The 13 references with contexts in paper A. Syroeshkin V., T. Pleteneva V., E. Uspenskaya V., O. Levitskaya V., А. Сыроешкин В., Т. Плетенева В., Е. Успенская В., О. Левицкая В. (2018) “Оптические методы в исследованиях хиральных свойств лекарственных средств. I. Валин в воде с различным содержанием дейтерия // Optical methods in the study of drug chiral proporties. I. Valine in aqueous solutions with different deuterium content” / spz:neicon:vedomostincesmp:y:2016:i:1:p:25-28

1
State Pharmacopoeia of the Russian Federation. 13th ed. V. 2. Moscow; 2015 (in Russian).
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    Íàïðèìåð, âêëþ÷åííûå â íîâóþ ôàðìàêîïåþ òàêèå ÎÔÑ, êàê «Ïîëÿðèìåòðèÿ» (îáíîâëåííûé âàðèàíò) è «Îïðåäåëåíèå ðàñïðåäåëåíèÿ ÷àñòèö ïî ðàçìåðó ìåòîäîì ëàçåðíîé äèôðàêöèè ñâåòà» (íîâàÿ ñòàòüÿ) ÿâëÿþòñÿ áàçîâûìè ïðè ðàçðàáîòêå è êîíòðîëå êà÷åñòâà ËÑ, îáëàäàþùèõ îïòè÷åñêîé àêòèâíîñòüþ
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    . Âíèìàíèå ìèðîâûõ ôàðìàêîïåé ê õèðàëüíîé ÷èñòîòå ñóáñòàíöèé äëÿ ôàðìàöåâòè÷åñêîãî ïðèìåíåíèÿ îáóñëîâëåíî ðàçëè÷èÿìè â áèîëîãè÷åñêîé àêòèâíîñòè îïòè÷åñêèõ àíòèïîäîâ è ðàâíîâåñíûìè ïðîöåññàìè ñ îáðàçîâàíèåì â îðãàíèçìå èõ òîêñè÷íûõ ôîðì [2].

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    Âëèÿíèå ïðèðîäû ðàñòâîðèòåëÿ íà îïòè÷åñêèå ñâîéñòâà îïèñàíî â ôàðìàêîïåéíîì àíàëèçå: ïðè çàìåíå ðàñòâîðèòåëÿ âåëè÷èíà óäåëüíîãî âðàùåíèÿ ðàñòâîðà ñóáñòàíöèè ìîæåò èçìåíÿòüñÿ âïëîòü äî ñìåíû çíàêà íà ïðîòèâîïîëîæíûé
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    [1, 4]
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    . Èçâåñòíî, ÷òî âîäà íå ÿâëÿåòñÿ îäíîêîìïîíåíòíîé ñèñòåìîé, íî ñîäåðæèò èçîòîïîëîãè, â òîì ÷èñëå H2O, HDO è D2O [5, 6]. Äåéòåðèé12H(D)— íåðàäèîàêòèâíûé òÿæåëûé èçîòîï âîäîðîäà — âëèÿåò íà ðàçìåð, êîëè÷åñòâî è âðåìÿ ðåëàêñàöèè ñóáìèëëèìåòðîâûõ ïëîòíîñòíûõ íåîäíîðîäíîñòåé — ãèãàíòñêèõ ãåòåðîôàçíûõ êëàñòåðîâ (ÃÃÊ) âîäû [7, 8].

2
Rehman W, Arfons LM, Lazarus HM. The rise, fall and subsequent triumph of thalidomide: lessons learned in drug development. The Adv Hematol. 2011; 2(5): 291–308.
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    Âíèìàíèå ìèðîâûõ ôàðìàêîïåé ê õèðàëüíîé ÷èñòîòå ñóáñòàíöèé äëÿ ôàðìàöåâòè÷åñêîãî ïðèìåíåíèÿ îáóñëîâëåíî ðàçëè÷èÿìè â áèîëîãè÷åñêîé àêòèâíîñòè îïòè÷åñêèõ àíòèïîäîâ è ðàâíîâåñíûìè ïðîöåññàìè ñ îáðàçîâàíèåì â îðãàíèçìå èõ òîêñè÷íûõ ôîðì
    Exact
    [2]
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    . Ðàâíîâåñíûå ïðîöåññû ñ ó÷àñòèåì îïòè÷åñêèõ àíòèïîäîâ ìíîãîîáðàçíû è ìàëî èçó÷åíû [3]. Òàê, ïðè ïåðåõîäå ñ îäíîãî èåðàðõè÷åñêîãî óðîâíÿ îðãàíèçàöèè æèâîé ìàòåðèè íà äðóãîé íàáëþäàåòñÿ çàìåíà îïòè÷åñêèõ èçîìåðîâ: íàïðèìåð, ïðèðîäíûå áåëêè ñîñòîÿò òîëüêî èç L-àìèíîêèñëîò, â òî âðåìÿ êàê â ñîñòàâ êëåòî÷íûõ ìåìáðàí âõîäÿò D-àìèíîêèñëîòû.

3
Tverdislov VA, Yakovenko LV, Zhavoronkov AA. Chirality as a problem of Biochemical Physics. Rossiyskiy himicheskiy zhurnal 2007; LI(1): 13–22 (in Russian).
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    Âíèìàíèå ìèðîâûõ ôàðìàêîïåé ê õèðàëüíîé ÷èñòîòå ñóáñòàíöèé äëÿ ôàðìàöåâòè÷åñêîãî ïðèìåíåíèÿ îáóñëîâëåíî ðàçëè÷èÿìè â áèîëîãè÷åñêîé àêòèâíîñòè îïòè÷åñêèõ àíòèïîäîâ è ðàâíîâåñíûìè ïðîöåññàìè ñ îáðàçîâàíèåì â îðãàíèçìå èõ òîêñè÷íûõ ôîðì [2]. Ðàâíîâåñíûå ïðîöåññû ñ ó÷àñòèåì îïòè÷åñêèõ àíòèïîäîâ ìíîãîîáðàçíû è ìàëî èçó÷åíû
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    [3]
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    . Òàê, ïðè ïåðåõîäå ñ îäíîãî èåðàðõè÷åñêîãî óðîâíÿ îðãàíèçàöèè æèâîé ìàòåðèè íà äðóãîé íàáëþäàåòñÿ çàìåíà îïòè÷åñêèõ èçîìåðîâ: íàïðèìåð, ïðèðîäíûå áåëêè ñîñòîÿò òîëüêî èç L-àìèíîêèñëîò, â òî âðåìÿ êàê â ñîñòàâ êëåòî÷íûõ ìåìáðàí âõîäÿò D-àìèíîêèñëîòû.

4
European Pharmacopoeia. 7.0.2011. V. 2. 3188.
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    Âëèÿíèå ïðèðîäû ðàñòâîðèòåëÿ íà îïòè÷åñêèå ñâîéñòâà îïèñàíî â ôàðìàêîïåéíîì àíàëèçå: ïðè çàìåíå ðàñòâîðèòåëÿ âåëè÷èíà óäåëüíîãî âðàùåíèÿ ðàñòâîðà ñóáñòàíöèè ìîæåò èçìåíÿòüñÿ âïëîòü äî ñìåíû çíàêà íà ïðîòèâîïîëîæíûé
    Exact
    [1, 4]
    Suffix
    . Èçâåñòíî, ÷òî âîäà íå ÿâëÿåòñÿ îäíîêîìïîíåíòíîé ñèñòåìîé, íî ñîäåðæèò èçîòîïîëîãè, â òîì ÷èñëå H2O, HDO è D2O [5, 6]. Äåéòåðèé12H(D)— íåðàäèîàêòèâíûé òÿæåëûé èçîòîï âîäîðîäà — âëèÿåò íà ðàçìåð, êîëè÷åñòâî è âðåìÿ ðåëàêñàöèè ñóáìèëëèìåòðîâûõ ïëîòíîñòíûõ íåîäíîðîäíîñòåé — ãèãàíòñêèõ ãåòåðîôàçíûõ êëàñòåðîâ (ÃÃÊ) âîäû [7, 8].

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    ÌÀÒÅÐÈÀËÛ È ÌÅÒÎÄÛ Ñóáñòàíöèè L- è D-âàëèíà (L- è D-2-àìèíî-3ìåòèëáóòàíîâàÿ êèñëîòà) ñ ñîäåðæàíèåì äåéñòâóþùåãî âåùåñòâà³98%, ïðîèçâîäèòåëü «Sigma-Aldrich».  êà÷åñòâå êîíòðîëüíûõ èñïîëüçîâàëè ðàñòâîðû L-âàëèíà, ïðèãîòîâëåííûå ñîãëàñíî Åâðîïåéñêîé ôàðìàêîïåå: 8% ðàñòâîð â 6 Ì HCl,[]aD20= = +26,5° ̧ +29,0°
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    . Äåèîíèçîâàííóþ âûñîêîîìíóþ âîäó (íå ìåíåå 18 ÌOì/ñì ïðè 25îÑ) ãîòîâèëè ïóòåì î÷èñòêè àïèðîãåííîé äèñòèëëèðîâàííîé âîäû â ñèñòåìå Milli-Q (ôèðìà «Millipore», Âåëèêîáðèòàíèÿ), ñîîòíîøåíèå D/H = 140 ppm.

5
Goncharuk VV, Lapshin VB, Burdeinaya TN, Pleteneva TV, Chernopyatko AS. Physicochemical Properties and Biological Activity of the Water Depleted of Heavy Isotopes. Journal of Water Chemistry and Technology 2011; 33(1): 8–13. Îïòè÷åñêèå ìåòîäû â èññëåäîâàíèÿõ õèðàëüíûõ ñâîéñòâ ëåêàðñòâåííûõ ñðåäñòâ
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    Âëèÿíèå ïðèðîäû ðàñòâîðèòåëÿ íà îïòè÷åñêèå ñâîéñòâà îïèñàíî â ôàðìàêîïåéíîì àíàëèçå: ïðè çàìåíå ðàñòâîðèòåëÿ âåëè÷èíà óäåëüíîãî âðàùåíèÿ ðàñòâîðà ñóáñòàíöèè ìîæåò èçìåíÿòüñÿ âïëîòü äî ñìåíû çíàêà íà ïðîòèâîïîëîæíûé [1, 4]. Èçâåñòíî, ÷òî âîäà íå ÿâëÿåòñÿ îäíîêîìïîíåíòíîé ñèñòåìîé, íî ñîäåðæèò èçîòîïîëîãè, â òîì ÷èñëå H2O, HDO è D2O
    Exact
    [5, 6]
    Suffix
    . Äåéòåðèé12H(D)— íåðàäèîàêòèâíûé òÿæåëûé èçîòîï âîäîðîäà — âëèÿåò íà ðàçìåð, êîëè÷åñòâî è âðåìÿ ðåëàêñàöèè ñóáìèëëèìåòðîâûõ ïëîòíîñòíûõ íåîäíîðîäíîñòåé — ãèãàíòñêèõ ãåòåðîôàçíûõ êëàñòåðîâ (ÃÃÊ) âîäû [7, 8].

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    Íàáëþäàåìûå çíà÷åíèÿ óäåëüíîãî âðàùåíèÿ ìîãóò ïðåäñòàâëÿòü ñîáîé àääèòèâíûå âåëè÷èíû ñ ó÷åòîì âêëàäà ðàñòâîðèòåëÿ â ðåçóëüòàòå ôîðìèðîâàíèÿ íàäìîëåêóëÿðíûõ ñòðóêòóð (ÃÃÊ), êðèòè÷åñêè çàâèñèìîãî îò êîíöåíòðàöèè äåéòåðèÿ. Íàøè ðàáîòû
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    è òðóäû ðÿäà äðóãèõ èññëåäîâàòåëåé [10–12] óêàçûâàþò íà ñóùåñòâîâàíèå äîëãîæèâóùèõ (÷àñû) ïëîòíîñòíûõ íåîäíîðîäíîñòåé â îáúåìíîé ôàçå âîäû.  êà÷åñòâå ïðèìåðà ïðåäñòàâëåí ïðèìåð ðàçëè÷èÿ ðàçìåðîâ ÃÃÊ âîäû äëÿ ýíàíòèîìåðîâ âàëèíà â ëåãêîé âîäå (ðèñ. 2).

6
Smirnov AN, Goncharuk VV, Uspenskaya EV, Nikolaev GM, Popov PI, Karmazina TV, et al. Water as a heterogeneous structure. Issledovano v Rossii 2006; 88: 843–54 (in Russian).
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    Âëèÿíèå ïðèðîäû ðàñòâîðèòåëÿ íà îïòè÷åñêèå ñâîéñòâà îïèñàíî â ôàðìàêîïåéíîì àíàëèçå: ïðè çàìåíå ðàñòâîðèòåëÿ âåëè÷èíà óäåëüíîãî âðàùåíèÿ ðàñòâîðà ñóáñòàíöèè ìîæåò èçìåíÿòüñÿ âïëîòü äî ñìåíû çíàêà íà ïðîòèâîïîëîæíûé [1, 4]. Èçâåñòíî, ÷òî âîäà íå ÿâëÿåòñÿ îäíîêîìïîíåíòíîé ñèñòåìîé, íî ñîäåðæèò èçîòîïîëîãè, â òîì ÷èñëå H2O, HDO è D2O
    Exact
    [5, 6]
    Suffix
    . Äåéòåðèé12H(D)— íåðàäèîàêòèâíûé òÿæåëûé èçîòîï âîäîðîäà — âëèÿåò íà ðàçìåð, êîëè÷åñòâî è âðåìÿ ðåëàêñàöèè ñóáìèëëèìåòðîâûõ ïëîòíîñòíûõ íåîäíîðîäíîñòåé — ãèãàíòñêèõ ãåòåðîôàçíûõ êëàñòåðîâ (ÃÃÊ) âîäû [7, 8].

7
Smirnov AN, Uspenskaya EV, Syroeshkin AV, Lapshin VB, Goncharuk VV, Pleteneva TV. The structure of water and laser rapid methods for determining authenticity. Farmatsiya 2007; (5): 21–23 (in Russian).
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    Äåéòåðèé12H(D)— íåðàäèîàêòèâíûé òÿæåëûé èçîòîï âîäîðîäà — âëèÿåò íà ðàçìåð, êîëè÷åñòâî è âðåìÿ ðåëàêñàöèè ñóáìèëëèìåòðîâûõ ïëîòíîñòíûõ íåîäíîðîäíîñòåé — ãèãàíòñêèõ ãåòåðîôàçíûõ êëàñòåðîâ (ÃÃÊ) âîäû
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    [7, 8]
    Suffix
    .  ñâÿçè ñ ýòèì îïòè÷åñêàÿ àêòèâíîñòü âîäíûõ ðàñòâîðîâ õèðàëüíûõ ëåêàðñòâ ÿâëÿåòñÿ ôóíêöèåé èçîòîïíîãî ñîñòàâà âîäû. Öåëü ðàáîòû— ìåòîäàìè ïîëÿðèìåòðèè è ëàçåðíîé äèôðàêöèè ñâåòà èññëåäîâàòü âëèÿíèå ñîîòíîøåíèÿ äåéòåðèé/ïðîòèé (D/Í) íà óäåëüíîå âðàùåíèå ðàñòâîðîâ îïòè÷åñêèõ èçîìåðîâ âàëèíà è ðàçìåðíûå ñïåêòðû ãèãàíòñêèõ ãåòåðîãåííûõ êëàñòåðîâ âîäû.

8
Smirnov AN, Syroeshkin AV. Supramolecular complexes of water. Rossiyskiy himicheskiy zhurnal 2004; 48(2): 125–35 (in Russian).
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    Äåéòåðèé12H(D)— íåðàäèîàêòèâíûé òÿæåëûé èçîòîï âîäîðîäà — âëèÿåò íà ðàçìåð, êîëè÷åñòâî è âðåìÿ ðåëàêñàöèè ñóáìèëëèìåòðîâûõ ïëîòíîñòíûõ íåîäíîðîäíîñòåé — ãèãàíòñêèõ ãåòåðîôàçíûõ êëàñòåðîâ (ÃÃÊ) âîäû
    Exact
    [7, 8]
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    .  ñâÿçè ñ ýòèì îïòè÷åñêàÿ àêòèâíîñòü âîäíûõ ðàñòâîðîâ õèðàëüíûõ ëåêàðñòâ ÿâëÿåòñÿ ôóíêöèåé èçîòîïíîãî ñîñòàâà âîäû. Öåëü ðàáîòû— ìåòîäàìè ïîëÿðèìåòðèè è ëàçåðíîé äèôðàêöèè ñâåòà èññëåäîâàòü âëèÿíèå ñîîòíîøåíèÿ äåéòåðèé/ïðîòèé (D/Í) íà óäåëüíîå âðàùåíèå ðàñòâîðîâ îïòè÷åñêèõ èçîìåðîâ âàëèíà è ðàçìåðíûå ñïåêòðû ãèãàíòñêèõ ãåòåðîãåííûõ êëàñòåðîâ âîäû.

9
Krestov GA, Korolev VP, Batov DV. The differentiating effect of protium deuterium substitution on the properties of the solvent. Doklady akademii nauk SSSR 1987; 293(4): 882–3 (in Russian).
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    Îáúåìíîå ðàñïðåäåëåíèå ÃÃÊ âîäû ïî ðàçìåðàì (ðàçìåðíûå ñïåêòðû) îïðåäåëÿëè ìåòîäîì ëàçåðíîé äèôðàêöèè ñâåòà ñ ïðèìåíåíèåì ëàçåðíîãî ìàëîóãëîâîãî èçìåðèòåëÿ äèñïåðñíîñòè (particle sizer) ïðîèçâîäñòâà ôèðìû «Malvern» (ìîäåëü 3600 Ec, ëó÷ ìàëîìîùíîãî (2 ìÂò) Íå-Ne ëàçåðà êîëëèìèðîâàí äî äèàìåòðà 8 ìì)
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    . Âñå èçìåðåíèÿ ïîâòîðåíû íå ìåíåå 5 ðàç; îòíîñèòåëüíàÿ îøèáêà èçìåðåíèé íå ïðåâûøàëà 20% ïðè äîâåðèòåëüíîé âåðîÿòíîñòè 0,95. ÐÅÇÓËÜÒÀÒÛ È ÈÕ ÎÁÑÓÆÄÅÍÈÅ Îáíàðóæåíî, ÷òî óäåëüíîå âðàùåíèå ðàñòâîðîâ îïòè÷åñêèõ èçîìåðîâ âàëèíà èìååò äîñòîâåðíûå ðàçëè÷èÿ â âîäàõ ñ ðàçíûì ñîîòíîøåíèåì D/H: äåèîíèçîâàííîé âûñîêîîìíîé — 140 ppm; îáåäíåííîé ïî äåéòåðèþ — 6 ppm; òÿæåëîé — 99,9% D2O (ðèñ. 1).

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    L-âàëèí èíäóöèðóåò ôîðìèðîâàíèå áîëåå êðóïíûõ ïëîòíîñòíûõ íåîäíîðîäíîñòåé (rmax= 100 ìêì) â îòëè÷èå îò D-âàëèíà, â ðàñòâîðå êîòîðîãî ñóùåñòâóþò äâå ðàçìåðíûå ãðóïïû êëàñòåðîâ:rmax1=15ìêìèrmax2= 50 ìêì. Òàêèì îáðàçîì, ðàçëè÷èÿ óäåëüíîãî âðàùåíèÿ èçîìåðîâ âàëèíà ìîæíî îáúÿñíèòü âëèÿíèåì õèðàëüíîé ñðåäû, êîòîðàÿ ñïîñîáíà èíäóöèðîâàòü èëè èçìåíÿòü îïòè÷åñêóþ àêòèâíîñòü ñóáñòàíöèè
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    [9, 13, 14]
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    . Ñëåäóåò ïîä÷åðêíóòü, ÷òî ñóììàðíîå êîëè÷åñòâî ÃÃÊ â ðàñòâîðå L-âàëèíà ñíèæàåòñÿ íà äâà ïîðÿäêà â èññëåäóåìîì èíòåðâàëå ðÍ (òàáë. 1).  òî æå âðåìÿ â ðàñòâîðàõ D-âàëèíà îáúåìíàÿ êîíöåíòðàöèÿ ÃÃÊ âîäû ïðàêòè÷åñêè íå ìåíÿåòñÿ, ÷òî êîððåëèðóåò ñ ïîëÿðèìåòðè÷åñêèìè ðåçóëüòàòàìè (ðèñ. 1).

10
Pollack GH. The role of aqueous interfaces in the cell. Advances in Colloid and Interface Science 2003; 103(2): 173–96.
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    Íàáëþäàåìûå çíà÷åíèÿ óäåëüíîãî âðàùåíèÿ ìîãóò ïðåäñòàâëÿòü ñîáîé àääèòèâíûå âåëè÷èíû ñ ó÷åòîì âêëàäà ðàñòâîðèòåëÿ â ðåçóëüòàòå ôîðìèðîâàíèÿ íàäìîëåêóëÿðíûõ ñòðóêòóð (ÃÃÊ), êðèòè÷åñêè çàâèñèìîãî îò êîíöåíòðàöèè äåéòåðèÿ. Íàøè ðàáîòû [5–8] è òðóäû ðÿäà äðóãèõ èññëåäîâàòåëåé
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    óêàçûâàþò íà ñóùåñòâîâàíèå äîëãîæèâóùèõ (÷àñû) ïëîòíîñòíûõ íåîäíîðîäíîñòåé â îáúåìíîé ôàçå âîäû.  êà÷åñòâå ïðèìåðà ïðåäñòàâëåí ïðèìåð ðàçëè÷èÿ ðàçìåðîâ ÃÃÊ âîäû äëÿ ýíàíòèîìåðîâ âàëèíà â ëåãêîé âîäå (ðèñ. 2).

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Lobyshev VI. Water as a sensor of weak interactions of physical and chemical nature. Rossiyskiy himicheskiy zhurnal 2007; 51(1): 107–14 (in Russian).
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    L-âàëèí èíäóöèðóåò ôîðìèðîâàíèå áîëåå êðóïíûõ ïëîòíîñòíûõ íåîäíîðîäíîñòåé (rmax= 100 ìêì) â îòëè÷èå îò D-âàëèíà, â ðàñòâîðå êîòîðîãî ñóùåñòâóþò äâå ðàçìåðíûå ãðóïïû êëàñòåðîâ:rmax1=15ìêìèrmax2= 50 ìêì. Òàêèì îáðàçîì, ðàçëè÷èÿ óäåëüíîãî âðàùåíèÿ èçîìåðîâ âàëèíà ìîæíî îáúÿñíèòü âëèÿíèåì õèðàëüíîé ñðåäû, êîòîðàÿ ñïîñîáíà èíäóöèðîâàòü èëè èçìåíÿòü îïòè÷åñêóþ àêòèâíîñòü ñóáñòàíöèè
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    . Ñëåäóåò ïîä÷åðêíóòü, ÷òî ñóììàðíîå êîëè÷åñòâî ÃÃÊ â ðàñòâîðå L-âàëèíà ñíèæàåòñÿ íà äâà ïîðÿäêà â èññëåäóåìîì èíòåðâàëå ðÍ (òàáë. 1).  òî æå âðåìÿ â ðàñòâîðàõ D-âàëèíà îáúåìíàÿ êîíöåíòðàöèÿ ÃÃÊ âîäû ïðàêòè÷åñêè íå ìåíÿåòñÿ, ÷òî êîððåëèðóåò ñ ïîëÿðèìåòðè÷åñêèìè ðåçóëüòàòàìè (ðèñ. 1).

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Natori K. Electron-electron interection in natural optical rotation. Journal of the faculty of engineering 1994; 74: 1–11.
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    L-âàëèí èíäóöèðóåò ôîðìèðîâàíèå áîëåå êðóïíûõ ïëîòíîñòíûõ íåîäíîðîäíîñòåé (rmax= 100 ìêì) â îòëè÷èå îò D-âàëèíà, â ðàñòâîðå êîòîðîãî ñóùåñòâóþò äâå ðàçìåðíûå ãðóïïû êëàñòåðîâ:rmax1=15ìêìèrmax2= 50 ìêì. Òàêèì îáðàçîì, ðàçëè÷èÿ óäåëüíîãî âðàùåíèÿ èçîìåðîâ âàëèíà ìîæíî îáúÿñíèòü âëèÿíèåì õèðàëüíîé ñðåäû, êîòîðàÿ ñïîñîáíà èíäóöèðîâàòü èëè èçìåíÿòü îïòè÷åñêóþ àêòèâíîñòü ñóáñòàíöèè
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    . Ñëåäóåò ïîä÷åðêíóòü, ÷òî ñóììàðíîå êîëè÷åñòâî ÃÃÊ â ðàñòâîðå L-âàëèíà ñíèæàåòñÿ íà äâà ïîðÿäêà â èññëåäóåìîì èíòåðâàëå ðÍ (òàáë. 1).  òî æå âðåìÿ â ðàñòâîðàõ D-âàëèíà îáúåìíàÿ êîíöåíòðàöèÿ ÃÃÊ âîäû ïðàêòè÷åñêè íå ìåíÿåòñÿ, ÷òî êîððåëèðóåò ñ ïîëÿðèìåòðè÷åñêèìè ðåçóëüòàòàìè (ðèñ. 1).

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Pleteneva TV, Popov PI, Syroeshkin AV, Berlyand AS, Shanazarov KS, Lesnikov EV, Bagirova VL. Project of pharmacopoeia article «Determination of particle size distribution by laser diffraction of light». Vedomosti Nauchnogo tsentra ekspertizy sredstv meditsinskogo primeneniya 2007; (4): 104–107 (in Russian).
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    Äàëüíåéøåå ðàçâèòèå Ãîñóäàðñòâåííîé ôàðìàêîïåè ïîòðåáóåò ðàçðàáîòêè è âêëþ÷åíèÿ ÎÔÑ, ñâÿçàííîé ñ õèðàëüíîñòüþ ôàðìàöåâòè÷åñêèõ ñóáñòàíöèé. Ìåòî äëàçåðíîé äèôðàêöèè ñâåòà, èñïîëüçîâàííûé íàìè ðàíåå äëÿ îöåíêè äèñïåðñíîñòè ãåòåðîôàçíûõ ñèñòåì
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    è âêëþ÷åííûé â ÃÔ XIII, ïîëó÷èò äàëüíåéøåå ðàçâèòèå â ïëàíå äåòàëèçàöèè âëèÿíèÿ èçîòîïíîãî ñîñòàâà âîäû íà êà÷åñòâî îïòè÷åñêè àêòèâíûõ ëåêàðñòâåííûõ ñðåäñòâ, âûïóñêàåìûõ â ÐÔ. ËÈÒÅÐÀÒÓÐÀ 1. Ãîñóäàðñòâåííàÿ ôàðìàêîïåÿÐîññèéñêîé Ôåäåðàöèè.13-å èçä.