The 8 references with contexts in paper G. Bobizoda M., N. Bunyatyan D., A. Shakhmatov N., Г. Бобизода М., Н. Бунятян Д., А. Шахматов Н. (2018) “Стандартизация пептидного препарата тимоцин // Standardization of the peptide preparation timocin” / spz:neicon:vedomostincesmp:y:2016:i:1:p:45-49

1
Morozov VG, Havinson VH, Malinin VV. Peptide Thymomimetics. St. Petersburg, Nauka, 2000 (in Russian).
Total in-text references: 1
  1. In-text reference with the coordinate start=1580
    Prefix
    Âåäîìîñòè Íàó÷íîãî öåíòðà ýêñïåðòèçû ñðåäñòâ ìåäèöèíñêîãî ïðèìåíåíèÿ 2016; (1): 45–49.  íàñòîÿùåå âðåìÿ óñòàíîâëåíî, ÷òî íåêîòîðûå íèçêîìîëåêóëÿðíûå ïåïòèäû îáëàäàþò èììóíîìîäóëèðóþùåé àêòèâíîñòüþ è ïðèìåíÿþòñÿ â êà÷åñòâå ïåïòèäíûõ ïðåïàðàòîâ
    Exact
    [1]
    Suffix
    . Òàêæå èçâåñòíî, ÷òî íåêîòîðûå ìèêðîýëåìåíòû èãðàþò âàæíóþ ðîëü â ôóíêöèîíèðîâàíèè èììóííîé ñèñòåìû. Îäíèì èç íàèáîëåå âàæíûõ ìèêðîýëåìåíòîâ â ýòîì ïëàíå ÿâëÿåòñÿ öèíê [2]. Êàê ðàíåå [3] áûëî ïîêàçàíî íà ëåêàðñòâåííûõ ïðåïàðàòàõ îðãàíè÷åñêîãî ïðîèñõîæäåíèÿ, êîìïëåêñîîáðàçîâàíèå ñ èîíàìè ðàçëè÷íûõ ìåòàëëîâ ïðèâîäèò ê óâåëè÷åíèþ ñïåöèôè÷åñêîé àêòèâíîñòè ýòèõ ïðåïàðàòîâ.

2
Kudrin AV, Gromova OA. Dietary elements in immunology and oncology. Ì: GEOTAR Media; 2007 (in Russian).
Total in-text references: 1
  1. In-text reference with the coordinate start=1754
    Prefix
     íàñòîÿùåå âðåìÿ óñòàíîâëåíî, ÷òî íåêîòîðûå íèçêîìîëåêóëÿðíûå ïåïòèäû îáëàäàþò èììóíîìîäóëèðóþùåé àêòèâíîñòüþ è ïðèìåíÿþòñÿ â êà÷åñòâå ïåïòèäíûõ ïðåïàðàòîâ [1]. Òàêæå èçâåñòíî, ÷òî íåêîòîðûå ìèêðîýëåìåíòû èãðàþò âàæíóþ ðîëü â ôóíêöèîíèðîâàíèè èììóííîé ñèñòåìû. Îäíèì èç íàèáîëåå âàæíûõ ìèêðîýëåìåíòîâ â ýòîì ïëàíå ÿâëÿåòñÿ öèíê
    Exact
    [2]
    Suffix
    . Êàê ðàíåå [3] áûëî ïîêàçàíî íà ëåêàðñòâåííûõ ïðåïàðàòàõ îðãàíè÷åñêîãî ïðîèñõîæäåíèÿ, êîìïëåêñîîáðàçîâàíèå ñ èîíàìè ðàçëè÷íûõ ìåòàëëîâ ïðèâîäèò ê óâåëè÷åíèþ ñïåöèôè÷åñêîé àêòèâíîñòè ýòèõ ïðåïàðàòîâ.

3
Kriss E, Volchenskova II, Budarin LI. Metal coordination compounds with drugs — new effective therapeutic agents. Koordinatsionnaya himiya 1990;16(1): 11–21 (in Russian).
Total in-text references: 1
  1. In-text reference with the coordinate start=1769
    Prefix
     íàñòîÿùåå âðåìÿ óñòàíîâëåíî, ÷òî íåêîòîðûå íèçêîìîëåêóëÿðíûå ïåïòèäû îáëàäàþò èììóíîìîäóëèðóþùåé àêòèâíîñòüþ è ïðèìåíÿþòñÿ â êà÷åñòâå ïåïòèäíûõ ïðåïàðàòîâ [1]. Òàêæå èçâåñòíî, ÷òî íåêîòîðûå ìèêðîýëåìåíòû èãðàþò âàæíóþ ðîëü â ôóíêöèîíèðîâàíèè èììóííîé ñèñòåìû. Îäíèì èç íàèáîëåå âàæíûõ ìèêðîýëåìåíòîâ â ýòîì ïëàíå ÿâëÿåòñÿ öèíê [2]. Êàê ðàíåå
    Exact
    [3]
    Suffix
    áûëî ïîêàçàíî íà ëåêàðñòâåííûõ ïðåïàðàòàõ îðãàíè÷åñêîãî ïðîèñõîæäåíèÿ, êîìïëåêñîîáðàçîâàíèå ñ èîíàìè ðàçëè÷íûõ ìåòàëëîâ ïðèâîäèò ê óâåëè÷åíèþ ñïåöèôè÷åñêîé àêòèâíîñòè ýòèõ ïðåïàðàòîâ. Áûëî îáíàðóæåíî ïîÿâëåíèå ñïåöèôè÷åñêîé àêòèâíîñòè ýíêåôàëèíîâ ïðè èõ êîìïëåêñîîáðàçîâàíèè ñ èîíîì ìåäè [4].

4
Mrabet B, Jouini M, Huet J, Lapluye G. Potentiometric, colorimetric and spectroscopic study of copper (II) complex of leucine — enkephalin and tripeptides, containing tyrosine. J Clin åt Phys–chim Biol. 1992; 89(11–12): 2187–2205.
Total in-text references: 1
  1. In-text reference with the coordinate start=2063
    Prefix
    Êàê ðàíåå [3] áûëî ïîêàçàíî íà ëåêàðñòâåííûõ ïðåïàðàòàõ îðãàíè÷åñêîãî ïðîèñõîæäåíèÿ, êîìïëåêñîîáðàçîâàíèå ñ èîíàìè ðàçëè÷íûõ ìåòàëëîâ ïðèâîäèò ê óâåëè÷åíèþ ñïåöèôè÷åñêîé àêòèâíîñòè ýòèõ ïðåïàðàòîâ. Áûëî îáíàðóæåíî ïîÿâëåíèå ñïåöèôè÷åñêîé àêòèâíîñòè ýíêåôàëèíîâ ïðè èõ êîìïëåêñîîáðàçîâàíèè ñ èîíîì ìåäè
    Exact
    [4]
    Suffix
    . Áûëî ïîêàçàíî, ÷òî êîìïëåêñîîáðàçîâàíèå ñ èîíàìè æåëåçà (II) è öèíêà ïðèâîäèò ê ïîâûøåíèþ èììóíîñòèìóëèðóþùåé àêòèâíîñòè ó äèïåïòèäà èçîëåéöèë-òðèïòîôàí [5]. Ýòè èññëåäîâàíèÿ ïîñëóæèëè îñíîâîé äëÿ ðàçðàáîòêè èììóíîñòèìóëèðóþùåãî ïðåïàðàòà òèìîöèí, ïðåäñòàâëÿþùåãî ñîáîé âîäíûé ðàñòâîð êîîðäèíàöèîííûõ ñîåäèíåíèé öèíêà ñ äèïåïòèäîì èçîëåéöèëòðèïòîôàí [6], êîòîðûé áûë çàðåãèñòðèðîâàí â Ðåñïóáëèêå Òà

5
Bobiev GM, Bunyatyan ND, Sayadyan HS, Sapovskiy MM. Immunoactive peptides and their coordination compounds in medicine. Moscow: Russkiy vrach; 2009 (in Russian).
Total in-text references: 2
  1. In-text reference with the coordinate start=2220
    Prefix
    Áûëî îáíàðóæåíî ïîÿâëåíèå ñïåöèôè÷åñêîé àêòèâíîñòè ýíêåôàëèíîâ ïðè èõ êîìïëåêñîîáðàçîâàíèè ñ èîíîì ìåäè [4]. Áûëî ïîêàçàíî, ÷òî êîìïëåêñîîáðàçîâàíèå ñ èîíàìè æåëåçà (II) è öèíêà ïðèâîäèò ê ïîâûøåíèþ èììóíîñòèìóëèðóþùåé àêòèâíîñòè ó äèïåïòèäà èçîëåéöèë-òðèïòîôàí
    Exact
    [5]
    Suffix
    . Ýòè èññëåäîâàíèÿ ïîñëóæèëè îñíîâîé äëÿ ðàçðàáîòêè èììóíîñòèìóëèðóþùåãî ïðåïàðàòà òèìîöèí, ïðåäñòàâëÿþùåãî ñîáîé âîäíûé ðàñòâîð êîîðäèíàöèîííûõ ñîåäèíåíèé öèíêà ñ äèïåïòèäîì èçîëåéöèëòðèïòîôàí [6], êîòîðûé áûë çàðåãèñòðèðîâàí â Ðåñïóáëèêå Òàäæèêèñòàí â êà÷åñòâå èììóíîìîäóëèðóþùåãî ïðåïàðàòà.

  2. In-text reference with the coordinate start=4564
    Prefix
    Òèìîöèí ïðåäñòàâëÿåò ñîáîé ðàñòâîð êîîðäèíàöèîííûõ ñîåäèíåíèé äèïåïòèäà H-Ile-Trp-OH ñ Zn2+,ñóùåñòâóþùèõ îäíîâðåìåííî â íåñêîëüêèõ êîìïëåêñíûõ ôîðìàõ, îáóñëîâëåííûõ ñòóïåí÷àòîé äèññîöèàöèåé äèïåïòèäà
    Exact
    [5]
    Suffix
    . Äàííûõ î âëèÿíèè ñîëå- è êîìïëåêñîîáðàçîâàíèÿ íà õðîìàòîãðàôè÷åñêèå ñâîéñòâà ïåïòèäîâ ïðàêòè÷åñêè íå èìååòñÿ. Òîëüêî Â. Ñ. Ñìèðíîâ (2003) ñîîáùàë, ÷òî ìîíîíàòðèåâàÿ ñîëü L-ãëóòàìèë-L-òðèïòîôàíà ïî äàííûì ÒÑÕ è ÂÝÆÕ èäåíòè÷íà äèïåïòèäó â âûáðàííûõ óñëîâèÿõ õðîìàòîãðàôèðîâàíèÿ.

6
Bobiev GM. A method for producing an immunostimulatory drug Timocin. Patent of the Republic of Tajikistan, ¹ TJ 282; 1998 (in Russian).
Total in-text references: 1
  1. In-text reference with the coordinate start=2418
    Prefix
    Áûëî ïîêàçàíî, ÷òî êîìïëåêñîîáðàçîâàíèå ñ èîíàìè æåëåçà (II) è öèíêà ïðèâîäèò ê ïîâûøåíèþ èììóíîñòèìóëèðóþùåé àêòèâíîñòè ó äèïåïòèäà èçîëåéöèë-òðèïòîôàí [5]. Ýòè èññëåäîâàíèÿ ïîñëóæèëè îñíîâîé äëÿ ðàçðàáîòêè èììóíîñòèìóëèðóþùåãî ïðåïàðàòà òèìîöèí, ïðåäñòàâëÿþùåãî ñîáîé âîäíûé ðàñòâîð êîîðäèíàöèîííûõ ñîåäèíåíèé öèíêà ñ äèïåïòèäîì èçîëåéöèëòðèïòîôàí
    Exact
    [6]
    Suffix
    , êîòîðûé áûë çàðåãèñòðèðîâàí â Ðåñïóáëèêå Òàäæèêèñòàí â êà÷åñòâå èììóíîìîäóëèðóþùåãî ïðåïàðàòà. Òèìîöèí îêàçàëñÿ ýôôåêòèâíûì ïðè ëå÷åíèè ðàçëè÷íûõ çàáîëåâàíèé, ñîïðîâîæäàþùèõñÿ âîçíèêíîâåíèåì âòîðè÷íûõ èììóíîäåôèöèòíûõ ñîñòîÿíèé [7, 8].

7
Mansurov HH, Mirodzhov GK, Mansurova FH, Bobiev GM, Holnazarov BM. Timocin in the treatment of chronic diffuse liver diseases. Problemy gastroenterologii 2010; 1–2: 40–49 (in Russian).
Total in-text references: 1
  1. In-text reference with the coordinate start=2654
    Prefix
    îñíîâîé äëÿ ðàçðàáîòêè èììóíîñòèìóëèðóþùåãî ïðåïàðàòà òèìîöèí, ïðåäñòàâëÿþùåãî ñîáîé âîäíûé ðàñòâîð êîîðäèíàöèîííûõ ñîåäèíåíèé öèíêà ñ äèïåïòèäîì èçîëåéöèëòðèïòîôàí [6], êîòîðûé áûë çàðåãèñòðèðîâàí â Ðåñïóáëèêå Òàäæèêèñòàí â êà÷åñòâå èììóíîìîäóëèðóþùåãî ïðåïàðàòà. Òèìîöèí îêàçàëñÿ ýôôåêòèâíûì ïðè ëå÷åíèè ðàçëè÷íûõ çàáîëåâàíèé, ñîïðîâîæäàþùèõñÿ âîçíèêíîâåíèåì âòîðè÷íûõ èììóíîäåôèöèòíûõ ñîñòîÿíèé
    Exact
    [7, 8]
    Suffix
    . Öåëüþ äàííîãî ñîîáùåíèÿ ÿâëÿåòñÿ ñòàíäàðòèçàöèÿ è ðàçðàáîòêà ôàðìàêîïåéíîé ñòàòüè íà òèìîöèí. Ïðè ñîçäàíèè ëåêàðñòâåííîé ôîðìû âûáðàíî ýêâèìîëÿðíîå ñîîòíîøåíèå äèïåïòèäà è èîíà ìåòàëëà ïðè êîíöåíòðàöèè äèïåïòèäà, êàêèâñëó÷àå òèìîãåíà è òèìîãàðà, 100 ìêã/ìë.

8
Mirzoeva DS, Bobiev GM, Anohina IV. Use of Timocin in the treatment of breast cancer. In: VI congress of oncologists and radiologists of CIS. Proceedings of the Congress: Dushanbe, 1–4 October 2010. Dushanbe; 2010 (in Russian). AUTHORS
Total in-text references: 1
  1. In-text reference with the coordinate start=2654
    Prefix
    îñíîâîé äëÿ ðàçðàáîòêè èììóíîñòèìóëèðóþùåãî ïðåïàðàòà òèìîöèí, ïðåäñòàâëÿþùåãî ñîáîé âîäíûé ðàñòâîð êîîðäèíàöèîííûõ ñîåäèíåíèé öèíêà ñ äèïåïòèäîì èçîëåéöèëòðèïòîôàí [6], êîòîðûé áûë çàðåãèñòðèðîâàí â Ðåñïóáëèêå Òàäæèêèñòàí â êà÷åñòâå èììóíîìîäóëèðóþùåãî ïðåïàðàòà. Òèìîöèí îêàçàëñÿ ýôôåêòèâíûì ïðè ëå÷åíèè ðàçëè÷íûõ çàáîëåâàíèé, ñîïðîâîæäàþùèõñÿ âîçíèêíîâåíèåì âòîðè÷íûõ èììóíîäåôèöèòíûõ ñîñòîÿíèé
    Exact
    [7, 8]
    Suffix
    . Öåëüþ äàííîãî ñîîáùåíèÿ ÿâëÿåòñÿ ñòàíäàðòèçàöèÿ è ðàçðàáîòêà ôàðìàêîïåéíîé ñòàòüè íà òèìîöèí. Ïðè ñîçäàíèè ëåêàðñòâåííîé ôîðìû âûáðàíî ýêâèìîëÿðíîå ñîîòíîøåíèå äèïåïòèäà è èîíà ìåòàëëà ïðè êîíöåíòðàöèè äèïåïòèäà, êàêèâñëó÷àå òèìîãåíà è òèìîãàðà, 100 ìêã/ìë.