñïåðñèîííûé àíàëèç îáðàçöîâ áóôåðíûõ è áåëêîâûõ ðàñòâîðîâ ïðîâîäèëè ñ ïðèìåíåíèåì ìåòîäîâ ìàëîóãëîâîãî ðàññåÿíèÿ ëàçåðíîãî èçëó÷åíèÿ(LALLS)èäèíàìè÷åñêîãîðàññåÿíèÿñâåòà(DLS) (ôîòîííàÿ êîððåëÿöèîííàÿ ñïåêòðîñêîïèÿ) íà ïðèáîðàõ Master Sizer 2000 è ZetaSizer NanoZS ïðîèçâî

8
Epshtein OI, Kolyadko TM, Shtark MB. A method of treating a pathological syndrome and drug. Patent RF, ¹ 2181297 RU; 2002 (in Russian).
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    Ïðè ïðîáîïîäãîòîâêå âñåõ îáðàçöîâ (ðàçâåäåíèé àíòèòåë è ãëèöèíîâîãî áóôåðà) èç ñîîòâåòñòâóþùåãî èñõîäíîãî ðàñòâîðà ïîñëåäîâàòåëüíî ãîòîâèëè ëèíåéêó ñîòåííûõ ðàçâåäåíèé â ëåãêîé âîäå Ñ1–Ñ50. Èñõîäíûé è êàæäûé ñòîêîâûé ðàñòâîð ïîñëåäîâàòåëüíî ïîäâåðãàëè ñîòåííîìó ðàçâåäåíèþ ñ ïîñëåäóþùèì àíàëèçîì
    Exact
    [7, 8]
    Suffix
    . Ðàçâåäåíèÿ Ñ1–Ñ50 ñîîòâåòñòâîâàëè èíòåðâàëó ðàñ÷åòíûõ êîíöåíòðàöèé àíòèòåë ê èíòåðôåðîíó-ãàììà (2,36·10–2– 2,36·10–100) ìã/ìë. Äèñïåðñèîííûé àíàëèç îáðàçöîâ áóôåðíûõ è áåëêîâûõ ðàñòâîðîâ ïðîâîäèëè ñ ïðèìåíåíèåì ìåòîäîâ ìàëîóãëîâîãî ðàññåÿíèÿ ëàçåðíîãî èçëó÷åíèÿ(LALLS)èäèíàìè÷åñêîãîðàññåÿíèÿñâåòà(DLS) (ôîòîííàÿ êîððåëÿöèîííàÿ ñïåêòðîñêîïèÿ) íà ïðèáîðàõ Master Sizer 2000 è ZetaSizer NanoZS ïðîèçâî

9
Syroeshkin AV, Smirnov AN, Goncharuk VV, et al. Water as a heterogeneous structure. Electronic journal «Issledovano v Rossii» 2006; 88: 843–54. Available from: http://www.sci-journal.ru/articles/2006/088.pdf (in Russian).
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    Äèñïåðñèîííûé àíàëèç îáðàçöîâ áóôåðíûõ è áåëêîâûõ ðàñòâîðîâ ïðîâîäèëè ñ ïðèìåíåíèåì ìåòîäîâ ìàëîóãëîâîãî ðàññåÿíèÿ ëàçåðíîãî èçëó÷åíèÿ(LALLS)èäèíàìè÷åñêîãîðàññåÿíèÿñâåòà(DLS) (ôîòîííàÿ êîððåëÿöèîííàÿ ñïåêòðîñêîïèÿ) íà ïðèáîðàõ Master Sizer 2000 è ZetaSizer NanoZS ïðîèçâîäñòâà ôèðìû MALVERN Instruments
    Exact
    [9, 10]
    Suffix
    . Äëÿ èçó÷åíèÿ êèíåòèêè ìåðöàíèÿ ãèãàíòñêèõ ãåòåðîôàçíûõ êëàñòåðîâ (ÃÃÊ) âîäû ïðèìåíÿëè ìåòîä ëàçåðíîãî 2D-ðàññåÿíèÿ ñâåòà, îñíîâàííûé íà ðàññåÿíèèìîíîõðîìàòè÷åñêîãîñâåòàèàíàëèçåäèíàìèêè ïîëó÷åííûõ èíòåðôåðåíöèîííûõ êàðòèí [4].

10
Syroeshkin AV, Popov PI, Grebennikova TV, et al. Laser diffraction for standartization of heterogeneous pharmaceutical preparations. J Pharm Biomed Anal. 2005;37(5): 927–30.
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    Äèñïåðñèîííûé àíàëèç îáðàçöîâ áóôåðíûõ è áåëêîâûõ ðàñòâîðîâ ïðîâîäèëè ñ ïðèìåíåíèåì ìåòîäîâ ìàëîóãëîâîãî ðàññåÿíèÿ ëàçåðíîãî èçëó÷åíèÿ(LALLS)èäèíàìè÷åñêîãîðàññåÿíèÿñâåòà(DLS) (ôîòîííàÿ êîððåëÿöèîííàÿ ñïåêòðîñêîïèÿ) íà ïðèáîðàõ Master Sizer 2000 è ZetaSizer NanoZS ïðîèçâîäñòâà ôèðìû MALVERN Instruments
    Exact
    [9, 10]
    Suffix
    . Äëÿ èçó÷åíèÿ êèíåòèêè ìåðöàíèÿ ãèãàíòñêèõ ãåòåðîôàçíûõ êëàñòåðîâ (ÃÃÊ) âîäû ïðèìåíÿëè ìåòîä ëàçåðíîãî 2D-ðàññåÿíèÿ ñâåòà, îñíîâàííûé íà ðàññåÿíèèìîíîõðîìàòè÷åñêîãîñâåòàèàíàëèçåäèíàìèêè ïîëó÷åííûõ èíòåðôåðåíöèîííûõ êàðòèí [4].

11
Popov PI, Syroeshkin AV. Vidan. RF Certificate of official registration of the computer program, ¹ 2005612135; 2005 (in Russian).
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    Ìàòåìàòè÷åñêóþ îáðàáîòêó ïðîâîäèëè ñ ïîìîùüþ òîïîëîãè÷åñêèõ äåñêðèïòîðîâd1,d2,d3(êðèòåðèåâ äèíàìèêè ðàçëè÷èÿ 2D-ðàñïðåäåëåíèÿ èíòåíñèâíîñòè ëàçåðíîãî ñâåòà, ïðîãðàììíîå îáåñïå÷åíèå «Vidan»), àíàëîãè÷íî QSAR ïîäõîäàì ê àíàëèçó îðãàíè÷åñêèõ ñîåäèíåíèé
    Exact
    [11, 12]
    Suffix
    . Êîíå÷íûå ðåçóëüòàòû ïðåäñòàâëÿëè â âèäå äèàãðàìì çàâèñèìîñòè âàðèàáåëüíîñòè sdi(t)îò çíà÷åíèÿ äåñêðèïòîðàdi(t),ãäåt— âðåìÿ èçìåðåíèÿ.  íàñòîÿùåé ðàáîòå äëÿ êàæäîãî òåñòèðóåìîãî ðàñòâîðà ïðîèçâîäèëè íå ìåíåå 350 èçìåðåíèé ïðèÒ= +22 °Ñ.

12
Syroeshkin AV, Stepanova NA, Popov PI, et al. Prognostication of toxicity of a group of chemical compounds comprising anti-tuberculosis medicines by the quantitative structure-activity correlation method. Forensic Med Exam 2009; (4): 210–7.
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    Ìàòåìàòè÷åñêóþ îáðàáîòêó ïðîâîäèëè ñ ïîìîùüþ òîïîëîãè÷åñêèõ äåñêðèïòîðîâd1,d2,d3(êðèòåðèåâ äèíàìèêè ðàçëè÷èÿ 2D-ðàñïðåäåëåíèÿ èíòåíñèâíîñòè ëàçåðíîãî ñâåòà, ïðîãðàììíîå îáåñïå÷åíèå «Vidan»), àíàëîãè÷íî QSAR ïîäõîäàì ê àíàëèçó îðãàíè÷åñêèõ ñîåäèíåíèé
    Exact
    [11, 12]
    Suffix
    . Êîíå÷íûå ðåçóëüòàòû ïðåäñòàâëÿëè â âèäå äèàãðàìì çàâèñèìîñòè âàðèàáåëüíîñòè sdi(t)îò çíà÷åíèÿ äåñêðèïòîðàdi(t),ãäåt— âðåìÿ èçìåðåíèÿ.  íàñòîÿùåé ðàáîòå äëÿ êàæäîãî òåñòèðóåìîãî ðàñòâîðà ïðîèçâîäèëè íå ìåíåå 350 èçìåðåíèé ïðèÒ= +22 °Ñ.

13
Epshtein OI. Extremely small doses (history of research). Moscow: RAMN; 2008 (in Russian).
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    Ðàíäîìèçèðîâàííûå êëèíè÷åñêèå èñïûòàíèÿ âûñîêèõ è ñâåðõâûñîêèõ ðàçâåäåíèé ëåêàðñòâåííûõ ñðåäñòâ äåìîíñòðèðóþò âûñîêèå ïîêàçàòåëè ïî òåðàïåâòè÷åñêîìó ýôôåêòó, íè÷åì íå óñòóïàþùèå àëëîïàòè÷åñêèì ñðåäñòâàì
    Exact
    [2, 13]
    Suffix
    .Âîòå÷åñòâåííîéïðàêòèêåòåõíîëîãèÿ ìíîãîêðàòíîãî ðàçâåäåíèÿ ðàñòâîðîâ, ñîäåðæàùèõ àôôèííî î÷èùåííûå àíòèòåëà ê ãàììà-èíòåðôåðîíó ÷åëîâåêà è ê ãèñòàìèíó, áûëà óñïåøíî ïðèìåíåíà äëÿ ðàçðàáîòêè îðèãèíàëüíûõ ëåêàðñòâåííûõ ñðåäñòâ [2].

14
Uspenskaya EV, Syroeshkin AV, Smirnov AN, et al. The structure of water and laser rapid methods for determining authenticity. Farmatsiya 2007; (5): 21–3 (in Russian).
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    Ôîðìóëèðóÿ ïîëîæåíèÿ îá ó÷àñòèè â ïåðåäà÷å áèîëîãè÷åñêè àêòèâíîãî «ñèãíàëà» ñóïðàìîëåêóëÿðíûõ ñòðóêòóð[2]ìûïðåäïîëîæèëè,÷òîàíòèòåëàêèíòåðôåðîíó-ãàììà èíäóöèðóþò äåéòåðèé-ñòàáèëèçèðîâàííûå Ãà Êâîäû
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    ñî ñïåöèôè÷åñêèì ðàçìåðíûì ñïåêòðîì. Äåéñòâèòåëüíî, ýòîò èíäóêöèîííûé ýôôåêò ïðîÿâèëè è áåëêîâûå íàíî÷àñòèöû, àíàëîãè÷íî ñòàíäàðòèçîâàííûì ëàòåêñíûì íàíî÷àñòèöàì [6]. Ìåòîäîì DLS (ïðåäåë îáíàðóæåíèÿ 2 ìêã/ìë) íàìè Ðèñ. 1.

15
Malyuchenko NV, Tonevitsky AG, Savvateev MN, et al. The study of the structural features of proteins intermittent-contact method of atomic force microscopy. Biofizika 2003;48(5): 830–6 (in Russian).
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    Òåêñòîâàÿ ìàðêèðîâêà ñîîòâåòñòâóåò íîìåðó ðàçâåäåíèÿ îáíàðóæåíû ìàêñèìóìû (10 è 130 íì) â ðàçìåðíîì ñïåêòðå ÃÃ Êâîäû ðàñòâîðà 0,02 ìã/ìë àíòèòåë ê èíòåðôåðîíó-ãàììà, ÷òî îòðàæàåò äèàìåòð ìîëåêóëû àíòèòåëà
    Exact
    [15]
    Suffix
    è, ïî-âèäèìîìó, êàæóùèéñÿ äèàìåòð àíòèòåë è èõ îëèãîìåðîâ [16]. Ìåòîäîì LALLS óäàëîñüîáíàðóæèòüâðàçìåðíîìñïåêòðåðàçâåäåíèéàíòèòåë Ñ1–Ñ10 äîïîëíèòåëüíî ìàêñèìóìû ïðè 20 è 100 ìêì, êîòîðûå îòðàæàþò íàëè÷èå áåëîê-èíäóöèðîâàííûõ ñóáìèëëèìåòðîâûõ êëàñòåðîâ â èññëåäóåìûõ ðàñòâîðàõ.

16
Bhattacharya A, Prajapati R, Chatterjee S, et al. Concentration-dependent reversible self-oligomerization of serum albumins through intermolecularb-sheetformation.Langmuir2014;30(49): 14894–904.
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    Òåêñòîâàÿ ìàðêèðîâêà ñîîòâåòñòâóåò íîìåðó ðàçâåäåíèÿ îáíàðóæåíû ìàêñèìóìû (10 è 130 íì) â ðàçìåðíîì ñïåêòðå ÃÃ Êâîäû ðàñòâîðà 0,02 ìã/ìë àíòèòåë ê èíòåðôåðîíó-ãàììà, ÷òî îòðàæàåò äèàìåòð ìîëåêóëû àíòèòåëà [15] è, ïî-âèäèìîìó, êàæóùèéñÿ äèàìåòð àíòèòåë è èõ îëèãîìåðîâ
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    . Ìåòîäîì LALLS óäàëîñüîáíàðóæèòüâðàçìåðíîìñïåêòðåðàçâåäåíèéàíòèòåë Ñ1–Ñ10 äîïîëíèòåëüíî ìàêñèìóìû ïðè 20 è 100 ìêì, êîòîðûå îòðàæàþò íàëè÷èå áåëîê-èíäóöèðîâàííûõ ñóáìèëëèìåòðîâûõ êëàñòåðîâ â èññëåäóåìûõ ðàñòâîðàõ.

17
Chikramane PS, Kalita D, Suresh AK, et al. Why extreme dilutions reach non-zero asymptotes: A nanoparticulate hypothesis based on froth flotation. Langmuir 2012; 28: 15864–75.
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    Ýòî äàåò âîçìîæíîñòü èñïîëüçîâàíèÿ äèàãðàììû sd3-d3 â êà÷åñòâå àíàëîãà êëàññè÷åñêîé êàëèáðîâêè. Ìû ïðåäïîëîæèëè, ÷òî ÿâëåíèå àäñîðáöèè íàíî÷àñòèö íà ìåæôàçíîé ãðàíèöå âîäà–âîçäóõ, îïóáëèêîâàííîå â
    Exact
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    , ìîæåò áûòü òàêæå ðåàëèçîâàíî íà ñâîåîáðàçíîé ìåæôàçíîé ãðàíèöå äåéòåðèé-ñòàáèëèçèðîâàííûõ ñóáìèëëèìåòðîâûõ ïëîòíîñòíûõ íåîäíîðîäíîñòåé, óâåëè÷èâàÿ èõ âðåìÿ ðåëàêñàöèè. Ïðèìåíåíèå ìóëüòèäåñêðèïòîðíîãî àíàëèçà (àíàëîãè÷íî ôèíãåðïðèíòó â ìîëåêóëÿðíîé áèîëîãèè)ïîçâîëÿåòíàãëÿäíîïðîèëëþñòðèðîâàòüòîïîëîãèþ ëàçåðíîãî 2D-ðàññåÿíèÿ äëÿ ñåðèé ðàçâåäåíèé (ðèñ. 2).

18
Smirnov AN, Syroeshkin AV. Supramolecular water complexes. Rossiyskiy himicheskiy zhurnal 2004;48(2): 125–35 (in Russian).
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    Äðóãàÿ âîçìîæíîñòü — çà ñ÷åò ñëîæíîé êèíåòèêè êîìáèíàöèè îáðàòèìûõ ïðîöåññîâ ñáîðêè ñóáìèëëèìåòðîâûõ ïëîòíîñòíûõ íåîäíîðîäíîñòåéèçáîëååìåëêèõ«âèõðåé»è/èëèäðîáëåíèå óæå ñôîðìèðîâàííûõ ãèãàíòñêèõ êëàñòåðîâ, êàê ðàíåå îòìå÷àëîñü íàìè
    Exact
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    . Ïîðÿäîê ðàçìåðîâ ñóáìèëëèìåòðîâûõ ïëîòíîñòíûõ íåîäíîðîäíîñòåé âîäû íå ñëó÷àéíî ñîâïàäàåò ñ êîëìîãîðîâñêèì ìàñøòàáîì ïåðåõîäà êèíåòè÷åñêîé ýíåðãèè â òåïëîâóþ (äëÿ âîäû — 0,1 ìì): â âîäå óæå ñóùåñòâóåò ñòðóêòóðà, îáåñïå÷èâàþùàÿ ñîïðÿæåíèå ýòèõ ïðîöåññîâ.

19
Kurihara K, Tamura M, Shohda K, et al. Self-reproduction of supramolecular giant vesicles combined with the amplification of encapsulated DNA. Nature Chemistry 2011; (3): 775–81.
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    ñóáìèëëèìåòðîâûõ ïëîòíîñòíûõ íåîäíîðîäíîñòåé âîäû íå ñëó÷àéíî ñîâïàäàåò ñ êîëìîãîðîâñêèì ìàñøòàáîì ïåðåõîäà êèíåòè÷åñêîé ýíåðãèè â òåïëîâóþ (äëÿ âîäû — 0,1 ìì): â âîäå óæå ñóùåñòâóåò ñòðóêòóðà, îáåñïå÷èâàþùàÿ ñîïðÿæåíèå ýòèõ ïðîöåññîâ. Òàê, ñîõðàíåíèå àíàëèòè÷åñêîãî ñèãíàëà âîçìîæíî ïðè ìîäåëè ñâîåîáðàçíîãî ðàçìíîæåíèÿ ñóáìèëëèìåòðîâûõ ïëîòíîñòíûõ íåîäíîðîäíîñòåé, ïîäîáíî êîàöåðâàòàì Îïàðèíà
    Exact
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    . Ïðèìåíåííûé â íàñòîÿùåé ðàáîòå àíàëèòè÷åñêèé ïîäõîä ìîæåò áûòü ðåàëèçîâàí äëÿ êîíòðîëÿ êà÷åñòâà âûñîêèõ è ñâåðõâûñîêèõ ðàçâåäåíèé ëåêàðñòâåííûõ ñðåäñòâ, ïðèãîòîâëåííûõ ïóòåì ïîñëåäîâàòåëüíîãî ìíîãîêðàòíîãî óìåíüøåíèÿ êîíöåíòðàöèè èñõîäíîãî âåùåñòâà [20].

20
Chernikov FR, Sorokin VN, Olenev AL, et al. The method for determining the quality of homeopathic medicinal products and devices for its implementation. Patent RF, ¹ 2112976 RU; 1998 (in Russian). AUTHORS Peoples’ Friendship University of Russia, Medical Institute, Miklukho-Maklaya street 8, Moscow 117198, Russian Federation.
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  1. In-text reference with the coordinate start=14055
    Prefix
    Ïðèìåíåííûé â íàñòîÿùåé ðàáîòå àíàëèòè÷åñêèé ïîäõîä ìîæåò áûòü ðåàëèçîâàí äëÿ êîíòðîëÿ êà÷åñòâà âûñîêèõ è ñâåðõâûñîêèõ ðàçâåäåíèé ëåêàðñòâåííûõ ñðåäñòâ, ïðèãîòîâëåííûõ ïóòåì ïîñëåäîâàòåëüíîãî ìíîãîêðàòíîãî óìåíüøåíèÿ êîíöåíòðàöèè èñõîäíîãî âåùåñòâà
    Exact
    [20]
    Suffix
    . ÂÛÂÎÄ Ñðàâíåíèå ñîòåííûõ ðàçâåäåíèé ïðåïàðàòîâ àíòèòåë ñ êîíòðîëüíûìè îáðàçöàìè â äèàïàçîíå îò Ñ10 äî Ñ50 ìåòîäîì ëàçåðíîãî 2D-ðàññåÿíèÿ ñâåòà íà îñíîâàíèèìóëüòèäåñêðèïòîðíîãîàíàëèçàïîêàçàëîñóùåñòâîâàíèå ðàçëè÷èé ìåæäó ðàçâåäåíèÿìè àíòèòåë è ðàçâåäåíèÿìè ãëèöèíîâîãî áóôåðà, îáóñëîâëåííûå ñ äåéòåðèé-ñòàáèëèçèðîâàííûìè ñóáìèëëèìåòðîâûìè ïëîòíîñòíûìè íåîäíîðîäíîñòÿìè.