The 122 references with contexts in paper E. KONYUCH A., A. NAUMOV V., N. PARAMONOVA S., Е. КОНЮХ А., А. НАУМОВ В., Н. ПАРАМОНОВА С. (2011) “ГОМОЦИСТЕИН: РОЛЬ В РАЗВИТИИ И ПРОГРЕССИРОВАНИИ ХРОНИЧЕСКОЙ БОЛЕЗНИ ПОЧЕК // HOMOCYSTEINE: ROLE IN THE DEVELOPMENT AND PROGRESSION OF CHRONIC RENAL DISEASE” / spz:neicon:nefr:y:2011:i:3:p:18-25

1
Vanholder R, Massy Z, Argiles A et al. Chronic kidney disease as cause of cardiovascularmorbidity and mortality. Nephrol Dial Transplant 2005; 20: 1048–1056
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    Ïðèñòàëüíîå âíèìàíèå îòå÷åñòâåííûõ è çàðóáåæíûõ ó÷åíûõ ê ïàòîãåíåòè÷åñêèì ìåõàíèçìàì ðàçâèòèÿ õðîíè÷åñêîé áîëåçíè ïî÷åê (ÕÁÏ), âîïðîñàì äèàãíîñòèêè, ëå÷åíèÿ è, ñëåäîâàòåëüíî, ïðîôèëàêòèêè ñâÿçàíî ñ òåì, ÷òî ïàòîëîãèÿ ïî÷åê â ñòðóêòóðå çàáîëåâàåìîñòè äåòåé è âçðîñëûõ çàíèìàåò îäíî èç âåäóùèõ ìåñò. ÕÁÏ ÷àñòî ÿâëÿåòñÿ ïðè÷èíîé ñåðäå÷íî-ñîñóäèñòûõ îñëîæíåíèé
    Exact
    [1]
    Suffix
    , êîòîðûå, â ñâîþ î÷åðåäü, ïðèâîäÿò ê ïðîãðåññèðîâàíèþ ÕÁÏ è ëåòàëüíîìó èñõîäó [2]. Ôàêòîðàìè ðèñêà ïðîãðåññèðîâàíèÿ ÕÁÏ ÿâëÿþòñÿ ñèñòåìíàÿ è ãëîìåðóëÿðíàÿ ãèïåðòåíçèÿ, ïðîòåèíóðèÿ, íàðàáîòêà öèòîêèíîâ è ôàêòîðîâ ðîñòà, ãèïîêñèÿ, íàðóøåíèÿ êëóáî÷êîâîé ôèëüòðàöèè, èçìåíåíèÿ ïîäîöèòîâ, à òàêæå íàðóøåíèå ïðîäóêöèè êëåòêàìè ýíäîòåëèÿ âàçîàêòèâíûõ âåùåñòâ [3, 4].

2
Баранов АА, Сергеева ТВ. Достижения и перспективы развития нефрологии детского возраста. Вопросы современной педиатрии 2007; 6: 20–24
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    ó÷åíûõ ê ïàòîãåíåòè÷åñêèì ìåõàíèçìàì ðàçâèòèÿ õðîíè÷åñêîé áîëåçíè ïî÷åê (ÕÁÏ), âîïðîñàì äèàãíîñòèêè, ëå÷åíèÿ è, ñëåäîâàòåëüíî, ïðîôèëàêòèêè ñâÿçàíî ñ òåì, ÷òî ïàòîëîãèÿ ïî÷åê â ñòðóêòóðå çàáîëåâàåìîñòè äåòåé è âçðîñëûõ çàíèìàåò îäíî èç âåäóùèõ ìåñò. ÕÁÏ ÷àñòî ÿâëÿåòñÿ ïðè÷èíîé ñåðäå÷íî-ñîñóäèñòûõ îñëîæíåíèé [1], êîòîðûå, â ñâîþ î÷åðåäü, ïðèâîäÿò ê ïðîãðåññèðîâàíèþ ÕÁÏ è ëåòàëüíîìó èñõîäó
    Exact
    [2]
    Suffix
    . Ôàêòîðàìè ðèñêà ïðîãðåññèðîâàíèÿ ÕÁÏ ÿâëÿþòñÿ ñèñòåìíàÿ è ãëîìåðóëÿðíàÿ ãèïåðòåíçèÿ, ïðîòåèíóðèÿ, íàðàáîòêà öèòîêèíîâ è ôàêòîðîâ ðîñòà, ãèïîêñèÿ, íàðóøåíèÿ êëóáî÷êîâîé ôèëüòðàöèè, èçìåíåíèÿ ïîäîöèòîâ, à òàêæå íàðóøåíèå ïðîäóêöèè êëåòêàìè ýíäîòåëèÿ âàçîàêòèâíûõ âåùåñòâ [3, 4].

3
Fogo AB. Mechanisms of progression of chronic kidney disease. Pediatr Nephrol 2007; 22: 2011–2022
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    Ôàêòîðàìè ðèñêà ïðîãðåññèðîâàíèÿ ÕÁÏ ÿâëÿþòñÿ ñèñòåìíàÿ è ãëîìåðóëÿðíàÿ ãèïåðòåíçèÿ, ïðîòåèíóðèÿ, íàðàáîòêà öèòîêèíîâ è ôàêòîðîâ ðîñòà, ãèïîêñèÿ, íàðóøåíèÿ êëóáî÷êîâîé ôèëüòðàöèè, èçìåíåíèÿ ïîäîöèòîâ, à òàêæå íàðóøåíèå ïðîäóêöèè êëåòêàìè ýíäîòåëèÿ âàçîàêòèâíûõ âåùåñòâ
    Exact
    [3, 4]
    Suffix
    . Îäíèì èç ôàêòîðîâ, êîòîðûé ñóùåñòâåííî íàðóøàåò ôóíêöèîíèðîâàíèå ïî÷åê, ñïîñîáñòâóåò ïðîãðåññèðîâàíèþ çàáîëåâàíèé è ïîâûøàåò ðèñê ðàííåãî ðàçâèòèÿ ñåðäå÷íî-ñîñóäèñòûõ îñëîæíåíèé, ÿâëÿåòñÿ ãîìîöèñòåèí (Hcy) [5].

4
Mackenzie HS, Brenner BM. Current strategies for retarding progression of renal disease. Am J Kidney Dis 1998; 31: 161–170
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    Ôàêòîðàìè ðèñêà ïðîãðåññèðîâàíèÿ ÕÁÏ ÿâëÿþòñÿ ñèñòåìíàÿ è ãëîìåðóëÿðíàÿ ãèïåðòåíçèÿ, ïðîòåèíóðèÿ, íàðàáîòêà öèòîêèíîâ è ôàêòîðîâ ðîñòà, ãèïîêñèÿ, íàðóøåíèÿ êëóáî÷êîâîé ôèëüòðàöèè, èçìåíåíèÿ ïîäîöèòîâ, à òàêæå íàðóøåíèå ïðîäóêöèè êëåòêàìè ýíäîòåëèÿ âàçîàêòèâíûõ âåùåñòâ
    Exact
    [3, 4]
    Suffix
    . Îäíèì èç ôàêòîðîâ, êîòîðûé ñóùåñòâåííî íàðóøàåò ôóíêöèîíèðîâàíèå ïî÷åê, ñïîñîáñòâóåò ïðîãðåññèðîâàíèþ çàáîëåâàíèé è ïîâûøàåò ðèñê ðàííåãî ðàçâèòèÿ ñåðäå÷íî-ñîñóäèñòûõ îñëîæíåíèé, ÿâëÿåòñÿ ãîìîöèñòåèí (Hcy) [5].

5
Shishehbor MH, Oliveira LP, Lauer MS, et al. Emerging cardiovascular risk factors that account for a significant portion of attributable mortality risk in chronic kidney disease. Am J Cardiol 2008; 101: 1741–1746
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  1. In-text reference with the coordinate start=2439
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    Îäíèì èç ôàêòîðîâ, êîòîðûé ñóùåñòâåííî íàðóøàåò ôóíêöèîíèðîâàíèå ïî÷åê, ñïîñîáñòâóåò ïðîãðåññèðîâàíèþ çàáîëåâàíèé è ïîâûøàåò ðèñê ðàííåãî ðàçâèòèÿ ñåðäå÷íî-ñîñóäèñòûõ îñëîæíåíèé, ÿâëÿåòñÿ ãîìîöèñòåèí (Hcy)
    Exact
    [5]
    Suffix
    . Ãîìîöèñòåèí: îáùàÿ õàðàêòåðèñòèêà Ãîìîöèñòåèí – ýòî ñåðîñîäåðæàùàÿ àìèíîêèñëîòà, êîòîðàÿ íå âñòðå÷àåòñÿ â ñîñòàâå áåëêîâ [6, 7], à ÿâëÿåòñÿ ïðîìåæóòî÷íûì ïðîäóêòîì âàæíåéøåãî ðåãóëÿòîðíîãî ïðîöåññà, ïðîòåêàþùåãî âî âñåõ êëåòêàõ – òðàíñìåòèëèðîâàíèÿ [8].

6
Schroecksnadel K, Frick B, Wirleitner B, et al. Moderate hyperhomocysteinemia and immune activation. Curr Pharm Biotechnol 2004; 5(1): 107–118
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    Îäíèì èç ôàêòîðîâ, êîòîðûé ñóùåñòâåííî íàðóøàåò ôóíêöèîíèðîâàíèå ïî÷åê, ñïîñîáñòâóåò ïðîãðåññèðîâàíèþ çàáîëåâàíèé è ïîâûøàåò ðèñê ðàííåãî ðàçâèòèÿ ñåðäå÷íî-ñîñóäèñòûõ îñëîæíåíèé, ÿâëÿåòñÿ ãîìîöèñòåèí (Hcy) [5]. Ãîìîöèñòåèí: îáùàÿ õàðàêòåðèñòèêà Ãîìîöèñòåèí – ýòî ñåðîñîäåðæàùàÿ àìèíîêèñëîòà, êîòîðàÿ íå âñòðå÷àåòñÿ â ñîñòàâå áåëêîâ
    Exact
    [6, 7]
    Suffix
    , à ÿâëÿåòñÿ ïðîìåæóòî÷íûì ïðîäóêòîì âàæíåéøåãî ðåãóëÿòîðíîãî ïðîöåññà, ïðîòåêàþùåãî âî âñåõ êëåòêàõ – òðàíñìåòèëèðîâàíèÿ [8]. Öèñòåèí (Cys), îñíîâíûì ïðåäøåñòâåííèêîì êîòîðîãî ÿâëÿåòñÿ Hcy, â ñâîþ î÷åðåäü, ñëóæèò ïðåäøåñòâåííèêîì ãëóòàòèîíà (GSH) – ãëàâíîãî ýíäîãåííîãî àíòèîêñèäàíòà êëåòîê æèâîòíûõ è ÷åëîâåêà [8].

7
Williams KT, Schalinske KL. Homocysteine metabolism and its relation to health and disease. Biofactors 2010; 36(1): 19–24
Total in-text references: 3
  1. In-text reference with the coordinate start=2564
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    Îäíèì èç ôàêòîðîâ, êîòîðûé ñóùåñòâåííî íàðóøàåò ôóíêöèîíèðîâàíèå ïî÷åê, ñïîñîáñòâóåò ïðîãðåññèðîâàíèþ çàáîëåâàíèé è ïîâûøàåò ðèñê ðàííåãî ðàçâèòèÿ ñåðäå÷íî-ñîñóäèñòûõ îñëîæíåíèé, ÿâëÿåòñÿ ãîìîöèñòåèí (Hcy) [5]. Ãîìîöèñòåèí: îáùàÿ õàðàêòåðèñòèêà Ãîìîöèñòåèí – ýòî ñåðîñîäåðæàùàÿ àìèíîêèñëîòà, êîòîðàÿ íå âñòðå÷àåòñÿ â ñîñòàâå áåëêîâ
    Exact
    [6, 7]
    Suffix
    , à ÿâëÿåòñÿ ïðîìåæóòî÷íûì ïðîäóêòîì âàæíåéøåãî ðåãóëÿòîðíîãî ïðîöåññà, ïðîòåêàþùåãî âî âñåõ êëåòêàõ – òðàíñìåòèëèðîâàíèÿ [8]. Öèñòåèí (Cys), îñíîâíûì ïðåäøåñòâåííèêîì êîòîðîãî ÿâëÿåòñÿ Hcy, â ñâîþ î÷åðåäü, ñëóæèò ïðåäøåñòâåííèêîì ãëóòàòèîíà (GSH) – ãëàâíîãî ýíäîãåííîãî àíòèîêñèäàíòà êëåòîê æèâîòíûõ è ÷åëîâåêà [8].

  2. In-text reference with the coordinate start=2974
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    Öèñòåèí (Cys), îñíîâíûì ïðåäøåñòâåííèêîì êîòîðîãî ÿâëÿåòñÿ Hcy, â ñâîþ î÷åðåäü, ñëóæèò ïðåäøåñòâåííèêîì ãëóòàòèîíà (GSH) – ãëàâíîãî ýíäîãåííîãî àíòèîêñèäàíòà êëåòîê æèâîòíûõ è ÷åëîâåêà [8].  ïëàçìå êðîâè çäîðîâîãî ÷åëîâåêà ñîäåðæàíèå Hcy íàõîäèòñÿ â äèàïàçîíå 5,0–7,0 ìêìîëü/ë
    Exact
    [7, 9]
    Suffix
    . Ó äåòåé è ïîäðîñòêîâ îáîåãî ïîëà óðîâåíü Hcy íåñêîëüêî íèæå (ïðèáëèçèòåëüíî 5,0 ìêìîëü/ë).  ïóáåðòàòíîì ïåðèîäå êîíöåíòðàöèÿ Hcy óâåëè÷èâàåòñÿ (äî 6,0-7,0 ìêìîëü/ë) [10], ïðè÷åì ó ìàëü÷èêîâ åãî óðîâåíü áîëüøå, ÷åì ó äåâî÷åê [11].

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     ïîñëåäíèå ãîäû èñïîëüçîâàíèå ìåòîäîâ âûñîêîýôôåêòèâíîé æèäêîñòíîé õðîìàòîãðàôèè (ÂÝÆÕ) ñ ïðåäêîëîíî÷íîé ìîäèôèêàöèåé ïîçâîëèëè îïðåäåëèòü, ÷òî ñðåäíèé óðîâåíü Hcy ïëàçìû êðîâè ó çäîðîâûõ ëþäåé êîëåáëåòñÿ â ïðåäåëàõ 4,8–7,6 ìêìîëü/ ë [9, 10, 15, 16]. Óðîâåíü Hcy ìîæåò âàðüèðîâàòü â ïëàçìå êðîâè â äîâîëüíî øèðîêèõ ïðåäåëàõ, òîãäà êàê â êëåòêàõ åãî ñîäåðæàíèå î÷åíü íåçíà÷èòåëüíî
    Exact
    [7]
    Suffix
    . Èç îáùåé êîíöåíòðàöèè ýòîãî ñîåäèíåíèÿ â ïëàçìå êðîâè ñâîáîäíàÿ ôîðìà Hcy ñîñòàâëÿåò ïðèáëèçèòåëüíî 1–2% [17]. Îñòàâøèåñÿ 98% – ñâÿçàííûé Hcy: 75% ñâÿçàíî äèñóëüôèäíûì ìîñòèêîì ñ öèñòåèíîì áåëêîâ, ïðåèìóùåñòâåííî àëüáóìèíà, à îñòàâøèåñÿ 25% ïðèñóòñòâóþò â âèäå ãîìîöèñòèíà, ãîìîöèñòåèí-öèñòåèí äèñóëüôèäà, ãîìîöèñòåèí-öèñòåèíèëãëèöèí äèñóëüôèäà è äð. [18, 19]. ×òîáû ïîääåðæèâàòü íèçêèé âíóòðèêëåòî

8
Наумов АВ. Роль нарушений процессов метилирования и обмена метионина в патогенезе заболеваний человека. Журн Гроднен гос мед ун-та 2007; 1: 4–7
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    Ãîìîöèñòåèí: îáùàÿ õàðàêòåðèñòèêà Ãîìîöèñòåèí – ýòî ñåðîñîäåðæàùàÿ àìèíîêèñëîòà, êîòîðàÿ íå âñòðå÷àåòñÿ â ñîñòàâå áåëêîâ [6, 7], à ÿâëÿåòñÿ ïðîìåæóòî÷íûì ïðîäóêòîì âàæíåéøåãî ðåãóëÿòîðíîãî ïðîöåññà, ïðîòåêàþùåãî âî âñåõ êëåòêàõ – òðàíñìåòèëèðîâàíèÿ
    Exact
    [8]
    Suffix
    . Öèñòåèí (Cys), îñíîâíûì ïðåäøåñòâåííèêîì êîòîðîãî ÿâëÿåòñÿ Hcy, â ñâîþ î÷åðåäü, ñëóæèò ïðåäøåñòâåííèêîì ãëóòàòèîíà (GSH) – ãëàâíîãî ýíäîãåííîãî àíòèîêñèäàíòà êëåòîê æèâîòíûõ è ÷åëîâåêà [8].  ïëàçìå êðîâè çäîðîâîãî ÷åëîâåêà ñîäåðæàíèå Hcy íàõîäèòñÿ â äèàïàçîíå 5,0–7,0 ìêìîëü/ë [7, 9].

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    – ýòî ñåðîñîäåðæàùàÿ àìèíîêèñëîòà, êîòîðàÿ íå âñòðå÷àåòñÿ â ñîñòàâå áåëêîâ [6, 7], à ÿâëÿåòñÿ ïðîìåæóòî÷íûì ïðîäóêòîì âàæíåéøåãî ðåãóëÿòîðíîãî ïðîöåññà, ïðîòåêàþùåãî âî âñåõ êëåòêàõ – òðàíñìåòèëèðîâàíèÿ [8]. Öèñòåèí (Cys), îñíîâíûì ïðåäøåñòâåííèêîì êîòîðîãî ÿâëÿåòñÿ Hcy, â ñâîþ î÷åðåäü, ñëóæèò ïðåäøåñòâåííèêîì ãëóòàòèîíà (GSH) – ãëàâíîãî ýíäîãåííîãî àíòèîêñèäàíòà êëåòîê æèâîòíûõ è ÷åëîâåêà
    Exact
    [8]
    Suffix
    .  ïëàçìå êðîâè çäîðîâîãî ÷åëîâåêà ñîäåðæàíèå Hcy íàõîäèòñÿ â äèàïàçîíå 5,0–7,0 ìêìîëü/ë [7, 9]. Ó äåòåé è ïîäðîñòêîâ îáîåãî ïîëà óðîâåíü Hcy íåñêîëüêî íèæå (ïðèáëèçèòåëüíî 5,0 ìêìîëü/ë).  ïóáåðòàòíîì ïåðèîäå êîíöåíòðàöèÿ Hcy óâåëè÷èâàåòñÿ (äî 6,0-7,0 ìêìîëü/ë) [10], ïðè÷åì ó ìàëü÷èêîâ åãî óðîâåíü áîëüøå, ÷åì ó äåâî÷åê [11].

9
Naumov AV, Pakulnevich YF, Doroshenko EM et al. Hyperhomocysteinaemia at various forms of pancreatitis. Acta Biochimica Polonica 2008; 55(3): 191
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  1. In-text reference with the coordinate start=2974
    Prefix
    Öèñòåèí (Cys), îñíîâíûì ïðåäøåñòâåííèêîì êîòîðîãî ÿâëÿåòñÿ Hcy, â ñâîþ î÷åðåäü, ñëóæèò ïðåäøåñòâåííèêîì ãëóòàòèîíà (GSH) – ãëàâíîãî ýíäîãåííîãî àíòèîêñèäàíòà êëåòîê æèâîòíûõ è ÷åëîâåêà [8].  ïëàçìå êðîâè çäîðîâîãî ÷åëîâåêà ñîäåðæàíèå Hcy íàõîäèòñÿ â äèàïàçîíå 5,0–7,0 ìêìîëü/ë
    Exact
    [7, 9]
    Suffix
    . Ó äåòåé è ïîäðîñòêîâ îáîåãî ïîëà óðîâåíü Hcy íåñêîëüêî íèæå (ïðèáëèçèòåëüíî 5,0 ìêìîëü/ë).  ïóáåðòàòíîì ïåðèîäå êîíöåíòðàöèÿ Hcy óâåëè÷èâàåòñÿ (äî 6,0-7,0 ìêìîëü/ë) [10], ïðè÷åì ó ìàëü÷èêîâ åãî óðîâåíü áîëüøå, ÷åì ó äåâî÷åê [11].

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    Prefix
     ïîñëåäíèå ãîäû èñïîëüçîâàíèå ìåòîäîâ âûñîêîýôôåêòèâíîé æèäêîñòíîé õðîìàòîãðàôèè (ÂÝÆÕ) ñ ïðåäêîëîíî÷íîé ìîäèôèêàöèåé ïîçâîëèëè îïðåäåëèòü, ÷òî ñðåäíèé óðîâåíü Hcy ïëàçìû êðîâè ó çäîðîâûõ ëþäåé êîëåáëåòñÿ â ïðåäåëàõ 4,8–7,6 ìêìîëü/ ë
    Exact
    [9, 10, 15, 16]
    Suffix
    . Óðîâåíü Hcy ìîæåò âàðüèðîâàòü â ïëàçìå êðîâè â äîâîëüíî øèðîêèõ ïðåäåëàõ, òîãäà êàê â êëåòêàõ åãî ñîäåðæàíèå î÷åíü íåçíà÷èòåëüíî [7]. Èç îáùåé êîíöåíòðàöèè ýòîãî ñîåäèíåíèÿ â ïëàçìå êðîâè ñâîáîäíàÿ ôîðìà Hcy ñîñòàâëÿåò ïðèáëèçèòåëüíî 1–2% [17].

10
Naumоv AV, Matveenko PA, Doroshenko EM et al. The level of total plasma homocysteine in adolescents from rural area of Belarus and its correction. Acta Biochimica Polonica 2009; 56(1.3): 198
Total in-text references: 5
  1. In-text reference with the coordinate start=3146
    Prefix
     ïëàçìå êðîâè çäîðîâîãî ÷åëîâåêà ñîäåðæàíèå Hcy íàõîäèòñÿ â äèàïàçîíå 5,0–7,0 ìêìîëü/ë [7, 9]. Ó äåòåé è ïîäðîñòêîâ îáîåãî ïîëà óðîâåíü Hcy íåñêîëüêî íèæå (ïðèáëèçèòåëüíî 5,0 ìêìîëü/ë).  ïóáåðòàòíîì ïåðèîäå êîíöåíòðàöèÿ Hcy óâåëè÷èâàåòñÿ (äî 6,0-7,0 ìêìîëü/ë)
    Exact
    [10]
    Suffix
    , ïðè÷åì ó ìàëü÷èêîâ åãî óðîâåíü áîëüøå, ÷åì ó äåâî÷åê [11]. P.M. Ueland è ñîàâò. ñ÷èòàþò, ÷òî äî 12 ëåò óðîâåíü Hcy ñîñòàâëÿåò 4,0–8,0 ìêìîëü/ë (60% óðîâíÿ âçðîñëûõ) [12].  òå÷åíèå æèçíè ñðåäíèé óðîâåíü Hcy óâåëè÷èâàåòñÿ íà 3,0–5,0 ìêìîëü/ë ó ïðåäñòàâèòåëåé îáîåãî ïîëà [13].

  2. In-text reference with the coordinate start=4209
    Prefix
     ïîñëåäíèå ãîäû èñïîëüçîâàíèå ìåòîäîâ âûñîêîýôôåêòèâíîé æèäêîñòíîé õðîìàòîãðàôèè (ÂÝÆÕ) ñ ïðåäêîëîíî÷íîé ìîäèôèêàöèåé ïîçâîëèëè îïðåäåëèòü, ÷òî ñðåäíèé óðîâåíü Hcy ïëàçìû êðîâè ó çäîðîâûõ ëþäåé êîëåáëåòñÿ â ïðåäåëàõ 4,8–7,6 ìêìîëü/ ë
    Exact
    [9, 10, 15, 16]
    Suffix
    . Óðîâåíü Hcy ìîæåò âàðüèðîâàòü â ïëàçìå êðîâè â äîâîëüíî øèðîêèõ ïðåäåëàõ, òîãäà êàê â êëåòêàõ åãî ñîäåðæàíèå î÷åíü íåçíà÷èòåëüíî [7]. Èç îáùåé êîíöåíòðàöèè ýòîãî ñîåäèíåíèÿ â ïëàçìå êðîâè ñâîáîäíàÿ ôîðìà Hcy ñîñòàâëÿåò ïðèáëèçèòåëüíî 1–2% [17].

  3. In-text reference with the coordinate start=17448
    Prefix
    Àâòîðû óêàçûâàþò, ÷òî ïðèìåíåíèå ýòîãî êîìïëåêñà âèòàìèíîâ – ýôôåêòèâíîå ñðåäñòâî ëå÷åíèÿ HHcy [111]. Ïî äàííûì äðóãèõ èññëåäîâàòåëåé, ïðèìåíåíèå âèòàìèíà B12 ïðèâîäèëî ê ñíèæåíèþ Hcy íà 15%, à âîò äîáàâëåíèå âèòàìèíà Â6 ïðàêòè÷åñêè íå âëèÿëî íà óðîâåíü Hcy
    Exact
    [10, 15]
    Suffix
    . M.E. Francis è ñîàâò. ñ÷èòàþò, ÷òî ïðè ÕÁÏ óðîâåíü ãîìîöèñòåèíà ïîâûøàåòñÿ íåçàâèñèìî îò ïðèåìà âèòàìèíîâ ãðóïïû  [31]. L. Brattstrum îòìå÷àåò, ÷òî âèòàìèíû Â12 è Â6 îêàçûâàþò âëèÿíèå íà óðîâåíü Hcy ëèøü â ñëó÷àÿõ èõ íåäîñòàòî÷íîñòè â îðãàíèçìå [112].

  4. In-text reference with the coordinate start=17756
    Prefix
    Francis è ñîàâò. ñ÷èòàþò, ÷òî ïðè ÕÁÏ óðîâåíü ãîìîöèñòåèíà ïîâûøàåòñÿ íåçàâèñèìî îò ïðèåìà âèòàìèíîâ ãðóïïû  [31]. L. Brattstrum îòìå÷àåò, ÷òî âèòàìèíû Â12 è Â6 îêàçûâàþò âëèÿíèå íà óðîâåíü Hcy ëèøü â ñëó÷àÿõ èõ íåäîñòàòî÷íîñòè â îðãàíèçìå [112]. Ïðîâåäåííûå èññëåäîâàíèÿ ñðåäè ìîëîäûõ ëþäåé
    Exact
    [10]
    Suffix
    ïîêàçàëè, ÷òî ó íèõ ñóùåñòâóåò èñõîäíàÿ íåäîñòàòî÷íîñòü âèòàìèíà Â12 è ôîëèåâîé êèñëîòû. Êàê ðàçäåëüíîå, òàê è ñîâìåñòíîå ââåäåíèå ýòèõ âèòàìèíîâ ñíèæàëî óðîâåíü Hcy êðîâè, ïðè÷ ̧ì ïðè ñîâìåñòíîì ââåäåíèè ýôôåêò ïðàêòè÷åñêè ñóììèðîâàëñÿ è ñîñòàâèë ïðèìåðíî 30%.

  5. In-text reference with the coordinate start=18694
    Prefix
    Ìíîãèìè àâòîðàìè ïîääåðæèâàåòñÿ íàçíà÷åíèå ôîëèåâîé êèñëîòû â äîçå, çíà÷èòåëüíî ïðåâûøàþùåé ñòàíäàðòíóþ ëå÷åáíóþ [53, 115, 116]. Ó ëèö ñ ñîõðàíåííîé ôóíêöèåé ïî÷åê ïðèìåíåíèå â äîçå 0,4– 0,5 ìã/ñóò ïðèâîäèò ê ñòîéêîìó ñíèæåíèþ óðîâíÿ Hcy
    Exact
    [10, 15, 117]
    Suffix
    . G. Buccianti è ñîàâò. [53] íàçíà÷àëè ïàöèåíòàì íà ãåìîäèàëèçå 5-ìåòèë-THF â òå÷åíèå 10 íåä. ïî 45 ìã/íåä âíóòðèâåííî, ïîñëåäíèå 2 íåä êîìáèíèðóÿ ñ 500 ìêã âèòàìèíà Â12 (ïîäêîæíî 2 ðàçà/íåä). Óðîâåíü Hcy ñíèçèëñÿ íà 47% ïîñëå ââåäåíèÿ ôîëàòà è åùå íà 13,6% ïîñëå äîáàâëåíèÿ âèòàìèíà Â12.

11
Minniti G, Cerone R, Piana A, et al. Plasma and serum total homocysteine concentrations in pediatric patients, evaluated by high-performance liquid chromatography with fluorescence. Clin Chem Lab Med 2000; 38: 675–676
Total in-text references: 1
  1. In-text reference with the coordinate start=3206
    Prefix
    Ó äåòåé è ïîäðîñòêîâ îáîåãî ïîëà óðîâåíü Hcy íåñêîëüêî íèæå (ïðèáëèçèòåëüíî 5,0 ìêìîëü/ë).  ïóáåðòàòíîì ïåðèîäå êîíöåíòðàöèÿ Hcy óâåëè÷èâàåòñÿ (äî 6,0-7,0 ìêìîëü/ë) [10], ïðè÷åì ó ìàëü÷èêîâ åãî óðîâåíü áîëüøå, ÷åì ó äåâî÷åê
    Exact
    [11]
    Suffix
    . P.M. Ueland è ñîàâò. ñ÷èòàþò, ÷òî äî 12 ëåò óðîâåíü Hcy ñîñòàâëÿåò 4,0–8,0 ìêìîëü/ë (60% óðîâíÿ âçðîñëûõ) [12].  òå÷åíèå æèçíè ñðåäíèé óðîâåíü Hcy óâåëè÷èâàåòñÿ íà 3,0–5,0 ìêìîëü/ë ó ïðåäñòàâèòåëåé îáîåãî ïîëà [13].

12
Ueland PM, Bjorke Monsen A-L. Total homocysteine is making its way into pediatric laboratory diagnostics. Eur J Clin Invest 2001; 31(11): 928–930
Total in-text references: 1
  1. In-text reference with the coordinate start=3319
    Prefix
     ïóáåðòàòíîì ïåðèîäå êîíöåíòðàöèÿ Hcy óâåëè÷èâàåòñÿ (äî 6,0-7,0 ìêìîëü/ë) [10], ïðè÷åì ó ìàëü÷èêîâ åãî óðîâåíü áîëüøå, ÷åì ó äåâî÷åê [11]. P.M. Ueland è ñîàâò. ñ÷èòàþò, ÷òî äî 12 ëåò óðîâåíü Hcy ñîñòàâëÿåò 4,0–8,0 ìêìîëü/ë (60% óðîâíÿ âçðîñëûõ)
    Exact
    [12]
    Suffix
    .  òå÷åíèå æèçíè ñðåäíèé óðîâåíü Hcy óâåëè÷èâàåòñÿ íà 3,0–5,0 ìêìîëü/ë ó ïðåäñòàâèòåëåé îáîåãî ïîëà [13]. Ïî äàííûì Àìåðèêàíñêîé àññîöèàöèè êàðäèîëîãîâ [14], óðîâåíü Hcy 10,0 ìêìîëü/ë ñ÷èòàåòñÿ ïîãðàíè÷íûì ó ëèö ñ íàëè÷èåì ôàêòîðîâ ðèñêà, íàïðèìåð, ñ ñèíäðîìîì íàðóøåííîãî êèøå÷íîãî âñàñûâàíèÿ, ãèïîòèðîèäèçìîì, ïî÷å÷íîé íåäîñòàòî÷íîñòüþ, ñ îòÿãîùåííûì ñåìåéíûì àíàìíåçîì â îòíîøåíèè âðîæäåííûõ ñåðä

13
Aguilar B, Rojas JC, Collados MT. Metabolism of homocysteine and its relationship with cardiovascular disease. J Thromb Thrombolysis 2004; 18(2): 75–87
Total in-text references: 1
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    Ueland è ñîàâò. ñ÷èòàþò, ÷òî äî 12 ëåò óðîâåíü Hcy ñîñòàâëÿåò 4,0–8,0 ìêìîëü/ë (60% óðîâíÿ âçðîñëûõ) [12].  òå÷åíèå æèçíè ñðåäíèé óðîâåíü Hcy óâåëè÷èâàåòñÿ íà 3,0–5,0 ìêìîëü/ë ó ïðåäñòàâèòåëåé îáîåãî ïîëà
    Exact
    [13]
    Suffix
    . Ïî äàííûì Àìåðèêàíñêîé àññîöèàöèè êàðäèîëîãîâ [14], óðîâåíü Hcy 10,0 ìêìîëü/ë ñ÷èòàåòñÿ ïîãðàíè÷íûì ó ëèö ñ íàëè÷èåì ôàêòîðîâ ðèñêà, íàïðèìåð, ñ ñèíäðîìîì íàðóøåííîãî êèøå÷íîãî âñàñûâàíèÿ, ãèïîòèðîèäèçìîì, ïî÷å÷íîé íåäîñòàòî÷íîñòüþ, ñ îòÿãîùåííûì ñåìåéíûì àíàìíåçîì â îòíîøåíèè âðîæäåííûõ ñåðäå÷íî-ñîñóäèñòûõ çàáîëåâàíèé, à òàêæå ó ëèö, Êîíþõ Å.

14
Robinson K. Data presented at: 69th Scientific Sessions of the American Heart Assosiation; November 12, 1996; New Orleans, La
Total in-text references: 1
  1. In-text reference with the coordinate start=3477
    Prefix
    Ueland è ñîàâò. ñ÷èòàþò, ÷òî äî 12 ëåò óðîâåíü Hcy ñîñòàâëÿåò 4,0–8,0 ìêìîëü/ë (60% óðîâíÿ âçðîñëûõ) [12].  òå÷åíèå æèçíè ñðåäíèé óðîâåíü Hcy óâåëè÷èâàåòñÿ íà 3,0–5,0 ìêìîëü/ë ó ïðåäñòàâèòåëåé îáîåãî ïîëà [13]. Ïî äàííûì Àìåðèêàíñêîé àññîöèàöèè êàðäèîëîãîâ
    Exact
    [14]
    Suffix
    , óðîâåíü Hcy 10,0 ìêìîëü/ë ñ÷èòàåòñÿ ïîãðàíè÷íûì ó ëèö ñ íàëè÷èåì ôàêòîðîâ ðèñêà, íàïðèìåð, ñ ñèíäðîìîì íàðóøåííîãî êèøå÷íîãî âñàñûâàíèÿ, ãèïîòèðîèäèçìîì, ïî÷å÷íîé íåäîñòàòî÷íîñòüþ, ñ îòÿãîùåííûì ñåìåéíûì àíàìíåçîì â îòíîøåíèè âðîæäåííûõ ñåðäå÷íî-ñîñóäèñòûõ çàáîëåâàíèé, à òàêæå ó ëèö, Êîíþõ Å.

15
Плоцкий АР, Егорова ТЮ, Наумов АВ. Возможности прогнозирования и диагностики врождённых пороков развития плода на основе определения уровня гомоцистеина в плазме крови беременных женщин. Журн Гроднен гос мед ун-та 2009; 1: 56–59
Total in-text references: 3
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    Prefix
     ïîñëåäíèå ãîäû èñïîëüçîâàíèå ìåòîäîâ âûñîêîýôôåêòèâíîé æèäêîñòíîé õðîìàòîãðàôèè (ÂÝÆÕ) ñ ïðåäêîëîíî÷íîé ìîäèôèêàöèåé ïîçâîëèëè îïðåäåëèòü, ÷òî ñðåäíèé óðîâåíü Hcy ïëàçìû êðîâè ó çäîðîâûõ ëþäåé êîëåáëåòñÿ â ïðåäåëàõ 4,8–7,6 ìêìîëü/ ë
    Exact
    [9, 10, 15, 16]
    Suffix
    . Óðîâåíü Hcy ìîæåò âàðüèðîâàòü â ïëàçìå êðîâè â äîâîëüíî øèðîêèõ ïðåäåëàõ, òîãäà êàê â êëåòêàõ åãî ñîäåðæàíèå î÷åíü íåçíà÷èòåëüíî [7]. Èç îáùåé êîíöåíòðàöèè ýòîãî ñîåäèíåíèÿ â ïëàçìå êðîâè ñâîáîäíàÿ ôîðìà Hcy ñîñòàâëÿåò ïðèáëèçèòåëüíî 1–2% [17].

  2. In-text reference with the coordinate start=17448
    Prefix
    Àâòîðû óêàçûâàþò, ÷òî ïðèìåíåíèå ýòîãî êîìïëåêñà âèòàìèíîâ – ýôôåêòèâíîå ñðåäñòâî ëå÷åíèÿ HHcy [111]. Ïî äàííûì äðóãèõ èññëåäîâàòåëåé, ïðèìåíåíèå âèòàìèíà B12 ïðèâîäèëî ê ñíèæåíèþ Hcy íà 15%, à âîò äîáàâëåíèå âèòàìèíà Â6 ïðàêòè÷åñêè íå âëèÿëî íà óðîâåíü Hcy
    Exact
    [10, 15]
    Suffix
    . M.E. Francis è ñîàâò. ñ÷èòàþò, ÷òî ïðè ÕÁÏ óðîâåíü ãîìîöèñòåèíà ïîâûøàåòñÿ íåçàâèñèìî îò ïðèåìà âèòàìèíîâ ãðóïïû  [31]. L. Brattstrum îòìå÷àåò, ÷òî âèòàìèíû Â12 è Â6 îêàçûâàþò âëèÿíèå íà óðîâåíü Hcy ëèøü â ñëó÷àÿõ èõ íåäîñòàòî÷íîñòè â îðãàíèçìå [112].

  3. In-text reference with the coordinate start=18694
    Prefix
    Ìíîãèìè àâòîðàìè ïîääåðæèâàåòñÿ íàçíà÷åíèå ôîëèåâîé êèñëîòû â äîçå, çíà÷èòåëüíî ïðåâûøàþùåé ñòàíäàðòíóþ ëå÷åáíóþ [53, 115, 116]. Ó ëèö ñ ñîõðàíåííîé ôóíêöèåé ïî÷åê ïðèìåíåíèå â äîçå 0,4– 0,5 ìã/ñóò ïðèâîäèò ê ñòîéêîìó ñíèæåíèþ óðîâíÿ Hcy
    Exact
    [10, 15, 117]
    Suffix
    . G. Buccianti è ñîàâò. [53] íàçíà÷àëè ïàöèåíòàì íà ãåìîäèàëèçå 5-ìåòèë-THF â òå÷åíèå 10 íåä. ïî 45 ìã/íåä âíóòðèâåííî, ïîñëåäíèå 2 íåä êîìáèíèðóÿ ñ 500 ìêã âèòàìèíà Â12 (ïîäêîæíî 2 ðàçà/íåä). Óðîâåíü Hcy ñíèçèëñÿ íà 47% ïîñëå ââåäåíèÿ ôîëàòà è åùå íà 13,6% ïîñëå äîáàâëåíèÿ âèòàìèíà Â12.

16
Плоцкий АР, Егорова ТЮ, Наумов АВ, и др. Коррекция уровня гомоцистеина в плазме крови женщин. Рецепт 2008; 59(3): 45–50
Total in-text references: 1
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    Prefix
     ïîñëåäíèå ãîäû èñïîëüçîâàíèå ìåòîäîâ âûñîêîýôôåêòèâíîé æèäêîñòíîé õðîìàòîãðàôèè (ÂÝÆÕ) ñ ïðåäêîëîíî÷íîé ìîäèôèêàöèåé ïîçâîëèëè îïðåäåëèòü, ÷òî ñðåäíèé óðîâåíü Hcy ïëàçìû êðîâè ó çäîðîâûõ ëþäåé êîëåáëåòñÿ â ïðåäåëàõ 4,8–7,6 ìêìîëü/ ë
    Exact
    [9, 10, 15, 16]
    Suffix
    . Óðîâåíü Hcy ìîæåò âàðüèðîâàòü â ïëàçìå êðîâè â äîâîëüíî øèðîêèõ ïðåäåëàõ, òîãäà êàê â êëåòêàõ åãî ñîäåðæàíèå î÷åíü íåçíà÷èòåëüíî [7]. Èç îáùåé êîíöåíòðàöèè ýòîãî ñîåäèíåíèÿ â ïëàçìå êðîâè ñâîáîäíàÿ ôîðìà Hcy ñîñòàâëÿåò ïðèáëèçèòåëüíî 1–2% [17].

17
Ueland PM. Homocysteine species as components of plasma redox thiol status. Clin Chem 1995;41(3): 340–342
Total in-text references: 1
  1. In-text reference with the coordinate start=4465
    Prefix
    Óðîâåíü Hcy ìîæåò âàðüèðîâàòü â ïëàçìå êðîâè â äîâîëüíî øèðîêèõ ïðåäåëàõ, òîãäà êàê â êëåòêàõ åãî ñîäåðæàíèå î÷åíü íåçíà÷èòåëüíî [7]. Èç îáùåé êîíöåíòðàöèè ýòîãî ñîåäèíåíèÿ â ïëàçìå êðîâè ñâîáîäíàÿ ôîðìà Hcy ñîñòàâëÿåò ïðèáëèçèòåëüíî 1–2%
    Exact
    [17]
    Suffix
    . Îñòàâøèåñÿ 98% – ñâÿçàííûé Hcy: 75% ñâÿçàíî äèñóëüôèäíûì ìîñòèêîì ñ öèñòåèíîì áåëêîâ, ïðåèìóùåñòâåííî àëüáóìèíà, à îñòàâøèåñÿ 25% ïðèñóòñòâóþò â âèäå ãîìîöèñòèíà, ãîìîöèñòåèí-öèñòåèí äèñóëüôèäà, ãîìîöèñòåèí-öèñòåèíèëãëèöèí äèñóëüôèäà è äð. [18, 19]. ×òîáû ïîääåðæèâàòü íèçêèé âíóòðèêëåòî÷íûé óðîâåíü ýòîãî öèòîòîêñè÷åñêîãî âåùåñòâà, èçáûòîê Hcy ñâÿçûâàåòñÿ ñî ñïåöèôè÷åñêèìè (íàñûùàåìûìè) ó÷àñòêàìè

18
Mudd SH, Finkelstein JD, Refsum H et al. Homocysteine and its disulfide derivatives: a suggested consensus terminology. Arterioscler Thromb Vasc Biol 2000; 20(7): 1704–1706
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    Prefix
    Îñòàâøèåñÿ 98% – ñâÿçàííûé Hcy: 75% ñâÿçàíî äèñóëüôèäíûì ìîñòèêîì ñ öèñòåèíîì áåëêîâ, ïðåèìóùåñòâåííî àëüáóìèíà, à îñòàâøèåñÿ 25% ïðèñóòñòâóþò â âèäå ãîìîöèñòèíà, ãîìîöèñòåèí-öèñòåèí äèñóëüôèäà, ãîìîöèñòåèí-öèñòåèíèëãëèöèí äèñóëüôèäà è äð.
    Exact
    [18, 19]
    Suffix
    . ×òîáû ïîääåðæèâàòü íèçêèé âíóòðèêëåòî÷íûé óðîâåíü ýòîãî öèòîòîêñè÷åñêîãî âåùåñòâà, èçáûòîê Hcy ñâÿçûâàåòñÿ ñî ñïåöèôè÷åñêèìè (íàñûùàåìûìè) ó÷àñòêàìè áåëêà ëèáî âûõîäèò â êðîâÿíîå ðóñëî [20]. Èíòåðåñíî, ÷òî ïîïàñòü Hcy îáðàòíî â êëåòêó äîñòàòî÷íî ïðîáëåìàòè÷íî: íà êóëüòóðå êëåòîê ãèñòèîöèòîâ ÷åëîâåêà ëèíèè U-937 áûëî ïîêàçàíî, ÷òî èç âíåñ ̧ííîãî â èíêóáàöèîííóþ ñðåäó Hcy âíóòðü êëåòêè ïîïàäàåò <

19
Glowacki R, Jakubowski H. Cross-talk between Cys34 and lysine residues in human serum albumin revealed by Nhomocysteinylation. J Biol Chem 2004; 279(12): 10864–10871
Total in-text references: 1
  1. In-text reference with the coordinate start=4712
    Prefix
    Îñòàâøèåñÿ 98% – ñâÿçàííûé Hcy: 75% ñâÿçàíî äèñóëüôèäíûì ìîñòèêîì ñ öèñòåèíîì áåëêîâ, ïðåèìóùåñòâåííî àëüáóìèíà, à îñòàâøèåñÿ 25% ïðèñóòñòâóþò â âèäå ãîìîöèñòèíà, ãîìîöèñòåèí-öèñòåèí äèñóëüôèäà, ãîìîöèñòåèí-öèñòåèíèëãëèöèí äèñóëüôèäà è äð.
    Exact
    [18, 19]
    Suffix
    . ×òîáû ïîääåðæèâàòü íèçêèé âíóòðèêëåòî÷íûé óðîâåíü ýòîãî öèòîòîêñè÷åñêîãî âåùåñòâà, èçáûòîê Hcy ñâÿçûâàåòñÿ ñî ñïåöèôè÷åñêèìè (íàñûùàåìûìè) ó÷àñòêàìè áåëêà ëèáî âûõîäèò â êðîâÿíîå ðóñëî [20]. Èíòåðåñíî, ÷òî ïîïàñòü Hcy îáðàòíî â êëåòêó äîñòàòî÷íî ïðîáëåìàòè÷íî: íà êóëüòóðå êëåòîê ãèñòèîöèòîâ ÷åëîâåêà ëèíèè U-937 áûëî ïîêàçàíî, ÷òî èç âíåñ ̧ííîãî â èíêóáàöèîííóþ ñðåäó Hcy âíóòðü êëåòêè ïîïàäàåò <

20
Friedman AN, Bostom AG, Selhub J et al. The kidney and homocysteine metabolism. J Am Soc Nephrol 2001; 12:
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  1. In-text reference with the coordinate start=4909
    Prefix
    ñâÿçàíî äèñóëüôèäíûì ìîñòèêîì ñ öèñòåèíîì áåëêîâ, ïðåèìóùåñòâåííî àëüáóìèíà, à îñòàâøèåñÿ 25% ïðèñóòñòâóþò â âèäå ãîìîöèñòèíà, ãîìîöèñòåèí-öèñòåèí äèñóëüôèäà, ãîìîöèñòåèí-öèñòåèíèëãëèöèí äèñóëüôèäà è äð. [18, 19]. ×òîáû ïîääåðæèâàòü íèçêèé âíóòðèêëåòî÷íûé óðîâåíü ýòîãî öèòîòîêñè÷åñêîãî âåùåñòâà, èçáûòîê Hcy ñâÿçûâàåòñÿ ñî ñïåöèôè÷åñêèìè (íàñûùàåìûìè) ó÷àñòêàìè áåëêà ëèáî âûõîäèò â êðîâÿíîå ðóñëî
    Exact
    [20]
    Suffix
    . Èíòåðåñíî, ÷òî ïîïàñòü Hcy îáðàòíî â êëåòêó äîñòàòî÷íî ïðîáëåìàòè÷íî: íà êóëüòóðå êëåòîê ãèñòèîöèòîâ ÷åëîâåêà ëèíèè U-937 áûëî ïîêàçàíî, ÷òî èç âíåñ ̧ííîãî â èíêóáàöèîííóþ ñðåäó Hcy âíóòðü êëåòêè ïîïàäàåò < 1% àìèíîêèñëîòû [21].

  2. In-text reference with the coordinate start=6105
    Prefix
    HHcy ÿâëÿåòñÿ ôàêòîðîì, êîòîðûé, êàê ïîêàçàëè ðåçóëüòàòû ðàçëè÷íûõ èññëåäîâàíèé, ñóùåñòâåííî ïîâûøàåò ðèñê ðàííåãî ðàçâèòèÿ àòåðîñêëåðîçà è òðîìáîçà êîðîíàðíûõ, öåðåáðàëüíûõ è ïåðèôåðè÷åñêèõ àðòåðèé íåçàâèñèìî îò äðóãèõ èçâåñòíûõ ôàêòîðîâ ðèñêà
    Exact
    [20, 34–37]
    Suffix
    . Âûñîêîå ñîäåðæàíèå Hcy â ïëàçìå êðîâè ïîëîæèòåëüíî êîððåëèðóåò ñ óðîâíåì çàáîëåâàåìîñòè, âåðîÿòíîñòüþ ðàçâèòèÿ îñëîæíåíèé è ñìåðòíîñòüþ ïðè ñåðäå÷íî-ñîñóäèñòîé è ïî÷å÷íîé ïàòîëîãèè, â ñâÿçè ñ ÷åì ðàññìàòðèâàåòñÿ â êà÷åñòâå ïðîãíîñòè÷åñêîãî ìàðêåðà íåáëàãîïðèÿòíîãî èñõîäà çàáîëåâàíèé [35].

21
1–2189 21. Hultberg B, Andersson A, Isaksson A. Metabolism of homocysteine, its relation to the other cellular thiols and its mechanism of cell damage in a cell culture line (human histiocytic cell line U-937). Biochim Biophys Acta 1995; 1269(1): 6–12
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    Prefix
    Èíòåðåñíî, ÷òî ïîïàñòü Hcy îáðàòíî â êëåòêó äîñòàòî÷íî ïðîáëåìàòè÷íî: íà êóëüòóðå êëåòîê ãèñòèîöèòîâ ÷åëîâåêà ëèíèè U-937 áûëî ïîêàçàíî, ÷òî èç âíåñ ̧ííîãî â èíêóáàöèîííóþ ñðåäó Hcy âíóòðü êëåòêè ïîïàäàåò < 1% àìèíîêèñëîòû
    Exact
    [21]
    Suffix
    . Ïîýòîìó ãèïåðãîìîöèñòåèíåìèÿ (HHcy) – ýòî ñîñòîÿíèå, êîãäà íàðóøàåòñÿ âíóòðèêëåòî÷íûé ìåòàáîëèçì Hcy è âîçðàñòàåò óðîâåíü åãî âûäåëåíèÿ â ïëàçìó ëèáî óìåíüøàåòñÿ êëèðåíñ Hcy, è/ èëè çíà÷èòåëüíî âîçðàñòàåò åãî ñèíòåç.

22
Bjorke-Monsen AL, Ueland PM, Vollset SE et al. Determinants of cobalamin status in newborns. Pediatrics 2001; 108: 624–630
Total in-text references: 1
  1. In-text reference with the coordinate start=5428
    Prefix
    Ïîýòîìó ãèïåðãîìîöèñòåèíåìèÿ (HHcy) – ýòî ñîñòîÿíèå, êîãäà íàðóøàåòñÿ âíóòðèêëåòî÷íûé ìåòàáîëèçì Hcy è âîçðàñòàåò óðîâåíü åãî âûäåëåíèÿ â ïëàçìó ëèáî óìåíüøàåòñÿ êëèðåíñ Hcy, è/ èëè çíà÷èòåëüíî âîçðàñòàåò åãî ñèíòåç. Îñíîâíûìè ïðè÷èíàìè HHcy ÿâëÿþòñÿ äåôèöèò âèòàìèíîâ B2, B6, B9 è B12
    Exact
    [22–26]
    Suffix
    ; ãåíåòè÷åñêèå äåôåêòû, îïðåäåëÿþùèå íèçêóþ êîíöåíòðàöèþ è àêòèâíîñòü ôåðìåíòîâ (ãåíåòè÷åñêè äåòåðìèíèðîâàííîå ñíèæåíèå àêòèâíîñòè ìåòèîíèí-ñèíòàçû (MS), N5,10-ìåòèëåí-òåòðàãèäðîôîëàò ðåäóêòàçû (MTHFR), öèñòàòèîíèí β-ñèíòàçû (CBS), áåòàèí ãîìîöèñòåèí ìåòèëòðàíñôåðàçû (BHMT) [27–30]; íàðóøåíèå ôóíêöèè ïî÷åê, îò êîòîðîé çàâèñèò íå òîëüêî âûâåäåíèå, íî è ìåòàáîëèçì Hcy [31]; ïðèåì íåêîòîðûõ ëåêàðñòâå

23
Delvin EE, Rozen R, Merouani A et al. Influence of methylenetetrahydrofolate reductase genotype, age, vitamine B12 and folate status on plasma homocysteine in children. Am J Clin Nutr 2000; 72: 1469–1473
Total in-text references: 1
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    Prefix
    Ïîýòîìó ãèïåðãîìîöèñòåèíåìèÿ (HHcy) – ýòî ñîñòîÿíèå, êîãäà íàðóøàåòñÿ âíóòðèêëåòî÷íûé ìåòàáîëèçì Hcy è âîçðàñòàåò óðîâåíü åãî âûäåëåíèÿ â ïëàçìó ëèáî óìåíüøàåòñÿ êëèðåíñ Hcy, è/ èëè çíà÷èòåëüíî âîçðàñòàåò åãî ñèíòåç. Îñíîâíûìè ïðè÷èíàìè HHcy ÿâëÿþòñÿ äåôèöèò âèòàìèíîâ B2, B6, B9 è B12
    Exact
    [22–26]
    Suffix
    ; ãåíåòè÷åñêèå äåôåêòû, îïðåäåëÿþùèå íèçêóþ êîíöåíòðàöèþ è àêòèâíîñòü ôåðìåíòîâ (ãåíåòè÷åñêè äåòåðìèíèðîâàííîå ñíèæåíèå àêòèâíîñòè ìåòèîíèí-ñèíòàçû (MS), N5,10-ìåòèëåí-òåòðàãèäðîôîëàò ðåäóêòàçû (MTHFR), öèñòàòèîíèí β-ñèíòàçû (CBS), áåòàèí ãîìîöèñòåèí ìåòèëòðàíñôåðàçû (BHMT) [27–30]; íàðóøåíèå ôóíêöèè ïî÷åê, îò êîòîðîé çàâèñèò íå òîëüêî âûâåäåíèå, íî è ìåòàáîëèçì Hcy [31]; ïðèåì íåêîòîðûõ ëåêàðñòâå

24
Prathapasinghe GA, Siow YL, Xu Z. Inhibition of cystathionine-beta-synthase activity during renal ischemiareperfusion: role of pH and nitric oxide. Am J Physiol Renal Physiol 2008; 295(4): F912–922
Total in-text references: 1
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    Prefix
    Ïîýòîìó ãèïåðãîìîöèñòåèíåìèÿ (HHcy) – ýòî ñîñòîÿíèå, êîãäà íàðóøàåòñÿ âíóòðèêëåòî÷íûé ìåòàáîëèçì Hcy è âîçðàñòàåò óðîâåíü åãî âûäåëåíèÿ â ïëàçìó ëèáî óìåíüøàåòñÿ êëèðåíñ Hcy, è/ èëè çíà÷èòåëüíî âîçðàñòàåò åãî ñèíòåç. Îñíîâíûìè ïðè÷èíàìè HHcy ÿâëÿþòñÿ äåôèöèò âèòàìèíîâ B2, B6, B9 è B12
    Exact
    [22–26]
    Suffix
    ; ãåíåòè÷åñêèå äåôåêòû, îïðåäåëÿþùèå íèçêóþ êîíöåíòðàöèþ è àêòèâíîñòü ôåðìåíòîâ (ãåíåòè÷åñêè äåòåðìèíèðîâàííîå ñíèæåíèå àêòèâíîñòè ìåòèîíèí-ñèíòàçû (MS), N5,10-ìåòèëåí-òåòðàãèäðîôîëàò ðåäóêòàçû (MTHFR), öèñòàòèîíèí β-ñèíòàçû (CBS), áåòàèí ãîìîöèñòåèí ìåòèëòðàíñôåðàçû (BHMT) [27–30]; íàðóøåíèå ôóíêöèè ïî÷åê, îò êîòîðîé çàâèñèò íå òîëüêî âûâåäåíèå, íî è ìåòàáîëèçì Hcy [31]; ïðèåì íåêîòîðûõ ëåêàðñòâå

25
Woo CW, Siow YL, Pierce GN et al. Hyperhomocysteinemia induces hepatic cholesterol biosynthesis and lipid accumulation via activation of transcription factors. Am J Physiol Endocrinol Metab 2005; 288(5): E1002–1010
Total in-text references: 1
  1. In-text reference with the coordinate start=5428
    Prefix
    Ïîýòîìó ãèïåðãîìîöèñòåèíåìèÿ (HHcy) – ýòî ñîñòîÿíèå, êîãäà íàðóøàåòñÿ âíóòðèêëåòî÷íûé ìåòàáîëèçì Hcy è âîçðàñòàåò óðîâåíü åãî âûäåëåíèÿ â ïëàçìó ëèáî óìåíüøàåòñÿ êëèðåíñ Hcy, è/ èëè çíà÷èòåëüíî âîçðàñòàåò åãî ñèíòåç. Îñíîâíûìè ïðè÷èíàìè HHcy ÿâëÿþòñÿ äåôèöèò âèòàìèíîâ B2, B6, B9 è B12
    Exact
    [22–26]
    Suffix
    ; ãåíåòè÷åñêèå äåôåêòû, îïðåäåëÿþùèå íèçêóþ êîíöåíòðàöèþ è àêòèâíîñòü ôåðìåíòîâ (ãåíåòè÷åñêè äåòåðìèíèðîâàííîå ñíèæåíèå àêòèâíîñòè ìåòèîíèí-ñèíòàçû (MS), N5,10-ìåòèëåí-òåòðàãèäðîôîëàò ðåäóêòàçû (MTHFR), öèñòàòèîíèí β-ñèíòàçû (CBS), áåòàèí ãîìîöèñòåèí ìåòèëòðàíñôåðàçû (BHMT) [27–30]; íàðóøåíèå ôóíêöèè ïî÷åê, îò êîòîðîé çàâèñèò íå òîëüêî âûâåäåíèå, íî è ìåòàáîëèçì Hcy [31]; ïðèåì íåêîòîðûõ ëåêàðñòâå

26
Clarke R, Refsum H, Birks J, et al. Screening for vitamin B-12 and folate deficiency in older persons. Am J Clin Nutr 2003; 77(5): 1241–1247
Total in-text references: 1
  1. In-text reference with the coordinate start=5428
    Prefix
    Ïîýòîìó ãèïåðãîìîöèñòåèíåìèÿ (HHcy) – ýòî ñîñòîÿíèå, êîãäà íàðóøàåòñÿ âíóòðèêëåòî÷íûé ìåòàáîëèçì Hcy è âîçðàñòàåò óðîâåíü åãî âûäåëåíèÿ â ïëàçìó ëèáî óìåíüøàåòñÿ êëèðåíñ Hcy, è/ èëè çíà÷èòåëüíî âîçðàñòàåò åãî ñèíòåç. Îñíîâíûìè ïðè÷èíàìè HHcy ÿâëÿþòñÿ äåôèöèò âèòàìèíîâ B2, B6, B9 è B12
    Exact
    [22–26]
    Suffix
    ; ãåíåòè÷åñêèå äåôåêòû, îïðåäåëÿþùèå íèçêóþ êîíöåíòðàöèþ è àêòèâíîñòü ôåðìåíòîâ (ãåíåòè÷åñêè äåòåðìèíèðîâàííîå ñíèæåíèå àêòèâíîñòè ìåòèîíèí-ñèíòàçû (MS), N5,10-ìåòèëåí-òåòðàãèäðîôîëàò ðåäóêòàçû (MTHFR), öèñòàòèîíèí β-ñèíòàçû (CBS), áåòàèí ãîìîöèñòåèí ìåòèëòðàíñôåðàçû (BHMT) [27–30]; íàðóøåíèå ôóíêöèè ïî÷åê, îò êîòîðîé çàâèñèò íå òîëüêî âûâåäåíèå, íî è ìåòàáîëèçì Hcy [31]; ïðèåì íåêîòîðûõ ëåêàðñòâå

27
Ames BN, Elson-Schwab I, Silver EA. High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased K(m)): relevance to genetic disease and polymorphisms. Am J Clin Nutr 2002; 75(4): 616–658
Total in-text references: 1
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    Prefix
    Îñíîâíûìè ïðè÷èíàìè HHcy ÿâëÿþòñÿ äåôèöèò âèòàìèíîâ B2, B6, B9 è B12 [22–26]; ãåíåòè÷åñêèå äåôåêòû, îïðåäåëÿþùèå íèçêóþ êîíöåíòðàöèþ è àêòèâíîñòü ôåðìåíòîâ (ãåíåòè÷åñêè äåòåðìèíèðîâàííîå ñíèæåíèå àêòèâíîñòè ìåòèîíèí-ñèíòàçû (MS), N5,10-ìåòèëåí-òåòðàãèäðîôîëàò ðåäóêòàçû (MTHFR), öèñòàòèîíèí β-ñèíòàçû (CBS), áåòàèí ãîìîöèñòåèí ìåòèëòðàíñôåðàçû (BHMT)
    Exact
    [27–30]
    Suffix
    ; íàðóøåíèå ôóíêöèè ïî÷åê, îò êîòîðîé çàâèñèò íå òîëüêî âûâåäåíèå, íî è ìåòàáîëèçì Hcy [31]; ïðèåì íåêîòîðûõ ëåêàðñòâåííûõ ïðåïàðàòîâ [32, 33]. HHcy ÿâëÿåòñÿ ôàêòîðîì, êîòîðûé, êàê ïîêàçàëè ðåçóëüòàòû ðàçëè÷íûõ èññëåäîâàíèé, ñóùåñòâåííî ïîâûøàåò ðèñê ðàííåãî ðàçâèòèÿ àòåðîñêëåðîçà è òðîìáîçà êîðîíàðíûõ, öåðåáðàëüíûõ è ïåðèôåðè÷åñêèõ àðòåðèé íåçàâèñèìî îò äðóãèõ èçâåñòíûõ ôàêòîðîâ ðèñêà [20, 34–37]

28
Obeid R, Herrmann W. Homocysteine and lipids: Sadenosyl methionine as a key intermediate. FEBS Lett 2009; 583(8): 1215-1225
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    Prefix
    Îñíîâíûìè ïðè÷èíàìè HHcy ÿâëÿþòñÿ äåôèöèò âèòàìèíîâ B2, B6, B9 è B12 [22–26]; ãåíåòè÷åñêèå äåôåêòû, îïðåäåëÿþùèå íèçêóþ êîíöåíòðàöèþ è àêòèâíîñòü ôåðìåíòîâ (ãåíåòè÷åñêè äåòåðìèíèðîâàííîå ñíèæåíèå àêòèâíîñòè ìåòèîíèí-ñèíòàçû (MS), N5,10-ìåòèëåí-òåòðàãèäðîôîëàò ðåäóêòàçû (MTHFR), öèñòàòèîíèí β-ñèíòàçû (CBS), áåòàèí ãîìîöèñòåèí ìåòèëòðàíñôåðàçû (BHMT)
    Exact
    [27–30]
    Suffix
    ; íàðóøåíèå ôóíêöèè ïî÷åê, îò êîòîðîé çàâèñèò íå òîëüêî âûâåäåíèå, íî è ìåòàáîëèçì Hcy [31]; ïðèåì íåêîòîðûõ ëåêàðñòâåííûõ ïðåïàðàòîâ [32, 33]. HHcy ÿâëÿåòñÿ ôàêòîðîì, êîòîðûé, êàê ïîêàçàëè ðåçóëüòàòû ðàçëè÷íûõ èññëåäîâàíèé, ñóùåñòâåííî ïîâûøàåò ðèñê ðàííåãî ðàçâèòèÿ àòåðîñêëåðîçà è òðîìáîçà êîðîíàðíûõ, öåðåáðàëüíûõ è ïåðèôåðè÷åñêèõ àðòåðèé íåçàâèñèìî îò äðóãèõ èçâåñòíûõ ôàêòîðîâ ðèñêà [20, 34–37]

29
Swanson DA, Liu ML, Baker PJ et al. Targeted disruption of the methionine synthase gene in mice. Mol Cell Biol 2001; 21(4): 1058–1065
Total in-text references: 1
  1. In-text reference with the coordinate start=5708
    Prefix
    Îñíîâíûìè ïðè÷èíàìè HHcy ÿâëÿþòñÿ äåôèöèò âèòàìèíîâ B2, B6, B9 è B12 [22–26]; ãåíåòè÷åñêèå äåôåêòû, îïðåäåëÿþùèå íèçêóþ êîíöåíòðàöèþ è àêòèâíîñòü ôåðìåíòîâ (ãåíåòè÷åñêè äåòåðìèíèðîâàííîå ñíèæåíèå àêòèâíîñòè ìåòèîíèí-ñèíòàçû (MS), N5,10-ìåòèëåí-òåòðàãèäðîôîëàò ðåäóêòàçû (MTHFR), öèñòàòèîíèí β-ñèíòàçû (CBS), áåòàèí ãîìîöèñòåèí ìåòèëòðàíñôåðàçû (BHMT)
    Exact
    [27–30]
    Suffix
    ; íàðóøåíèå ôóíêöèè ïî÷åê, îò êîòîðîé çàâèñèò íå òîëüêî âûâåäåíèå, íî è ìåòàáîëèçì Hcy [31]; ïðèåì íåêîòîðûõ ëåêàðñòâåííûõ ïðåïàðàòîâ [32, 33]. HHcy ÿâëÿåòñÿ ôàêòîðîì, êîòîðûé, êàê ïîêàçàëè ðåçóëüòàòû ðàçëè÷íûõ èññëåäîâàíèé, ñóùåñòâåííî ïîâûøàåò ðèñê ðàííåãî ðàçâèòèÿ àòåðîñêëåðîçà è òðîìáîçà êîðîíàðíûõ, öåðåáðàëüíûõ è ïåðèôåðè÷åñêèõ àðòåðèé íåçàâèñèìî îò äðóãèõ èçâåñòíûõ ôàêòîðîâ ðèñêà [20, 34–37]

30
Brustolin S, Giugliani R, Felix TM. Genetics of homocysteine metabolism and associated disorders. Braz J Med Biol Res 2010; 43: 1–5
Total in-text references: 1
  1. In-text reference with the coordinate start=5708
    Prefix
    Îñíîâíûìè ïðè÷èíàìè HHcy ÿâëÿþòñÿ äåôèöèò âèòàìèíîâ B2, B6, B9 è B12 [22–26]; ãåíåòè÷åñêèå äåôåêòû, îïðåäåëÿþùèå íèçêóþ êîíöåíòðàöèþ è àêòèâíîñòü ôåðìåíòîâ (ãåíåòè÷åñêè äåòåðìèíèðîâàííîå ñíèæåíèå àêòèâíîñòè ìåòèîíèí-ñèíòàçû (MS), N5,10-ìåòèëåí-òåòðàãèäðîôîëàò ðåäóêòàçû (MTHFR), öèñòàòèîíèí β-ñèíòàçû (CBS), áåòàèí ãîìîöèñòåèí ìåòèëòðàíñôåðàçû (BHMT)
    Exact
    [27–30]
    Suffix
    ; íàðóøåíèå ôóíêöèè ïî÷åê, îò êîòîðîé çàâèñèò íå òîëüêî âûâåäåíèå, íî è ìåòàáîëèçì Hcy [31]; ïðèåì íåêîòîðûõ ëåêàðñòâåííûõ ïðåïàðàòîâ [32, 33]. HHcy ÿâëÿåòñÿ ôàêòîðîì, êîòîðûé, êàê ïîêàçàëè ðåçóëüòàòû ðàçëè÷íûõ èññëåäîâàíèé, ñóùåñòâåííî ïîâûøàåò ðèñê ðàííåãî ðàçâèòèÿ àòåðîñêëåðîçà è òðîìáîçà êîðîíàðíûõ, öåðåáðàëüíûõ è ïåðèôåðè÷åñêèõ àðòåðèé íåçàâèñèìî îò äðóãèõ èçâåñòíûõ ôàêòîðîâ ðèñêà [20, 34–37]

31
Francis ME, Eggers PW, Hostetter TH, et al. Association between serum homocysteine and markers of impaired kidney function in adults in the United States. Kidney Int 2004; 66(1): 303–312
Total in-text references: 5
  1. In-text reference with the coordinate start=5800
    Prefix
    B2, B6, B9 è B12 [22–26]; ãåíåòè÷åñêèå äåôåêòû, îïðåäåëÿþùèå íèçêóþ êîíöåíòðàöèþ è àêòèâíîñòü ôåðìåíòîâ (ãåíåòè÷åñêè äåòåðìèíèðîâàííîå ñíèæåíèå àêòèâíîñòè ìåòèîíèí-ñèíòàçû (MS), N5,10-ìåòèëåí-òåòðàãèäðîôîëàò ðåäóêòàçû (MTHFR), öèñòàòèîíèí β-ñèíòàçû (CBS), áåòàèí ãîìîöèñòåèí ìåòèëòðàíñôåðàçû (BHMT) [27–30]; íàðóøåíèå ôóíêöèè ïî÷åê, îò êîòîðîé çàâèñèò íå òîëüêî âûâåäåíèå, íî è ìåòàáîëèçì Hcy
    Exact
    [31]
    Suffix
    ; ïðèåì íåêîòîðûõ ëåêàðñòâåííûõ ïðåïàðàòîâ [32, 33]. HHcy ÿâëÿåòñÿ ôàêòîðîì, êîòîðûé, êàê ïîêàçàëè ðåçóëüòàòû ðàçëè÷íûõ èññëåäîâàíèé, ñóùåñòâåííî ïîâûøàåò ðèñê ðàííåãî ðàçâèòèÿ àòåðîñêëåðîçà è òðîìáîçà êîðîíàðíûõ, öåðåáðàëüíûõ è ïåðèôåðè÷åñêèõ àðòåðèé íåçàâèñèìî îò äðóãèõ èçâåñòíûõ ôàêòîðîâ ðèñêà [20, 34–37].

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    Ïîâûøåíèå óðîâíÿ Hcy ïëàçìû ïðîèñõîäèò, íà÷èíàÿ ñ ðàííèõ ñòàäèé ÕÁÏ [94]. Ìàêñèìàëüíî âûñîêèõ öèôð óðîâåíü HHcy äîñòèãàåò ó ïàöèåíòîâ, ïîëó÷àþùèõ òåðàïèþ äèàëèçîì, ÷òî îáúÿñíÿåò áîëåå òÿæåëîå òå÷åíèå ñåðäå÷íî-ñîñóäèñòûõ çàáîëåâàíèé, âîçíèêàþùèõ íà ôîíå ÕÁÏ
    Exact
    [31]
    Suffix
    . Êîëëåêòèâ àâòîðîâ [95] îòìå÷àåò, ÷òî ðàñïðîñòðàíåííîñòü HHcy íà ðàííèõ ñòàäèÿõ ÕÁÏ äîñòèãàåò 40%, óâåëè÷èâàåòñÿ äî 90% íà ïðåääèàëèçíîì ýòàïå è äî 94,7% – ó äèàëèçíûõ ïàöèåíòîâ. Âûÿâëåíà îáðàòíàÿ çàâèñèìîñòü ìåæäó âåëè÷èíîé ñêîðîñòè êëóáî÷êîâîé ôèëüòðàöèè (ÑÊÔ) è óðîâíåì Hcy ïëàçìû êðîâè [31, 95, 96].

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    Êîëëåêòèâ àâòîðîâ [95] îòìå÷àåò, ÷òî ðàñïðîñòðàíåííîñòü HHcy íà ðàííèõ ñòàäèÿõ ÕÁÏ äîñòèãàåò 40%, óâåëè÷èâàåòñÿ äî 90% íà ïðåääèàëèçíîì ýòàïå è äî 94,7% – ó äèàëèçíûõ ïàöèåíòîâ. Âûÿâëåíà îáðàòíàÿ çàâèñèìîñòü ìåæäó âåëè÷èíîé ñêîðîñòè êëóáî÷êîâîé ôèëüòðàöèè (ÑÊÔ) è óðîâíåì Hcy ïëàçìû êðîâè
    Exact
    [31, 95, 96]
    Suffix
    . Ïðè ñíèæåíèè ÑÊÔ îò 60 äî 90 ìë/ìèí óðîâåíü Hcy ïîâûøàåòñÿ ïðèìåðíî â 2 ðàçà, à ïðè êîíöåíòðàöèè ìåíåå 60 ìë/ìèí – â 9–11 ðàç [31]. Ïðè÷èíû ðàçâèòèÿ HHcy íà ðàçíûõ ñòàäèÿõ ðàçâèòèÿ ÕÁÏ ñâÿçûâàþò ñ ïîÿâëåíèåì òóáóëîèíòåðñòèöèàëüíûõ ïîâðåæäåíèé [97], ñíèæåíèåì ïî÷å÷íûõ ôóíêöèé [39] è íàðóøåíèåì ìåòàáîëèçìà Hcy â ïî÷êàõ (ñíèæåíèå ïðîöåññîâ ðåìåòèëèðîâàíèÿ, òðàíñìåòèëèðîâàíèÿ, òðàíññóëüôóðèðîâàíèÿ)

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    Âûÿâëåíà îáðàòíàÿ çàâèñèìîñòü ìåæäó âåëè÷èíîé ñêîðîñòè êëóáî÷êîâîé ôèëüòðàöèè (ÑÊÔ) è óðîâíåì Hcy ïëàçìû êðîâè [31, 95, 96]. Ïðè ñíèæåíèè ÑÊÔ îò 60 äî 90 ìë/ìèí óðîâåíü Hcy ïîâûøàåòñÿ ïðèìåðíî â 2 ðàçà, à ïðè êîíöåíòðàöèè ìåíåå 60 ìë/ìèí – â 9–11 ðàç
    Exact
    [31]
    Suffix
    . Ïðè÷èíû ðàçâèòèÿ HHcy íà ðàçíûõ ñòàäèÿõ ðàçâèòèÿ ÕÁÏ ñâÿçûâàþò ñ ïîÿâëåíèåì òóáóëîèíòåðñòèöèàëüíûõ ïîâðåæäåíèé [97], ñíèæåíèåì ïî÷å÷íûõ ôóíêöèé [39] è íàðóøåíèåì ìåòàáîëèçìà Hcy â ïî÷êàõ (ñíèæåíèå ïðîöåññîâ ðåìåòèëèðîâàíèÿ, òðàíñìåòèëèðîâàíèÿ, òðàíññóëüôóðèðîâàíèÿ) [98].

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    Ïî äàííûì äðóãèõ èññëåäîâàòåëåé, ïðèìåíåíèå âèòàìèíà B12 ïðèâîäèëî ê ñíèæåíèþ Hcy íà 15%, à âîò äîáàâëåíèå âèòàìèíà Â6 ïðàêòè÷åñêè íå âëèÿëî íà óðîâåíü Hcy [10, 15]. M.E. Francis è ñîàâò. ñ÷èòàþò, ÷òî ïðè ÕÁÏ óðîâåíü ãîìîöèñòåèíà ïîâûøàåòñÿ íåçàâèñèìî îò ïðèåìà âèòàìèíîâ ãðóïïû Â
    Exact
    [31]
    Suffix
    . L. Brattstrum îòìå÷àåò, ÷òî âèòàìèíû Â12 è Â6 îêàçûâàþò âëèÿíèå íà óðîâåíü Hcy ëèøü â ñëó÷àÿõ èõ íåäîñòàòî÷íîñòè â îðãàíèçìå [112]. Ïðîâåäåííûå èññëåäîâàíèÿ ñðåäè ìîëîäûõ ëþäåé [10] ïîêàçàëè, ÷òî ó íèõ ñóùåñòâóåò èñõîäíàÿ íåäîñòàòî÷íîñòü âèòàìèíà Â12 è ôîëèåâîé êèñëîòû.

32
Finkelstein JD. Methionine metabolism in mammals. J Nutr Biochem 1990; 1(5): 228–237
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  1. In-text reference with the coordinate start=5848
    Prefix
    , îïðåäåëÿþùèå íèçêóþ êîíöåíòðàöèþ è àêòèâíîñòü ôåðìåíòîâ (ãåíåòè÷åñêè äåòåðìèíèðîâàííîå ñíèæåíèå àêòèâíîñòè ìåòèîíèí-ñèíòàçû (MS), N5,10-ìåòèëåí-òåòðàãèäðîôîëàò ðåäóêòàçû (MTHFR), öèñòàòèîíèí β-ñèíòàçû (CBS), áåòàèí ãîìîöèñòåèí ìåòèëòðàíñôåðàçû (BHMT) [27–30]; íàðóøåíèå ôóíêöèè ïî÷åê, îò êîòîðîé çàâèñèò íå òîëüêî âûâåäåíèå, íî è ìåòàáîëèçì Hcy [31]; ïðèåì íåêîòîðûõ ëåêàðñòâåííûõ ïðåïàðàòîâ
    Exact
    [32, 33]
    Suffix
    . HHcy ÿâëÿåòñÿ ôàêòîðîì, êîòîðûé, êàê ïîêàçàëè ðåçóëüòàòû ðàçëè÷íûõ èññëåäîâàíèé, ñóùåñòâåííî ïîâûøàåò ðèñê ðàííåãî ðàçâèòèÿ àòåðîñêëåðîçà è òðîìáîçà êîðîíàðíûõ, öåðåáðàëüíûõ è ïåðèôåðè÷åñêèõ àðòåðèé íåçàâèñèìî îò äðóãèõ èçâåñòíûõ ôàêòîðîâ ðèñêà [20, 34–37].

33
Hoekstra M, Haagsma CJ, Doelman CJ, et al. Intermittent rises in plasma homocysteine in patients with rheumatoid arthritis treated with higher dose methotrexate. Ann Rheum Dis 2005; 64(1): 141–143
Total in-text references: 1
  1. In-text reference with the coordinate start=5848
    Prefix
    , îïðåäåëÿþùèå íèçêóþ êîíöåíòðàöèþ è àêòèâíîñòü ôåðìåíòîâ (ãåíåòè÷åñêè äåòåðìèíèðîâàííîå ñíèæåíèå àêòèâíîñòè ìåòèîíèí-ñèíòàçû (MS), N5,10-ìåòèëåí-òåòðàãèäðîôîëàò ðåäóêòàçû (MTHFR), öèñòàòèîíèí β-ñèíòàçû (CBS), áåòàèí ãîìîöèñòåèí ìåòèëòðàíñôåðàçû (BHMT) [27–30]; íàðóøåíèå ôóíêöèè ïî÷åê, îò êîòîðîé çàâèñèò íå òîëüêî âûâåäåíèå, íî è ìåòàáîëèçì Hcy [31]; ïðèåì íåêîòîðûõ ëåêàðñòâåííûõ ïðåïàðàòîâ
    Exact
    [32, 33]
    Suffix
    . HHcy ÿâëÿåòñÿ ôàêòîðîì, êîòîðûé, êàê ïîêàçàëè ðåçóëüòàòû ðàçëè÷íûõ èññëåäîâàíèé, ñóùåñòâåííî ïîâûøàåò ðèñê ðàííåãî ðàçâèòèÿ àòåðîñêëåðîçà è òðîìáîçà êîðîíàðíûõ, öåðåáðàëüíûõ è ïåðèôåðè÷åñêèõ àðòåðèé íåçàâèñèìî îò äðóãèõ èçâåñòíûõ ôàêòîðîâ ðèñêà [20, 34–37].

34
Lawrence de Koning AB, Werstuck GH, Zhou J, et al. Hyperhomocysteinemia and its role in the development of atherosclerosis. Clin Biochem 2003; 36(6): 431–441
Total in-text references: 3
  1. In-text reference with the coordinate start=6105
    Prefix
    HHcy ÿâëÿåòñÿ ôàêòîðîì, êîòîðûé, êàê ïîêàçàëè ðåçóëüòàòû ðàçëè÷íûõ èññëåäîâàíèé, ñóùåñòâåííî ïîâûøàåò ðèñê ðàííåãî ðàçâèòèÿ àòåðîñêëåðîçà è òðîìáîçà êîðîíàðíûõ, öåðåáðàëüíûõ è ïåðèôåðè÷åñêèõ àðòåðèé íåçàâèñèìî îò äðóãèõ èçâåñòíûõ ôàêòîðîâ ðèñêà
    Exact
    [20, 34–37]
    Suffix
    . Âûñîêîå ñîäåðæàíèå Hcy â ïëàçìå êðîâè ïîëîæèòåëüíî êîððåëèðóåò ñ óðîâíåì çàáîëåâàåìîñòè, âåðîÿòíîñòüþ ðàçâèòèÿ îñëîæíåíèé è ñìåðòíîñòüþ ïðè ñåðäå÷íî-ñîñóäèñòîé è ïî÷å÷íîé ïàòîëîãèè, â ñâÿçè ñ ÷åì ðàññìàòðèâàåòñÿ â êà÷åñòâå ïðîãíîñòè÷åñêîãî ìàðêåðà íåáëàãîïðèÿòíîãî èñõîäà çàáîëåâàíèé [35].

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    Óãíåòåíèå ñèíòåçà òðîìáîìîäóëèíà âûçûâàåò ïîäàâëåíèå òðîìáîìîäóëèí-çàâèñèìîé àêòèâàöèè ïðîòåèíîâ C è S, îáëàäàþùèõ àíòèêîàãóëÿíòíîé àêòèâíîñòüþ [76]. Ïðè÷ ̧ì óñòàíîâëåíî, ÷òî èíäóöèðîâàííûå ãîìîöèñòåèíîì òðîìáîçû ÿâëÿþòñÿ ñêîðåå ðåçóëüòàòîì íàðóøåíèé ñî ñòîðîíû ýíäîòåëèàëüíûõ êëåòîê, ÷åì èçìåíåíèé â ôèçèîëîãèè ñàìèõ òðîìáîöèòîâ
    Exact
    [34]
    Suffix
    .  ïîñëåäíèå ãîäû óäåëÿåòñÿ îñîáîå âíèìàíèå ðîëè îêñèäàòèâíîãî ñòðåññà â ïàòîãåíåçå ñåðäå÷íî-ñîñóäèñòûõ îñëîæíåíèé ïðè ÕÁÏ [77–79]. Ðàçâèòèþ îêñèäàòèâíîãî ñòðåññà ñïîñîáñòâóåò è HHcy [34–36, 80–82].

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    Prefix
    Ïðè÷ ̧ì óñòàíîâëåíî, ÷òî èíäóöèðîâàííûå ãîìîöèñòåèíîì òðîìáîçû ÿâëÿþòñÿ ñêîðåå ðåçóëüòàòîì íàðóøåíèé ñî ñòîðîíû ýíäîòåëèàëüíûõ êëåòîê, ÷åì èçìåíåíèé â ôèçèîëîãèè ñàìèõ òðîìáîöèòîâ [34].  ïîñëåäíèå ãîäû óäåëÿåòñÿ îñîáîå âíèìàíèå ðîëè îêñèäàòèâíîãî ñòðåññà â ïàòîãåíåçå ñåðäå÷íî-ñîñóäèñòûõ îñëîæíåíèé ïðè ÕÁÏ [77–79]. Ðàçâèòèþ îêñèäàòèâíîãî ñòðåññà ñïîñîáñòâóåò è HHcy
    Exact
    [34–36, 80–82]
    Suffix
    . Ñóùåñòâóåò ãèïîòåçà, ÷òî Hcy ëåãêî àóòîîêèñëÿåòñÿ ñ îáðàçîâàíèåì ãîìîöèñòèíà, ãîìîöèñòåèí-ñìåøàííûõ äèñóëüôèäîâ è òèîëàêòîíà ãîìîöèñòåèíà. Ïðè îêèñëåíèè ñóëüôãèäðèëüíûõ ãðóïï ãåíåðèðóþòñÿ ñóïåðîêñèä àíèîí (Η) èëè ïåðåêèñü âîäîðîäà (H2O2), êîòîðûå ñîáñòâåííî è îïðåäåëÿþò öèòîòîêñè÷íîñòü Hcy [80].

35
McCully KS. Chemical pathology of homocysteine. IV. Excitotoxicity, oxidative stress, endothelial dysfunction, and inflammation. Ann Clin Lab Sci 2009; 39(3): 219–232
Total in-text references: 4
  1. In-text reference with the coordinate start=6105
    Prefix
    HHcy ÿâëÿåòñÿ ôàêòîðîì, êîòîðûé, êàê ïîêàçàëè ðåçóëüòàòû ðàçëè÷íûõ èññëåäîâàíèé, ñóùåñòâåííî ïîâûøàåò ðèñê ðàííåãî ðàçâèòèÿ àòåðîñêëåðîçà è òðîìáîçà êîðîíàðíûõ, öåðåáðàëüíûõ è ïåðèôåðè÷åñêèõ àðòåðèé íåçàâèñèìî îò äðóãèõ èçâåñòíûõ ôàêòîðîâ ðèñêà
    Exact
    [20, 34–37]
    Suffix
    . Âûñîêîå ñîäåðæàíèå Hcy â ïëàçìå êðîâè ïîëîæèòåëüíî êîððåëèðóåò ñ óðîâíåì çàáîëåâàåìîñòè, âåðîÿòíîñòüþ ðàçâèòèÿ îñëîæíåíèé è ñìåðòíîñòüþ ïðè ñåðäå÷íî-ñîñóäèñòîé è ïî÷å÷íîé ïàòîëîãèè, â ñâÿçè ñ ÷åì ðàññìàòðèâàåòñÿ â êà÷åñòâå ïðîãíîñòè÷åñêîãî ìàðêåðà íåáëàãîïðèÿòíîãî èñõîäà çàáîëåâàíèé [35].

  2. In-text reference with the coordinate start=6401
    Prefix
    Âûñîêîå ñîäåðæàíèå Hcy â ïëàçìå êðîâè ïîëîæèòåëüíî êîððåëèðóåò ñ óðîâíåì çàáîëåâàåìîñòè, âåðîÿòíîñòüþ ðàçâèòèÿ îñëîæíåíèé è ñìåðòíîñòüþ ïðè ñåðäå÷íî-ñîñóäèñòîé è ïî÷å÷íîé ïàòîëîãèè, â ñâÿçè ñ ÷åì ðàññìàòðèâàåòñÿ â êà÷åñòâå ïðîãíîñòè÷åñêîãî ìàðêåðà íåáëàãîïðèÿòíîãî èñõîäà çàáîëåâàíèé
    Exact
    [35]
    Suffix
    . Èíòåðåñ èññëåäîâàòåëåé ê HHcy ïðè ÕÁÏ âûçâàí òåì, ÷òî ïî÷êè – ýòî îñíîâíîå ìåñòî ýëèìèíàöèè Hcy èç êðîâîòîêà. Îêîëî 20% Hcy êðîâè óäàëÿåòñÿ ïî÷êàìè, ïðè÷ ̧ì â îñíîâíîì áëàãîäàðÿ ðåàêöèÿì òðàíññóëüôóðèðîâàíèÿ (78%), òîãäà êàê óðîâåíü íåïîñðåäñòâåííîé ýêñêðåöèè åãî â ìî÷ó âåñüìà íåçíà÷èòåëåí [38].

  3. In-text reference with the coordinate start=8379
    Prefix
    ó÷èòûâàëèñü âîçðàñò, ïîë, óðîâåíü àðòåðèàëüíîãî äàâëåíèÿ è õîëåñòåðèíà, èñïîëüçîâàíèå ãèïîòåíçèâíûõ ñðåäñòâ, óðîâåíü ôîëèåâîé êèñëîòû, îòìå÷åíî, ÷òî òîëüêî HHcy áûëà ïðåäèêòîðîì íàðóøåíèÿ ýíäîòåëèàëüíîé äèñôóíêöèè. Àíàëîãè÷íûå äàííûå ïîëó÷åíû è ó ïàöèåíòîâ, íàõîäÿùèõñÿ íà ãåìîäèàëèçå [53]. Ïðåäïîëàãàþò, ÷òî ìåõàíèçì äèñôóíêöèè îáóñëîâëåí òåì, ÷òî Hcy ïîäàâëÿåò ýêñïðåññèþ ôåðìåíòîâ-àíòèîêñèäàíòîâ
    Exact
    [35, 36, 47]
    Suffix
    è íàðóøàåò áèîäîñòóïíîñòü ýíäîòåëèàëüíîé NOS (eNOS), èíãèáèðóÿ àêòèâíîñòü ãëóòàòèîí ïåðîêñèäàçû [54, 55]. Òàêèì îáðàçîì, Hcy ïîâûøàåò ÷óâñòâèòåëüíîñòü êëåòêè ê öèòîòîêñè÷åñêîìó äåéñòâèþ àãåíòîâ è ñîçäà ̧ò áëàãîïðèÿòíûå óñëîâèÿ äëÿ ãåíåðàöèè ñâîáîäíûõ ðàäèêàëîâ êèñëîðîäà.

  4. In-text reference with the coordinate start=13028
    Prefix
    Ïðè÷ ̧ì óñòàíîâëåíî, ÷òî èíäóöèðîâàííûå ãîìîöèñòåèíîì òðîìáîçû ÿâëÿþòñÿ ñêîðåå ðåçóëüòàòîì íàðóøåíèé ñî ñòîðîíû ýíäîòåëèàëüíûõ êëåòîê, ÷åì èçìåíåíèé â ôèçèîëîãèè ñàìèõ òðîìáîöèòîâ [34].  ïîñëåäíèå ãîäû óäåëÿåòñÿ îñîáîå âíèìàíèå ðîëè îêñèäàòèâíîãî ñòðåññà â ïàòîãåíåçå ñåðäå÷íî-ñîñóäèñòûõ îñëîæíåíèé ïðè ÕÁÏ [77–79]. Ðàçâèòèþ îêñèäàòèâíîãî ñòðåññà ñïîñîáñòâóåò è HHcy
    Exact
    [34–36, 80–82]
    Suffix
    . Ñóùåñòâóåò ãèïîòåçà, ÷òî Hcy ëåãêî àóòîîêèñëÿåòñÿ ñ îáðàçîâàíèåì ãîìîöèñòèíà, ãîìîöèñòåèí-ñìåøàííûõ äèñóëüôèäîâ è òèîëàêòîíà ãîìîöèñòåèíà. Ïðè îêèñëåíèè ñóëüôãèäðèëüíûõ ãðóïï ãåíåðèðóþòñÿ ñóïåðîêñèä àíèîí (Η) èëè ïåðåêèñü âîäîðîäà (H2O2), êîòîðûå ñîáñòâåííî è îïðåäåëÿþò öèòîòîêñè÷íîñòü Hcy [80].

36
Massy ZA, Ceballos I, Chadefaux-Vekemens B, еt al. Homocyst(e)ine, oxidative stress, and endothelium function in uremic patients. Kidney Int Suppl 2001; 78: S243–S245
Total in-text references: 3
  1. In-text reference with the coordinate start=6105
    Prefix
    HHcy ÿâëÿåòñÿ ôàêòîðîì, êîòîðûé, êàê ïîêàçàëè ðåçóëüòàòû ðàçëè÷íûõ èññëåäîâàíèé, ñóùåñòâåííî ïîâûøàåò ðèñê ðàííåãî ðàçâèòèÿ àòåðîñêëåðîçà è òðîìáîçà êîðîíàðíûõ, öåðåáðàëüíûõ è ïåðèôåðè÷åñêèõ àðòåðèé íåçàâèñèìî îò äðóãèõ èçâåñòíûõ ôàêòîðîâ ðèñêà
    Exact
    [20, 34–37]
    Suffix
    . Âûñîêîå ñîäåðæàíèå Hcy â ïëàçìå êðîâè ïîëîæèòåëüíî êîððåëèðóåò ñ óðîâíåì çàáîëåâàåìîñòè, âåðîÿòíîñòüþ ðàçâèòèÿ îñëîæíåíèé è ñìåðòíîñòüþ ïðè ñåðäå÷íî-ñîñóäèñòîé è ïî÷å÷íîé ïàòîëîãèè, â ñâÿçè ñ ÷åì ðàññìàòðèâàåòñÿ â êà÷åñòâå ïðîãíîñòè÷åñêîãî ìàðêåðà íåáëàãîïðèÿòíîãî èñõîäà çàáîëåâàíèé [35].

  2. In-text reference with the coordinate start=8379
    Prefix
    ó÷èòûâàëèñü âîçðàñò, ïîë, óðîâåíü àðòåðèàëüíîãî äàâëåíèÿ è õîëåñòåðèíà, èñïîëüçîâàíèå ãèïîòåíçèâíûõ ñðåäñòâ, óðîâåíü ôîëèåâîé êèñëîòû, îòìå÷åíî, ÷òî òîëüêî HHcy áûëà ïðåäèêòîðîì íàðóøåíèÿ ýíäîòåëèàëüíîé äèñôóíêöèè. Àíàëîãè÷íûå äàííûå ïîëó÷åíû è ó ïàöèåíòîâ, íàõîäÿùèõñÿ íà ãåìîäèàëèçå [53]. Ïðåäïîëàãàþò, ÷òî ìåõàíèçì äèñôóíêöèè îáóñëîâëåí òåì, ÷òî Hcy ïîäàâëÿåò ýêñïðåññèþ ôåðìåíòîâ-àíòèîêñèäàíòîâ
    Exact
    [35, 36, 47]
    Suffix
    è íàðóøàåò áèîäîñòóïíîñòü ýíäîòåëèàëüíîé NOS (eNOS), èíãèáèðóÿ àêòèâíîñòü ãëóòàòèîí ïåðîêñèäàçû [54, 55]. Òàêèì îáðàçîì, Hcy ïîâûøàåò ÷óâñòâèòåëüíîñòü êëåòêè ê öèòîòîêñè÷åñêîìó äåéñòâèþ àãåíòîâ è ñîçäà ̧ò áëàãîïðèÿòíûå óñëîâèÿ äëÿ ãåíåðàöèè ñâîáîäíûõ ðàäèêàëîâ êèñëîðîäà.

  3. In-text reference with the coordinate start=13028
    Prefix
    Ïðè÷ ̧ì óñòàíîâëåíî, ÷òî èíäóöèðîâàííûå ãîìîöèñòåèíîì òðîìáîçû ÿâëÿþòñÿ ñêîðåå ðåçóëüòàòîì íàðóøåíèé ñî ñòîðîíû ýíäîòåëèàëüíûõ êëåòîê, ÷åì èçìåíåíèé â ôèçèîëîãèè ñàìèõ òðîìáîöèòîâ [34].  ïîñëåäíèå ãîäû óäåëÿåòñÿ îñîáîå âíèìàíèå ðîëè îêñèäàòèâíîãî ñòðåññà â ïàòîãåíåçå ñåðäå÷íî-ñîñóäèñòûõ îñëîæíåíèé ïðè ÕÁÏ [77–79]. Ðàçâèòèþ îêñèäàòèâíîãî ñòðåññà ñïîñîáñòâóåò è HHcy
    Exact
    [34–36, 80–82]
    Suffix
    . Ñóùåñòâóåò ãèïîòåçà, ÷òî Hcy ëåãêî àóòîîêèñëÿåòñÿ ñ îáðàçîâàíèåì ãîìîöèñòèíà, ãîìîöèñòåèí-ñìåøàííûõ äèñóëüôèäîâ è òèîëàêòîíà ãîìîöèñòåèíà. Ïðè îêèñëåíèè ñóëüôãèäðèëüíûõ ãðóïï ãåíåðèðóþòñÿ ñóïåðîêñèä àíèîí (Η) èëè ïåðåêèñü âîäîðîäà (H2O2), êîòîðûå ñîáñòâåííî è îïðåäåëÿþò öèòîòîêñè÷íîñòü Hcy [80].

37
Goligorsky MS. Frontiers in Nephrology: Viewing the Kidney through the Heart-Endothelial Dysfunction in Chronic Kidney Disease. J Am Soc Nephrol 2007; 18: 2833–2835
Total in-text references: 1
  1. In-text reference with the coordinate start=6105
    Prefix
    HHcy ÿâëÿåòñÿ ôàêòîðîì, êîòîðûé, êàê ïîêàçàëè ðåçóëüòàòû ðàçëè÷íûõ èññëåäîâàíèé, ñóùåñòâåííî ïîâûøàåò ðèñê ðàííåãî ðàçâèòèÿ àòåðîñêëåðîçà è òðîìáîçà êîðîíàðíûõ, öåðåáðàëüíûõ è ïåðèôåðè÷åñêèõ àðòåðèé íåçàâèñèìî îò äðóãèõ èçâåñòíûõ ôàêòîðîâ ðèñêà
    Exact
    [20, 34–37]
    Suffix
    . Âûñîêîå ñîäåðæàíèå Hcy â ïëàçìå êðîâè ïîëîæèòåëüíî êîððåëèðóåò ñ óðîâíåì çàáîëåâàåìîñòè, âåðîÿòíîñòüþ ðàçâèòèÿ îñëîæíåíèé è ñìåðòíîñòüþ ïðè ñåðäå÷íî-ñîñóäèñòîé è ïî÷å÷íîé ïàòîëîãèè, â ñâÿçè ñ ÷åì ðàññìàòðèâàåòñÿ â êà÷åñòâå ïðîãíîñòè÷åñêîãî ìàðêåðà íåáëàãîïðèÿòíîãî èñõîäà çàáîëåâàíèé [35].

38
Bostom A, Brosnan JT, Hall B et al. Net uptake of plasma homocysteine by the rat kidney in vivo. Atherosclerosis 1995; 116(1): 59–62
Total in-text references: 1
  1. In-text reference with the coordinate start=6694
    Prefix
    Èíòåðåñ èññëåäîâàòåëåé ê HHcy ïðè ÕÁÏ âûçâàí òåì, ÷òî ïî÷êè – ýòî îñíîâíîå ìåñòî ýëèìèíàöèè Hcy èç êðîâîòîêà. Îêîëî 20% Hcy êðîâè óäàëÿåòñÿ ïî÷êàìè, ïðè÷ ̧ì â îñíîâíîì áëàãîäàðÿ ðåàêöèÿì òðàíññóëüôóðèðîâàíèÿ (78%), òîãäà êàê óðîâåíü íåïîñðåäñòâåííîé ýêñêðåöèè åãî â ìî÷ó âåñüìà íåçíà÷èòåëåí
    Exact
    [38]
    Suffix
    . Ðåçóëüòàòû ýïèäåìèîëîãè÷åñêèõ ðàáîò ñâèäåòåëüñòâóþò î òåñíîé âçàèìîñâÿçè ìåæäó HHcy è ðàçâèòèåì ÕÁÏ [39]. Ãèïåðãîìîöèñòåèíåìèÿ è ôóíêöèîíàëüíîå ñîñòîÿíèå ýíäîòåëèÿ Ïîâûøåíèå óðîâíÿ Hcy â ïëàçìå êðîâè îêàçûâàåò ïîâðåæäàþùåå äåéñòâèå íà ñòðóêòóðó ñòåíîê ñîñóäîâ è ôóíêöèþ ýíäîòåëèÿ.

39
Ninomiya T, Kiyohara Y, Kubo M et al. Hyperhomocysteinemia and the development of chronic kidney disease in a general population: the Hisayama study. Am J Kidney Dis 2004; 44(3): 437–445
Total in-text references: 2
  1. In-text reference with the coordinate start=6802
    Prefix
    Îêîëî 20% Hcy êðîâè óäàëÿåòñÿ ïî÷êàìè, ïðè÷ ̧ì â îñíîâíîì áëàãîäàðÿ ðåàêöèÿì òðàíññóëüôóðèðîâàíèÿ (78%), òîãäà êàê óðîâåíü íåïîñðåäñòâåííîé ýêñêðåöèè åãî â ìî÷ó âåñüìà íåçíà÷èòåëåí [38]. Ðåçóëüòàòû ýïèäåìèîëîãè÷åñêèõ ðàáîò ñâèäåòåëüñòâóþò î òåñíîé âçàèìîñâÿçè ìåæäó HHcy è ðàçâèòèåì ÕÁÏ
    Exact
    [39]
    Suffix
    . Ãèïåðãîìîöèñòåèíåìèÿ è ôóíêöèîíàëüíîå ñîñòîÿíèå ýíäîòåëèÿ Ïîâûøåíèå óðîâíÿ Hcy â ïëàçìå êðîâè îêàçûâàåò ïîâðåæäàþùåå äåéñòâèå íà ñòðóêòóðó ñòåíîê ñîñóäîâ è ôóíêöèþ ýíäîòåëèÿ. Hcy ñòèìóëèðóåò ïðîëèôåðàöèþ êóëüòèâèðóåìûõ ãëàäêîìûøå÷íûõ êëåòîê ñîñóäîâ è ñèíòåç èìè êîëëàãåíà [40–43], âûçûâàåò äèñôóíêöèþ ýíäîòåëèÿ (âêëþ÷àÿ íåïîñðåäñòâåííîå ïîâðåæäåíèå êëåòîê) [44– 46], ïîäàâëÿåò ðåãåíåðàöèþ êëåòîê ýí

  2. In-text reference with the coordinate start=15131
    Prefix
    Ïðè ñíèæåíèè ÑÊÔ îò 60 äî 90 ìë/ìèí óðîâåíü Hcy ïîâûøàåòñÿ ïðèìåðíî â 2 ðàçà, à ïðè êîíöåíòðàöèè ìåíåå 60 ìë/ìèí – â 9–11 ðàç [31]. Ïðè÷èíû ðàçâèòèÿ HHcy íà ðàçíûõ ñòàäèÿõ ðàçâèòèÿ ÕÁÏ ñâÿçûâàþò ñ ïîÿâëåíèåì òóáóëîèíòåðñòèöèàëüíûõ ïîâðåæäåíèé [97], ñíèæåíèåì ïî÷å÷íûõ ôóíêöèé
    Exact
    [39]
    Suffix
    è íàðóøåíèåì ìåòàáîëèçìà Hcy â ïî÷êàõ (ñíèæåíèå ïðîöåññîâ ðåìåòèëèðîâàíèÿ, òðàíñìåòèëèðîâàíèÿ, òðàíññóëüôóðèðîâàíèÿ) [98]. B. Fowler îòìå÷àåò, ÷òî ó ïàöèåíòîâ â IV ñòàäèè ÕÁÏ îïðåäåëÿþòñÿ íàðóøåíèÿ ìåòàáîëèçìà ôîëèåâîé êèñëîòû, ñíèæåíà àêòèâíîñòü ôîëèëïîëèãëóòàìàò êîíüþãàçû (EC 3.4.19.9)* êèøå÷íèêà [99]. (*ýêçîñîìàëüíàÿ ïåïòèäàçà ñëèçèñòîé êèøå÷íèêà, ïðåâðàùàþùàÿ ôîëàòû èç ïîëèãëóòàìàòíîé ôîðìû â

40
Taha S, Azzi A, Ozer NK. Homocysteine induces DNA synthesis and proliferation of vascular smooth muscle cells by a hydrogen peroxide–independent mechanism. Antioxid Redox Signal 199l; 1(3): 365–369
Total in-text references: 1
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    Prefix
    Ãèïåðãîìîöèñòåèíåìèÿ è ôóíêöèîíàëüíîå ñîñòîÿíèå ýíäîòåëèÿ Ïîâûøåíèå óðîâíÿ Hcy â ïëàçìå êðîâè îêàçûâàåò ïîâðåæäàþùåå äåéñòâèå íà ñòðóêòóðó ñòåíîê ñîñóäîâ è ôóíêöèþ ýíäîòåëèÿ. Hcy ñòèìóëèðóåò ïðîëèôåðàöèþ êóëüòèâèðóåìûõ ãëàäêîìûøå÷íûõ êëåòîê ñîñóäîâ è ñèíòåç èìè êîëëàãåíà
    Exact
    [40–43]
    Suffix
    , âûçûâàåò äèñôóíêöèþ ýíäîòåëèÿ (âêëþ÷àÿ íåïîñðåäñòâåííîå ïîâðåæäåíèå êëåòîê) [44– 46], ïîäàâëÿåò ðåãåíåðàöèþ êëåòîê ýíäîòåëèÿ è ñïîñîáñòâóåò èñòîí÷åíèþ èíòèìû ñîñóäîâ [47], èçìåíÿåò óðîâåíü ïðîöåññîâ ìåòèëèðîâàíèÿ â êëåòêå [48], âåä ̧ò ê èçìåíåíèþ ïðîäóêöèè ýíäîòåëèåì îêñèäà àçîòà (NO) [49].

41
Tsai JC, Wang H, Perrella MA, et al. Induction of cyclin A gene expression by homocysteine in vascular smooth muscle cells. J Clin Invest 1996; 97(1): 146–153
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    Ãèïåðãîìîöèñòåèíåìèÿ è ôóíêöèîíàëüíîå ñîñòîÿíèå ýíäîòåëèÿ Ïîâûøåíèå óðîâíÿ Hcy â ïëàçìå êðîâè îêàçûâàåò ïîâðåæäàþùåå äåéñòâèå íà ñòðóêòóðó ñòåíîê ñîñóäîâ è ôóíêöèþ ýíäîòåëèÿ. Hcy ñòèìóëèðóåò ïðîëèôåðàöèþ êóëüòèâèðóåìûõ ãëàäêîìûøå÷íûõ êëåòîê ñîñóäîâ è ñèíòåç èìè êîëëàãåíà
    Exact
    [40–43]
    Suffix
    , âûçûâàåò äèñôóíêöèþ ýíäîòåëèÿ (âêëþ÷àÿ íåïîñðåäñòâåííîå ïîâðåæäåíèå êëåòîê) [44– 46], ïîäàâëÿåò ðåãåíåðàöèþ êëåòîê ýíäîòåëèÿ è ñïîñîáñòâóåò èñòîí÷åíèþ èíòèìû ñîñóäîâ [47], èçìåíÿåò óðîâåíü ïðîöåññîâ ìåòèëèðîâàíèÿ â êëåòêå [48], âåä ̧ò ê èçìåíåíèþ ïðîäóêöèè ýíäîòåëèåì îêñèäà àçîòà (NO) [49].

42
Majors AK, Sengupta S, Jacobsen DW, et al. Upregulation of smooth muscle cell collagen production by homocysteine–insight into the pathogenesis of homocystinuria. Mol Genet Metab 2002; 76(2): 92–99
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    Ãèïåðãîìîöèñòåèíåìèÿ è ôóíêöèîíàëüíîå ñîñòîÿíèå ýíäîòåëèÿ Ïîâûøåíèå óðîâíÿ Hcy â ïëàçìå êðîâè îêàçûâàåò ïîâðåæäàþùåå äåéñòâèå íà ñòðóêòóðó ñòåíîê ñîñóäîâ è ôóíêöèþ ýíäîòåëèÿ. Hcy ñòèìóëèðóåò ïðîëèôåðàöèþ êóëüòèâèðóåìûõ ãëàäêîìûøå÷íûõ êëåòîê ñîñóäîâ è ñèíòåç èìè êîëëàãåíà
    Exact
    [40–43]
    Suffix
    , âûçûâàåò äèñôóíêöèþ ýíäîòåëèÿ (âêëþ÷àÿ íåïîñðåäñòâåííîå ïîâðåæäåíèå êëåòîê) [44– 46], ïîäàâëÿåò ðåãåíåðàöèþ êëåòîê ýíäîòåëèÿ è ñïîñîáñòâóåò èñòîí÷åíèþ èíòèìû ñîñóäîâ [47], èçìåíÿåò óðîâåíü ïðîöåññîâ ìåòèëèðîâàíèÿ â êëåòêå [48], âåä ̧ò ê èçìåíåíèþ ïðîäóêöèè ýíäîòåëèåì îêñèäà àçîòà (NO) [49].

43
Prichard S. Risk factors for coronary artery disease in patients with renal failure. Am J Med Sci 2003; 325(4): 209–213
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    Ãèïåðãîìîöèñòåèíåìèÿ è ôóíêöèîíàëüíîå ñîñòîÿíèå ýíäîòåëèÿ Ïîâûøåíèå óðîâíÿ Hcy â ïëàçìå êðîâè îêàçûâàåò ïîâðåæäàþùåå äåéñòâèå íà ñòðóêòóðó ñòåíîê ñîñóäîâ è ôóíêöèþ ýíäîòåëèÿ. Hcy ñòèìóëèðóåò ïðîëèôåðàöèþ êóëüòèâèðóåìûõ ãëàäêîìûøå÷íûõ êëåòîê ñîñóäîâ è ñèíòåç èìè êîëëàãåíà
    Exact
    [40–43]
    Suffix
    , âûçûâàåò äèñôóíêöèþ ýíäîòåëèÿ (âêëþ÷àÿ íåïîñðåäñòâåííîå ïîâðåæäåíèå êëåòîê) [44– 46], ïîäàâëÿåò ðåãåíåðàöèþ êëåòîê ýíäîòåëèÿ è ñïîñîáñòâóåò èñòîí÷åíèþ èíòèìû ñîñóäîâ [47], èçìåíÿåò óðîâåíü ïðîöåññîâ ìåòèëèðîâàíèÿ â êëåòêå [48], âåä ̧ò ê èçìåíåíèþ ïðîäóêöèè ýíäîòåëèåì îêñèäà àçîòà (NO) [49].

44
Sierakowska-Fijaіek A, Baj Z, Kaczmarek P, et al. Estimation of relation between homocysteine concentration and selected lipid parameters and adhesion molecules concentration in children with atherosclerosis risk factors. Pol Merkur Lekarski 2008; 25(148): 356–360
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    Prefix
    Ãèïåðãîìîöèñòåèíåìèÿ è ôóíêöèîíàëüíîå ñîñòîÿíèå ýíäîòåëèÿ Ïîâûøåíèå óðîâíÿ Hcy â ïëàçìå êðîâè îêàçûâàåò ïîâðåæäàþùåå äåéñòâèå íà ñòðóêòóðó ñòåíîê ñîñóäîâ è ôóíêöèþ ýíäîòåëèÿ. Hcy ñòèìóëèðóåò ïðîëèôåðàöèþ êóëüòèâèðóåìûõ ãëàäêîìûøå÷íûõ êëåòîê ñîñóäîâ è ñèíòåç èìè êîëëàãåíà [40–43], âûçûâàåò äèñôóíêöèþ ýíäîòåëèÿ (âêëþ÷àÿ íåïîñðåäñòâåííîå ïîâðåæäåíèå êëåòîê)
    Exact
    [44– 46]
    Suffix
    , ïîäàâëÿåò ðåãåíåðàöèþ êëåòîê ýíäîòåëèÿ è ñïîñîáñòâóåò èñòîí÷åíèþ èíòèìû ñîñóäîâ [47], èçìåíÿåò óðîâåíü ïðîöåññîâ ìåòèëèðîâàíèÿ â êëåòêå [48], âåä ̧ò ê èçìåíåíèþ ïðîäóêöèè ýíäîòåëèåì îêñèäà àçîòà (NO) [49].

45
Liang JQ, Wu YL, Xu HB et al. The endothelium injuries caused by homocysteine and treatmental effects of Tongxinluo powder. Zhongguo Ying Yong Sheng Li Xue Za Zhi 2008; 24(1): 66–70
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    Ãèïåðãîìîöèñòåèíåìèÿ è ôóíêöèîíàëüíîå ñîñòîÿíèå ýíäîòåëèÿ Ïîâûøåíèå óðîâíÿ Hcy â ïëàçìå êðîâè îêàçûâàåò ïîâðåæäàþùåå äåéñòâèå íà ñòðóêòóðó ñòåíîê ñîñóäîâ è ôóíêöèþ ýíäîòåëèÿ. Hcy ñòèìóëèðóåò ïðîëèôåðàöèþ êóëüòèâèðóåìûõ ãëàäêîìûøå÷íûõ êëåòîê ñîñóäîâ è ñèíòåç èìè êîëëàãåíà [40–43], âûçûâàåò äèñôóíêöèþ ýíäîòåëèÿ (âêëþ÷àÿ íåïîñðåäñòâåííîå ïîâðåæäåíèå êëåòîê)
    Exact
    [44– 46]
    Suffix
    , ïîäàâëÿåò ðåãåíåðàöèþ êëåòîê ýíäîòåëèÿ è ñïîñîáñòâóåò èñòîí÷åíèþ èíòèìû ñîñóäîâ [47], èçìåíÿåò óðîâåíü ïðîöåññîâ ìåòèëèðîâàíèÿ â êëåòêå [48], âåä ̧ò ê èçìåíåíèþ ïðîäóêöèè ýíäîòåëèåì îêñèäà àçîòà (NO) [49].

46
Weiss N, Keller C, Hoffmann U, et al. Endothelial dysfunction and atherothrombosis in mild hyperhomocysteinemia. Vasc Med 2002; 7(3): 227–239
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    Ãèïåðãîìîöèñòåèíåìèÿ è ôóíêöèîíàëüíîå ñîñòîÿíèå ýíäîòåëèÿ Ïîâûøåíèå óðîâíÿ Hcy â ïëàçìå êðîâè îêàçûâàåò ïîâðåæäàþùåå äåéñòâèå íà ñòðóêòóðó ñòåíîê ñîñóäîâ è ôóíêöèþ ýíäîòåëèÿ. Hcy ñòèìóëèðóåò ïðîëèôåðàöèþ êóëüòèâèðóåìûõ ãëàäêîìûøå÷íûõ êëåòîê ñîñóäîâ è ñèíòåç èìè êîëëàãåíà [40–43], âûçûâàåò äèñôóíêöèþ ýíäîòåëèÿ (âêëþ÷àÿ íåïîñðåäñòâåííîå ïîâðåæäåíèå êëåòîê)
    Exact
    [44– 46]
    Suffix
    , ïîäàâëÿåò ðåãåíåðàöèþ êëåòîê ýíäîòåëèÿ è ñïîñîáñòâóåò èñòîí÷åíèþ èíòèìû ñîñóäîâ [47], èçìåíÿåò óðîâåíü ïðîöåññîâ ìåòèëèðîâàíèÿ â êëåòêå [48], âåä ̧ò ê èçìåíåíèþ ïðîäóêöèè ýíäîòåëèåì îêñèäà àçîòà (NO) [49].

47
Outinen PA, Sood SK, Pfeifer SI, et al. Homocysteine– induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells. Blood 1999; 94(3): 959–967
Total in-text references: 2
  1. In-text reference with the coordinate start=7258
    Prefix
    Hcy ñòèìóëèðóåò ïðîëèôåðàöèþ êóëüòèâèðóåìûõ ãëàäêîìûøå÷íûõ êëåòîê ñîñóäîâ è ñèíòåç èìè êîëëàãåíà [40–43], âûçûâàåò äèñôóíêöèþ ýíäîòåëèÿ (âêëþ÷àÿ íåïîñðåäñòâåííîå ïîâðåæäåíèå êëåòîê) [44– 46], ïîäàâëÿåò ðåãåíåðàöèþ êëåòîê ýíäîòåëèÿ è ñïîñîáñòâóåò èñòîí÷åíèþ èíòèìû ñîñóäîâ
    Exact
    [47]
    Suffix
    , èçìåíÿåò óðîâåíü ïðîöåññîâ ìåòèëèðîâàíèÿ â êëåòêå [48], âåä ̧ò ê èçìåíåíèþ ïðîäóêöèè ýíäîòåëèåì îêñèäà àçîòà (NO) [49]. Èçìåíåíèÿ ñåðäå÷íî-ñîñóäèñòîé ñèñòåìû ïðè ÕÁÏ ìíîãèå èññëåäîâàòåëè ñâÿçûâàþò ñ âëèÿíèåì HHcy íà ôóíêöèîíàëüíîå ñîñòîÿíèå ýíäîòåëèÿ ñîñóäîâ ýòèõ îðãàíîâ è ïðîäóêöèþ ýíäîòåëèàëüíûìè êëåòêàìè îäíîãî èç ñàìûõ ìîùíûõ ýíäîãåííûõ ðåãóëÿòîðîâ ñîñóäèñòîãî òîíóñà – NO [50, 51].

  2. In-text reference with the coordinate start=8379
    Prefix
    ó÷èòûâàëèñü âîçðàñò, ïîë, óðîâåíü àðòåðèàëüíîãî äàâëåíèÿ è õîëåñòåðèíà, èñïîëüçîâàíèå ãèïîòåíçèâíûõ ñðåäñòâ, óðîâåíü ôîëèåâîé êèñëîòû, îòìå÷åíî, ÷òî òîëüêî HHcy áûëà ïðåäèêòîðîì íàðóøåíèÿ ýíäîòåëèàëüíîé äèñôóíêöèè. Àíàëîãè÷íûå äàííûå ïîëó÷åíû è ó ïàöèåíòîâ, íàõîäÿùèõñÿ íà ãåìîäèàëèçå [53]. Ïðåäïîëàãàþò, ÷òî ìåõàíèçì äèñôóíêöèè îáóñëîâëåí òåì, ÷òî Hcy ïîäàâëÿåò ýêñïðåññèþ ôåðìåíòîâ-àíòèîêñèäàíòîâ
    Exact
    [35, 36, 47]
    Suffix
    è íàðóøàåò áèîäîñòóïíîñòü ýíäîòåëèàëüíîé NOS (eNOS), èíãèáèðóÿ àêòèâíîñòü ãëóòàòèîí ïåðîêñèäàçû [54, 55]. Òàêèì îáðàçîì, Hcy ïîâûøàåò ÷óâñòâèòåëüíîñòü êëåòêè ê öèòîòîêñè÷åñêîìó äåéñòâèþ àãåíòîâ è ñîçäà ̧ò áëàãîïðèÿòíûå óñëîâèÿ äëÿ ãåíåðàöèè ñâîáîäíûõ ðàäèêàëîâ êèñëîðîäà.

48
Lee ME, Wang H. Homocysteine and hypomethylation. A novel link to vascular disease. Trends Cardiovasc Med 1999; 9(1-2): 49–54
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  1. In-text reference with the coordinate start=7314
    Prefix
    Hcy ñòèìóëèðóåò ïðîëèôåðàöèþ êóëüòèâèðóåìûõ ãëàäêîìûøå÷íûõ êëåòîê ñîñóäîâ è ñèíòåç èìè êîëëàãåíà [40–43], âûçûâàåò äèñôóíêöèþ ýíäîòåëèÿ (âêëþ÷àÿ íåïîñðåäñòâåííîå ïîâðåæäåíèå êëåòîê) [44– 46], ïîäàâëÿåò ðåãåíåðàöèþ êëåòîê ýíäîòåëèÿ è ñïîñîáñòâóåò èñòîí÷åíèþ èíòèìû ñîñóäîâ [47], èçìåíÿåò óðîâåíü ïðîöåññîâ ìåòèëèðîâàíèÿ â êëåòêå
    Exact
    [48]
    Suffix
    , âåä ̧ò ê èçìåíåíèþ ïðîäóêöèè ýíäîòåëèåì îêñèäà àçîòà (NO) [49]. Èçìåíåíèÿ ñåðäå÷íî-ñîñóäèñòîé ñèñòåìû ïðè ÕÁÏ ìíîãèå èññëåäîâàòåëè ñâÿçûâàþò ñ âëèÿíèåì HHcy íà ôóíêöèîíàëüíîå ñîñòîÿíèå ýíäîòåëèÿ ñîñóäîâ ýòèõ îðãàíîâ è ïðîäóêöèþ ýíäîòåëèàëüíûìè êëåòêàìè îäíîãî èç ñàìûõ ìîùíûõ ýíäîãåííûõ ðåãóëÿòîðîâ ñîñóäèñòîãî òîíóñà – NO [50, 51].

49
Tyagi SC, Smiley LM, Mujumdar VS. Homocyst(e)ine impairs endocardial endothelial function. Can J Physiol Pharmacol 1999; 77(12): 950–957
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  1. In-text reference with the coordinate start=7377
    Prefix
    Hcy ñòèìóëèðóåò ïðîëèôåðàöèþ êóëüòèâèðóåìûõ ãëàäêîìûøå÷íûõ êëåòîê ñîñóäîâ è ñèíòåç èìè êîëëàãåíà [40–43], âûçûâàåò äèñôóíêöèþ ýíäîòåëèÿ (âêëþ÷àÿ íåïîñðåäñòâåííîå ïîâðåæäåíèå êëåòîê) [44– 46], ïîäàâëÿåò ðåãåíåðàöèþ êëåòîê ýíäîòåëèÿ è ñïîñîáñòâóåò èñòîí÷åíèþ èíòèìû ñîñóäîâ [47], èçìåíÿåò óðîâåíü ïðîöåññîâ ìåòèëèðîâàíèÿ â êëåòêå [48], âåä ̧ò ê èçìåíåíèþ ïðîäóêöèè ýíäîòåëèåì îêñèäà àçîòà (NO)
    Exact
    [49]
    Suffix
    . Èçìåíåíèÿ ñåðäå÷íî-ñîñóäèñòîé ñèñòåìû ïðè ÕÁÏ ìíîãèå èññëåäîâàòåëè ñâÿçûâàþò ñ âëèÿíèåì HHcy íà ôóíêöèîíàëüíîå ñîñòîÿíèå ýíäîòåëèÿ ñîñóäîâ ýòèõ îðãàíîâ è ïðîäóêöèþ ýíäîòåëèàëüíûìè êëåòêàìè îäíîãî èç ñàìûõ ìîùíûõ ýíäîãåííûõ ðåãóëÿòîðîâ ñîñóäèñòîãî òîíóñà – NO [50, 51].

50
Upchurch GR, Welch GN, Fabian AJ, et al. Stimulation of endothelial nitric oxide production by homocyst(e)ine. Atherosclerosis 1997; 132: 177–185
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  1. In-text reference with the coordinate start=7642
    Prefix
    Èçìåíåíèÿ ñåðäå÷íî-ñîñóäèñòîé ñèñòåìû ïðè ÕÁÏ ìíîãèå èññëåäîâàòåëè ñâÿçûâàþò ñ âëèÿíèåì HHcy íà ôóíêöèîíàëüíîå ñîñòîÿíèå ýíäîòåëèÿ ñîñóäîâ ýòèõ îðãàíîâ è ïðîäóêöèþ ýíäîòåëèàëüíûìè êëåòêàìè îäíîãî èç ñàìûõ ìîùíûõ ýíäîãåííûõ ðåãóëÿòîðîâ ñîñóäèñòîãî òîíóñà – NO
    Exact
    [50, 51]
    Suffix
    . À. Tawakol è ñîàâò. [52] èçó÷àëè ñîñòîÿíèå ýíäîòåëèé-çàâèñèìîé è ýíäîòåëèé-íåçàâèñèìîé âàçîäèëàòàöèè ó âçðîñëûõ ñ HHcy (>16ìêìîëü/ë). Ýíäîòåëèé-çàâèñèìàÿ âàçîäèëàòàöèÿ áûëà çíà÷èòåëüíî ñíèæåíà ó áîëüíûõ ñ ïîâûøåííûì óðîâíåì Hcy, ýíäîòåëèé-íåçàâèñèìàÿ – íå îòëè÷àëàñü îò ïîêàçàòåëåé â êîíòðîëüíîé ãðóïïå.

51
Tyagi N, Gillespie W, Vacek JC, et al. Activation of GABA–A receptor ameliorates homocysteine-induced MMP-9 activation by ERK pathway. J Cell Physiol 2009; 220: 57–266
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    Prefix
    Èçìåíåíèÿ ñåðäå÷íî-ñîñóäèñòîé ñèñòåìû ïðè ÕÁÏ ìíîãèå èññëåäîâàòåëè ñâÿçûâàþò ñ âëèÿíèåì HHcy íà ôóíêöèîíàëüíîå ñîñòîÿíèå ýíäîòåëèÿ ñîñóäîâ ýòèõ îðãàíîâ è ïðîäóêöèþ ýíäîòåëèàëüíûìè êëåòêàìè îäíîãî èç ñàìûõ ìîùíûõ ýíäîãåííûõ ðåãóëÿòîðîâ ñîñóäèñòîãî òîíóñà – NO
    Exact
    [50, 51]
    Suffix
    . À. Tawakol è ñîàâò. [52] èçó÷àëè ñîñòîÿíèå ýíäîòåëèé-çàâèñèìîé è ýíäîòåëèé-íåçàâèñèìîé âàçîäèëàòàöèè ó âçðîñëûõ ñ HHcy (>16ìêìîëü/ë). Ýíäîòåëèé-çàâèñèìàÿ âàçîäèëàòàöèÿ áûëà çíà÷èòåëüíî ñíèæåíà ó áîëüíûõ ñ ïîâûøåííûì óðîâíåì Hcy, ýíäîòåëèé-íåçàâèñèìàÿ – íå îòëè÷àëàñü îò ïîêàçàòåëåé â êîíòðîëüíîé ãðóïïå.

52
Tawakol A, Omland T, Gerhard M, еt al. Hyperhomocysteinemia is associated with impaired endothelium-dependent vasodilation in humans. Circulation 1997; 95: 1119–1121
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    Èçìåíåíèÿ ñåðäå÷íî-ñîñóäèñòîé ñèñòåìû ïðè ÕÁÏ ìíîãèå èññëåäîâàòåëè ñâÿçûâàþò ñ âëèÿíèåì HHcy íà ôóíêöèîíàëüíîå ñîñòîÿíèå ýíäîòåëèÿ ñîñóäîâ ýòèõ îðãàíîâ è ïðîäóêöèþ ýíäîòåëèàëüíûìè êëåòêàìè îäíîãî èç ñàìûõ ìîùíûõ ýíäîãåííûõ ðåãóëÿòîðîâ ñîñóäèñòîãî òîíóñà – NO [50, 51]. À. Tawakol è ñîàâò.
    Exact
    [52]
    Suffix
    èçó÷àëè ñîñòîÿíèå ýíäîòåëèé-çàâèñèìîé è ýíäîòåëèé-íåçàâèñèìîé âàçîäèëàòàöèè ó âçðîñëûõ ñ HHcy (>16ìêìîëü/ë). Ýíäîòåëèé-çàâèñèìàÿ âàçîäèëàòàöèÿ áûëà çíà÷èòåëüíî ñíèæåíà ó áîëüíûõ ñ ïîâûøåííûì óðîâíåì Hcy, ýíäîòåëèé-íåçàâèñèìàÿ – íå îòëè÷àëàñü îò ïîêàçàòåëåé â êîíòðîëüíîé ãðóïïå.

53
Buccianti G, Raselli S, Baragetti I, et al. 5methyltetrahydrofolate restores endothelial function in uraemic patients on convective haemodialysis. Nephrol Dial Transplant 2002; 17(5): 857–864
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  1. In-text reference with the coordinate start=8267
    Prefix
    Õîòÿ, êðîìå óðîâíÿ Hcy, ó÷èòûâàëèñü âîçðàñò, ïîë, óðîâåíü àðòåðèàëüíîãî äàâëåíèÿ è õîëåñòåðèíà, èñïîëüçîâàíèå ãèïîòåíçèâíûõ ñðåäñòâ, óðîâåíü ôîëèåâîé êèñëîòû, îòìå÷åíî, ÷òî òîëüêî HHcy áûëà ïðåäèêòîðîì íàðóøåíèÿ ýíäîòåëèàëüíîé äèñôóíêöèè. Àíàëîãè÷íûå äàííûå ïîëó÷åíû è ó ïàöèåíòîâ, íàõîäÿùèõñÿ íà ãåìîäèàëèçå
    Exact
    [53]
    Suffix
    . Ïðåäïîëàãàþò, ÷òî ìåõàíèçì äèñôóíêöèè îáóñëîâëåí òåì, ÷òî Hcy ïîäàâëÿåò ýêñïðåññèþ ôåðìåíòîâ-àíòèîêñèäàíòîâ [35, 36, 47] è íàðóøàåò áèîäîñòóïíîñòü ýíäîòåëèàëüíîé NOS (eNOS), èíãèáèðóÿ àêòèâíîñòü ãëóòàòèîí ïåðîêñèäàçû [54, 55].

  2. In-text reference with the coordinate start=18570
    Prefix
    Äèñêóòèðóåòñÿ òàêæå ýôôåêòèâíîñòü ïðèìåíåíèÿ ôîëèåâîé êèñëîòû äëÿ êîððåêöèè HHcy. Ìíîãèìè àâòîðàìè ïîääåðæèâàåòñÿ íàçíà÷åíèå ôîëèåâîé êèñëîòû â äîçå, çíà÷èòåëüíî ïðåâûøàþùåé ñòàíäàðòíóþ ëå÷åáíóþ
    Exact
    [53, 115, 116]
    Suffix
    . Ó ëèö ñ ñîõðàíåííîé ôóíêöèåé ïî÷åê ïðèìåíåíèå â äîçå 0,4– 0,5 ìã/ñóò ïðèâîäèò ê ñòîéêîìó ñíèæåíèþ óðîâíÿ Hcy [10, 15, 117]. G. Buccianti è ñîàâò. [53] íàçíà÷àëè ïàöèåíòàì íà ãåìîäèàëèçå 5-ìåòèë-THF â òå÷åíèå 10 íåä. ïî 45 ìã/íåä âíóòðèâåííî, ïîñëåäíèå 2 íåä êîìáèíèðóÿ ñ 500 ìêã âèòàìèíà Â12 (ïîäêîæíî 2 ðàçà/íåä).

  3. In-text reference with the coordinate start=18730
    Prefix
    Ìíîãèìè àâòîðàìè ïîääåðæèâàåòñÿ íàçíà÷åíèå ôîëèåâîé êèñëîòû â äîçå, çíà÷èòåëüíî ïðåâûøàþùåé ñòàíäàðòíóþ ëå÷åáíóþ [53, 115, 116]. Ó ëèö ñ ñîõðàíåííîé ôóíêöèåé ïî÷åê ïðèìåíåíèå â äîçå 0,4– 0,5 ìã/ñóò ïðèâîäèò ê ñòîéêîìó ñíèæåíèþ óðîâíÿ Hcy [10, 15, 117]. G. Buccianti è ñîàâò.
    Exact
    [53]
    Suffix
    íàçíà÷àëè ïàöèåíòàì íà ãåìîäèàëèçå 5-ìåòèë-THF â òå÷åíèå 10 íåä. ïî 45 ìã/íåä âíóòðèâåííî, ïîñëåäíèå 2 íåä êîìáèíèðóÿ ñ 500 ìêã âèòàìèíà Â12 (ïîäêîæíî 2 ðàçà/íåä). Óðîâåíü Hcy ñíèçèëñÿ íà 47% ïîñëå ââåäåíèÿ ôîëàòà è åùå íà 13,6% ïîñëå äîáàâëåíèÿ âèòàìèíà Â12.

54
Upchurch GR, Welch GN, Randev N, et al. The effect of homocysteine on endothelial nitric oxide production. FASEB J 1995; 9: A876. Abstract
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  1. In-text reference with the coordinate start=8487
    Prefix
    Ïðåäïîëàãàþò, ÷òî ìåõàíèçì äèñôóíêöèè îáóñëîâëåí òåì, ÷òî Hcy ïîäàâëÿåò ýêñïðåññèþ ôåðìåíòîâ-àíòèîêñèäàíòîâ [35, 36, 47] è íàðóøàåò áèîäîñòóïíîñòü ýíäîòåëèàëüíîé NOS (eNOS), èíãèáèðóÿ àêòèâíîñòü ãëóòàòèîí ïåðîêñèäàçû
    Exact
    [54, 55]
    Suffix
    . Òàêèì îáðàçîì, Hcy ïîâûøàåò ÷óâñòâèòåëüíîñòü êëåòêè ê öèòîòîêñè÷åñêîìó äåéñòâèþ àãåíòîâ è ñîçäà ̧ò áëàãîïðèÿòíûå óñëîâèÿ äëÿ ãåíåðàöèè ñâîáîäíûõ ðàäèêàëîâ êèñëîðîäà. Ïðè ýòîì ñòîèò îáðàòèòü âíèìàíèå, ÷òî åñòü çíà÷èòåëüíàÿ ðàçíèöà â óðîâíÿõ íàðàáîòêè è ëîêàëèçàöèè NO, ñèíòåçèðóåìûõ ðàçíûìè NOS.

55
Huang RF, Hsu YC, Lin HL, et al. Folate depletion and elevated plasma homocysteine promote oxidative stress in rat livers. J Nutr 2001; 131(1): 33–38
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  1. In-text reference with the coordinate start=8487
    Prefix
    Ïðåäïîëàãàþò, ÷òî ìåõàíèçì äèñôóíêöèè îáóñëîâëåí òåì, ÷òî Hcy ïîäàâëÿåò ýêñïðåññèþ ôåðìåíòîâ-àíòèîêñèäàíòîâ [35, 36, 47] è íàðóøàåò áèîäîñòóïíîñòü ýíäîòåëèàëüíîé NOS (eNOS), èíãèáèðóÿ àêòèâíîñòü ãëóòàòèîí ïåðîêñèäàçû
    Exact
    [54, 55]
    Suffix
    . Òàêèì îáðàçîì, Hcy ïîâûøàåò ÷óâñòâèòåëüíîñòü êëåòêè ê öèòîòîêñè÷åñêîìó äåéñòâèþ àãåíòîâ è ñîçäà ̧ò áëàãîïðèÿòíûå óñëîâèÿ äëÿ ãåíåðàöèè ñâîáîäíûõ ðàäèêàëîâ êèñëîðîäà. Ïðè ýòîì ñòîèò îáðàòèòü âíèìàíèå, ÷òî åñòü çíà÷èòåëüíàÿ ðàçíèöà â óðîâíÿõ íàðàáîòêè è ëîêàëèçàöèè NO, ñèíòåçèðóåìûõ ðàçíûìè NOS.

56
Cattell V. Nitric oxide and glomerulonephritis. Kidney Int 2002; 61(3): 816–821
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  1. In-text reference with the coordinate start=9090
    Prefix
    È åñëè eNOS ôóíêöèîíèðóåò â ýíäîòåëèàëüíûõ êëåòêàõ (ñîñóäèñòûé êîíòðîëü), òî ýêñïðåññèÿ èíäóöèáåëüíîé NO-ñèíòàçû (iNOS) ñî çíà÷èòåëüíûì ðîñòîì ñèíòåçà NO íàáëþäàåòñÿ â ìåçàíãèàëüíûõ êëåòêàõ, ÷òî îòìå÷åíî ïðè ìîäåëèðîâàíèè ãëîìåðóëîíåôðèòà ó æèâîòíûõ
    Exact
    [56]
    Suffix
    . Ââåäåíèå æèâîòíûì èíãèáèòîðîâ eNOS [(ω-NG,NG-àñèììåòðè÷íûé äèìåòèëàðãèíèí (aDMA) è ω-NG-ìîíîìåòèë-L-àðãèíèí (L-NMMA)] óñóãóáëÿëî êëèíèêî-ëàáîðàòîðíûå ïðîÿâëåíèÿ çàáîëåâàíèÿ, ÷òî ãîâîðèò î íåêîòîðîì çàùèòíîì ýôôåêòå NO ïðè ïîâðåæäåíèè ãëîìåðóë [57–61].

57
Ishizuka S, Cunard R, Poucell-Hatton S, et al. Agmatine inhibits cell proliferation and improves renal function in antithy-1 glomerulonephritis. J Am Soc Nephrol 2000; 11(12): 2256– 2264
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  1. In-text reference with the coordinate start=9337
    Prefix
    Ââåäåíèå æèâîòíûì èíãèáèòîðîâ eNOS [(ω-NG,NG-àñèììåòðè÷íûé äèìåòèëàðãèíèí (aDMA) è ω-NG-ìîíîìåòèë-L-àðãèíèí (L-NMMA)] óñóãóáëÿëî êëèíèêî-ëàáîðàòîðíûå ïðîÿâëåíèÿ çàáîëåâàíèÿ, ÷òî ãîâîðèò î íåêîòîðîì çàùèòíîì ýôôåêòå NO ïðè ïîâðåæäåíèè ãëîìåðóë
    Exact
    [57–61]
    Suffix
    .  ðåçóëüòàòå õðîíè÷åñêîãî ñíèæåíèÿ áèîäîñòóïíîñòè NO è àêòèâàöèè ñèíòåçà ñâîáîäíûõ ðàäèêàëîâ êèñëîðîäà (ROS) ó ýêñïåðèìåíòàëüíûõ ìûøåé â òêàíè ïî÷åê (â ýíäîòåëèàëüíûõ êëåòêàõ ñîñóäîâ) îòìå÷àëîñü ðàçðàñòàíèå êîìïîíåíòîâ èíòåðñòèöèàëüíîãî ìàòðèêñà, ïîâûøåíèå àêòèâíîñòè èíòåðñòèöèàëüíûõ ôèáðîáëàñòîâ è íàêîïëåíèå èìè ëèïîôóñöèíà, îòñëîåíèå ýíäîòåëèàëüíûõ êëåòîê îò áàçàëüíîé ìåìáðàíû, å ̧ ðàññëàèâàíè

58
Stoessel A, Paliege A, Theilig F, et al. Indolent course of tubulointerstitial disease in a mouse model of subpressor, lowdose nitric oxide synthase inhibition. Am J Physiol Renal Physiol 2008; 295(3): F717–725
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  1. In-text reference with the coordinate start=9337
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    Ââåäåíèå æèâîòíûì èíãèáèòîðîâ eNOS [(ω-NG,NG-àñèììåòðè÷íûé äèìåòèëàðãèíèí (aDMA) è ω-NG-ìîíîìåòèë-L-àðãèíèí (L-NMMA)] óñóãóáëÿëî êëèíèêî-ëàáîðàòîðíûå ïðîÿâëåíèÿ çàáîëåâàíèÿ, ÷òî ãîâîðèò î íåêîòîðîì çàùèòíîì ýôôåêòå NO ïðè ïîâðåæäåíèè ãëîìåðóë
    Exact
    [57–61]
    Suffix
    .  ðåçóëüòàòå õðîíè÷åñêîãî ñíèæåíèÿ áèîäîñòóïíîñòè NO è àêòèâàöèè ñèíòåçà ñâîáîäíûõ ðàäèêàëîâ êèñëîðîäà (ROS) ó ýêñïåðèìåíòàëüíûõ ìûøåé â òêàíè ïî÷åê (â ýíäîòåëèàëüíûõ êëåòêàõ ñîñóäîâ) îòìå÷àëîñü ðàçðàñòàíèå êîìïîíåíòîâ èíòåðñòèöèàëüíîãî ìàòðèêñà, ïîâûøåíèå àêòèâíîñòè èíòåðñòèöèàëüíûõ ôèáðîáëàñòîâ è íàêîïëåíèå èìè ëèïîôóñöèíà, îòñëîåíèå ýíäîòåëèàëüíûõ êëåòîê îò áàçàëüíîé ìåìáðàíû, å ̧ ðàññëàèâàíè

59
O’Riordan E, Mendelev N, Patschan S, et al. Chronic NOS inhibition actuates endothelial-mesenchymal transformation. Am J Physiol Heart Circ Physiol 2007; 292(1): H285–294
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  1. In-text reference with the coordinate start=9337
    Prefix
    Ââåäåíèå æèâîòíûì èíãèáèòîðîâ eNOS [(ω-NG,NG-àñèììåòðè÷íûé äèìåòèëàðãèíèí (aDMA) è ω-NG-ìîíîìåòèë-L-àðãèíèí (L-NMMA)] óñóãóáëÿëî êëèíèêî-ëàáîðàòîðíûå ïðîÿâëåíèÿ çàáîëåâàíèÿ, ÷òî ãîâîðèò î íåêîòîðîì çàùèòíîì ýôôåêòå NO ïðè ïîâðåæäåíèè ãëîìåðóë
    Exact
    [57–61]
    Suffix
    .  ðåçóëüòàòå õðîíè÷åñêîãî ñíèæåíèÿ áèîäîñòóïíîñòè NO è àêòèâàöèè ñèíòåçà ñâîáîäíûõ ðàäèêàëîâ êèñëîðîäà (ROS) ó ýêñïåðèìåíòàëüíûõ ìûøåé â òêàíè ïî÷åê (â ýíäîòåëèàëüíûõ êëåòêàõ ñîñóäîâ) îòìå÷àëîñü ðàçðàñòàíèå êîìïîíåíòîâ èíòåðñòèöèàëüíîãî ìàòðèêñà, ïîâûøåíèå àêòèâíîñòè èíòåðñòèöèàëüíûõ ôèáðîáëàñòîâ è íàêîïëåíèå èìè ëèïîôóñöèíà, îòñëîåíèå ýíäîòåëèàëüíûõ êëåòîê îò áàçàëüíîé ìåìáðàíû, å ̧ ðàññëàèâàíè

60
Addabbo F, Ratliff B, Park HC, et al. The Krebs cycle and mitochondrial mass are early victims of endothelial dysfunction: proteomic approach. Am J Pathol 2009; 174(1): 34–43
Total in-text references: 1
  1. In-text reference with the coordinate start=9337
    Prefix
    Ââåäåíèå æèâîòíûì èíãèáèòîðîâ eNOS [(ω-NG,NG-àñèììåòðè÷íûé äèìåòèëàðãèíèí (aDMA) è ω-NG-ìîíîìåòèë-L-àðãèíèí (L-NMMA)] óñóãóáëÿëî êëèíèêî-ëàáîðàòîðíûå ïðîÿâëåíèÿ çàáîëåâàíèÿ, ÷òî ãîâîðèò î íåêîòîðîì çàùèòíîì ýôôåêòå NO ïðè ïîâðåæäåíèè ãëîìåðóë
    Exact
    [57–61]
    Suffix
    .  ðåçóëüòàòå õðîíè÷åñêîãî ñíèæåíèÿ áèîäîñòóïíîñòè NO è àêòèâàöèè ñèíòåçà ñâîáîäíûõ ðàäèêàëîâ êèñëîðîäà (ROS) ó ýêñïåðèìåíòàëüíûõ ìûøåé â òêàíè ïî÷åê (â ýíäîòåëèàëüíûõ êëåòêàõ ñîñóäîâ) îòìå÷àëîñü ðàçðàñòàíèå êîìïîíåíòîâ èíòåðñòèöèàëüíîãî ìàòðèêñà, ïîâûøåíèå àêòèâíîñòè èíòåðñòèöèàëüíûõ ôèáðîáëàñòîâ è íàêîïëåíèå èìè ëèïîôóñöèíà, îòñëîåíèå ýíäîòåëèàëüíûõ êëåòîê îò áàçàëüíîé ìåìáðàíû, å ̧ ðàññëàèâàíè

61
Antoniades C, Shirodaria C, Leeson P, et al. Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis. Eur Heart J 2009; 30(9):1142–1150
Total in-text references: 1
  1. In-text reference with the coordinate start=9337
    Prefix
    Ââåäåíèå æèâîòíûì èíãèáèòîðîâ eNOS [(ω-NG,NG-àñèììåòðè÷íûé äèìåòèëàðãèíèí (aDMA) è ω-NG-ìîíîìåòèë-L-àðãèíèí (L-NMMA)] óñóãóáëÿëî êëèíèêî-ëàáîðàòîðíûå ïðîÿâëåíèÿ çàáîëåâàíèÿ, ÷òî ãîâîðèò î íåêîòîðîì çàùèòíîì ýôôåêòå NO ïðè ïîâðåæäåíèè ãëîìåðóë
    Exact
    [57–61]
    Suffix
    .  ðåçóëüòàòå õðîíè÷åñêîãî ñíèæåíèÿ áèîäîñòóïíîñòè NO è àêòèâàöèè ñèíòåçà ñâîáîäíûõ ðàäèêàëîâ êèñëîðîäà (ROS) ó ýêñïåðèìåíòàëüíûõ ìûøåé â òêàíè ïî÷åê (â ýíäîòåëèàëüíûõ êëåòêàõ ñîñóäîâ) îòìå÷àëîñü ðàçðàñòàíèå êîìïîíåíòîâ èíòåðñòèöèàëüíîãî ìàòðèêñà, ïîâûøåíèå àêòèâíîñòè èíòåðñòèöèàëüíûõ ôèáðîáëàñòîâ è íàêîïëåíèå èìè ëèïîôóñöèíà, îòñëîåíèå ýíäîòåëèàëüíûõ êëåòîê îò áàçàëüíîé ìåìáðàíû, å ̧ ðàññëàèâàíè

62
Stühlinger MC, Tsao PS, Her JH, Kimoto M et al. Homocysteine impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine. Circulation 2001; 104(21): 2569-2575
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    Prefix
     ðåçóëüòàòå ðåàêöèè îáðàçóåòñÿ S-àäåíîçèëãîìîöèñòåèí (S-AH), êîòîðûé ðàñïàäàåòñÿ äî àäåíîçèíà è Hcy. Íàêîïëåíèå Hcy ïðè ïðîòåêàíèè ìåòèëòðàíñôåðàçíûõ ðåàêöèé âåäåò ê HHcy. Íåêîòîðûå èññëåäîâàòåëè, íàïðèìåð, ñ÷èòàþò, ÷òî ïàòîãåííûé ýôôåêò Hcy ñâÿçàí ñ åãî âëèÿíèåì íà óðîâåíü aDMA
    Exact
    [62, 63]
    Suffix
    .  îïûòàõ in vitro Hcy ñíèæàë âûðàáîòêó ýíäîòåëèîöèòàìè ñîñóäîâ NO è ïðè ýòîì ïîâûøàë óðîâåíü èíãèáèòîðà NOS – aDMA [64]. Ðàñïàä aDMA è L-NMMA ïðîèñõîäèò ïðè ó÷àñòèè Zn(II)-ñîäåðæàùåãî ôåðìåíòà NG, NG-äèìåòèëàðãèíèí äèìåòèëàìèíîãèäðîëàçû (DDAH).

  2. In-text reference with the coordinate start=11098
    Prefix
    Íàïðèìåð, àêòèâíîñòü ôåðìåíòà ñíèæàåòñÿ ïðè ãèïîêñèè ëþáîé ýòèîëîãèè, HHcy, ãèïåðõîëåñòåðèíåìèè, ñàõàðíîì äèàáåòå, â ïðèñóòñòâèè ôàêòîðà íåêðîçà îïóõîëåé α (TNF-α), îêñèäàòèâíîì ñòðåññå è íàêîïëåíèè îêèñëåííûõ ëèïîïðîòåèäîâ íèçêîé ïëîòíîñòè (ox-LDL), ÷òî ïðèâîäèò ê íàêîïëåíèþ aDMA â ïëàçìå êðîâè
    Exact
    [62, 66–68]
    Suffix
    . Ýêñïåðèìåíòàëüíî äîêàçàíî, ÷òî ââåäåíèå êðûñàì Hcy (10 ìã/ñóò â/â, â òå÷åíèå 4 íåä) ïîâûøàåò óðîâåíü aDMA â ïëàçìå êðîâè æèâîòíûõ â 2 ðàçà [69]. Ïðè ýòîì ïîêàçàíî, ÷òî Hcy ñïîñîáåí äîçîçàâèñèìî èíãèáèðîâàòü DDAH [62].

  3. In-text reference with the coordinate start=11322
    Prefix
    Ýêñïåðèìåíòàëüíî äîêàçàíî, ÷òî ââåäåíèå êðûñàì Hcy (10 ìã/ñóò â/â, â òå÷åíèå 4 íåä) ïîâûøàåò óðîâåíü aDMA â ïëàçìå êðîâè æèâîòíûõ â 2 ðàçà [69]. Ïðè ýòîì ïîêàçàíî, ÷òî Hcy ñïîñîáåí äîçîçàâèñèìî èíãèáèðîâàòü DDAH
    Exact
    [62]
    Suffix
    . Òàê, îñòðîå ââåäåíèå Hcy ïîâûøàåò óðîâåíü aDMA, à õðîíè÷åñêàÿ HHcy êîìïåíñèðóåò èçìåíåíèå óðîâíÿ aDMA, õîòÿ ìåõàíèçìû êîìïåíñàöèè åùå íå óñòàíîâëåíû [70].  ýêñïåðèìåíòàõ áûëî ïîêàçàíî, ÷òî ïîâûøåíèå óðîâíÿ Hcy ïðîèñõîäèò òàêæå ïðè ïåðîðàëüíîé íàãðóçêå ìåòèîíèíîì (100 ìã/êã), íî ïîëó÷åííûå ïðè ýòîì èçìåíåíèÿ óðîâíÿ aDMA áûëè ñòàòèñòè÷åñêè íåäîñòîâåðíû [66, 71].

63
Lentz SR, Rodionov RN, Dayal S. Hyperhomocysteinemia, endothelial dysfunction, and cardiovascular risk: the potential role of ADMA. Atheroscler Suppl 2003; 4(4): 61–65
Total in-text references: 1
  1. In-text reference with the coordinate start=10260
    Prefix
     ðåçóëüòàòå ðåàêöèè îáðàçóåòñÿ S-àäåíîçèëãîìîöèñòåèí (S-AH), êîòîðûé ðàñïàäàåòñÿ äî àäåíîçèíà è Hcy. Íàêîïëåíèå Hcy ïðè ïðîòåêàíèè ìåòèëòðàíñôåðàçíûõ ðåàêöèé âåäåò ê HHcy. Íåêîòîðûå èññëåäîâàòåëè, íàïðèìåð, ñ÷èòàþò, ÷òî ïàòîãåííûé ýôôåêò Hcy ñâÿçàí ñ åãî âëèÿíèåì íà óðîâåíü aDMA
    Exact
    [62, 63]
    Suffix
    .  îïûòàõ in vitro Hcy ñíèæàë âûðàáîòêó ýíäîòåëèîöèòàìè ñîñóäîâ NO è ïðè ýòîì ïîâûøàë óðîâåíü èíãèáèòîðà NOS – aDMA [64]. Ðàñïàä aDMA è L-NMMA ïðîèñõîäèò ïðè ó÷àñòèè Zn(II)-ñîäåðæàùåãî ôåðìåíòà NG, NG-äèìåòèëàðãèíèí äèìåòèëàìèíîãèäðîëàçû (DDAH).

64
Qureshi I, Chen H, Brown AT, et al. Homocysteineinduced vascular dysregulation is mediated by the NMDA receptor. Vasc Med 2005; 10(3): 215–223
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  1. In-text reference with the coordinate start=10385
    Prefix
    Íåêîòîðûå èññëåäîâàòåëè, íàïðèìåð, ñ÷èòàþò, ÷òî ïàòîãåííûé ýôôåêò Hcy ñâÿçàí ñ åãî âëèÿíèåì íà óðîâåíü aDMA [62, 63].  îïûòàõ in vitro Hcy ñíèæàë âûðàáîòêó ýíäîòåëèîöèòàìè ñîñóäîâ NO è ïðè ýòîì ïîâûøàë óðîâåíü èíãèáèòîðà NOS – aDMA
    Exact
    [64]
    Suffix
    . Ðàñïàä aDMA è L-NMMA ïðîèñõîäèò ïðè ó÷àñòèè Zn(II)-ñîäåðæàùåãî ôåðìåíòà NG, NG-äèìåòèëàðãèíèí äèìåòèëàìèíîãèäðîëàçû (DDAH).  ïî÷êàõ íàáëþäàåòñÿ ñïåöèôè÷åñêîå ðàñïðåäåëåíèå àêòèâíîñòè DDAH, ÷òî ïîçâîëÿåò äèôôåðåíöèðîâàííî ðåãóëèðîâàòü ïðîñâåò àôôåðåíòíûõ è ýôôåðåíòíûõ àðòåðèé [65].

65
Onozato ML, Tojo A, Leiper J, et al. Expression of NG, NG-dimethylarginine dimethylaminohydrolase and protein arginine N-methyltransferase isoforms in diabetic rat kidney: effects of angiotensin II receptor blockers. Diabetes 2008; 57(1): 172–180
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  1. In-text reference with the coordinate start=10669
    Prefix
    Ðàñïàä aDMA è L-NMMA ïðîèñõîäèò ïðè ó÷àñòèè Zn(II)-ñîäåðæàùåãî ôåðìåíòà NG, NG-äèìåòèëàðãèíèí äèìåòèëàìèíîãèäðîëàçû (DDAH).  ïî÷êàõ íàáëþäàåòñÿ ñïåöèôè÷åñêîå ðàñïðåäåëåíèå àêòèâíîñòè DDAH, ÷òî ïîçâîëÿåò äèôôåðåíöèðîâàííî ðåãóëèðîâàòü ïðîñâåò àôôåðåíòíûõ è ýôôåðåíòíûõ àðòåðèé
    Exact
    [65]
    Suffix
    . Ñëåäîâàòåëüíî, íàðóøåíèå àêòèâíîñòè DDAH ìîæåò ïðèíèìàòü ó÷àñòèå â ðàçâèòèè öåëîãî ðÿäà ïàòîëîãè÷åñêèõ ïðîöåññîâ. Íàïðèìåð, àêòèâíîñòü ôåðìåíòà ñíèæàåòñÿ ïðè ãèïîêñèè ëþáîé ýòèîëîãèè, HHcy, ãèïåðõîëåñòåðèíåìèè, ñàõàðíîì äèàáåòå, â ïðèñóòñòâèè ôàêòîðà íåêðîçà îïóõîëåé α (TNF-α), îêñèäàòèâíîì ñòðåññå è íàêîïëåíèè îêèñëåííûõ ëèïîïðîòåèäîâ íèçêîé ïëîòíîñòè (ox-LDL), ÷òî ïðèâîäèò ê íàêîïëåíèþ aD

66
Dayal S, Rodionov RN, Arning E, et al. Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia. Am J Physiol Heart Circ Physiol 2008; 295(2): H816–H825
Total in-text references: 2
  1. In-text reference with the coordinate start=11098
    Prefix
    Íàïðèìåð, àêòèâíîñòü ôåðìåíòà ñíèæàåòñÿ ïðè ãèïîêñèè ëþáîé ýòèîëîãèè, HHcy, ãèïåðõîëåñòåðèíåìèè, ñàõàðíîì äèàáåòå, â ïðèñóòñòâèè ôàêòîðà íåêðîçà îïóõîëåé α (TNF-α), îêñèäàòèâíîì ñòðåññå è íàêîïëåíèè îêèñëåííûõ ëèïîïðîòåèäîâ íèçêîé ïëîòíîñòè (ox-LDL), ÷òî ïðèâîäèò ê íàêîïëåíèþ aDMA â ïëàçìå êðîâè
    Exact
    [62, 66–68]
    Suffix
    . Ýêñïåðèìåíòàëüíî äîêàçàíî, ÷òî ââåäåíèå êðûñàì Hcy (10 ìã/ñóò â/â, â òå÷åíèå 4 íåä) ïîâûøàåò óðîâåíü aDMA â ïëàçìå êðîâè æèâîòíûõ â 2 ðàçà [69]. Ïðè ýòîì ïîêàçàíî, ÷òî Hcy ñïîñîáåí äîçîçàâèñèìî èíãèáèðîâàòü DDAH [62].

  2. In-text reference with the coordinate start=11678
    Prefix
    Òàê, îñòðîå ââåäåíèå Hcy ïîâûøàåò óðîâåíü aDMA, à õðîíè÷åñêàÿ HHcy êîìïåíñèðóåò èçìåíåíèå óðîâíÿ aDMA, õîòÿ ìåõàíèçìû êîìïåíñàöèè åùå íå óñòàíîâëåíû [70].  ýêñïåðèìåíòàõ áûëî ïîêàçàíî, ÷òî ïîâûøåíèå óðîâíÿ Hcy ïðîèñõîäèò òàêæå ïðè ïåðîðàëüíîé íàãðóçêå ìåòèîíèíîì (100 ìã/êã), íî ïîëó÷åííûå ïðè ýòîì èçìåíåíèÿ óðîâíÿ aDMA áûëè ñòàòèñòè÷åñêè íåäîñòîâåðíû
    Exact
    [66, 71]
    Suffix
    . Èçáûòîê Hcy â ñîñóäèñòîì ðóñëå ïðèâîäèò ê íàðóøåíèþ ðåöåïòîðíîãî àïïàðàòà ýíäîòåëèàëüíîé âûñòèëêè ñîñóäîâ. Ïîä âëèÿíèåì ïîâûøåííûõ êîíöåíòðàöèé Hcy ñíèæàåòñÿ ñâÿçûâàíèå òêàíåâîãî àêòèâàòîðà ïëàçìèíîãåíà ñ ðåöåïòîðàìè ýíäîòåëèàëüíûõ êëåòîê [72].

67
Ueda S, Yamagishi S, Matsumoto Y, et al. Asymmetric dimethylarginine (ADMA) is a novel emerging risk factor for cardiovascular disease and the development of renal injury in chronic kidney disease. Clin Exp Nephrol 2007; 11(2): 115–121
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  1. In-text reference with the coordinate start=11098
    Prefix
    Íàïðèìåð, àêòèâíîñòü ôåðìåíòà ñíèæàåòñÿ ïðè ãèïîêñèè ëþáîé ýòèîëîãèè, HHcy, ãèïåðõîëåñòåðèíåìèè, ñàõàðíîì äèàáåòå, â ïðèñóòñòâèè ôàêòîðà íåêðîçà îïóõîëåé α (TNF-α), îêñèäàòèâíîì ñòðåññå è íàêîïëåíèè îêèñëåííûõ ëèïîïðîòåèäîâ íèçêîé ïëîòíîñòè (ox-LDL), ÷òî ïðèâîäèò ê íàêîïëåíèþ aDMA â ïëàçìå êðîâè
    Exact
    [62, 66–68]
    Suffix
    . Ýêñïåðèìåíòàëüíî äîêàçàíî, ÷òî ââåäåíèå êðûñàì Hcy (10 ìã/ñóò â/â, â òå÷åíèå 4 íåä) ïîâûøàåò óðîâåíü aDMA â ïëàçìå êðîâè æèâîòíûõ â 2 ðàçà [69]. Ïðè ýòîì ïîêàçàíî, ÷òî Hcy ñïîñîáåí äîçîçàâèñèìî èíãèáèðîâàòü DDAH [62].

68
Nangaku M, Nishi H, Miyata T. Role of chronic hypoxia and hypoxia inducible factor in kidney disease. Chin Med J (Engl) 2008; 121(3): 257–264
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  1. In-text reference with the coordinate start=11098
    Prefix
    Íàïðèìåð, àêòèâíîñòü ôåðìåíòà ñíèæàåòñÿ ïðè ãèïîêñèè ëþáîé ýòèîëîãèè, HHcy, ãèïåðõîëåñòåðèíåìèè, ñàõàðíîì äèàáåòå, â ïðèñóòñòâèè ôàêòîðà íåêðîçà îïóõîëåé α (TNF-α), îêñèäàòèâíîì ñòðåññå è íàêîïëåíèè îêèñëåííûõ ëèïîïðîòåèäîâ íèçêîé ïëîòíîñòè (ox-LDL), ÷òî ïðèâîäèò ê íàêîïëåíèþ aDMA â ïëàçìå êðîâè
    Exact
    [62, 66–68]
    Suffix
    . Ýêñïåðèìåíòàëüíî äîêàçàíî, ÷òî ââåäåíèå êðûñàì Hcy (10 ìã/ñóò â/â, â òå÷åíèå 4 íåä) ïîâûøàåò óðîâåíü aDMA â ïëàçìå êðîâè æèâîòíûõ â 2 ðàçà [69]. Ïðè ýòîì ïîêàçàíî, ÷òî Hcy ñïîñîáåí äîçîçàâèñèìî èíãèáèðîâàòü DDAH [62].

69
Fu YF, Xiong Y, Guo Z. A reduction of endogenous asymmetric dimethylarginine contributes to the effect of captopril on endothelial dysfunction induced by homocysteine in rats. Eur J Pharmacol 2005; 508(1–3): 167–175
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  1. In-text reference with the coordinate start=11248
    Prefix
    ëþáîé ýòèîëîãèè, HHcy, ãèïåðõîëåñòåðèíåìèè, ñàõàðíîì äèàáåòå, â ïðèñóòñòâèè ôàêòîðà íåêðîçà îïóõîëåé α (TNF-α), îêñèäàòèâíîì ñòðåññå è íàêîïëåíèè îêèñëåííûõ ëèïîïðîòåèäîâ íèçêîé ïëîòíîñòè (ox-LDL), ÷òî ïðèâîäèò ê íàêîïëåíèþ aDMA â ïëàçìå êðîâè [62, 66–68]. Ýêñïåðèìåíòàëüíî äîêàçàíî, ÷òî ââåäåíèå êðûñàì Hcy (10 ìã/ñóò â/â, â òå÷åíèå 4 íåä) ïîâûøàåò óðîâåíü aDMA â ïëàçìå êðîâè æèâîòíûõ â 2 ðàçà
    Exact
    [69]
    Suffix
    . Ïðè ýòîì ïîêàçàíî, ÷òî Hcy ñïîñîáåí äîçîçàâèñèìî èíãèáèðîâàòü DDAH [62]. Òàê, îñòðîå ââåäåíèå Hcy ïîâûøàåò óðîâåíü aDMA, à õðîíè÷åñêàÿ HHcy êîìïåíñèðóåò èçìåíåíèå óðîâíÿ aDMA, õîòÿ ìåõàíèçìû êîìïåíñàöèè åùå íå óñòàíîâëåíû [70].

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Notsu Y, Nabika T, Bokura H, et al. Evaluation of asymmetric dimethylarginine and homocysteine in microangiopathy-related cerebral damage. Am J Hypertens 2009; 22(3): 257–262
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    Prefix
    Ïðè ýòîì ïîêàçàíî, ÷òî Hcy ñïîñîáåí äîçîçàâèñèìî èíãèáèðîâàòü DDAH [62]. Òàê, îñòðîå ââåäåíèå Hcy ïîâûøàåò óðîâåíü aDMA, à õðîíè÷åñêàÿ HHcy êîìïåíñèðóåò èçìåíåíèå óðîâíÿ aDMA, õîòÿ ìåõàíèçìû êîìïåíñàöèè åùå íå óñòàíîâëåíû
    Exact
    [70]
    Suffix
    .  ýêñïåðèìåíòàõ áûëî ïîêàçàíî, ÷òî ïîâûøåíèå óðîâíÿ Hcy ïðîèñõîäèò òàêæå ïðè ïåðîðàëüíîé íàãðóçêå ìåòèîíèíîì (100 ìã/êã), íî ïîëó÷åííûå ïðè ýòîì èçìåíåíèÿ óðîâíÿ aDMA áûëè ñòàòèñòè÷åñêè íåäîñòîâåðíû [66, 71].

71
Pexa A, Boeger RH, Henle T, et al. Effects of moderate hyperhomocysteinaemia induced by 4 weeks methionineenriched diet on metabolite profile and mesenteric artery function in rats. Br J Nutr 2008; 99(5): 993–999
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  1. In-text reference with the coordinate start=11678
    Prefix
    Òàê, îñòðîå ââåäåíèå Hcy ïîâûøàåò óðîâåíü aDMA, à õðîíè÷åñêàÿ HHcy êîìïåíñèðóåò èçìåíåíèå óðîâíÿ aDMA, õîòÿ ìåõàíèçìû êîìïåíñàöèè åùå íå óñòàíîâëåíû [70].  ýêñïåðèìåíòàõ áûëî ïîêàçàíî, ÷òî ïîâûøåíèå óðîâíÿ Hcy ïðîèñõîäèò òàêæå ïðè ïåðîðàëüíîé íàãðóçêå ìåòèîíèíîì (100 ìã/êã), íî ïîëó÷åííûå ïðè ýòîì èçìåíåíèÿ óðîâíÿ aDMA áûëè ñòàòèñòè÷åñêè íåäîñòîâåðíû
    Exact
    [66, 71]
    Suffix
    . Èçáûòîê Hcy â ñîñóäèñòîì ðóñëå ïðèâîäèò ê íàðóøåíèþ ðåöåïòîðíîãî àïïàðàòà ýíäîòåëèàëüíîé âûñòèëêè ñîñóäîâ. Ïîä âëèÿíèåì ïîâûøåííûõ êîíöåíòðàöèé Hcy ñíèæàåòñÿ ñâÿçûâàíèå òêàíåâîãî àêòèâàòîðà ïëàçìèíîãåíà ñ ðåöåïòîðàìè ýíäîòåëèàëüíûõ êëåòîê [72].

72
Подчерняева НС, Вашакмадзе НС, Меграбян МФ. Факторы риска развития тромботических осложнений при системной красной волчанке и дерматомиозите у детей. Российский педиатрический журнал 2006; 5: 30–34
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  1. In-text reference with the coordinate start=11925
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    Èçáûòîê Hcy â ñîñóäèñòîì ðóñëå ïðèâîäèò ê íàðóøåíèþ ðåöåïòîðíîãî àïïàðàòà ýíäîòåëèàëüíîé âûñòèëêè ñîñóäîâ. Ïîä âëèÿíèåì ïîâûøåííûõ êîíöåíòðàöèé Hcy ñíèæàåòñÿ ñâÿçûâàíèå òêàíåâîãî àêòèâàòîðà ïëàçìèíîãåíà ñ ðåöåïòîðàìè ýíäîòåëèàëüíûõ êëåòîê
    Exact
    [72]
    Suffix
    . Ïîâûøåííûé óðîâåíü Hcy äåéñòâóåò êàê ïðîêîàãóëÿíò, ïîâûøàÿ àêòèâíîñòü òêàíåâîãî ôàêòîðà (TF) [73] è ôàêòîðà Âèëëåáðàíäà (vWF) [74]. Ïîâûøåííîå òðîìáîîáðàçîâàíèå ïðè HHcy ÿâëÿåòñÿ ñëåäñòâèåì àêòèâàöèè âñåõ êîìïîíåíòîâ ãåìîñòàçà: ñîñóäèñòîé ñòåíêè, òðîìáîöèòàðíîãî è ïëàçìåííî-êîàãóëÿöèîííîãî çâåíüåâ.

73
Khajuria A, Houston DS. Induction of monocyte tissue factor expression by homocysteine: a possible mechanism for thrombosis. Blood 2000; 96(3): 966–972
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    Prefix
    Ïîä âëèÿíèåì ïîâûøåííûõ êîíöåíòðàöèé Hcy ñíèæàåòñÿ ñâÿçûâàíèå òêàíåâîãî àêòèâàòîðà ïëàçìèíîãåíà ñ ðåöåïòîðàìè ýíäîòåëèàëüíûõ êëåòîê [72]. Ïîâûøåííûé óðîâåíü Hcy äåéñòâóåò êàê ïðîêîàãóëÿíò, ïîâûøàÿ àêòèâíîñòü òêàíåâîãî ôàêòîðà (TF)
    Exact
    [73]
    Suffix
    è ôàêòîðà Âèëëåáðàíäà (vWF) [74]. Ïîâûøåííîå òðîìáîîáðàçîâàíèå ïðè HHcy ÿâëÿåòñÿ ñëåäñòâèåì àêòèâàöèè âñåõ êîìïîíåíòîâ ãåìîñòàçà: ñîñóäèñòîé ñòåíêè, òðîìáîöèòàðíîãî è ïëàçìåííî-êîàãóëÿöèîííîãî çâåíüåâ.

74
Rodgers GM, Kane WH. Activation of endogenous factor V by a homocysteine-induced vascular endothelial cell activator. J Clin Invest 1986; 77(6): 1909–1916
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    Ïîä âëèÿíèåì ïîâûøåííûõ êîíöåíòðàöèé Hcy ñíèæàåòñÿ ñâÿçûâàíèå òêàíåâîãî àêòèâàòîðà ïëàçìèíîãåíà ñ ðåöåïòîðàìè ýíäîòåëèàëüíûõ êëåòîê [72]. Ïîâûøåííûé óðîâåíü Hcy äåéñòâóåò êàê ïðîêîàãóëÿíò, ïîâûøàÿ àêòèâíîñòü òêàíåâîãî ôàêòîðà (TF) [73] è ôàêòîðà Âèëëåáðàíäà (vWF)
    Exact
    [74]
    Suffix
    . Ïîâûøåííîå òðîìáîîáðàçîâàíèå ïðè HHcy ÿâëÿåòñÿ ñëåäñòâèåì àêòèâàöèè âñåõ êîìïîíåíòîâ ãåìîñòàçà: ñîñóäèñòîé ñòåíêè, òðîìáîöèòàðíîãî è ïëàçìåííî-êîàãóëÿöèîííîãî çâåíüåâ. HHcy ñïîñîáñòâóåò ïîâûøåíèþ àãðåãàöèîííîé ñïîñîáíîñòè òðîìáîöèòîâ è èõ àäãåçèâíûõ ñâîéñòâ.

75
Stein J, Mc Bride PE. Hyperhomocysteinemia and atherosclerotic vascular disease. Arch Intern Med 1998; 158(12): 1301–1306
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    HHcy ñïîñîáñòâóåò ïîâûøåíèþ àãðåãàöèîííîé ñïîñîáíîñòè òðîìáîöèòîâ è èõ àäãåçèâíûõ ñâîéñòâ. Çà ñ÷åò ïîíèæåíèÿ àêòèâíîñòè àíòèòðîìáèíà III è ýíäîãåííîãî ãåïàðèíà ïîä âëèÿíèåì HHcy óâåëè÷èâàåòñÿ àêòèâíîñòü òðîìáèíà, ïîâûøàåòñÿ àêòèâíîñòü V, VIII è XII ôàêòîðîâ ñâåðòûâàíèÿ êðîâè
    Exact
    [75]
    Suffix
    . Óãíåòåíèå ñèíòåçà òðîìáîìîäóëèíà âûçûâàåò ïîäàâëåíèå òðîìáîìîäóëèí-çàâèñèìîé àêòèâàöèè ïðîòåèíîâ C è S, îáëàäàþùèõ àíòèêîàãóëÿíòíîé àêòèâíîñòüþ [76]. Ïðè÷ ̧ì óñòàíîâëåíî, ÷òî èíäóöèðîâàííûå ãîìîöèñòåèíîì òðîìáîçû ÿâëÿþòñÿ ñêîðåå ðåçóëüòàòîì íàðóøåíèé ñî ñòîðîíû ýíäîòåëèàëüíûõ êëåòîê, ÷åì èçìåíåíèé â ôèçèîëîãèè ñàìèõ òðîìáîöèòîâ [34].

76
Lentz SR, Salder JE Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine. J Clin Invest 1991; 88: 1906–1914
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    Çà ñ÷åò ïîíèæåíèÿ àêòèâíîñòè àíòèòðîìáèíà III è ýíäîãåííîãî ãåïàðèíà ïîä âëèÿíèåì HHcy óâåëè÷èâàåòñÿ àêòèâíîñòü òðîìáèíà, ïîâûøàåòñÿ àêòèâíîñòü V, VIII è XII ôàêòîðîâ ñâåðòûâàíèÿ êðîâè [75]. Óãíåòåíèå ñèíòåçà òðîìáîìîäóëèíà âûçûâàåò ïîäàâëåíèå òðîìáîìîäóëèí-çàâèñèìîé àêòèâàöèè ïðîòåèíîâ C è S, îáëàäàþùèõ àíòèêîàãóëÿíòíîé àêòèâíîñòüþ
    Exact
    [76]
    Suffix
    . Ïðè÷ ̧ì óñòàíîâëåíî, ÷òî èíäóöèðîâàííûå ãîìîöèñòåèíîì òðîìáîçû ÿâëÿþòñÿ ñêîðåå ðåçóëüòàòîì íàðóøåíèé ñî ñòîðîíû ýíäîòåëèàëüíûõ êëåòîê, ÷åì èçìåíåíèé â ôèçèîëîãèè ñàìèõ òðîìáîöèòîâ [34].  ïîñëåäíèå ãîäû óäåëÿåòñÿ îñîáîå âíèìàíèå ðîëè îêñèäàòèâíîãî ñòðåññà â ïàòîãåíåçå ñåðäå÷íî-ñîñóäèñòûõ îñëîæíåíèé ïðè ÕÁÏ [77–79].

77
Himmelfarb J, Stanvinkel P, Ikizler TA, et al. The elephant in uremia: oxidant stress as a unifying concept of cardiovascular disease in uremia. Kidney Int 2002; 62: 1524–1538
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    Ïðè÷ ̧ì óñòàíîâëåíî, ÷òî èíäóöèðîâàííûå ãîìîöèñòåèíîì òðîìáîçû ÿâëÿþòñÿ ñêîðåå ðåçóëüòàòîì íàðóøåíèé ñî ñòîðîíû ýíäîòåëèàëüíûõ êëåòîê, ÷åì èçìåíåíèé â ôèçèîëîãèè ñàìèõ òðîìáîöèòîâ [34].  ïîñëåäíèå ãîäû óäåëÿåòñÿ îñîáîå âíèìàíèå ðîëè îêñèäàòèâíîãî ñòðåññà â ïàòîãåíåçå ñåðäå÷íî-ñîñóäèñòûõ îñëîæíåíèé ïðè ÕÁÏ
    Exact
    [77–79]
    Suffix
    . Ðàçâèòèþ îêñèäàòèâíîãî ñòðåññà ñïîñîáñòâóåò è HHcy [34–36, 80–82]. Ñóùåñòâóåò ãèïîòåçà, ÷òî Hcy ëåãêî àóòîîêèñëÿåòñÿ ñ îáðàçîâàíèåì ãîìîöèñòèíà, ãîìîöèñòåèí-ñìåøàííûõ äèñóëüôèäîâ è òèîëàêòîíà ãîìîöèñòåèíà.

78
Terawaki H, Yoshimura K, Hasegawa T, et al. Oxidative stress in enhanced in correlation with renal dysfunction: examination with the redox state of albumin. Kidney Int 2004; 66: 1988–1993
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    Prefix
    Ïðè÷ ̧ì óñòàíîâëåíî, ÷òî èíäóöèðîâàííûå ãîìîöèñòåèíîì òðîìáîçû ÿâëÿþòñÿ ñêîðåå ðåçóëüòàòîì íàðóøåíèé ñî ñòîðîíû ýíäîòåëèàëüíûõ êëåòîê, ÷åì èçìåíåíèé â ôèçèîëîãèè ñàìèõ òðîìáîöèòîâ [34].  ïîñëåäíèå ãîäû óäåëÿåòñÿ îñîáîå âíèìàíèå ðîëè îêñèäàòèâíîãî ñòðåññà â ïàòîãåíåçå ñåðäå÷íî-ñîñóäèñòûõ îñëîæíåíèé ïðè ÕÁÏ
    Exact
    [77–79]
    Suffix
    . Ðàçâèòèþ îêñèäàòèâíîãî ñòðåññà ñïîñîáñòâóåò è HHcy [34–36, 80–82]. Ñóùåñòâóåò ãèïîòåçà, ÷òî Hcy ëåãêî àóòîîêèñëÿåòñÿ ñ îáðàçîâàíèåì ãîìîöèñòèíà, ãîìîöèñòåèí-ñìåøàííûõ äèñóëüôèäîâ è òèîëàêòîíà ãîìîöèñòåèíà.

79
Vaziri ND. Roles of oxidative stress and antioxidant therapy in chronic kidney disease and hypertension. Curr Opin Nephrol Hypertens 2004; 13: 93–99
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    Ïðè÷ ̧ì óñòàíîâëåíî, ÷òî èíäóöèðîâàííûå ãîìîöèñòåèíîì òðîìáîçû ÿâëÿþòñÿ ñêîðåå ðåçóëüòàòîì íàðóøåíèé ñî ñòîðîíû ýíäîòåëèàëüíûõ êëåòîê, ÷åì èçìåíåíèé â ôèçèîëîãèè ñàìèõ òðîìáîöèòîâ [34].  ïîñëåäíèå ãîäû óäåëÿåòñÿ îñîáîå âíèìàíèå ðîëè îêñèäàòèâíîãî ñòðåññà â ïàòîãåíåçå ñåðäå÷íî-ñîñóäèñòûõ îñëîæíåíèé ïðè ÕÁÏ
    Exact
    [77–79]
    Suffix
    . Ðàçâèòèþ îêñèäàòèâíîãî ñòðåññà ñïîñîáñòâóåò è HHcy [34–36, 80–82]. Ñóùåñòâóåò ãèïîòåçà, ÷òî Hcy ëåãêî àóòîîêèñëÿåòñÿ ñ îáðàçîâàíèåì ãîìîöèñòèíà, ãîìîöèñòåèí-ñìåøàííûõ äèñóëüôèäîâ è òèîëàêòîíà ãîìîöèñòåèíà.

80
Tyagi N, Ovechkin AV, Lominadze D, et al. Mitochondrial mechanism of microvascular endothelial cells apoptosis in hyperhomocysteinemia. J Cell Biochem 2006; 98(5): 1150–1162
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    Prefix
    Ïðè÷ ̧ì óñòàíîâëåíî, ÷òî èíäóöèðîâàííûå ãîìîöèñòåèíîì òðîìáîçû ÿâëÿþòñÿ ñêîðåå ðåçóëüòàòîì íàðóøåíèé ñî ñòîðîíû ýíäîòåëèàëüíûõ êëåòîê, ÷åì èçìåíåíèé â ôèçèîëîãèè ñàìèõ òðîìáîöèòîâ [34].  ïîñëåäíèå ãîäû óäåëÿåòñÿ îñîáîå âíèìàíèå ðîëè îêñèäàòèâíîãî ñòðåññà â ïàòîãåíåçå ñåðäå÷íî-ñîñóäèñòûõ îñëîæíåíèé ïðè ÕÁÏ [77–79]. Ðàçâèòèþ îêñèäàòèâíîãî ñòðåññà ñïîñîáñòâóåò è HHcy
    Exact
    [34–36, 80–82]
    Suffix
    . Ñóùåñòâóåò ãèïîòåçà, ÷òî Hcy ëåãêî àóòîîêèñëÿåòñÿ ñ îáðàçîâàíèåì ãîìîöèñòèíà, ãîìîöèñòåèí-ñìåøàííûõ äèñóëüôèäîâ è òèîëàêòîíà ãîìîöèñòåèíà. Ïðè îêèñëåíèè ñóëüôãèäðèëüíûõ ãðóïï ãåíåðèðóþòñÿ ñóïåðîêñèä àíèîí (Η) èëè ïåðåêèñü âîäîðîäà (H2O2), êîòîðûå ñîáñòâåííî è îïðåäåëÿþò öèòîòîêñè÷íîñòü Hcy [80].

  2. In-text reference with the coordinate start=13335
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    Ñóùåñòâóåò ãèïîòåçà, ÷òî Hcy ëåãêî àóòîîêèñëÿåòñÿ ñ îáðàçîâàíèåì ãîìîöèñòèíà, ãîìîöèñòåèí-ñìåøàííûõ äèñóëüôèäîâ è òèîëàêòîíà ãîìîöèñòåèíà. Ïðè îêèñëåíèè ñóëüôãèäðèëüíûõ ãðóïï ãåíåðèðóþòñÿ ñóïåðîêñèä àíèîí (Η) èëè ïåðåêèñü âîäîðîäà (H2O2), êîòîðûå ñîáñòâåííî è îïðåäåëÿþò öèòîòîêñè÷íîñòü Hcy
    Exact
    [80]
    Suffix
    . Ñíèæåíèå îáìåíà Hcy, íèçêîå ñîäåðæàíèå àíòèîêñèäàíòîâ èëè âûñîêèé óðîâåíü àíãèîòåíçèíà II (Ang II) èçìåíÿþò áàëàíñ ìåæäó ïðîäóêöèåé ñâîáîäíûõ ðàäèêàëîâ è èõ íåéòðàëèçàöèåé, ïðèâîäÿ ê ñíèæåíèþ óðîâíÿ NO, óñóãóáëÿÿ ïîâðåæäåíèå ñîñóäèñòîãî ýíäîòåëèÿ [83–85] è íàðóøàÿ íîðìàëüíóþ ýíäîòåëèé-çàâèñèìóþ âàçîäèëàòàöèþ [86, 87].

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    âûñîêèé óðîâåíü àíãèîòåíçèíà II (Ang II) èçìåíÿþò áàëàíñ ìåæäó ïðîäóêöèåé ñâîáîäíûõ ðàäèêàëîâ è èõ íåéòðàëèçàöèåé, ïðèâîäÿ ê ñíèæåíèþ óðîâíÿ NO, óñóãóáëÿÿ ïîâðåæäåíèå ñîñóäèñòîãî ýíäîòåëèÿ [83–85] è íàðóøàÿ íîðìàëüíóþ ýíäîòåëèé-çàâèñèìóþ âàçîäèëàòàöèþ [86, 87]. Èññëåäîâàíèÿ ïîñëåäíèõ ëåò ïîçâîëèëè óñòàíîâèòü, ÷òî îêñèäàòèâíûé ñòðåññ ïðèâîäèò ê ïîâðåæäåíèþ ÄÍÊ è îñîáåííî ìèòîõîíäðèàëüíîé ìòÄÍÊ
    Exact
    [80, 88]
    Suffix
    , ðàçâèòèþ ìåòàáîëè÷åñêîãî ñèíäðîìà, êàðäèîìèîïàòèè, ñåðäå÷íîé íåäîñòàòî÷íîñòè è ðàííåé ñìåðòíîñòè [89–91]. Îñíîâíîå ïàòîãåííîå äåéñòâèå ñâîáîäíûõ ðàäèêàëîâ êèñëîðîäà â ìèòîõîíäðèÿõ çàêëþ÷àåòñÿ â îêèñëåíèè è ìîäèôèêàöèè îñíîâàíèé è ôåðìåíòîâ, ó÷àñòâóþùèõ â ðåïàðàöèè [92].

81
Au–Yeung KK, Woo CW, Sung FL, et al. Hyperhomocysteinemia activates nuclear factor-kappaB in endothelial cells via oxidative stress. Circ Res 2004; 94(1): 28– 36
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    Ïðè÷ ̧ì óñòàíîâëåíî, ÷òî èíäóöèðîâàííûå ãîìîöèñòåèíîì òðîìáîçû ÿâëÿþòñÿ ñêîðåå ðåçóëüòàòîì íàðóøåíèé ñî ñòîðîíû ýíäîòåëèàëüíûõ êëåòîê, ÷åì èçìåíåíèé â ôèçèîëîãèè ñàìèõ òðîìáîöèòîâ [34].  ïîñëåäíèå ãîäû óäåëÿåòñÿ îñîáîå âíèìàíèå ðîëè îêñèäàòèâíîãî ñòðåññà â ïàòîãåíåçå ñåðäå÷íî-ñîñóäèñòûõ îñëîæíåíèé ïðè ÕÁÏ [77–79]. Ðàçâèòèþ îêñèäàòèâíîãî ñòðåññà ñïîñîáñòâóåò è HHcy
    Exact
    [34–36, 80–82]
    Suffix
    . Ñóùåñòâóåò ãèïîòåçà, ÷òî Hcy ëåãêî àóòîîêèñëÿåòñÿ ñ îáðàçîâàíèåì ãîìîöèñòèíà, ãîìîöèñòåèí-ñìåøàííûõ äèñóëüôèäîâ è òèîëàêòîíà ãîìîöèñòåèíà. Ïðè îêèñëåíèè ñóëüôãèäðèëüíûõ ãðóïï ãåíåðèðóþòñÿ ñóïåðîêñèä àíèîí (Η) èëè ïåðåêèñü âîäîðîäà (H2O2), êîòîðûå ñîáñòâåííî è îïðåäåëÿþò öèòîòîêñè÷íîñòü Hcy [80].

82
Faraci FM, Lentz SR. Hyperhomocysteinemia, oxidative stress, and cerebral vascular dysfunction. Stroke 2004; 35(2): 345–347
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    Ïðè÷ ̧ì óñòàíîâëåíî, ÷òî èíäóöèðîâàííûå ãîìîöèñòåèíîì òðîìáîçû ÿâëÿþòñÿ ñêîðåå ðåçóëüòàòîì íàðóøåíèé ñî ñòîðîíû ýíäîòåëèàëüíûõ êëåòîê, ÷åì èçìåíåíèé â ôèçèîëîãèè ñàìèõ òðîìáîöèòîâ [34].  ïîñëåäíèå ãîäû óäåëÿåòñÿ îñîáîå âíèìàíèå ðîëè îêñèäàòèâíîãî ñòðåññà â ïàòîãåíåçå ñåðäå÷íî-ñîñóäèñòûõ îñëîæíåíèé ïðè ÕÁÏ [77–79]. Ðàçâèòèþ îêñèäàòèâíîãî ñòðåññà ñïîñîáñòâóåò è HHcy
    Exact
    [34–36, 80–82]
    Suffix
    . Ñóùåñòâóåò ãèïîòåçà, ÷òî Hcy ëåãêî àóòîîêèñëÿåòñÿ ñ îáðàçîâàíèåì ãîìîöèñòèíà, ãîìîöèñòåèí-ñìåøàííûõ äèñóëüôèäîâ è òèîëàêòîíà ãîìîöèñòåèíà. Ïðè îêèñëåíèè ñóëüôãèäðèëüíûõ ãðóïï ãåíåðèðóþòñÿ ñóïåðîêñèä àíèîí (Η) èëè ïåðåêèñü âîäîðîäà (H2O2), êîòîðûå ñîáñòâåííî è îïðåäåëÿþò öèòîòîêñè÷íîñòü Hcy [80].

83
Garaliene V. The main determinants of endothelial dysfunction. Medicina (Kaunas) 2006; 42(5): 362–369
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    Prefix
    Ñíèæåíèå îáìåíà Hcy, íèçêîå ñîäåðæàíèå àíòèîêñèäàíòîâ èëè âûñîêèé óðîâåíü àíãèîòåíçèíà II (Ang II) èçìåíÿþò áàëàíñ ìåæäó ïðîäóêöèåé ñâîáîäíûõ ðàäèêàëîâ è èõ íåéòðàëèçàöèåé, ïðèâîäÿ ê ñíèæåíèþ óðîâíÿ NO, óñóãóáëÿÿ ïîâðåæäåíèå ñîñóäèñòîãî ýíäîòåëèÿ
    Exact
    [83–85]
    Suffix
    è íàðóøàÿ íîðìàëüíóþ ýíäîòåëèé-çàâèñèìóþ âàçîäèëàòàöèþ [86, 87]. Èññëåäîâàíèÿ ïîñëåäíèõ ëåò ïîçâîëèëè óñòàíîâèòü, ÷òî îêñèäàòèâíûé ñòðåññ ïðèâîäèò ê ïîâðåæäåíèþ ÄÍÊ è îñîáåííî ìèòîõîíäðèàëüíîé ìòÄÍÊ [80, 88], ðàçâèòèþ ìåòàáîëè÷åñêîãî ñèíäðîìà, êàðäèîìèîïàòèè, ñåðäå÷íîé íåäîñòàòî÷íîñòè è ðàííåé ñìåðòíîñòè [89–91].

84
Fischer PA, Dominguez GN, Cuniberti LA, et al. Hyperhomocysteinemia induces renal hemodynamic dysfunction: is nitric oxide involved? J Am Soc Nephrol 2003; 14(3): 653–660
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    Prefix
    Ñíèæåíèå îáìåíà Hcy, íèçêîå ñîäåðæàíèå àíòèîêñèäàíòîâ èëè âûñîêèé óðîâåíü àíãèîòåíçèíà II (Ang II) èçìåíÿþò áàëàíñ ìåæäó ïðîäóêöèåé ñâîáîäíûõ ðàäèêàëîâ è èõ íåéòðàëèçàöèåé, ïðèâîäÿ ê ñíèæåíèþ óðîâíÿ NO, óñóãóáëÿÿ ïîâðåæäåíèå ñîñóäèñòîãî ýíäîòåëèÿ
    Exact
    [83–85]
    Suffix
    è íàðóøàÿ íîðìàëüíóþ ýíäîòåëèé-çàâèñèìóþ âàçîäèëàòàöèþ [86, 87]. Èññëåäîâàíèÿ ïîñëåäíèõ ëåò ïîçâîëèëè óñòàíîâèòü, ÷òî îêñèäàòèâíûé ñòðåññ ïðèâîäèò ê ïîâðåæäåíèþ ÄÍÊ è îñîáåííî ìèòîõîíäðèàëüíîé ìòÄÍÊ [80, 88], ðàçâèòèþ ìåòàáîëè÷åñêîãî ñèíäðîìà, êàðäèîìèîïàòèè, ñåðäå÷íîé íåäîñòàòî÷íîñòè è ðàííåé ñìåðòíîñòè [89–91].

85
Eberhardt RT, Forgione MA, Cap A, et al. Endothelial dysfunction in a murine model of mild hyperhomocyst(e)inemia. J Clin Invest 2000; 106(4): 483–491
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  1. In-text reference with the coordinate start=13589
    Prefix
    Ñíèæåíèå îáìåíà Hcy, íèçêîå ñîäåðæàíèå àíòèîêñèäàíòîâ èëè âûñîêèé óðîâåíü àíãèîòåíçèíà II (Ang II) èçìåíÿþò áàëàíñ ìåæäó ïðîäóêöèåé ñâîáîäíûõ ðàäèêàëîâ è èõ íåéòðàëèçàöèåé, ïðèâîäÿ ê ñíèæåíèþ óðîâíÿ NO, óñóãóáëÿÿ ïîâðåæäåíèå ñîñóäèñòîãî ýíäîòåëèÿ
    Exact
    [83–85]
    Suffix
    è íàðóøàÿ íîðìàëüíóþ ýíäîòåëèé-çàâèñèìóþ âàçîäèëàòàöèþ [86, 87]. Èññëåäîâàíèÿ ïîñëåäíèõ ëåò ïîçâîëèëè óñòàíîâèòü, ÷òî îêñèäàòèâíûé ñòðåññ ïðèâîäèò ê ïîâðåæäåíèþ ÄÍÊ è îñîáåííî ìèòîõîíäðèàëüíîé ìòÄÍÊ [80, 88], ðàçâèòèþ ìåòàáîëè÷åñêîãî ñèíäðîìà, êàðäèîìèîïàòèè, ñåðäå÷íîé íåäîñòàòî÷íîñòè è ðàííåé ñìåðòíîñòè [89–91].

86
Weiss N, Keller C, Hoffmann U, et al. Endothelial dysfunction and atherothrombosis in mild hyperhomocysteinemia. Vasc Med 2002; 7(3): 227–239
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    Ñíèæåíèå îáìåíà Hcy, íèçêîå ñîäåðæàíèå àíòèîêñèäàíòîâ èëè âûñîêèé óðîâåíü àíãèîòåíçèíà II (Ang II) èçìåíÿþò áàëàíñ ìåæäó ïðîäóêöèåé ñâîáîäíûõ ðàäèêàëîâ è èõ íåéòðàëèçàöèåé, ïðèâîäÿ ê ñíèæåíèþ óðîâíÿ NO, óñóãóáëÿÿ ïîâðåæäåíèå ñîñóäèñòîãî ýíäîòåëèÿ [83–85] è íàðóøàÿ íîðìàëüíóþ ýíäîòåëèé-çàâèñèìóþ âàçîäèëàòàöèþ
    Exact
    [86, 87]
    Suffix
    . Èññëåäîâàíèÿ ïîñëåäíèõ ëåò ïîçâîëèëè óñòàíîâèòü, ÷òî îêñèäàòèâíûé ñòðåññ ïðèâîäèò ê ïîâðåæäåíèþ ÄÍÊ è îñîáåííî ìèòîõîíäðèàëüíîé ìòÄÍÊ [80, 88], ðàçâèòèþ ìåòàáîëè÷åñêîãî ñèíäðîìà, êàðäèîìèîïàòèè, ñåðäå÷íîé íåäîñòàòî÷íîñòè è ðàííåé ñìåðòíîñòè [89–91].

87
Lang D, Kredan MB, Moat SJ, et al. Homocysteineinduced inhibition of endothelium-dependent relaxation in rabbit aorta: role for superoxide anions. Arterioscler Thromb Vasc Biol 2000; 20(2): 422–427
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  1. In-text reference with the coordinate start=13701
    Prefix
    Ñíèæåíèå îáìåíà Hcy, íèçêîå ñîäåðæàíèå àíòèîêñèäàíòîâ èëè âûñîêèé óðîâåíü àíãèîòåíçèíà II (Ang II) èçìåíÿþò áàëàíñ ìåæäó ïðîäóêöèåé ñâîáîäíûõ ðàäèêàëîâ è èõ íåéòðàëèçàöèåé, ïðèâîäÿ ê ñíèæåíèþ óðîâíÿ NO, óñóãóáëÿÿ ïîâðåæäåíèå ñîñóäèñòîãî ýíäîòåëèÿ [83–85] è íàðóøàÿ íîðìàëüíóþ ýíäîòåëèé-çàâèñèìóþ âàçîäèëàòàöèþ
    Exact
    [86, 87]
    Suffix
    . Èññëåäîâàíèÿ ïîñëåäíèõ ëåò ïîçâîëèëè óñòàíîâèòü, ÷òî îêñèäàòèâíûé ñòðåññ ïðèâîäèò ê ïîâðåæäåíèþ ÄÍÊ è îñîáåííî ìèòîõîíäðèàëüíîé ìòÄÍÊ [80, 88], ðàçâèòèþ ìåòàáîëè÷åñêîãî ñèíäðîìà, êàðäèîìèîïàòèè, ñåðäå÷íîé íåäîñòàòî÷íîñòè è ðàííåé ñìåðòíîñòè [89–91].

88
Ricci C, Pastukh V, Leonard J, et al. Mitochondrial DNA damage triggers mitochondrial-superoxide generation and apoptosis. Am J Physiol Cell Physiol 2008; 294(2): C413–422
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  1. In-text reference with the coordinate start=13845
    Prefix
    âûñîêèé óðîâåíü àíãèîòåíçèíà II (Ang II) èçìåíÿþò áàëàíñ ìåæäó ïðîäóêöèåé ñâîáîäíûõ ðàäèêàëîâ è èõ íåéòðàëèçàöèåé, ïðèâîäÿ ê ñíèæåíèþ óðîâíÿ NO, óñóãóáëÿÿ ïîâðåæäåíèå ñîñóäèñòîãî ýíäîòåëèÿ [83–85] è íàðóøàÿ íîðìàëüíóþ ýíäîòåëèé-çàâèñèìóþ âàçîäèëàòàöèþ [86, 87]. Èññëåäîâàíèÿ ïîñëåäíèõ ëåò ïîçâîëèëè óñòàíîâèòü, ÷òî îêñèäàòèâíûé ñòðåññ ïðèâîäèò ê ïîâðåæäåíèþ ÄÍÊ è îñîáåííî ìèòîõîíäðèàëüíîé ìòÄÍÊ
    Exact
    [80, 88]
    Suffix
    , ðàçâèòèþ ìåòàáîëè÷åñêîãî ñèíäðîìà, êàðäèîìèîïàòèè, ñåðäå÷íîé íåäîñòàòî÷íîñòè è ðàííåé ñìåðòíîñòè [89–91]. Îñíîâíîå ïàòîãåííîå äåéñòâèå ñâîáîäíûõ ðàäèêàëîâ êèñëîðîäà â ìèòîõîíäðèÿõ çàêëþ÷àåòñÿ â îêèñëåíèè è ìîäèôèêàöèè îñíîâàíèé è ôåðìåíòîâ, ó÷àñòâóþùèõ â ðåïàðàöèè [92].

89
Vartanian V, Lowell B, Minko IG, et al. The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase. Proc Natl Acad Sci USA 2006; 103(6): 1864–1869
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  1. In-text reference with the coordinate start=13954
    Prefix
    Èññëåäîâàíèÿ ïîñëåäíèõ ëåò ïîçâîëèëè óñòàíîâèòü, ÷òî îêñèäàòèâíûé ñòðåññ ïðèâîäèò ê ïîâðåæäåíèþ ÄÍÊ è îñîáåííî ìèòîõîíäðèàëüíîé ìòÄÍÊ [80, 88], ðàçâèòèþ ìåòàáîëè÷åñêîãî ñèíäðîìà, êàðäèîìèîïàòèè, ñåðäå÷íîé íåäîñòàòî÷íîñòè è ðàííåé ñìåðòíîñòè
    Exact
    [89–91]
    Suffix
    . Îñíîâíîå ïàòîãåííîå äåéñòâèå ñâîáîäíûõ ðàäèêàëîâ êèñëîðîäà â ìèòîõîíäðèÿõ çàêëþ÷àåòñÿ â îêèñëåíèè è ìîäèôèêàöèè îñíîâàíèé è ôåðìåíòîâ, ó÷àñòâóþùèõ â ðåïàðàöèè [92]. Êàê îêàçàëîñü, â ýòîì æå çàêëþ÷àåòñÿ è îäíî èç îñíîâíûõ ïîâðåæäàþùèõ äåéñòâèé Hcy [93].

90
Zhang D, Mott JL, Farrar P, et al. Mitochondrial DNA mutations activate the mitochondrial apoptotic pathway and cause dilated cardiomyopathy. Cardiovasc Res 2003; 57(1): 147– 157
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  1. In-text reference with the coordinate start=13954
    Prefix
    Èññëåäîâàíèÿ ïîñëåäíèõ ëåò ïîçâîëèëè óñòàíîâèòü, ÷òî îêñèäàòèâíûé ñòðåññ ïðèâîäèò ê ïîâðåæäåíèþ ÄÍÊ è îñîáåííî ìèòîõîíäðèàëüíîé ìòÄÍÊ [80, 88], ðàçâèòèþ ìåòàáîëè÷åñêîãî ñèíäðîìà, êàðäèîìèîïàòèè, ñåðäå÷íîé íåäîñòàòî÷íîñòè è ðàííåé ñìåðòíîñòè
    Exact
    [89–91]
    Suffix
    . Îñíîâíîå ïàòîãåííîå äåéñòâèå ñâîáîäíûõ ðàäèêàëîâ êèñëîðîäà â ìèòîõîíäðèÿõ çàêëþ÷àåòñÿ â îêèñëåíèè è ìîäèôèêàöèè îñíîâàíèé è ôåðìåíòîâ, ó÷àñòâóþùèõ â ðåïàðàöèè [92]. Êàê îêàçàëîñü, â ýòîì æå çàêëþ÷àåòñÿ è îäíî èç îñíîâíûõ ïîâðåæäàþùèõ äåéñòâèé Hcy [93].

91
Lewis W, Day BJ, Kohler JJ, et al. Decreased mtDNA, oxidative stress, cardiomyopathy, and death from transgenic cardiac targeted human mutant polymerase gamma. Lab Invest 2007; 87(4): 326–335
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  1. In-text reference with the coordinate start=13954
    Prefix
    Èññëåäîâàíèÿ ïîñëåäíèõ ëåò ïîçâîëèëè óñòàíîâèòü, ÷òî îêñèäàòèâíûé ñòðåññ ïðèâîäèò ê ïîâðåæäåíèþ ÄÍÊ è îñîáåííî ìèòîõîíäðèàëüíîé ìòÄÍÊ [80, 88], ðàçâèòèþ ìåòàáîëè÷åñêîãî ñèíäðîìà, êàðäèîìèîïàòèè, ñåðäå÷íîé íåäîñòàòî÷íîñòè è ðàííåé ñìåðòíîñòè
    Exact
    [89–91]
    Suffix
    . Îñíîâíîå ïàòîãåííîå äåéñòâèå ñâîáîäíûõ ðàäèêàëîâ êèñëîðîäà â ìèòîõîíäðèÿõ çàêëþ÷àåòñÿ â îêèñëåíèè è ìîäèôèêàöèè îñíîâàíèé è ôåðìåíòîâ, ó÷àñòâóþùèõ â ðåïàðàöèè [92]. Êàê îêàçàëîñü, â ýòîì æå çàêëþ÷àåòñÿ è îäíî èç îñíîâíûõ ïîâðåæäàþùèõ äåéñòâèé Hcy [93].

92
Hegde ML, Hazra TK, Mitra S. Functions of disordered regions in mammalian early base excision repair proteins. Cell Mol Life Sci 2010; 67(21): 3573–3587
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  1. In-text reference with the coordinate start=14122
    Prefix
    ïîñëåäíèõ ëåò ïîçâîëèëè óñòàíîâèòü, ÷òî îêñèäàòèâíûé ñòðåññ ïðèâîäèò ê ïîâðåæäåíèþ ÄÍÊ è îñîáåííî ìèòîõîíäðèàëüíîé ìòÄÍÊ [80, 88], ðàçâèòèþ ìåòàáîëè÷åñêîãî ñèíäðîìà, êàðäèîìèîïàòèè, ñåðäå÷íîé íåäîñòàòî÷íîñòè è ðàííåé ñìåðòíîñòè [89–91]. Îñíîâíîå ïàòîãåííîå äåéñòâèå ñâîáîäíûõ ðàäèêàëîâ êèñëîðîäà â ìèòîõîíäðèÿõ çàêëþ÷àåòñÿ â îêèñëåíèè è ìîäèôèêàöèè îñíîâàíèé è ôåðìåíòîâ, ó÷àñòâóþùèõ â ðåïàðàöèè
    Exact
    [92]
    Suffix
    . Êàê îêàçàëîñü, â ýòîì æå çàêëþ÷àåòñÿ è îäíî èç îñíîâíûõ ïîâðåæäàþùèõ äåéñòâèé Hcy [93]. Õî÷åòñÿ îòìåòèòü, ÷òî ïðè ÕÁÏ óðîâåíü Hcy ðàçëè÷åí íà ðàçíûõ ýòàïàõ åå ðàçâèòèÿ. Ïîâûøåíèå óðîâíÿ Hcy ïëàçìû ïðîèñõîäèò, íà÷èíàÿ ñ ðàííèõ ñòàäèé ÕÁÏ [94].

93
Duthie SJ, Grant G, Pirie LP, et al. Folate deficiency alters hepatic and colon MGMT and OGG-1 DNA repair protein expression in rats but has no effect on genome-wide DNA methylation. Cancer Prev Res (Phila) 2010; 3(1): 92–100
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  1. In-text reference with the coordinate start=14209
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    Îñíîâíîå ïàòîãåííîå äåéñòâèå ñâîáîäíûõ ðàäèêàëîâ êèñëîðîäà â ìèòîõîíäðèÿõ çàêëþ÷àåòñÿ â îêèñëåíèè è ìîäèôèêàöèè îñíîâàíèé è ôåðìåíòîâ, ó÷àñòâóþùèõ â ðåïàðàöèè [92]. Êàê îêàçàëîñü, â ýòîì æå çàêëþ÷àåòñÿ è îäíî èç îñíîâíûõ ïîâðåæäàþùèõ äåéñòâèé Hcy
    Exact
    [93]
    Suffix
    . Õî÷åòñÿ îòìåòèòü, ÷òî ïðè ÕÁÏ óðîâåíü Hcy ðàçëè÷åí íà ðàçíûõ ýòàïàõ åå ðàçâèòèÿ. Ïîâûøåíèå óðîâíÿ Hcy ïëàçìû ïðîèñõîäèò, íà÷èíàÿ ñ ðàííèõ ñòàäèé ÕÁÏ [94]. Ìàêñèìàëüíî âûñîêèõ öèôð óðîâåíü HHcy äîñòèãàåò ó ïàöèåíòîâ, ïîëó÷àþùèõ òåðàïèþ äèàëèçîì, ÷òî îáúÿñíÿåò áîëåå òÿæåëîå òå÷åíèå ñåðäå÷íî-ñîñóäèñòûõ çàáîëåâàíèé, âîçíèêàþùèõ íà ôîíå ÕÁÏ [31].

94
Bostom AG, Kronenberg F, Jacques PF, et al. Proteinuria and plasma total homocysteine levels in chronic renal disease patients with a normal range serum creatinine: critical impact of true glomerular filtration rate. Atherosclerosis 2001; 159(1): 219–223
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    Êàê îêàçàëîñü, â ýòîì æå çàêëþ÷àåòñÿ è îäíî èç îñíîâíûõ ïîâðåæäàþùèõ äåéñòâèé Hcy [93]. Õî÷åòñÿ îòìåòèòü, ÷òî ïðè ÕÁÏ óðîâåíü Hcy ðàçëè÷åí íà ðàçíûõ ýòàïàõ åå ðàçâèòèÿ. Ïîâûøåíèå óðîâíÿ Hcy ïëàçìû ïðîèñõîäèò, íà÷èíàÿ ñ ðàííèõ ñòàäèé ÕÁÏ
    Exact
    [94]
    Suffix
    . Ìàêñèìàëüíî âûñîêèõ öèôð óðîâåíü HHcy äîñòèãàåò ó ïàöèåíòîâ, ïîëó÷àþùèõ òåðàïèþ äèàëèçîì, ÷òî îáúÿñíÿåò áîëåå òÿæåëîå òå÷åíèå ñåðäå÷íî-ñîñóäèñòûõ çàáîëåâàíèé, âîçíèêàþùèõ íà ôîíå ÕÁÏ [31]. Êîëëåêòèâ àâòîðîâ [95] îòìå÷àåò, ÷òî ðàñïðîñòðàíåííîñòü HHcy íà ðàííèõ ñòàäèÿõ ÕÁÏ äîñòèãàåò 40%, óâåëè÷èâàåòñÿ äî 90% íà ïðåääèàëèçíîì ýòàïå è äî 94,7% – ó äèàëèçíûõ ïàöèåíòîâ.

95
Смирнов АВ, Добронравов ВА, Голубев РВ и др. Распространенность гипергомоцистеинемии в зависимости от стадии хронической болезни почек Нефрология 2005; 9(2): 48–52
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  1. In-text reference with the coordinate start=14575
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    Ìàêñèìàëüíî âûñîêèõ öèôð óðîâåíü HHcy äîñòèãàåò ó ïàöèåíòîâ, ïîëó÷àþùèõ òåðàïèþ äèàëèçîì, ÷òî îáúÿñíÿåò áîëåå òÿæåëîå òå÷åíèå ñåðäå÷íî-ñîñóäèñòûõ çàáîëåâàíèé, âîçíèêàþùèõ íà ôîíå ÕÁÏ [31]. Êîëëåêòèâ àâòîðîâ
    Exact
    [95]
    Suffix
    îòìå÷àåò, ÷òî ðàñïðîñòðàíåííîñòü HHcy íà ðàííèõ ñòàäèÿõ ÕÁÏ äîñòèãàåò 40%, óâåëè÷èâàåòñÿ äî 90% íà ïðåääèàëèçíîì ýòàïå è äî 94,7% – ó äèàëèçíûõ ïàöèåíòîâ. Âûÿâëåíà îáðàòíàÿ çàâèñèìîñòü ìåæäó âåëè÷èíîé ñêîðîñòè êëóáî÷êîâîé ôèëüòðàöèè (ÑÊÔ) è óðîâíåì Hcy ïëàçìû êðîâè [31, 95, 96].

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    Êîëëåêòèâ àâòîðîâ [95] îòìå÷àåò, ÷òî ðàñïðîñòðàíåííîñòü HHcy íà ðàííèõ ñòàäèÿõ ÕÁÏ äîñòèãàåò 40%, óâåëè÷èâàåòñÿ äî 90% íà ïðåääèàëèçíîì ýòàïå è äî 94,7% – ó äèàëèçíûõ ïàöèåíòîâ. Âûÿâëåíà îáðàòíàÿ çàâèñèìîñòü ìåæäó âåëè÷èíîé ñêîðîñòè êëóáî÷êîâîé ôèëüòðàöèè (ÑÊÔ) è óðîâíåì Hcy ïëàçìû êðîâè
    Exact
    [31, 95, 96]
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    . Ïðè ñíèæåíèè ÑÊÔ îò 60 äî 90 ìë/ìèí óðîâåíü Hcy ïîâûøàåòñÿ ïðèìåðíî â 2 ðàçà, à ïðè êîíöåíòðàöèè ìåíåå 60 ìë/ìèí – â 9–11 ðàç [31]. Ïðè÷èíû ðàçâèòèÿ HHcy íà ðàçíûõ ñòàäèÿõ ðàçâèòèÿ ÕÁÏ ñâÿçûâàþò ñ ïîÿâëåíèåì òóáóëîèíòåðñòèöèàëüíûõ ïîâðåæäåíèé [97], ñíèæåíèåì ïî÷å÷íûõ ôóíêöèé [39] è íàðóøåíèåì ìåòàáîëèçìà Hcy â ïî÷êàõ (ñíèæåíèå ïðîöåññîâ ðåìåòèëèðîâàíèÿ, òðàíñìåòèëèðîâàíèÿ, òðàíññóëüôóðèðîâàíèÿ)

96
Perna AF, Ingrosso D, Lombardi C, et al. Homocysteine in uremia. Am J Kidney Dis 2003; 41(3, S1.): 123–126
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    Êîëëåêòèâ àâòîðîâ [95] îòìå÷àåò, ÷òî ðàñïðîñòðàíåííîñòü HHcy íà ðàííèõ ñòàäèÿõ ÕÁÏ äîñòèãàåò 40%, óâåëè÷èâàåòñÿ äî 90% íà ïðåääèàëèçíîì ýòàïå è äî 94,7% – ó äèàëèçíûõ ïàöèåíòîâ. Âûÿâëåíà îáðàòíàÿ çàâèñèìîñòü ìåæäó âåëè÷èíîé ñêîðîñòè êëóáî÷êîâîé ôèëüòðàöèè (ÑÊÔ) è óðîâíåì Hcy ïëàçìû êðîâè
    Exact
    [31, 95, 96]
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    . Ïðè ñíèæåíèè ÑÊÔ îò 60 äî 90 ìë/ìèí óðîâåíü Hcy ïîâûøàåòñÿ ïðèìåðíî â 2 ðàçà, à ïðè êîíöåíòðàöèè ìåíåå 60 ìë/ìèí – â 9–11 ðàç [31]. Ïðè÷èíû ðàçâèòèÿ HHcy íà ðàçíûõ ñòàäèÿõ ðàçâèòèÿ ÕÁÏ ñâÿçûâàþò ñ ïîÿâëåíèåì òóáóëîèíòåðñòèöèàëüíûõ ïîâðåæäåíèé [97], ñíèæåíèåì ïî÷å÷íûõ ôóíêöèé [39] è íàðóøåíèåì ìåòàáîëèçìà Hcy â ïî÷êàõ (ñíèæåíèå ïðîöåññîâ ðåìåòèëèðîâàíèÿ, òðàíñìåòèëèðîâàíèÿ, òðàíññóëüôóðèðîâàíèÿ)

97
Kumagai H, Katoh S. Hirosawa K. Renal tubulointerstitial injury in weanling rats with hyperhomocysteinemia. Kidney Int 2002; 62: 1219–1228
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    Ïðè ñíèæåíèè ÑÊÔ îò 60 äî 90 ìë/ìèí óðîâåíü Hcy ïîâûøàåòñÿ ïðèìåðíî â 2 ðàçà, à ïðè êîíöåíòðàöèè ìåíåå 60 ìë/ìèí – â 9–11 ðàç [31]. Ïðè÷èíû ðàçâèòèÿ HHcy íà ðàçíûõ ñòàäèÿõ ðàçâèòèÿ ÕÁÏ ñâÿçûâàþò ñ ïîÿâëåíèåì òóáóëîèíòåðñòèöèàëüíûõ ïîâðåæäåíèé
    Exact
    [97]
    Suffix
    , ñíèæåíèåì ïî÷å÷íûõ ôóíêöèé [39] è íàðóøåíèåì ìåòàáîëèçìà Hcy â ïî÷êàõ (ñíèæåíèå ïðîöåññîâ ðåìåòèëèðîâàíèÿ, òðàíñìåòèëèðîâàíèÿ, òðàíññóëüôóðèðîâàíèÿ) [98]. B. Fowler îòìå÷àåò, ÷òî ó ïàöèåíòîâ â IV ñòàäèè ÕÁÏ îïðåäåëÿþòñÿ íàðóøåíèÿ ìåòàáîëèçìà ôîëèåâîé êèñëîòû, ñíèæåíà àêòèâíîñòü ôîëèëïîëèãëóòàìàò êîíüþãàçû (EC 3.4.19.9)* êèøå÷íèêà [99]. (*ýêçîñîìàëüíàÿ ïåïòèäàçà ñëèçèñòîé êèøå÷íèêà, ïðåâðàùàþùàÿ

98
Hultberg B, Andersson A, Sterner G. Plasma homocysteine in renal failure. Clin Nephrol 1993; 40(4): 230– 235
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    Ïðè÷èíû ðàçâèòèÿ HHcy íà ðàçíûõ ñòàäèÿõ ðàçâèòèÿ ÕÁÏ ñâÿçûâàþò ñ ïîÿâëåíèåì òóáóëîèíòåðñòèöèàëüíûõ ïîâðåæäåíèé [97], ñíèæåíèåì ïî÷å÷íûõ ôóíêöèé [39] è íàðóøåíèåì ìåòàáîëèçìà Hcy â ïî÷êàõ (ñíèæåíèå ïðîöåññîâ ðåìåòèëèðîâàíèÿ, òðàíñìåòèëèðîâàíèÿ, òðàíññóëüôóðèðîâàíèÿ)
    Exact
    [98]
    Suffix
    . B. Fowler îòìå÷àåò, ÷òî ó ïàöèåíòîâ â IV ñòàäèè ÕÁÏ îïðåäåëÿþòñÿ íàðóøåíèÿ ìåòàáîëèçìà ôîëèåâîé êèñëîòû, ñíèæåíà àêòèâíîñòü ôîëèëïîëèãëóòàìàò êîíüþãàçû (EC 3.4.19.9)* êèøå÷íèêà [99]. (*ýêçîñîìàëüíàÿ ïåïòèäàçà ñëèçèñòîé êèøå÷íèêà, ïðåâðàùàþùàÿ ôîëàòû èç ïîëèãëóòàìàòíîé ôîðìû â ìîíîãëóòàìàòíóþ äëÿ àáñîðáöèè ýíòåðîöèòàìè.

99
Fowler B. The folat cycle and disease in humans. Kidney Int 2001; 59(S 78): 221–229
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    ñâÿçûâàþò ñ ïîÿâëåíèåì òóáóëîèíòåðñòèöèàëüíûõ ïîâðåæäåíèé [97], ñíèæåíèåì ïî÷å÷íûõ ôóíêöèé [39] è íàðóøåíèåì ìåòàáîëèçìà Hcy â ïî÷êàõ (ñíèæåíèå ïðîöåññîâ ðåìåòèëèðîâàíèÿ, òðàíñìåòèëèðîâàíèÿ, òðàíññóëüôóðèðîâàíèÿ) [98]. B. Fowler îòìå÷àåò, ÷òî ó ïàöèåíòîâ â IV ñòàäèè ÕÁÏ îïðåäåëÿþòñÿ íàðóøåíèÿ ìåòàáîëèçìà ôîëèåâîé êèñëîòû, ñíèæåíà àêòèâíîñòü ôîëèëïîëèãëóòàìàò êîíüþãàçû (EC 3.4.19.9)* êèøå÷íèêà
    Exact
    [99]
    Suffix
    . (*ýêçîñîìàëüíàÿ ïåïòèäàçà ñëèçèñòîé êèøå÷íèêà, ïðåâðàùàþùàÿ ôîëàòû èç ïîëèãëóòàìàòíîé ôîðìû â ìîíîãëóòàìàòíóþ äëÿ àáñîðáöèè ýíòåðîöèòàìè. Ýíäîïåòèäàçà ëîêàëèçóåòñÿ âíóòðèêëåòî÷íî è îáåñïå÷èâàåò âûõîä ìîíîãëóòàìàòíîé ôîðìû ôîëàòà ÷åðåç áàçîëàòåðàëüíóþ ìåìáðàíó â êðîâü).

100
Guldener C, Donker AJM, Jacobs C et al. No net renal extraction of homocysteine in fasting humans. Kidney Int 1998; 54(1): 166–169
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    Ýêñêðåöèÿ Hcy ñ ìî÷îé ó çäîðîâîãî ÷åëîâåêà êðàéíå íåçíà÷èòåëüíà (3–10 ìêìîëü/ñóò). Ïðè àíàëèçå àðòåðèîâåíîçíîé ðàçíèöû óðîâíÿ Hcy â ïî÷êàõ ëþäåé ñ ñîõðàíåííîé èõ ôóíêöèåé êàê ïî îáùåìó, òàê è ïî ñâîáîäíîìó Hcy, C. van Guldener è ñîàâò.
    Exact
    [100]
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    íå îáíàðóæèëè ñóùåñòâåííîé ðàçíèöû, ÷òî òàêæå íå ïîçâîëÿåò îáúÿñíÿòü HHcy òîëüêî íàðóøåííûì ïî÷å÷íûì ìåòàáîëèçìîì àìèíîêèñëîòû. Êîððåêöèÿ ãèïåðãîìîöèñòåèíåìèè Ýôôåêòèâíîñòü ñïîñîáîâ íîðìàëèçàöèè HHcy äî íàñòîÿùåãî âðåìåíè îñòàåòñÿ ñïîðíîé.

101
Hustad S, Ueland PM, Vollset SE, et al. Riboflavin as a determinant of plasma total homocysteine: effect modification by the methylenetetrahydrofolate reductase C677T polymorphism. Clin Chem 2000; 46(8 Pt1): 1065–1071
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    Êîððåêöèÿ ãèïåðãîìîöèñòåèíåìèè Ýôôåêòèâíîñòü ñïîñîáîâ íîðìàëèçàöèè HHcy äî íàñòîÿùåãî âðåìåíè îñòàåòñÿ ñïîðíîé. Äëÿ êîððåêöèè HHcy îñîáåííî âàæåí óðîâåíü îáåñïå÷åííîñòè îðãàíèçìà âèòàìèíàìè Â6, Â9, B2 è Â12 è áåòàèíîì
    Exact
    [101–104]
    Suffix
    .  íåêîòîðûõ ñëó÷àÿõ äîñòàòî÷íî ââåäåíèÿ íåäîñòàþùèõ âèòàìèíîâ è áåòàèíà ëèáî òîëüêî (!) áåòàèíà [105–107], ÷òîáû ñíèçèòü óðîâåíü HHcy. Îäíàêî ïðè òåðàïèè áåòàèíîì ñëåäóåò ïðîÿâëÿòü ÷ðåçâû÷àéíóþ îñòîðîæíîñòü.

102
Schroecksnadel K, Frick B, Wirleitner B, et al. Moderate hyperhomocysteinemia and immune activation. Curr Pharm Biotechnol 2004; 5(1): 107–118
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    Êîððåêöèÿ ãèïåðãîìîöèñòåèíåìèè Ýôôåêòèâíîñòü ñïîñîáîâ íîðìàëèçàöèè HHcy äî íàñòîÿùåãî âðåìåíè îñòàåòñÿ ñïîðíîé. Äëÿ êîððåêöèè HHcy îñîáåííî âàæåí óðîâåíü îáåñïå÷åííîñòè îðãàíèçìà âèòàìèíàìè Â6, Â9, B2 è Â12 è áåòàèíîì
    Exact
    [101–104]
    Suffix
    .  íåêîòîðûõ ñëó÷àÿõ äîñòàòî÷íî ââåäåíèÿ íåäîñòàþùèõ âèòàìèíîâ è áåòàèíà ëèáî òîëüêî (!) áåòàèíà [105–107], ÷òîáû ñíèçèòü óðîâåíü HHcy. Îäíàêî ïðè òåðàïèè áåòàèíîì ñëåäóåò ïðîÿâëÿòü ÷ðåçâû÷àéíóþ îñòîðîæíîñòü.

103
Kluijtmans LA, Young IS, Boreham CA, et al. Genetic and nutritional factors contributing to hyperhomocysteinemia in young adults. Blood 2003; 101(7): 2483–2488
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    Êîððåêöèÿ ãèïåðãîìîöèñòåèíåìèè Ýôôåêòèâíîñòü ñïîñîáîâ íîðìàëèçàöèè HHcy äî íàñòîÿùåãî âðåìåíè îñòàåòñÿ ñïîðíîé. Äëÿ êîððåêöèè HHcy îñîáåííî âàæåí óðîâåíü îáåñïå÷åííîñòè îðãàíèçìà âèòàìèíàìè Â6, Â9, B2 è Â12 è áåòàèíîì
    Exact
    [101–104]
    Suffix
    .  íåêîòîðûõ ñëó÷àÿõ äîñòàòî÷íî ââåäåíèÿ íåäîñòàþùèõ âèòàìèíîâ è áåòàèíà ëèáî òîëüêî (!) áåòàèíà [105–107], ÷òîáû ñíèçèòü óðîâåíü HHcy. Îäíàêî ïðè òåðàïèè áåòàèíîì ñëåäóåò ïðîÿâëÿòü ÷ðåçâû÷àéíóþ îñòîðîæíîñòü.

104
Craig SA. Betaine in human nutrition. Am J Clin Nutr 2004; 80(3): 539–549
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    Êîððåêöèÿ ãèïåðãîìîöèñòåèíåìèè Ýôôåêòèâíîñòü ñïîñîáîâ íîðìàëèçàöèè HHcy äî íàñòîÿùåãî âðåìåíè îñòàåòñÿ ñïîðíîé. Äëÿ êîððåêöèè HHcy îñîáåííî âàæåí óðîâåíü îáåñïå÷åííîñòè îðãàíèçìà âèòàìèíàìè Â6, Â9, B2 è Â12 è áåòàèíîì
    Exact
    [101–104]
    Suffix
    .  íåêîòîðûõ ñëó÷àÿõ äîñòàòî÷íî ââåäåíèÿ íåäîñòàþùèõ âèòàìèíîâ è áåòàèíà ëèáî òîëüêî (!) áåòàèíà [105–107], ÷òîáû ñíèçèòü óðîâåíü HHcy. Îäíàêî ïðè òåðàïèè áåòàèíîì ñëåäóåò ïðîÿâëÿòü ÷ðåçâû÷àéíóþ îñòîðîæíîñòü.

105
Schwab U, Turrunen A, Toppinen L, et al. Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects. Am J Clin Nutr 2002; 76(5): 961–967
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    Äëÿ êîððåêöèè HHcy îñîáåííî âàæåí óðîâåíü îáåñïå÷åííîñòè îðãàíèçìà âèòàìèíàìè Â6, Â9, B2 è Â12 è áåòàèíîì [101–104].  íåêîòîðûõ ñëó÷àÿõ äîñòàòî÷íî ââåäåíèÿ íåäîñòàþùèõ âèòàìèíîâ è áåòàèíà ëèáî òîëüêî (!) áåòàèíà
    Exact
    [105–107]
    Suffix
    , ÷òîáû ñíèçèòü óðîâåíü HHcy. Îäíàêî ïðè òåðàïèè áåòàèíîì ñëåäóåò ïðîÿâëÿòü ÷ðåçâû÷àéíóþ îñòîðîæíîñòü.  ëèòåðàòóðå îïèñàíû ñëó÷àè, êîãäà ó ïàöèåíòîâ ñ Â6-íå÷óâñòâèòåëüíûì äåôåêòîì öèñòåèí β-ñèíòàçû ââåäåíèå áåòàèíà ïðèâîäèëî ê ðàçâèòèþ ìàññèâíîãî îò ̧êà ìîçãà [108].

106
Steenge GR, Verhoef P, Katan MB. Betaine supplementation lowers plasma homocysteine in healthy men and women. J Nutr 2003; 133(5): 1291–1295
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    Äëÿ êîððåêöèè HHcy îñîáåííî âàæåí óðîâåíü îáåñïå÷åííîñòè îðãàíèçìà âèòàìèíàìè Â6, Â9, B2 è Â12 è áåòàèíîì [101–104].  íåêîòîðûõ ñëó÷àÿõ äîñòàòî÷íî ââåäåíèÿ íåäîñòàþùèõ âèòàìèíîâ è áåòàèíà ëèáî òîëüêî (!) áåòàèíà
    Exact
    [105–107]
    Suffix
    , ÷òîáû ñíèçèòü óðîâåíü HHcy. Îäíàêî ïðè òåðàïèè áåòàèíîì ñëåäóåò ïðîÿâëÿòü ÷ðåçâû÷àéíóþ îñòîðîæíîñòü.  ëèòåðàòóðå îïèñàíû ñëó÷àè, êîãäà ó ïàöèåíòîâ ñ Â6-íå÷óâñòâèòåëüíûì äåôåêòîì öèñòåèí β-ñèíòàçû ââåäåíèå áåòàèíà ïðèâîäèëî ê ðàçâèòèþ ìàññèâíîãî îò ̧êà ìîçãà [108].

107
Olthof MR, van Vliet T, Boelsma E, et al. Low dose betaine supplementation leads to immediate and long term lowering of plasma homocysteine in healthy men and women. J Nutr 2003; 133(12): 4135–4138
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    Äëÿ êîððåêöèè HHcy îñîáåííî âàæåí óðîâåíü îáåñïå÷åííîñòè îðãàíèçìà âèòàìèíàìè Â6, Â9, B2 è Â12 è áåòàèíîì [101–104].  íåêîòîðûõ ñëó÷àÿõ äîñòàòî÷íî ââåäåíèÿ íåäîñòàþùèõ âèòàìèíîâ è áåòàèíà ëèáî òîëüêî (!) áåòàèíà
    Exact
    [105–107]
    Suffix
    , ÷òîáû ñíèçèòü óðîâåíü HHcy. Îäíàêî ïðè òåðàïèè áåòàèíîì ñëåäóåò ïðîÿâëÿòü ÷ðåçâû÷àéíóþ îñòîðîæíîñòü.  ëèòåðàòóðå îïèñàíû ñëó÷àè, êîãäà ó ïàöèåíòîâ ñ Â6-íå÷óâñòâèòåëüíûì äåôåêòîì öèñòåèí β-ñèíòàçû ââåäåíèå áåòàèíà ïðèâîäèëî ê ðàçâèòèþ ìàññèâíîãî îò ̧êà ìîçãà [108].

108
Yaghmai R, Kashani AH, Geraghty MT, et al. Progressive cerebral edema associated with high methionine levels and betaine therapy in a patient with cystathionine beta-synthase (CBS) deficiency. Am J Med Genet 2002; 108(1): 57–63
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    Îäíàêî ïðè òåðàïèè áåòàèíîì ñëåäóåò ïðîÿâëÿòü ÷ðåçâû÷àéíóþ îñòîðîæíîñòü.  ëèòåðàòóðå îïèñàíû ñëó÷àè, êîãäà ó ïàöèåíòîâ ñ Â6-íå÷óâñòâèòåëüíûì äåôåêòîì öèñòåèí β-ñèíòàçû ââåäåíèå áåòàèíà ïðèâîäèëî ê ðàçâèòèþ ìàññèâíîãî îò ̧êà ìîçãà
    Exact
    [108]
    Suffix
    . Ñóùåñòâóåò ïðèðîäíûé àíàëîã áåòàèíà – äèìåòèëñóëüôîïðîïèîíàò (DMSP, dimethyl propionate), ñîäåðæèòñÿ â áîëüøèõ êîëè÷åñòâàõ â ìîðñêèõ âîäîðîñëÿõ. Ïðè ââåäåíèè æèâîòíûì îòìå÷åíî, ÷òî îí çíà÷èòåëüíî ïðåâîñõîäèò áåòàèí ïî ýôôåêòèâíîñòè ñíèæåíèÿ óðîâíÿ Hcy [109, 110].

109
Collinsova M, Strakova J, Jiracek J, et al. Inhibition of betaine–homocysteine S-methyltransferase causes hyperhomocysteinemia in mice. J Nutr 2006; 136(6): 1493–1497
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    Ñóùåñòâóåò ïðèðîäíûé àíàëîã áåòàèíà – äèìåòèëñóëüôîïðîïèîíàò (DMSP, dimethyl propionate), ñîäåðæèòñÿ â áîëüøèõ êîëè÷åñòâàõ â ìîðñêèõ âîäîðîñëÿõ. Ïðè ââåäåíèè æèâîòíûì îòìå÷åíî, ÷òî îí çíà÷èòåëüíî ïðåâîñõîäèò áåòàèí ïî ýôôåêòèâíîñòè ñíèæåíèÿ óðîâíÿ Hcy
    Exact
    [109, 110]
    Suffix
    . U. Poge è ñîàâò. íàáëþäàëè 13 áîëüíûõ, íàõîäÿùèõñÿ íà õðîíè÷åñêîì ãåìîäèàëèçå ïî ïîâîäó êîíå÷íîé ñòàäèè ÕÁÏ, è îòðàáàòûâàëè òåðàïèþ HHcy â/â êðàòêîñðî÷íûì ââåäåíèåì ìàññèâíûõ äîç âèòàìèíîâ (B6, B9, B12) ñ ïîñëåäóþùèì óìåíüøåíèåì èõ äîçèðîâêè.

110
Strakova J, Williams KT, Gupta S, et al. Dietary intake of S-(alpha–carboxybutyl)-DL-homocysteine induces hyperhomocysteinemia in rats. Nutr Res 2010; 30(7): 492–500
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  1. In-text reference with the coordinate start=16935
    Prefix
    Ñóùåñòâóåò ïðèðîäíûé àíàëîã áåòàèíà – äèìåòèëñóëüôîïðîïèîíàò (DMSP, dimethyl propionate), ñîäåðæèòñÿ â áîëüøèõ êîëè÷åñòâàõ â ìîðñêèõ âîäîðîñëÿõ. Ïðè ââåäåíèè æèâîòíûì îòìå÷åíî, ÷òî îí çíà÷èòåëüíî ïðåâîñõîäèò áåòàèí ïî ýôôåêòèâíîñòè ñíèæåíèÿ óðîâíÿ Hcy
    Exact
    [109, 110]
    Suffix
    . U. Poge è ñîàâò. íàáëþäàëè 13 áîëüíûõ, íàõîäÿùèõñÿ íà õðîíè÷åñêîì ãåìîäèàëèçå ïî ïîâîäó êîíå÷íîé ñòàäèè ÕÁÏ, è îòðàáàòûâàëè òåðàïèþ HHcy â/â êðàòêîñðî÷íûì ââåäåíèåì ìàññèâíûõ äîç âèòàìèíîâ (B6, B9, B12) ñ ïîñëåäóþùèì óìåíüøåíèåì èõ äîçèðîâêè.

111
Poge U, Look M, Gerhardt T, et al. Intravenous treatment of hyperhomocysteinemia in patients on chronic hemodialysis. A pilot study. Renal Failure 2004; 26(6): 703–708
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  1. In-text reference with the coordinate start=17285
    Prefix
    Poge è ñîàâò. íàáëþäàëè 13 áîëüíûõ, íàõîäÿùèõñÿ íà õðîíè÷åñêîì ãåìîäèàëèçå ïî ïîâîäó êîíå÷íîé ñòàäèè ÕÁÏ, è îòðàáàòûâàëè òåðàïèþ HHcy â/â êðàòêîñðî÷íûì ââåäåíèåì ìàññèâíûõ äîç âèòàìèíîâ (B6, B9, B12) ñ ïîñëåäóþùèì óìåíüøåíèåì èõ äîçèðîâêè. Àâòîðû óêàçûâàþò, ÷òî ïðèìåíåíèå ýòîãî êîìïëåêñà âèòàìèíîâ – ýôôåêòèâíîå ñðåäñòâî ëå÷åíèÿ HHcy
    Exact
    [111]
    Suffix
    . Ïî äàííûì äðóãèõ èññëåäîâàòåëåé, ïðèìåíåíèå âèòàìèíà B12 ïðèâîäèëî ê ñíèæåíèþ Hcy íà 15%, à âîò äîáàâëåíèå âèòàìèíà Â6 ïðàêòè÷åñêè íå âëèÿëî íà óðîâåíü Hcy [10, 15]. M.E. Francis è ñîàâò. ñ÷èòàþò, ÷òî ïðè ÕÁÏ óðîâåíü ãîìîöèñòåèíà ïîâûøàåòñÿ íåçàâèñèìî îò ïðèåìà âèòàìèíîâ ãðóïïû  [31].

112
Brattstrum L. Vitamins as homocysteine-lowering agents. J Nutr 1996; 126(4 Suppl): 1276S–1280S
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  1. In-text reference with the coordinate start=17703
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    Francis è ñîàâò. ñ÷èòàþò, ÷òî ïðè ÕÁÏ óðîâåíü ãîìîöèñòåèíà ïîâûøàåòñÿ íåçàâèñèìî îò ïðèåìà âèòàìèíîâ ãðóïïû  [31]. L. Brattstrum îòìå÷àåò, ÷òî âèòàìèíû Â12 è Â6 îêàçûâàþò âëèÿíèå íà óðîâåíü Hcy ëèøü â ñëó÷àÿõ èõ íåäîñòàòî÷íîñòè â îðãàíèçìå
    Exact
    [112]
    Suffix
    . Ïðîâåäåííûå èññëåäîâàíèÿ ñðåäè ìîëîäûõ ëþäåé [10] ïîêàçàëè, ÷òî ó íèõ ñóùåñòâóåò èñõîäíàÿ íåäîñòàòî÷íîñòü âèòàìèíà Â12 è ôîëèåâîé êèñëîòû. Êàê ðàçäåëüíîå, òàê è ñîâìåñòíîå ââåäåíèå ýòèõ âèòàìèíîâ ñíèæàëî óðîâåíü Hcy êðîâè, ïðè÷ ̧ì ïðè ñîâìåñòíîì ââåäåíèè ýôôåêò ïðàêòè÷åñêè ñóììèðîâàëñÿ è ñîñòàâèë ïðèìåðíî 30%.

113
Cattaneo M. Hyperhomocysteinemia: an important risk factor for cardiovascular disease? Potentially,yes. J Thromb Haemost 2003; 1: 1878–1879
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  1. In-text reference with the coordinate start=18267
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    Íåò îäíîçíà÷íîãî ìíåíèÿ î âëèÿíèè âèòàìèíîâ Â12 è Â6 íà ñîñòîÿíèå ýíäîòåëèÿ. Ïî äàííûì îäíèõ èññëåäîâàòåëåé, òåðàïèÿ âèòàìèíàìè ýòîé ãðóïïû íå óëó÷øàåò ôóíêöèîíàëüíîå ñîñòîÿíèå ýíäîòåëèÿ è, ñëåäîâàòåëüíî, íå óìåíüøàåò ñîñóäèñòûå îñëîæíåíèÿ
    Exact
    [113]
    Suffix
    , äðóãèå – èìåþò ïðîòèâîïîëîæíóþ òî÷êó çðåíèÿ [114]. Äèñêóòèðóåòñÿ òàêæå ýôôåêòèâíîñòü ïðèìåíåíèÿ ôîëèåâîé êèñëîòû äëÿ êîððåêöèè HHcy. Ìíîãèìè àâòîðàìè ïîääåðæèâàåòñÿ íàçíà÷åíèå ôîëèåâîé êèñëîòû â äîçå, çíà÷èòåëüíî ïðåâûøàþùåé ñòàíäàðòíóþ ëå÷åáíóþ [53, 115, 116].

114
Chambers JC, Ueland PM, Obeid OA, et al. Improved vascular endothelial function after oral B vitamins: An effect mediated through reduced concentrations of free plasma homocysteine. Circulation 2000; 102(20): 2479–2483
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  1. In-text reference with the coordinate start=18319
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    Ïî äàííûì îäíèõ èññëåäîâàòåëåé, òåðàïèÿ âèòàìèíàìè ýòîé ãðóïïû íå óëó÷øàåò ôóíêöèîíàëüíîå ñîñòîÿíèå ýíäîòåëèÿ è, ñëåäîâàòåëüíî, íå óìåíüøàåò ñîñóäèñòûå îñëîæíåíèÿ [113], äðóãèå – èìåþò ïðîòèâîïîëîæíóþ òî÷êó çðåíèÿ
    Exact
    [114]
    Suffix
    . Äèñêóòèðóåòñÿ òàêæå ýôôåêòèâíîñòü ïðèìåíåíèÿ ôîëèåâîé êèñëîòû äëÿ êîððåêöèè HHcy. Ìíîãèìè àâòîðàìè ïîääåðæèâàåòñÿ íàçíà÷åíèå ôîëèåâîé êèñëîòû â äîçå, çíà÷èòåëüíî ïðåâûøàþùåé ñòàíäàðòíóþ ëå÷åáíóþ [53, 115, 116].

115
Stam F, van Guldener C. Effect of folic acid on methionine and homocysteine metabolism in end-stage renal disease. Kidney Int 2005; 67(1): 259–264
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  1. In-text reference with the coordinate start=18570
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    Äèñêóòèðóåòñÿ òàêæå ýôôåêòèâíîñòü ïðèìåíåíèÿ ôîëèåâîé êèñëîòû äëÿ êîððåêöèè HHcy. Ìíîãèìè àâòîðàìè ïîääåðæèâàåòñÿ íàçíà÷åíèå ôîëèåâîé êèñëîòû â äîçå, çíà÷èòåëüíî ïðåâûøàþùåé ñòàíäàðòíóþ ëå÷åáíóþ
    Exact
    [53, 115, 116]
    Suffix
    . Ó ëèö ñ ñîõðàíåííîé ôóíêöèåé ïî÷åê ïðèìåíåíèå â äîçå 0,4– 0,5 ìã/ñóò ïðèâîäèò ê ñòîéêîìó ñíèæåíèþ óðîâíÿ Hcy [10, 15, 117]. G. Buccianti è ñîàâò. [53] íàçíà÷àëè ïàöèåíòàì íà ãåìîäèàëèçå 5-ìåòèë-THF â òå÷åíèå 10 íåä. ïî 45 ìã/íåä âíóòðèâåííî, ïîñëåäíèå 2 íåä êîìáèíèðóÿ ñ 500 ìêã âèòàìèíà Â12 (ïîäêîæíî 2 ðàçà/íåä).

116
McCully KS. Homocysteine, vitamins, and vascular disease prevention. Am J Clin Nutr 2007; 86: 1563S–1568S
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  1. In-text reference with the coordinate start=18570
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    Äèñêóòèðóåòñÿ òàêæå ýôôåêòèâíîñòü ïðèìåíåíèÿ ôîëèåâîé êèñëîòû äëÿ êîððåêöèè HHcy. Ìíîãèìè àâòîðàìè ïîääåðæèâàåòñÿ íàçíà÷åíèå ôîëèåâîé êèñëîòû â äîçå, çíà÷èòåëüíî ïðåâûøàþùåé ñòàíäàðòíóþ ëå÷åáíóþ
    Exact
    [53, 115, 116]
    Suffix
    . Ó ëèö ñ ñîõðàíåííîé ôóíêöèåé ïî÷åê ïðèìåíåíèå â äîçå 0,4– 0,5 ìã/ñóò ïðèâîäèò ê ñòîéêîìó ñíèæåíèþ óðîâíÿ Hcy [10, 15, 117]. G. Buccianti è ñîàâò. [53] íàçíà÷àëè ïàöèåíòàì íà ãåìîäèàëèçå 5-ìåòèë-THF â òå÷åíèå 10 íåä. ïî 45 ìã/íåä âíóòðèâåííî, ïîñëåäíèå 2 íåä êîìáèíèðóÿ ñ 500 ìêã âèòàìèíà Â12 (ïîäêîæíî 2 ðàçà/íåä).

117
Samman S, Sivarajah G, Man JC, et al. A mixed fruit and vegetable concentrate increases plasma antioxidant vitamins and folate and lowers plasma homocysteine in men. J Nutr 2003; 133(7): 2188–2193
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  1. In-text reference with the coordinate start=18694
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    Ìíîãèìè àâòîðàìè ïîääåðæèâàåòñÿ íàçíà÷åíèå ôîëèåâîé êèñëîòû â äîçå, çíà÷èòåëüíî ïðåâûøàþùåé ñòàíäàðòíóþ ëå÷åáíóþ [53, 115, 116]. Ó ëèö ñ ñîõðàíåííîé ôóíêöèåé ïî÷åê ïðèìåíåíèå â äîçå 0,4– 0,5 ìã/ñóò ïðèâîäèò ê ñòîéêîìó ñíèæåíèþ óðîâíÿ Hcy
    Exact
    [10, 15, 117]
    Suffix
    . G. Buccianti è ñîàâò. [53] íàçíà÷àëè ïàöèåíòàì íà ãåìîäèàëèçå 5-ìåòèë-THF â òå÷åíèå 10 íåä. ïî 45 ìã/íåä âíóòðèâåííî, ïîñëåäíèå 2 íåä êîìáèíèðóÿ ñ 500 ìêã âèòàìèíà Â12 (ïîäêîæíî 2 ðàçà/íåä). Óðîâåíü Hcy ñíèçèëñÿ íà 47% ïîñëå ââåäåíèÿ ôîëàòà è åùå íà 13,6% ïîñëå äîáàâëåíèÿ âèòàìèíà Â12.

118
Stroes ESG, van Faassen EE, Martasek P, et al. Folic acid reverts dysfunction of endothelial nitric oxide synthase. Circ Res 2000; 86(11): 1129–1134
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  1. In-text reference with the coordinate start=19240
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    Ýíäîòåëèé-çàâèñèìàÿ âàçîäèëàòàöèÿ óëó÷øèëàñü íà 12,52% ïîñëå íàçíà÷åíèÿ ôîëàòà è íå èçìåíÿëàñü ïîñëå äîáàâëåíèÿ âèòàìèíà Â12. E.S.G. Stroes òàêæå îòìå÷àåò, ÷òî ïðè ïðèìåíåíèè ôîëèåâîé êèñëîòû óìåíüøàåòñÿ ïðîäóêöèÿ ñóïåðîêñèäà è ïîâûøàåòñÿ ïðîäóêöèÿ NO
    Exact
    [118]
    Suffix
    .  ëèòåðàòóðå îáñóæäàåòñÿ è ïðèìåíåíèå ñòàòèíîâ äëÿ íîðìàëèçàöèè îêñèäàíòíîãî ñòàòóñà îðãàíèçìà. Ó ïàöèåíòîâ ñ ãèïåðõîëåñòåðèíåìèåé îòìå÷åíà ïîëîæèòåëüíàÿ äèíàìèêà íà ôîíå ëå÷åíèÿ [119, 120]. Ðÿäîì àâòîðîâ èçó÷àëîñü ïðèìåíåíèå ãèïîëèïèäåìè÷åñêèõ ïðåïàðàòîâ íà ôîíå äèàëèçíîé òåðàïèè.

119
Sakabe K, Fukuda N, Wakayama K, et al. Lipidaltering changes and pleiotropic effects of atorvastatin in patients with hypercholesterolemia. Am J Cardiol 2004; 94: 497–500
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  1. In-text reference with the coordinate start=19425
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    Stroes òàêæå îòìå÷àåò, ÷òî ïðè ïðèìåíåíèè ôîëèåâîé êèñëîòû óìåíüøàåòñÿ ïðîäóêöèÿ ñóïåðîêñèäà è ïîâûøàåòñÿ ïðîäóêöèÿ NO [118].  ëèòåðàòóðå îáñóæäàåòñÿ è ïðèìåíåíèå ñòàòèíîâ äëÿ íîðìàëèçàöèè îêñèäàíòíîãî ñòàòóñà îðãàíèçìà. Ó ïàöèåíòîâ ñ ãèïåðõîëåñòåðèíåìèåé îòìå÷åíà ïîëîæèòåëüíàÿ äèíàìèêà íà ôîíå ëå÷åíèÿ
    Exact
    [119, 120]
    Suffix
    . Ðÿäîì àâòîðîâ èçó÷àëîñü ïðèìåíåíèå ãèïîëèïèäåìè÷åñêèõ ïðåïàðàòîâ íà ôîíå äèàëèçíîé òåðàïèè. Ðåçóëüòàòû îêàçàëèñü ïðîòèâîðå÷èâûìè: îòñóòñòâèå ýôôåêòà ïðè èçîëèðîâàííîì ïðèåìå ñòàòèíîâ [121] è ïîëîæèòåëüíûé ðåçóëüòàò ïðè ñî÷åòàíèè ñòàòèíîâ ñ âèòàìèíîì Å, ôîëèåâîé êèñëîòîé, ïèðèäîêñèíîì è öèàíîêîáàëàìèíîì [122].

120
Zhang B, Noda K, Matsunaga A, et al. A comparative crossover study of the effects of fluvastatin and pravastatin (FP-COS) on circulating autoantibodies to oxidized LDL in patients with hypercholesterolemia. J Atheroscler Thromb 2005; 12: 41–47
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  1. In-text reference with the coordinate start=19425
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    Stroes òàêæå îòìå÷àåò, ÷òî ïðè ïðèìåíåíèè ôîëèåâîé êèñëîòû óìåíüøàåòñÿ ïðîäóêöèÿ ñóïåðîêñèäà è ïîâûøàåòñÿ ïðîäóêöèÿ NO [118].  ëèòåðàòóðå îáñóæäàåòñÿ è ïðèìåíåíèå ñòàòèíîâ äëÿ íîðìàëèçàöèè îêñèäàíòíîãî ñòàòóñà îðãàíèçìà. Ó ïàöèåíòîâ ñ ãèïåðõîëåñòåðèíåìèåé îòìå÷åíà ïîëîæèòåëüíàÿ äèíàìèêà íà ôîíå ëå÷åíèÿ
    Exact
    [119, 120]
    Suffix
    . Ðÿäîì àâòîðîâ èçó÷àëîñü ïðèìåíåíèå ãèïîëèïèäåìè÷åñêèõ ïðåïàðàòîâ íà ôîíå äèàëèçíîé òåðàïèè. Ðåçóëüòàòû îêàçàëèñü ïðîòèâîðå÷èâûìè: îòñóòñòâèå ýôôåêòà ïðè èçîëèðîâàííîì ïðèåìå ñòàòèíîâ [121] è ïîëîæèòåëüíûé ðåçóëüòàò ïðè ñî÷åòàíèè ñòàòèíîâ ñ âèòàìèíîì Å, ôîëèåâîé êèñëîòîé, ïèðèäîêñèíîì è öèàíîêîáàëàìèíîì [122].

121
Wanner C, Krane V, Marz W, et al. Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis. N Engl J Med 2005; 353: 238–248
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  1. In-text reference with the coordinate start=19622
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    Ó ïàöèåíòîâ ñ ãèïåðõîëåñòåðèíåìèåé îòìå÷åíà ïîëîæèòåëüíàÿ äèíàìèêà íà ôîíå ëå÷åíèÿ [119, 120]. Ðÿäîì àâòîðîâ èçó÷àëîñü ïðèìåíåíèå ãèïîëèïèäåìè÷åñêèõ ïðåïàðàòîâ íà ôîíå äèàëèçíîé òåðàïèè. Ðåçóëüòàòû îêàçàëèñü ïðîòèâîðå÷èâûìè: îòñóòñòâèå ýôôåêòà ïðè èçîëèðîâàííîì ïðèåìå ñòàòèíîâ
    Exact
    [121]
    Suffix
    è ïîëîæèòåëüíûé ðåçóëüòàò ïðè ñî÷åòàíèè ñòàòèíîâ ñ âèòàìèíîì Å, ôîëèåâîé êèñëîòîé, ïèðèäîêñèíîì è öèàíîêîáàëàìèíîì [122]. Òàêèì îáðàçîì, íå îñòàâëÿåò ñîìíåíèÿ âëèÿíèå ãèïåðãîìîöèñòåèíåìèè, êàê îäíîãî èç ôàêòîðîâ, ñïîñîáñòâóþùèõ ðàçâèòèþ è ïðîãðåññèðîâàíèþ õðîíè÷åñêîé áîëåçíè ïî÷åê.

122
Nanayakkara WB, van Guldener C, ter Wee PM, et al. Effect of a treatment strategy consisting of pravastatin, vitamin E, and homocysteine lowering on carotid intima-media thickness, endothelial function, and renal function in patients with mild to moderate chronic kidney disease results from the
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  1. In-text reference with the coordinate start=19741
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    Ðåçóëüòàòû îêàçàëèñü ïðîòèâîðå÷èâûìè: îòñóòñòâèå ýôôåêòà ïðè èçîëèðîâàííîì ïðèåìå ñòàòèíîâ [121] è ïîëîæèòåëüíûé ðåçóëüòàò ïðè ñî÷åòàíèè ñòàòèíîâ ñ âèòàìèíîì Å, ôîëèåâîé êèñëîòîé, ïèðèäîêñèíîì è öèàíîêîáàëàìèíîì
    Exact
    [122]
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    . Òàêèì îáðàçîì, íå îñòàâëÿåò ñîìíåíèÿ âëèÿíèå ãèïåðãîìîöèñòåèíåìèè, êàê îäíîãî èç ôàêòîðîâ, ñïîñîáñòâóþùèõ ðàçâèòèþ è ïðîãðåññèðîâàíèþ õðîíè÷åñêîé áîëåçíè ïî÷åê. Èññëåäîâàíèå óðîâíÿ ãîìîöèñòåèíà â êëèíè÷åñêîé ïðàêòèêå ïðè çàáîëåâàíèÿõ ïî÷åê îñîáåííî íåîáõîäèìî íà ðàííèõ ñòàäèÿõ ðàçâèòèÿ ÕÁÏ.