The 8 references with contexts in paper Yu. Burda E., S. Nadezhdin V., E. Zubareva V., M. Pokrovsky V., S. Burda Yu., M. Shirina S., Ю. Бурда Е., С. Надеждин В., Е. Зубарева В., М. Покровский В., С. Бурда Ю., М. Ширина С. (2018) “Тест-система для оценки активности ингибиторов GSK-3 в качестве антигипоксантов и индукторов дифференцировки эндотелиальных предшественников in vitro // Test-system for the assessment of GSK-3 inhibitors activity as antihypoxants and endothelial differentiation stimulators in vitro” / spz:neicon:vedomostincesmp:y:2016:i:1:p:29-32

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Osolodkin DI. Molecular design of potential glycogen synthase kinase 3 inhibitors: Dr. Chem. Sci [dissertation]. Moscow; 2011 (in Russian).
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    Èíãèáèòîðû àêòèâíîñòè GSK-3 ÿâëÿþòñÿ ìíîãîîáåùàþùèìè ïðåòåíäåíòàìè íà ðîëü ëåêàðñòâ ïðè ìíîãèõ çàáîëåâàíèÿõ, â òîì ÷èñëå â êà÷åñòâå ñòèìóëÿòîðîâ ðåïàðàöèè òêàíåé è íåîàíãèîãåíåçà, èíäóêòîðîâ ìèåëîïîýçà è â ðÿäå èíûõ íàïðàâëåíèé
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    . Îäíîé èç çàäà÷ ïðè ðàçðàáîòêå íîâûõ ëåêàðñòâåííûõ ïðåïàðàòîâ ÿâëÿåòñÿ ïðîâåäåíèå ñêðèíèíãà áèîëîãè÷åñêîé àêòèâíîñòè ñèíòåçèðóåìûõ ìîëåêóë-ïðåòåíäåíòîâ.  íàñòîÿùåå âðåìÿ áîëüøàÿ ÷àñòü ýêñïåðèìåíòàëüíûõ è äîêëèíè÷åñêèõ èññëåäîâàíèé â Ðîññèè ïðîâîäèòñÿ ñ èñïîëüçîâàíèåì ëàáîðàòîðíûõ æèâîòíûõ, ÷òî íå ÿâëÿåòñÿ, íà íàø âçãëÿä, îïòèìàëüíûì ðåøåíèåì.

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    äàííûé ôåíîìåí îáóñëîâëåí àíòèàïîïòîãåííûì ýôôåêòîìb4-òèìîçèíà è íå îáëàäàåò ëè ïîñëåäíèé ñâîéñòâîì ñòèìóëèðîâàòü ïðîëèôåðàöèþ êëåòîê, ýêñïåðèìåíò îòâåòà íå äàåò, ò.ê. èçó÷åíèå äàííûõ ìåõàíèçìîâ íå ïðîâîäèëè.  ëèòåðàòóðå åñòü ñâåäåíèÿ êàê î ñòèìóëèðóþùåì, òàê è èíãèáèðóþùåì âëèÿíèèb4-òèìîçèíà íà ïðîëèôåðàòèâíóþ àêòèâíîñòü êëåòîê ÷åðåç ðåàëèçàöèþ Wnt è èíñóëèíîâîãî ïóòåé ïåðåäà÷è ñèãíàëîâ
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    . Ñëåäóþùèì ýòàïîì ýêñïåðèìåíòà ñòàëî èçó÷åíèå ýíäîòåëèàëüíîé äèôôåðåíöèðîâêè àäãåçèðóþùåé ôðàêöèè êîñòíîìîçãîâûõ ìîíîíóêëåàðîâ, äëÿ ÷åãî áûë ïðîèçâåäåí ïîäñ÷åò ÷èñëà êëåòîê, ýêñïðåññèðóþùèõ ìàðêåð ýíäîòåëèàëüíûõ ïðîãåíèòîðíûõ êëåòîê — ðàííèõ ïðåäøåñòâåíèêîâ ýíäîòåëèîöèòî⠗ Flk-1 (VEGFR), ïðåäñòàâëÿþùèé ñîáîé ðåöåïòîð ñîñóäèñòî-ýíäîòåëèàëüíîãî ôàêòîðà ðîñòà.

2
Shamanskaya TV, Osipova EYu, Rumyantsev SA. Ex vivo expansion of cord blood-derived hemopoietic stem cells (review). Onkogematologiya 2012; (1): 35–44 (in Russian).
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    Èíãèáèòîðû àêòèâíîñòè GSK-3 ÿâëÿþòñÿ ìíîãîîáåùàþùèìè ïðåòåíäåíòàìè íà ðîëü ëåêàðñòâ ïðè ìíîãèõ çàáîëåâàíèÿõ, â òîì ÷èñëå â êà÷åñòâå ñòèìóëÿòîðîâ ðåïàðàöèè òêàíåé è íåîàíãèîãåíåçà, èíäóêòîðîâ ìèåëîïîýçà è â ðÿäå èíûõ íàïðàâëåíèé
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    . Îäíîé èç çàäà÷ ïðè ðàçðàáîòêå íîâûõ ëåêàðñòâåííûõ ïðåïàðàòîâ ÿâëÿåòñÿ ïðîâåäåíèå ñêðèíèíãà áèîëîãè÷åñêîé àêòèâíîñòè ñèíòåçèðóåìûõ ìîëåêóë-ïðåòåíäåíòîâ.  íàñòîÿùåå âðåìÿ áîëüøàÿ ÷àñòü ýêñïåðèìåíòàëüíûõ è äîêëèíè÷åñêèõ èññëåäîâàíèé â Ðîññèè ïðîâîäèòñÿ ñ èñïîëüçîâàíèåì ëàáîðàòîðíûõ æèâîòíûõ, ÷òî íå ÿâëÿåòñÿ, íà íàø âçãëÿä, îïòèìàëüíûì ðåøåíèåì.

3
Xu TJ, et al. A novel dimeric thymosin beta 4 with enhanced activities accelerates the rate of wound healing. Drug Design, Development and Therapy 2013; 7: 1075–88.
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    Äëÿ ëþáîé ìîäåëè íåîáõîäèìî èñïîëüçîâàíèå íåêîãî êîíòðîëüíîãî âåùåñòâà, îáëàäàþùåãî èçâåñòíîé àêòèâíîñòüþ, äëÿ ïðîâåäåíèÿ ñðàâíèòåëüíîãî èññëåäîâàíèÿ íîâûõ ìîëåêóë. Äëÿ èíãèáèòîðîâ GSK-3 íàìè áûë âûáðàíb4-òèìîçèí, èçó÷åííûé â ñïîðòèâíîé ôàðìàêîëîãèè è â íåêîòîðûõ äðóãèõ îáëàñòÿõ ìåäèöèíû
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    è äîñòóïíûé â êà÷åñòâå ãîòîâîé ñóáñòàíöèè. ÌÀÒÅÐÈÀËÛ È ÌÅÒÎÄÛ Ýíäîòåëèàëüíûå ïðåäøåñòâåííèêè ïîëó÷àëè èç êîñòíîãî ìîçãà 10 êðûñ Wistar âîçðàñòà 3–4 íåäåëè, óìåðùâëåííûõ äåêàïèòàöèåé ïîä ýôèðíûì íàðêîçîì, ïî ìîäèôèöèðîâàííîìó ìåòîäó Nana Y. è ñîàâò. [7].

5
Yanbo Z, et al. Thymosinb4 activates integrin-linked kinase and decreases endothelial progenitor cells apoptosis under serum deprivation. Journal of Cellular Physiology 2011; 226: 2798–2806.
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    ,142,2±2,1* % Flk-1+êëåòîê50,6±4,782,8±2,2* * —p< 0,05 Áîëåå âûðàæåííûé ïðîòåêòèâíûé ýôôåêòb4-òèìîçèíà íà âûæèâàåìîñòü êëåòîê â óñëîâèÿõ ãèïîêñèè è ñî÷åòàíèÿ ãèïîêñèè ñ «ãîëîäàíèåì» âèäåí íà ðèñóíêàõ3è4,ãäå÷èñëî è äîëÿ æèâûõ êëåòîê â êîíòðîëå çíà÷èòåëüíî íèæå, ÷åì â îïûòíûõ îáðàçöàõ. Ïî äàííûì ëèòåðàòóðû èçâåñòíî, ÷òîb4-òèìîçèí ïðåäîòâðàùàåò àïîïòîç ýíäîòåëèàëüíûõ ïðîãåíèòîðíûõ êëåòîê â êóëüòóðå
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    . Ýòîé åãî ñïîñîáíîñòüþ, ïî-âèäèìîìó, è îáúÿñíÿåòñÿ áîëüøàÿ äîëÿ æèâûõ êëåòîê â îïûòíûõ îáðàçöàõ ïî ñðàâíåíèþ ñ êîíòðîëåì. Íî â èññëåäîâàíèè îáíàðóæåíî, ÷òî èñõîäíîå êîëè÷åñòâî êëåòîê â ëóíêàõ, ãäå êóëüòèâèðîâàíèå ïðîâîäèëîñü â òå÷åíèå 3-õ ñóòîê â ïðèñóòñòâèèb4-òèìîçèíà, âûøå, ÷åì â ëóíêàõ áåç åãî ïðèñóòñòâèÿ (ñòîëáöû Ê íà ðèñ. 1).

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Hinkel R, et al. Thymosinb4 Is an Essential Paracrine Factor of Embryonic Endothelial Progenitor Cell-Mediated Cardioprotection. Circulation 2008; 117: 2232–40.
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    1 ðåçóëüòàòû ïîêàçûâàþò, ÷òî ïðèñóòñòâèåb4-òèìîçèíà íå ïðîñòî óâåëè÷èâàåò îáùåå ÷èñëî êëåòîê, íî è çàìåòíî ïîâûøàåò ïðîöåíò êëåòîê, ýêñïðåññèðóþùèé óêàçàííûé ìàðêåð ýíäîòåëèàëüíûõ ïðåäøåñòâåííèêî⠗ 50,6±4,7% Flk+êëåòîê â êîíòðîëå è 82,8±2,2% — ïðè êóëüòèâèðîâàíèè â òå÷åíèå 3-õ ñóòîê ñb4-òèìîçèíîì. Íàðÿäó ñ ïîêàçàííûìè äðóãèìè èññëåäîâàòåëÿìè êàðäèîïðîòåêòèâíûìè ñâîéñòâàìè èíãèáèòîðîâ GSK-3b
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    , ñïîñîáíîñòü ñòèìóëèðîâàòü äèôôåðåíöèðîâêó ÌÑÊ â ýíäîòåëèàëüíîì íàïðàâëåíèè äåëàåò åùå áîëåå ïåðñïåêòèâíûì èõ èçó÷åíèå â ïëàíå ïðîôèëàêòèêè è ëå÷åíèÿ èøåìè÷åñêîé áîëåçíè ñåðäöà è îáëèòåðèðóþùèõ çàáîëåâàíèé àðòåðèé.

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Nana Y. The characteristics of endothelial progenitor cells derived from mononuclear cells of rat bone marrow in different culture conditions. Cytotechnology 2011; 63: 217–26.
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    ÌÀÒÅÐÈÀËÛ È ÌÅÒÎÄÛ Ýíäîòåëèàëüíûå ïðåäøåñòâåííèêè ïîëó÷àëè èç êîñòíîãî ìîçãà 10 êðûñ Wistar âîçðàñòà 3–4 íåäåëè, óìåðùâëåííûõ äåêàïèòàöèåé ïîä ýôèðíûì íàðêîçîì, ïî ìîäèôèöèðîâàííîìó ìåòîäó Nana Y. è ñîàâò.
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    . Êîñòíûé ìîçã âûìûâàëè ñ ïîìîùüþ øïðèöà ôîñôàòíî-ñîëåâûì áóôåðîì (ÔÑÁ, ðÍ=7,4; Ïàíýêî #Ð074) èç äèàôèçîâ è ìåõàíè÷åñêè èçìåëü÷åííûõ ýïèôèçîâ òðóá÷àòûõ êîñòåé êîíå÷íîñòåé. Äëÿ î÷èñòêè îò ôðàãìåíòîâ êîñòíîé, ìûøå÷íîé è ñîåäèíèòåëüíîé òêàíè âûìûòûé êîñòíûé ìîçãà ôèëüòðîâàëè ÷åðåç íåéëîíîâûå ôèëüòðû (SPL LifeSciences#93100) ñ äèàìåòðîì ïîð 100 ìêì.

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Miura T, Nishihara M, Miki T. Drug Development Targeting the Glycogen Synthase Kinase-3b(GSK-3b)-Mediated Signal Transduction Pathway: Role of GSK-3bin Myocardial Protection Against Ischemia/Reperfusion Injury. J Pharmacol Sci. 2009; 109: 162–67.
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    1 ðåçóëüòàòû ïîêàçûâàþò, ÷òî ïðèñóòñòâèåb4-òèìîçèíà íå ïðîñòî óâåëè÷èâàåò îáùåå ÷èñëî êëåòîê, íî è çàìåòíî ïîâûøàåò ïðîöåíò êëåòîê, ýêñïðåññèðóþùèé óêàçàííûé ìàðêåð ýíäîòåëèàëüíûõ ïðåäøåñòâåííèêî⠗ 50,6±4,7% Flk+êëåòîê â êîíòðîëå è 82,8±2,2% — ïðè êóëüòèâèðîâàíèè â òå÷åíèå 3-õ ñóòîê ñb4-òèìîçèíîì. Íàðÿäó ñ ïîêàçàííûìè äðóãèìè èññëåäîâàòåëÿìè êàðäèîïðîòåêòèâíûìè ñâîéñòâàìè èíãèáèòîðîâ GSK-3b
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    , ñïîñîáíîñòü ñòèìóëèðîâàòü äèôôåðåíöèðîâêó ÌÑÊ â ýíäîòåëèàëüíîì íàïðàâëåíèè äåëàåò åùå áîëåå ïåðñïåêòèâíûì èõ èçó÷åíèå â ïëàíå ïðîôèëàêòèêè è ëå÷åíèÿ èøåìè÷åñêîé áîëåçíè ñåðäöà è îáëèòåðèðóþùèõ çàáîëåâàíèé àðòåðèé.

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Marx U, Sandig V, eds. Drug Testing In Vitro. WILEY-VCH; 2007. AUTHORS Belgorod State National Research University, Pobedy street, 85, Belgorod, 308015, Russian Federation. Burda YuE.Associate professor of the Pharmacology Department. Candidate of Medical Sciences. Nadezhdin SV.Head of the Experimental-Industrial Department «Cellular and Assisted Reproductive Technologies». Candidate of Biological Sciences.
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    Òàêæå ñóùåñòâóþò âîïðîñû îá ýòè÷íîñòè èñïîëüçîâàíèÿ æèâûõ ìîäåëåé è îá îòñóòñòâèè ìîäåëüíûõ æèâîòíûõ äëÿ íåêîòîðûõ ñîñòîÿíèé è áîëåçíåé.  ñâÿçè ñ ýòèì ôàðìàêîëîãàìè è ôàðìïðîèçâîäèòåëÿìè íà íà÷àëüíûõ ýòàïàõ ðàçðàáîòêè è òåñòèðîâàíèÿ íîâûõ ëåêàðñòâåííûõ ïðåïàðàòîâ âñå àêòèâíåå èñïîëüçóþòñÿ êëåòî÷íûå êóëüòóðû
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    . Óêàçàííûé ïîäõîä ëèøåí îïèñàííûõ äëÿ æèâîòíûõ íåäîñòàòêîâ, ïðè ýòîì øèðî÷àéøèé âûáîð ñòàíäàðòèçèðîâàííûõ è ïåðâè÷íûõ êëåòî÷íûõ ëèíèé ïîçâîëÿåò ðàçðàáîòàòü àäåêâàòíóþ ìîäåëü ïðàêòè÷åñêè äëÿ ëþáîãî ïîòåíöèàëüíîãî ëåêàðñòâà è ïðîâåäåíèÿ ñêðèíèíãà áèîëîãè÷åñêîé àêòèâíîñòè ñèíòåçèðóåìûõ ìîëåêóëïðåòåíäåíòîâ.